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Today — December 3rd 2024دانشگاه‌ها
  • ✇MIT News
  • How mass migration remade postwar EuropePeter Dizikes | MIT News
    Migrants have become a flashpoint in global politics. But new research by an MIT political scientist, focused on West Germany and Poland after World War II, shows that in the long term, those countries developed stronger states, more prosperous economies, and more entrepreneurship after receiving a large influx of immigrants.Those findings come from a close examination, at the local level over many decades, of the communities receiving migrants as millions of people relocated westward when Europ
     

How mass migration remade postwar Europe

December 3rd 2024 at 9:00 pm

Migrants have become a flashpoint in global politics. But new research by an MIT political scientist, focused on West Germany and Poland after World War II, shows that in the long term, those countries developed stronger states, more prosperous economies, and more entrepreneurship after receiving a large influx of immigrants.

Those findings come from a close examination, at the local level over many decades, of the communities receiving migrants as millions of people relocated westward when Europe’s postwar borders were redrawn.

“I found that places experiencing large-scale displacement [immigration] wound up accumulating state capacity, versus places that did not,” says Volha Charnysh, the Ford Career Development Associate Professor in MIT’s Department of Political Science.

Charnysh’s new book, “Uprooted: How Post-WWII Population Transfers Remade Europe,” published by Cambridge University Press, challenges the notion that migrants have a negative impact on receiving communities.

The time frame of the analysis is important. Much discussion about refugees involves the short-term strains they place on institutions or the backlash they provoke in local communities. Charnysh’s research does reveal tensions in the postwar communities that received large numbers of refugees. But her work, distinctively, also quantifies long-run outcomes, producing a different overall picture.

As Charnysh writes in the book, “Counterintuitively, mass displacement ended up strengthening the state and improving economic performance in the long run.”

Extracting data from history

World War II wrought a colossal amount of death, destruction, and suffering, including the Holocaust, the genocide of about 6 million European Jews. The ensuing peace settlement among the Allied Powers led to large-scale population transfers. Poland saw its borders moved about 125 miles west; it was granted formerly German territory while ceding eastern territory to the Soviet Union. Its new region became 80 percent filled by new migrants, including Poles displaced from the east and voluntary migrants from other parts of the country and from abroad. West Germany received an influx of 12.5 million Germans displaced from Poland and other parts of Europe.

To study the impact of these population transfers, Charnysh used historical records to create four original quantitative datasets at the municipal and county level, while also examining archival documents, memoirs, and newspapers to better understand the texture of the time. The assignment of refugees to specific communities within Poland and West Germany amounted to a kind of historical natural experiment, allowing her to compare how the size and regional composition of the migrant population affected otherwise similar areas.

Additionally, studying forced displacement — as opposed to the movement of a self-selected group of immigrants — meant Charnysh could rigorously examine the scaled-up effects of mass migration.

“It has been an opportunity to study in a more robust way the consequences of displacement,” Charnysh says.

The Holocaust, followed by the redrawing of borders, expulsions, and mass relocations, appeared to increase the homogeneity of the populations within them: In 1931 Poland consisted of about one-third ethnic minorities, whereas after the war it became almost ethnically uniform. But one insight of Charnysh’s research is that shared ethnic or national identification does not guarantee social acceptance for migrants.

“Even if you just rearrange ethnically homogenous populations, new cleavages emerge,” Charnysh says. “People will not necessarily see others as being the same. Those who are displaced have suffered together, have a particular status in their new place, and realize their commonalities. For the native population, migrants’ arrival increased competition for jobs, housing, and state resources, so shared identities likewise emerged, and this ethnic homogeneity didn’t automatically translate into more harmonious relations.”

Yet, West Germany and Poland did assimilate these groups of immgrants into their countries. In both places, state capacity grew in the decades after the war, with the countries becoming better able to administer resources for their populations.

“The very problem, that migration and diversity can create conflict, can also create the demand for more state presence and, in cases where states are willing and able to step in, allow for the accumulation of greater state capacity over time,” Charnysh says.

State investment in migrant-receiving localities paid off. By the 1980s in West Germany, areas with greater postwar migration had higher levels of education, with more business enterprises being founded. That economic pattern emerged in Poland after it switched to a market economy in the 1990s.

Needed: Property rights and liberties

In “Uprooted,” Charnysh also discusses the conditions in which the example of West Germany and Poland may apply to other countries. For one thing, the phenomenon of migrants bolstering the economy is likeliest to occur where states offer what the scholars Daron Acemoglu and Simon Johnson of MIT and James Robinson of the University of Chicago have called “inclusive institutions,” such as property rights, additional liberties, and a commitment to the rule of law. Poland, while increasing its state capacity during the Cold War, did not realize the economic benefits of migration until the Cold War ended and it changed to a more democratic government.

Additionally, Charnysh observes, West Germany and Poland were granting citizenship to the migrants they received, making it easier for those migrants to assimilate and make demands on the state. “My complete account probably applies best to cases where migrants receive full citizenship rights,” she acknowledges.

“Uprooted” has earned praise from leading scholars. David Stasavage, dean for the social sciences and a professor of politics at New York University, has called the book a “pathbreaking study” that “upends what we thought we knew about the interaction between social cohesion and state capacity.” Charnysh’s research, he adds, “shows convincingly that areas with more diverse populations after the transfers saw greater improvements in state capacity and economic performance. This is a major addition to scholarship.”

Today there may be about 100 million displaced people around the world, including perhaps 14 million Ukrainians uprooted by war. Absorbing refugees may always be a matter of political contention. But as “Uprooted” shows, countries may realize benefits from it if they take a long-term perspective.

“When states treat refugees as temporary, they don’t provide opportunities for them to contribute and assimilate,” Charnysh says. “It’s not that I don’t think cultural differences matter to people, but it’s not as big a factor as state policies.” 

© Credit: Courtesy of Volha Charnysh and Cambridge University Press

Volha Charnysh, an assistant professor in MIT’s Department of Political Science, is the author of a new book, “Uprooted: How Post-WWII Population Transfers Remade Europe.”
  • ✇MIT News
  • An inflatable gastric balloon could help people lose weightAnne Trafton | MIT News
    Gastric balloons — silicone balloons filled with air or saline and placed in the stomach — can help people lose weight by making them feel too full to overeat. However, this effect eventually can wear off as the stomach becomes used to the sensation of fullness.To overcome that limitation, MIT engineers have designed a new type of gastric balloon that can be inflated and deflated as needed. In an animal study, they showed that inflating the balloon before a meal caused the animals to reduce thei
     

An inflatable gastric balloon could help people lose weight

December 3rd 2024 at 7:30 pm

Gastric balloons — silicone balloons filled with air or saline and placed in the stomach — can help people lose weight by making them feel too full to overeat. However, this effect eventually can wear off as the stomach becomes used to the sensation of fullness.

To overcome that limitation, MIT engineers have designed a new type of gastric balloon that can be inflated and deflated as needed. In an animal study, they showed that inflating the balloon before a meal caused the animals to reduce their food intake by 60 percent.

This type of intervention could offer an alternative for people who don’t want to undergo more invasive treatments such as gastric bypass surgery, or people who don’t respond well to weight-loss drugs, the researchers say.

“The basic concept is we can have this balloon that is dynamic, so it would be inflated right before a meal and then you wouldn’t feel hungry. Then it would be deflated in between meals,” says Giovanni Traverso, an associate professor of mechanical engineering at MIT, a gastroenterologist at Brigham and Women’s Hospital, and the senior author of the study.

Neil Zixun Jia, who received a PhD from MIT in 2023, is the lead author of the paper, which appears today in the journal Device.

An inflatable balloon

Gastric balloons filled with saline are currently approved for use in the United States. These balloons stimulate a sense of fullness in the stomach, and studies have shown that they work well, but the benefits are often temporary.

“Gastric balloons do work initially. Historically, what has been seen is that the balloon is associated with weight loss. But then in general, the weight gain resumes the same trajectory,” Traverso says. “What we reasoned was perhaps if we had a system that simulates that fullness in a transient way, meaning right before a meal, that could be a way of inducing weight loss.”

To achieve a longer-lasting effect in patients, the researchers set out to design a device that could expand and contract on demand. They created two prototypes: One is a traditional balloon that inflates and deflates, and the other is a mechanical device with four arms that expand outward, pushing out an elastic polymer shell that presses on the stomach wall.

In animal tests, the researchers found that the mechanical-arm device could effectively expand to fill the stomach, but they ended up deciding to pursue the balloon option instead.

“Our sense was that the balloon probably distributed the force better, and down the line, if you have balloon that is applying the pressure, that is probably a safer approach in the long run,” Traverso says.

The researchers’ new balloon is similar to a traditional gastric balloon, but it is inserted into the stomach through an incision in the abdominal wall. The balloon is connected to an external controller that can be attached to the skin and contains a pump that inflates and deflates the balloon when needed. Inserting this device would be similar to the procedure used to place a feeding tube into a patient’s stomach, which is commonly done for people who are unable to eat or drink.

“If people, for example, are unable to swallow, they receive food through a tube like this. We know that we can keep tubes in for years, so there is already precedent for other systems that can stay in the body for a very long time. That gives us some confidence in the longer-term compatibility of this system,” Traverso says.

Reduced food intake

In tests in animals, the researchers found that inflating the balloon before meals led to a 60 percent reduction in the amount of food consumed. These studies were done over the course of a month, but the researchers now plan to do longer-term studies to see if this reduction leads to weight loss.

“The deployment for traditional gastric balloons is usually six months, if not more, and only then you will see good amount of weight loss. We will have to evaluate our device in a similar or longer time span to prove it really works better,” Jia says.

If developed for use in humans, the new gastric balloon could offer an alternative to existing obesity treatments. Other treatments for obesity include gastric bypass surgery, “stomach stapling” (a surgical procedure in which the stomach capacity is reduced), and drugs including GLP-1 receptor agonists such as semaglutide.

The gastric balloon could be an option for patients who are not good candidates for surgery or don’t respond well to weight-loss drugs, Traverso says.

“For certain patients who are higher-risk, who cannot undergo surgery, or did not tolerate the medication or had some other contraindication, there are limited options,” he says. “Traditional gastric balloons are still being used, but they come with a caveat that eventually the weight loss can plateau, so this is a way of trying to address that fundamental limitation.”

The research was funded by MIT’s Department of Mechanical Engineering, the Karl van Tassel Career Development Professorship, the Whitaker Health Sciences Fund Fellowship, the T.S. Lin Fellowship, the MIT Undergraduate Research Opportunities Program, and the Boston University Yawkey Funded Internship Program. 

© Image: Courtesy of the researchers

The new balloon is similar to a traditional gastric balloon. It is connected to an external controller that can be attached to the skin, and the system contains a pump that inflates and deflates the balloon when needed.
  • ✇University of Cambridge
  • Professor Joya Chatterji awarded Wolfson History Prize 2024Anonymous
    This year’s Wolfson History Prize has been awarded to Joya Chatterji, Emeritus Professor of South Asian History and Fellow of Trinity College, for her book Shadows At Noon: The South Asian Twentieth Century, first published in 2023. The book charts the story of the subcontinent from the British Raj through independence and partition to the forging of the modern nations of India, Pakistan and Bangladesh. Chatterji’s history pushes back against standard narratives that emphasise differences betw
     

Professor Joya Chatterji awarded Wolfson History Prize 2024

By: Anonymous
December 3rd 2024 at 4:21 pm
Joya Chatterji at the award ceremony for the Wolfson History Prize 2024

This year’s Wolfson History Prize has been awarded to Joya Chatterji, Emeritus Professor of South Asian History and Fellow of Trinity College, for her book Shadows At Noon: The South Asian Twentieth Century, first published in 2023.

The book charts the story of the subcontinent from the British Raj through independence and partition to the forging of the modern nations of India, Pakistan and Bangladesh.

Chatterji’s history pushes back against standard narratives that emphasise differences between the three countries, and instead seeks to highlight what unites these nations and their peoples.

Interwoven with Chatterji’s personal reflections on growing up in India, this distinctive academic work uses a conversational writing style and takes a thematic rather than chronological approach. It adds to the discussions of politics and nationhood typical of other histories of the region by weaving in everyday experiences of food, cinema, and domestic life.

As a result, the cultural vibrancy of South Asia shines through the research, according to the Wolfson History Prize judges, allowing readers a more nuanced understanding of South Asian history.

A judging panel that included fellow Cambridge historians Prof Mary Beard and Prof Richard Evans, and headed by panel chair Prof David Cannadine, described Chatterji’s book as “written with verve and energy”, and said that it “beautifully blends the personal and the historical”.

“Shadows at Noon is a highly ambitious history of twentieth-century South Asia that defies easy categorisation, combining rigorous historical research with personal reminiscence and family anecdotes,” said Cannadine.  

“Chatterji writes with wit and perception, shining a light on themes that have shaped the subcontinent during this period. We extend our warmest congratulations to Joya Chatterji on her Wolfson History Prize win.”

“For over fifty years, the Wolfson History Prize has celebrated exceptional history writing that is rooted in meticulous research with engaging and accessible prose,” said Paul Ramsbottom, Chief Executive of the Wolfson Foundation.

“Shadows at Noon is a remarkable example of this, and Joya Chatterji captivates readers with her compelling storytelling of modern South Asian history.”

Shadows at Noon was also longlisted for the Women’s Prize for Non-Fiction 2024 and shortlisted for the Cundill History Prize 2024.

Now in its 52nd year, the Wolfson History Prize celebrates books that combine excellence in research with readability for a general audience.

Recent winners have included other Cambridge historians: Clare Jackson, Honorary Professor of Early Modern History, for Devil-Land: England Under Siege, 1588-1688 (2022) and David Abulafia, Professor Emeritus of Mediterranean History, for The Boundless Sea: A Human History of the Oceans (2020). Helen McCarthy, Professor of Modern and Contemporary British History, was shortlisted for Double Lives: A History of Working Motherhood in 2021.

Chatterji wins for Shadows at Noon, her genre-defying history of South Asia during the twentieth century.

Joya Chatterji at the award ceremony for the Wolfson History Prize 2024

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Yes

Prof Prakash Kumar receives 2024 Distinguished Scientist Award from the Society for In Vitro Biology, USA

Professor Prakash Kumar, from the Department of Biological Sciences at the NUS Faculty of Science, was honoured with the Distinguished Scientist Award at the 2024 World Congress on In Vitro Biology Meeting held in St. Louis, Missouri, in the United States. This award recognises outstanding scientists who have made significant contributions to the field of in vitro biology and in the development of novel technologies that have advanced in vitro biology.

A prominent figure in plant biotechnology, Prof Prakash’s primary research focuses on the physiological and molecular mechanisms of vegetative shoot development and plant responses to abiotic stresses. He has also conducted research on biomimetic membranes as an energy-saving alternative to traditional water purification methods. 

Prof Prakash believes that it is important to translate basic science research into practice. He is the founding Director of the Research Centre on Sustainable Urban Farming at NUS, which conducts research to facilitate tripling the percentage of locally grown food in Singapore. The multidisciplinary approach envisioned by the Centre focuses on optimising in vitro techniques for leafy green vegetables to address the challenges of food self-sufficiency, especially in land-scarce and densely-populated urban environments.

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  • ✇MIT News
  • Q&A: Transforming research through global collaborationsMIT Center for International Studies
    The MIT Global Seed Funds (GSF) program fosters global research collaborations with MIT faculty and their peers abroad — creating partnerships that tackle complex global issues, from climate change to health-care challenges and beyond. Administered by the MIT Center for International Studies (CIS), the GSF program has awarded more than $26 million to over 1,200 faculty research projects since its inception in 2008. Through its unique funding structure — comprising a general fund for unrestricted
     

Q&A: Transforming research through global collaborations

December 3rd 2024 at 2:15 am

The MIT Global Seed Funds (GSF) program fosters global research collaborations with MIT faculty and their peers abroad — creating partnerships that tackle complex global issues, from climate change to health-care challenges and beyond. Administered by the MIT Center for International Studies (CIS), the GSF program has awarded more than $26 million to over 1,200 faculty research projects since its inception in 2008. Through its unique funding structure — comprising a general fund for unrestricted geographical use and several specific funds within individual countries, regions, and universities — GSF supports a wide range of projects. The current call for proposals from MIT faculty and researchers with principal investigator status is open until Dec. 10

CIS recently sat down with faculty recipients Josephine Carstensen and David McGee to discuss the value and impact GSF added to their research. Carstensen, the Gilbert W. Winslow Career Development Associate Professor of Civil and Environmental Engineering, generates computational designs for large-scale structures with the intent of designing novel low-carbon solutions. McGee, the William R. Kenan, Jr. Professor in the Department of Earth, Atmospheric and Planetary Sciences (EAPS), reconstructs the patterns, pace, and magnitudes of past hydro-climate changes.

Q: How did the Global Seed Funds program connect you with global partnerships related to your research?

Carstensen: One of the projects my lab is working on is to unlock the potential of complex cast-glass structures. Through our GSF partnership with researchers at TUDelft (Netherlands), my group was able to leverage our expertise in generative design algorithms alongside the TUDelft team, who are experts in the physical casting and fabrication of glass structures. Our initial connection to TUDelft was actually through one of my graduate students who was at a conference and met TUDelft researchers. He was inspired by their work and felt there could be synergy between our labs. The question then became: How do we connect with TUDelft? And that was what led us to the Global Seed Funds program. 

McGee: Our research is based in fieldwork conducted in partnership with experts who have a rich understanding of local environments. These locations range from lake basins in Chile and Argentina to caves in northern Mexico, Vietnam, and Madagascar. GSF has been invaluable for helping foster partnerships with collaborators and universities in these different locations, enabling the pilot work and relationship-building necessary to establish longer-term, externally funded projects.

Q: Tell us more about your GSF-funded work.

Carstensen: In my research group at MIT, we live mainly in a computational regime, and we do very little proof-of-concept testing. To that point, we do not even have the facilities nor experience to physically build large-scale structures, or even specialized structures. GSF has enabled us to connect with the researchers at TUDelft who do much more experimental testing than we do. Being able to work with the experts at TUDelft within their physical realm provided valuable insights into their way of approaching problems. And, likewise, the researchers at TUDelft benefited from our expertise. It has been fruitful in ways we couldn’t have imagined within our lab at MIT.

McGee: The collaborative work supported by the GSF has focused on reconstructing how past climate changes impacted rainfall patterns around the world, using natural archives like lake sediments and cave formations. One particularly successful project has been our work in caves in northeastern Mexico, which has been conducted in partnership with researchers from the National Autonomous University of Mexico (UNAM) and a local caving group. This project has involved several MIT undergraduate and graduate students, sponsored a research symposium in Mexico City, and helped us obtain funding from the National Science Foundation for a longer-term project.

Q: You both mentioned the involvement of your graduate students. How exactly has the GSF augmented the research experience of your students?

Carstensen: The collaboration has especially benefited the graduate students from both the MIT and TUDelft teams. The opportunity presented through this project to engage in research at an international peer institution has been extremely beneficial for their academic growth and maturity. It has facilitated training in new and complementary technical areas that they would not have had otherwise and allowed them to engage with leading world experts. An example of this aspect of the project's success is that the collaboration has inspired one of my graduate students to actively pursue postdoc opportunities in Europe (including at TU Delft) after his graduation.

McGee: MIT students have traveled to caves in northeastern Mexico and to lake basins in northern Chile to conduct fieldwork and build connections with local collaborators. Samples enabled by GSF-supported projects became the focus of two graduate students’ PhD theses, two EAPS undergraduate senior theses, and multiple UROP [Undergraduate Research Opportunity Program] projects.

Q: Were there any unexpected benefits to the work funded by GSF?

Carstensen: The success of this project would not have been possible without this specific international collaboration. Both the Delft and MIT teams bring highly different essential expertise that has been necessary for the successful project outcome. It allowed both the Delft and MIT teams to gain an in-depth understanding of the expertise areas and resources of the other collaborators. Both teams have been deeply inspired. This partnership has fueled conversations about potential future projects and provided multiple outcomes, including a plan to publish two journal papers on the project outcome. The first invited publication is being finalized now.

McGee: GSF’s focus on reciprocal exchange has enabled external collaborators to spend time at MIT, sharing their work and exchanging ideas. Other funding is often focused on sending MIT researchers and students out, but GSF has helped us bring collaborators here, making the relationship more equal. A GSF-supported visit by Argentinian researchers last year made it possible for them to interact not just with my group, but with students and faculty across EAPS.

"The success of this project would not have been possible without this specific international collaboration," says Associate Professor Josephine Carstensen (left). "A GSF-supported visit by Argentinian researchers last year made it possible for them to interact not just with my group, but with students and faculty across EAPS," says Professor David McGee (right).
  • ✇Harvard Gazette
  • ‘Because Larry has shown up for us’ Al Powell
    Nation & World ‘Because Larry has shown up for us’  Friends, colleagues gather for 70th birthday conference honoring economic scholar, former Treasury Secretary and University President Lawrence Summers Alvin Powell Harvard Staff Writer December 2, 2024 4 min read Jason Furman (from left), Olivier Blanchard, and Brad DeLong. Photos by Niles Singer/Harvard Staff Photographer In introdu
     

‘Because Larry has shown up for us’ 

By: Al Powell
December 3rd 2024 at 12:13 am
Nation & World

‘Because Larry has shown up for us’ 

Friends, colleagues gather for 70th birthday conference honoring economic scholar, former Treasury Secretary and University President Lawrence Summers

Alvin Powell

Harvard Staff Writer

4 min read
Jason Furman (from left), Olivier Blanchard, and Brad DeLong speaking during the event.

Jason Furman (from left), Olivier Blanchard, and Brad DeLong.

Photos by Niles Singer/Harvard Staff Photographer

In introducing the final panel, Gene Sperling, who directed the National Economic Council for Presidents Bill Clinton and Barack Obama, remarked, “This is not a roast.”

But the recent economic policy conference marking Lawrence H. Summers’ 70th birthday was often roast-like — although always affectionate — interspersed with anecdotes from computer labs during Summers’ student days, the halls of Washington, D.C., and the president’s office in Mass Hall. Pointed comments about economic concepts prompted laughter, as did Summers — seated in the front row — who offered some good-natured rebuttals to the ribbing.

The gathering featured panels on Summers’ impact on modern finance, labor and public economics, and macroeconomics and policy. Speakers described a colleague and friend who has had a deep impact on those around him. His trademark probing questions have pushed others to think deeper, while his public positions have made a difference on topics as disparate as the recent rise and fall of inflation, passage of the Affordable Care Act, and his early recognition, in 1992, of the importance of educating girls in the developing world.

Lawrence H. Summers (pictured) speaking during the event.
Summers offered some good-natured rebuttals to the ribbing.

“No one was talking about this, but Larry did, and he single-handedly took that issue from something that education ministers care about to something finance ministers care about,” said former Meta chief operating officer Sheryl Sandberg, “And we all know the power difference between those two posts. Literally millions and millions of girls owe a change in their lives and futures to that speech.”

Today, Summers is the Charles W. Eliot University Professor and the Frank and Denie Weil Director of the Mossavar-Rahmani Center for Business and Government at the Kennedy School. His career spans studies at MIT and Harvard; the World Bank, where he was chief economist; the U.S. Treasury department, where he was secretary from 1999 to 2001; Harvard’s president’s office from 2001 to 2006; and the National Economic Council, which he directed from 2009 to 2011 under Obama.

Panelists painted a portrait of a scholar and public servant who is an innovative thinker and fearless in his thoughts and beliefs: Summers at one point remarked about a fundamental concept he still disagrees with, to knowing laughter. “I’ve lost that argument with the world, largely. I’m aware of that, but not to the extent of giving it up.”

Sheryl Sandberg.
Sheryl Sandberg described Summers’ impact on her career as profound.

Jason Furman, former chair of the Council of Economic Advisors and HKS’ Aetna Professor of the Practice of Economic Policy, described Summers’ ability to extract knowledge from those around him by focusing on a single issue or question and probing it until he was satisfied he had learned all he could. UC Berkeley Professor Brad DeLong said Summer’s questioning style went both ways: People learned more than facts and figures from him. They learned how to think differently.

“Larry’s nearly unique edge, I think, is an extremely, extremely sharp eye for what pain points are about to become salient, over and over seeing when things are changing in the macro economy so we really need to change our models to deal with skating where the puck is going to be,” said DeLong, who has been a co-author with Summers. “Because the important questions are about now and the next decade. You write even a good paper about an important question in macro from a decade ago, and you have written a paper about an unimportant question.” 

Sandberg, who graduated from Harvard Business School in 1995, said Summers’ impact on her career has been profound. She met him as a student, he advised her thesis, gave her a job at the World Bank when he was chief economist, and later at the Treasury, where she was his chief of staff. Through her career he was always willing to listen, she said, and she knows he listened to others even when they were facing public scrutiny, a time when many would shrink from associating with them.

“He never worried that he would somehow get dragged into someone else’s mess. He just showed up,” Sandberg said. “I know all of us here showed up for this day because Larry has shown up for us.” 

  • ✇Harvard Gazette
  • Score another point for the plantsTerry Murphy
    Health Score another point for the plants Study finds 1:2 ratio of plant to animal protein lowers risk of heart disease Maya Brownstein Harvard Chan School Communications December 2, 2024 4 min read Increasing the ratio of plant-based protein in your diet may reduce your risk of cardiovascular disease and coronary heart disease, finds a new study led by researchers at Harvard T.H. Chan S
     

Score another point for the plants

December 2nd 2024 at 11:56 pm
Photo of plant and meat protein sources.
Health

Score another point for the plants

Study finds 1:2 ratio of plant to animal protein lowers risk of heart disease

Maya Brownstein

Harvard Chan School Communications

4 min read

Increasing the ratio of plant-based protein in your diet may reduce your risk of cardiovascular disease and coronary heart disease, finds a new study led by researchers at Harvard T.H. Chan School of Public Health.

According to the researchers, these risk reductions are likely driven by the replacement of red and processed meats. The researchers also observed that a combination of consuming more plant protein and higher protein intake overall provided the most heart health benefits.

While global dietary guidelines recommend higher intake of plant protein, the ideal ratio of plant to animal protein has remained unknown. The study is the first to investigate this ratio and how it impacts health, specifically heart health.

Risk reductions are likely driven by the replacement of red and processed meat with several plant protein sources, particularly nuts and legumes.

“The average American eats a 1:3 plant to animal protein ratio. Our findings suggest a ratio of at least 1:2 is much more effective in preventing cardiovascular disease. For coronary heart disease prevention, a ratio of 1:1.3 or higher should come from plants,” said lead author Andrea Glenn, visiting scientist in the Department of Nutrition. Glenn worked on the study as a postdoctoral fellow at Harvard Chan School and is now an assistant professor in the Department of Nutrition and Food Studies at NYU Steinhardt.

The study was published Dec. 2 in the American Journal of Clinical Nutrition.

The researchers used 30 years of data on diet, lifestyle, and heart health among nearly 203,000 men and women enrolled in the Nurses’ Health Studies I and II and the Health Professionals’ Follow-up Study. Participants reported their dietary intake every four years. The researchers calculated each participant’s total protein intake, measured in grams per day, as well as their specific intakes of animal and plant proteins. Over the course of the study period, 16,118 cardiovascular disease cases, including over 10,000 coronary heart disease cases and over 6,000 stroke cases, were documented.

After adjusting for participants’ health history and sociodemographic and lifestyle factors, the study found that eating a higher ratio of plant to animal protein was associated with lower risks of cardiovascular disease and coronary heart disease. Compared to participants who consumed the lowest plant to animal protein ratio (~1:4.2), participants who consumed the highest (~1:1.3) had a 19 percent lower risk of cardiovascular disease and a 27 percent lower risk of coronary heart disease. These risk reductions were even higher among participants who ate more protein overall. Those who consumed the most protein (21 percent of energy coming from protein) and adhered to a higher plant to animal protein ratio saw a 28 percent lower risk of cardiovascular disease and a 36 percent lower risk of coronary heart disease, compared to those who consumed the least protein (16 percent of energy). No significant associations were found for stroke risk and the ratio; however, replacing red and processed meat in the diet with several plant sources, such as nuts, showed a lower risk of stroke.

The researchers also examined if there’s a point at which eating more plant protein stops having added benefits or could even have negative implications. They found that risk reduction for cardiovascular disease begins to plateau around a 1:2 ratio, but that coronary heart disease risk continues to decrease at higher ratios of plant to animal protein.

According to the researchers, replaving red and processed meat with plant protein sources, particularly nuts and legumes, have been found to improve cardiometabolic risk factors, including blood lipids and blood pressure as well as inflammatory biomarkers. This is partly because plant proteins are often accompanied by high amounts of fiber, antioxidant vitamins, minerals, and healthy fats.

“Most of us need to begin shifting our diets toward plant-based proteins,” said senior author Frank Hu, Fredrick J. Stare Professor of Nutrition and Epidemiology at Harvard Chan School. “We can do so by cutting down on meat, especially red and processed meats, and eating more legumes and nuts. Such a dietary pattern is beneficial not just for human health but also the health of our planet.”

The researchers pointed out that the ratios they identified are estimates, and that further studies are needed to determine the optimal balance between plant and animal protein. Additionally, further research is needed to determine how stroke risk may be impacted by protein intake.

Other Harvard Chan authors included Fenglei WangAnne-Julie TessierJoAnn MansonEric RimmKen MukamalQi Sun, and Walter Willett.

The Nurses’ Health Studies and Health Professional Follow-up Studies are supported by National Institutes of Health grants UM1 CA186107, R01 CA49449, R01 HL034594, U01 HL145386, R01 HL088521, U01 CA176726, R01 CA49449, U01 CA167552, R01 HL60712, and R01 HL35464.

Yesterday — December 2nd 2024دانشگاه‌ها
  • ✇MIT News
  • Photonic processor could enable ultrafast AI computations with extreme energy efficiencyAdam Zewe | MIT News
    The deep neural network models that power today’s most demanding machine-learning applications have grown so large and complex that they are pushing the limits of traditional electronic computing hardware.Photonic hardware, which can perform machine-learning computations with light, offers a faster and more energy-efficient alternative. However, there are some types of neural network computations that a photonic device can’t perform, requiring the use of off-chip electronics or other techniques
     

Photonic processor could enable ultrafast AI computations with extreme energy efficiency

December 2nd 2024 at 7:30 pm

The deep neural network models that power today’s most demanding machine-learning applications have grown so large and complex that they are pushing the limits of traditional electronic computing hardware.

Photonic hardware, which can perform machine-learning computations with light, offers a faster and more energy-efficient alternative. However, there are some types of neural network computations that a photonic device can’t perform, requiring the use of off-chip electronics or other techniques that hamper speed and efficiency.

Building on a decade of research, scientists from MIT and elsewhere have developed a new photonic chip that overcomes these roadblocks. They demonstrated a fully integrated photonic processor that can perform all the key computations of a deep neural network optically on the chip.

The optical device was able to complete the key computations for a machine-learning classification task in less than half a nanosecond while achieving more than 92 percent accuracy — performance that is on par with traditional hardware.

The chip, composed of interconnected modules that form an optical neural network, is fabricated using commercial foundry processes, which could enable the scaling of the technology and its integration into electronics.

In the long run, the photonic processor could lead to faster and more energy-efficient deep learning for computationally demanding applications like lidar, scientific research in astronomy and particle physics, or high-speed telecommunications.

“There are a lot of cases where how well the model performs isn’t the only thing that matters, but also how fast you can get an answer. Now that we have an end-to-end system that can run a neural network in optics, at a nanosecond time scale, we can start thinking at a higher level about applications and algorithms,” says Saumil Bandyopadhyay ’17, MEng ’18, PhD ’23, a visiting scientist in the Quantum Photonics and AI Group within the Research Laboratory of Electronics (RLE) and a postdoc at NTT Research, Inc., who is the lead author of a paper on the new chip.

Bandyopadhyay is joined on the paper by Alexander Sludds ’18, MEng ’19, PhD ’23; Nicholas Harris PhD ’17; Darius Bunandar PhD ’19; Stefan Krastanov, a former RLE research scientist who is now an assistant professor at the University of Massachusetts at Amherst; Ryan Hamerly, a visiting scientist at RLE and senior scientist at NTT Research; Matthew Streshinsky, a former silicon photonics lead at Nokia who is now co-founder and CEO of Enosemi; Michael Hochberg, president of Periplous, LLC; and Dirk Englund, a professor in the Department of Electrical Engineering and Computer Science, principal investigator of the Quantum Photonics and Artificial Intelligence Group and of RLE, and senior author of the paper. The research appears today in Nature Photonics.

Machine learning with light

Deep neural networks are composed of many interconnected layers of nodes, or neurons, that operate on input data to produce an output. One key operation in a deep neural network involves the use of linear algebra to perform matrix multiplication, which transforms data as it is passed from layer to layer.

But in addition to these linear operations, deep neural networks perform nonlinear operations that help the model learn more intricate patterns. Nonlinear operations, like activation functions, give deep neural networks the power to solve complex problems.

In 2017, Englund’s group, along with researchers in the lab of Marin Soljačić, the Cecil and Ida Green Professor of Physics, demonstrated an optical neural network on a single photonic chip that could perform matrix multiplication with light.

But at the time, the device couldn’t perform nonlinear operations on the chip. Optical data had to be converted into electrical signals and sent to a digital processor to perform nonlinear operations.

“Nonlinearity in optics is quite challenging because photons don’t interact with each other very easily. That makes it very power consuming to trigger optical nonlinearities, so it becomes challenging to build a system that can do it in a scalable way,” Bandyopadhyay explains.

They overcame that challenge by designing devices called nonlinear optical function units (NOFUs), which combine electronics and optics to implement nonlinear operations on the chip.

The researchers built an optical deep neural network on a photonic chip using three layers of devices that perform linear and nonlinear operations.

A fully-integrated network

At the outset, their system encodes the parameters of a deep neural network into light. Then, an array of programmable beamsplitters, which was demonstrated in the 2017 paper, performs matrix multiplication on those inputs.

The data then pass to programmable NOFUs, which implement nonlinear functions by siphoning off a small amount of light to photodiodes that convert optical signals to electric current. This process, which eliminates the need for an external amplifier, consumes very little energy.

“We stay in the optical domain the whole time, until the end when we want to read out the answer. This enables us to achieve ultra-low latency,” Bandyopadhyay says.

Achieving such low latency enabled them to efficiently train a deep neural network on the chip, a process known as in situ training that typically consumes a huge amount of energy in digital hardware.

“This is especially useful for systems where you are doing in-domain processing of optical signals, like navigation or telecommunications, but also in systems that you want to learn in real time,” he says.

The photonic system achieved more than 96 percent accuracy during training tests and more than 92 percent accuracy during inference, which is comparable to traditional hardware. In addition, the chip performs key computations in less than half a nanosecond.     

“This work demonstrates that computing — at its essence, the mapping of inputs to outputs — can be compiled onto new architectures of linear and nonlinear physics that enable a fundamentally different scaling law of computation versus effort needed,” says Englund.

The entire circuit was fabricated using the same infrastructure and foundry processes that produce CMOS computer chips. This could enable the chip to be manufactured at scale, using tried-and-true techniques that introduce very little error into the fabrication process.

Scaling up their device and integrating it with real-world electronics like cameras or telecommunications systems will be a major focus of future work, Bandyopadhyay says. In addition, the researchers want to explore algorithms that can leverage the advantages of optics to train systems faster and with better energy efficiency.

This research was funded, in part, by the U.S. National Science Foundation, the U.S. Air Force Office of Scientific Research, and NTT Research.

© Image: Sampson Wilcox, Research Laboratory of Electronics.

Researchers demonstrated a fully integrated photonic processor that can perform all key computations of a deep neural network optically on the chip, which could enable faster and more energy-efficient deep learning for computationally demanding applications like lidar or high-speed telecommunications.
  • ✇University of Cambridge
  • New datasets will train AI models to think like scientistssc604
    The initiative, called Polymathic AI, uses technology like that powering large language models such as OpenAI’s ChatGPT or Google’s Gemini. But instead of ingesting text, the project’s models learn using scientific datasets from across astrophysics, biology, acoustics, chemistry, fluid dynamics and more, essentially giving the models cross-disciplinary scientific knowledge. “These datasets are by far the most diverse large-scale collections of high-quality data for machine learning training eve
     

New datasets will train AI models to think like scientists

By: sc604
December 2nd 2024 at 7:29 pm
A mosaic of simulations included in the Well collection of datasets

The initiative, called Polymathic AI, uses technology like that powering large language models such as OpenAI’s ChatGPT or Google’s Gemini. But instead of ingesting text, the project’s models learn using scientific datasets from across astrophysics, biology, acoustics, chemistry, fluid dynamics and more, essentially giving the models cross-disciplinary scientific knowledge.

“These datasets are by far the most diverse large-scale collections of high-quality data for machine learning training ever assembled for these fields,” said team member Michael McCabe from the Flatiron Institute in New York City. “Curating these datasets is a critical step in creating multidisciplinary AI models that will enable new discoveries about our universe.”

Today (2 December), the Polymathic AI team has released two of its open-source training dataset collections to the public — a colossal 115 terabytes, from dozens of sources — for the scientific community to use to train AI models and enable new scientific discoveries. For comparison, GPT-3 used 45 terabytes of uncompressed, unformatted text for training, which ended up being around 0.5 terabytes after filtering.

The full datasets are available to download for free on HuggingFace, a platform hosting AI models and datasets. The Polymathic AI team provides further information about the datasets in two papers accepted for presentation at the NeurIPS machine learning conference, to be held later this month in Vancouver, Canada.

“Just as LLMs such as ChatGPT learn to use common grammatical structure across languages, these new scientific foundation models might reveal deep connections across disciplines that we’ve never noticed before,” said Cambridge team lead Dr Miles Cranmer from Cambridge’s Institute of Astronomy. “We might uncover patterns that no human can see, simply because no one has ever had both this breadth of scientific knowledge and the ability to compress it into a single framework.”

AI tools such as machine learning are increasingly common in scientific research, and were recognised in two of this year’s Nobel Prizes. Still, such tools are typically purpose-built for a specific application and trained using data from that field. The Polymathic AI project instead aims to develop models that are truly polymathic, like people whose expert knowledge spans multiple areas. The project’s team reflects intellectual diversity, with physicists, astrophysicists, mathematicians, computer scientists and neuroscientists.

The first of the two new training dataset collections focuses on astrophysics. Dubbed the Multimodal Universe, the dataset contains hundreds of millions of astronomical observations and measurements, such as portraits of galaxies taken by NASA’s James Webb Space Telescope and measurements of our galaxy’s stars made by the European Space Agency’s Gaia spacecraft.

The other collection — called the Well — comprises over 15 terabytes of data from 16 diverse datasets. These datasets contain numerical simulations of biological systems, fluid dynamics, acoustic scattering, supernova explosions and other complicated processes. Cambridge researchers played a major role in developing both dataset collections, working alongside PolymathicAI and other international collaborators.

While these diverse datasets may seem disconnected at first, they all require the modelling of mathematical equations called partial differential equations. Such equations pop up in problems related to everything from quantum mechanics to embryo development and can be incredibly difficult to solve, even for supercomputers. One of the goals of the Well is to enable AI models to churn out approximate solutions to these equations quickly and accurately.

“By uniting these rich datasets, we can drive advancements in artificial intelligence not only for scientific discovery, but also for addressing similar problems in everyday life,” said Ben Boyd, PhD student in the Institute of Astronomy.

Gathering the data for those datasets posed a challenge, said team member Ruben Ohana from the Flatiron Institute. The team collaborated with scientists to gather and create data for the project. “The creators of numerical simulations are sometimes sceptical of machine learning because of all the hype, but they’re curious about it and how it can benefit their research and accelerate scientific discovery,” he said.

The Polymathic AI team is now using the datasets to train AI models. In the coming months, they will deploy these models on various tasks to see how successful these well-rounded, well-trained AIs are at tackling complex scientific problems.

“It will be exciting to see if the complexity of these datasets can push AI models to go beyond merely recognising patterns, encouraging them to reason and generalise across scientific domains,” said Dr Payel Mukhopadhyay from the Institute of Astronomy. “Such generalisation is essential if we ever want to build AI models that can truly assist in conducting meaningful science.”

“Until now, haven’t had a curated scientific-quality dataset cover such a wide variety of fields,” said Cranmer, who is also a member of Cambridge’s Department of Applied Mathematics and Theoretical Physics. “These datasets are opening the door to true generalist scientific foundation models for the first time. What new scientific principles might we discover? We're about to find out, and that's incredibly exciting.”

The Polymathic AI project is run by researchers from the Simons Foundation and its Flatiron Institute, New York University, the University of Cambridge, Princeton University, the French Centre National de la Recherche Scientifique and the Lawrence Berkeley National Laboratory.

Members of the Polymathic AI team from the University of Cambridge include PhD students, postdoctoral researchers and faculty across four departments: the Department of Applied Mathematics and Theoretical Physics, the Department of Pure Mathematics and Mathematical Statistics, the Institute of Astronomy and the Kavli Institute for Cosmology.

What can exploding stars teach us about how blood flows through an artery? Or swimming bacteria about how the ocean’s layers mix? A collaboration of researchers, including from the University of Cambridge, has reached a milestone toward training artificial intelligence models to find and use transferable knowledge between fields to drive scientific discovery.

A mosaic of simulations included in the Well collection of datasets

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The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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  • ✇Harvard Gazette
  • Dance the audience can feel — through their phonesEileen O'Grady
    Shriya Srinivasan, artistic director of Anubhava Dance Company (second from left), performing at the Harvard Art Museums.Photo by Jodi Hilton Arts & Culture Dance the audience can feel — through their phones Eileen O’Grady Harvard Staff Writer December 2, 2024 5 min read Engineer harnesses haptics to translate movement, make her art more accessible Shriya Srinivasan danced with preci
     

Dance the audience can feel — through their phones

December 2nd 2024 at 7:32 pm
Shriya Srinivasan with Anubhava Dance Company,

Shriya Srinivasan, artistic director of Anubhava Dance Company (second from left), performing at the Harvard Art Museums.

Photo by Jodi Hilton

Arts & Culture

Dance the audience can feel — through their phones

Eileen O’Grady

Harvard Staff Writer

5 min read

Engineer harnesses haptics to translate movement, make her art more accessible

Shriya Srinivasan danced with precise steps, using graceful flicks of her wrists to depict a heroine holding a mirror and applying makeup and perfume, her expressions lit by hope and excitement. Behind her, centuries-old Indian watercolors depicted similar heroines.

The assistant professor of bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences was performing a bharata natyam dance about a common archetype in Indian paintings and dance — a vasakasajja nayika, or heroine eagerly preparing to meet her lover — for a recent event at the Harvard Art Museums. Before the dance, she explained to the audience how the brain’s prefrontal cortex heightens feelings of excitement and anticipation in love by tapping into memories and activating reward centers.

“As a dancer, I aim to enter the emotional and physiological state of the character I am playing, inducing a faster heart rate or slowing the breath, to simulate anxiety or deep loss, for example,” she said. “Mirror neurons in the viewer then assimilate these cues and allow them to resonate with the emotional experience and catharsis of the character.”

Srinivasan combines her passions for science and dance as director of Harvard’s Biohybrid Organs and Neuroprosthetics Lab and co-founder and artistic director of the Anubhava Dance Company, an Indian classical dance ensemble that performs nationally.

A recent collaboration between the lab and Anubhava led to the creation of an app that allows audience members to feel dancers’ movements through a smartphone’s vibrations, a project featured last month on the PBS Nova docuseries “Building Stuff.”

“The scientific question at hand was: How can we enhance the experience of dance, reaching beyond just audio and visual input into tactile or other forms of sensory input?” Srinivasan said.

Her research and development team, which included Isabella Gomez ’24 and Krithika Swaminathan, Ph.D. ’23, developed custom sensing devices that are placed on the ankles of Anubhava dancers to capture and classify their complex footwork into patterns. A smartphone app transmits the movements into audience members’ hands. Srinivasan says the technology has the potential to make dance performances more accessible for the lay viewer, as well as visually- or hearing-impaired people.

“Choreographing a piece is akin to designing a system — both involve carefully crafting elements to achieve a specific effect.”

Shriya Srinivasan
Shriya Srinivasan

Srinivasan, assistant professor of bioengineering, in her office.

Photo by Grace DuVal

To make the haptic feedback stimuli convey the feel of the footwork, researchers set the vibrations to different intensity levels. Light, flowing movements were represented by vibrations targeting surface-level mechanoreceptors in the skin, while more intense, punchier movements penetrated to deeper skin layers, Srinivasan explained. The project culminated in a dance titled “Decoded Rhythms” for an audience at the ArtLab, where Srinivasan did a 2023-2024 faculty residency.

“For me, dance and engineering are similar in process,” Srinivasan said. “Choreographing a piece is akin to designing a system — both involve carefully crafting elements to achieve a specific effect. Just as engineers design a system to meet certain requirements, dancers create choreography to evoke a particular emotion or reaction from the audience. It’s about problem-solving and design.”

Srinivasan, who grew up dancing bharata natyam under the tutelage of her mother Sujatha Srinivasan, established Anubhava in 2015 with co-founder Joshua George in the hopes of creating a space for Indian forms in the American dance world while also merging arts, science, and humanities onstage.

“There’s a high level of rhythmic and mathematical complexity that goes into the choreography that we produce that might not always translate to an audience if they’re not familiar with the style of music that we utilize, or if they’ve not been trained in the dance form,” George said.

Since this collaboration, Srinivasan said Anubhava has been diving deeper into neuroscience, psychology, and mental health, incorporating portrayals of emotions such as fear and anxiety, which she said are not commonly explored in Indian classical dance tradition, into their recent performances.

“I find it immensely fulfilling to engage in work at the intersection of disciplines,” Srinivasan said. “Exploring a problem from different perspectives can help you envision solutions that aren’t visible from traditional silos.”

Srinivasan is especially interested in further research on how physiological changes in the body of a dancer portraying emotions onstage might evoke a similar response in audience members.

“There are vast opportunities to study why the world makes us feel the way we do. When I experience art, it evokes a certain emotional response in me. Understanding why is deeply fundamental to the work of an artist, but doing so with the lens of science gives me this tangible way to say, ‘OK, if I modulate ABC, I can get somebody to feel XYZ.’ To me, that’s nuanced insight.”

  • ✇University of Cambridge
  • CISL appoints Lindsay Hooper permanent CEOplc32
    Lindsay’s appointment comes at a critical moment for the sustainability movement and for CISL.  Following another year of record temperatures, extreme weather events and sustained biodiversity loss, the evidence is clear that the world is not on track. Confidence within the sustainability movement has faltered and big questions are being asked about what is needed to deliver the change we need. Under Lindsay’s leadership as interim CEO the Institute has engaged with these important questions. R
     

CISL appoints Lindsay Hooper permanent CEO

By: plc32
December 2nd 2024 at 4:51 pm
Photo of Lindsay Hooper

Lindsay’s appointment comes at a critical moment for the sustainability movement and for CISL. 

Following another year of record temperatures, extreme weather events and sustained biodiversity loss, the evidence is clear that the world is not on track. Confidence within the sustainability movement has faltered and big questions are being asked about what is needed to deliver the change we need. Under Lindsay’s leadership as interim CEO the Institute has engaged with these important questions. Read more about Lindsay Hooper's appointment here

The University of Cambridge Institute for Sustainability Leadership announces it has appointed Lindsay Hooper its permanent CEO and Head of Department.

The need for CISL’s work has never been greater and I’m delighted to be working with an exceptional team
CISL CEO Lindsay Hooper
Photo of Lindsay Hooper

Creative Commons License.
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes
  • ✇University of Cambridge
  • Marking a milestone in English language examshcf38
    In June 1913, three candidates in the UK took the first ever Cambridge English exam. Since then, Cambridge English exams have become available in 130 countries and are recognised by more than 25,000 organisations around the world, including governments, universities and employers, as reliable proof of English language ability. The Cambridge English exams, which are designed for all levels of English language ability, include Cambridge English Qualifications, Linguaskill and IELTS, the English l
     

Marking a milestone in English language exams

By: hcf38
December 2nd 2024 at 3:51 pm
100 million Cambridge English exams taken since 1913

In June 1913, three candidates in the UK took the first ever Cambridge English exam. Since then, Cambridge English exams have become available in 130 countries and are recognised by more than 25,000 organisations around the world, including governments, universities and employers, as reliable proof of English language ability.

The Cambridge English exams, which are designed for all levels of English language ability, include Cambridge English Qualifications, Linguaskill and IELTS, the English language test.

Read more on the Cambridge University Press & Assessment website.

100 million Cambridge English exams and tests have been taken around the world since 1913, according to figures from Cambridge University Press & Assessment.

Creative Commons License.
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

AI’s challenge to universities: What happens when EQ trumps IQ?

November 28th 2024 at 12:18 pm

By Prof Simon Chesterman, NUS Vice Provost (Educational Innovation) and Dean of NUS College, and Assoc Prof Loy Hui Chieh, from the Dept of Philosophy, Faculty of Arts and Social Sciences at NUS, and Vice Dean (Academic Affairs) at NUS College

  • ✇NUS - National University of Singapore Newsroom
  • A meeting of minds on Singapore’s strategies for navigating global challenges
    About 100 alumni, students, and staff attended a panel discussion which brought together distinguished thought leaders to explore the pressing issues facing Singapore as part of the Alumni Reunion @BTC event held on 26 October 2024.The event began with an opening address by NUS President Professor Tan Eng Chye (Science ‘85) that reflected on the nostalgic significance of NUS’ Bukit Timah Campus for generations of graduates, resonating with the shared history and deep alumni connections to the ic
     

A meeting of minds on Singapore’s strategies for navigating global challenges

About 100 alumni, students, and staff attended a panel discussion which brought together distinguished thought leaders to explore the pressing issues facing Singapore as part of the Alumni Reunion @BTC event held on 26 October 2024.

The event began with an opening address by NUS President Professor Tan Eng Chye (Science ‘85) that reflected on the nostalgic significance of NUS’ Bukit Timah Campus for generations of graduates, resonating with the shared history and deep alumni connections to the iconic grounds. Looking ahead, Prof Tan highlighted the upcoming celebration of the University’s 120th anniversary, which will be marked by various key events, including a fun NUS120 charity walk around campus in February 2025.

The reflective theme of the event set the tone for the panel discussion that followed. Titled “How Can Singapore Navigate the Continuing Storms of Geopolitical Rivalry?”, it provided insights into how Singapore can continue to navigate the complexities of a polarised world while safeguarding its national interests.

Moderated by Professor Tan Tai Yong (Arts & Social Sciences ‘86, MA ‘89), Chairman of the NUS Institute of South Asian Studies and President of the Singapore University of Social Sciences, the panel featured Dr Selina Ho (Arts & Social Sciences ‘94), Assistant Professor in International Affairs and Co-Director of the Centre on Asia and Globalisation (CAG) at the Lee Kuan Yew School of Public Policy (LKYSPP); Professor Khong Yuen Foong, Li Ka Shing Professor in Political Science and Co-Director of CAG; Mr Kishore Mahbubani (Arts & Social Sciences ‘71), Distinguished Fellow, Asia Research Institute; and Professor Danny Quah, Dean and Li Ka Shing Professor in Economics at LKYSPP.

Adapting to a new global order

Dr Ho highlighted the challenges Singapore faces due to rising tensions over Taiwan and the broader US-China rivalry. She emphasised that Singapore is in a better position than most to navigate these challenges, as it has been diplomatically nimble and has taken a balanced approach to both sides. Dr Ho also stressed the importance of continuing to diversify our relationships with major stakeholders, engaging with multiple global players, and building national resilience through Total Defence.

Meanwhile, Mr Mahbubani noted that Singapore’s success has been driven by strong leadership and a once-functional Western-led world order that facilitated global trade. However, he cautioned that challenges lie in navigating a shift to a more dysfunctional state of affairs internationally, which could impact the country’s ability to thrive.

Strengthening cooperation

Prof Quah emphasised the importance of bolstering Singapore’s economic resilience and strengthening security measures to protect the nation in an uncertain global environment. He also called for greater multilateralism as a way forward.

Participant Mr Chim Teng Lee (Engineering ’90) found the session insightful. Despite geopolitical tensions, he suggested that NUS can foster collaboration and bridge differences by bringing together local and overseas alumni to share their expertise. By doing so, he believes Singapore can promote better relations and explore new opportunities for cooperation between ASEAN countries, to strengthen regional ties and create mutual benefit.

Another participant, Ms Chew Tai Wen (Arts & Social Sciences ’20), enjoyed the personal anecdotes that were shared by the panellists. Her key takeaway was that while Singapore must brace for uncertainties ahead, she has confidence in the country’s leaders to navigate these challenges effectively. 

 

By NUS Office of Alumni Relations

Before yesterdayدانشگاه‌ها

Sustainability in action: Deep diving into environmental issues and building the greenest campus in Singapore

November 29th 2024 at 10:32 am

In conjunction with Clean & Green Singapore (CGS) Day 2024 held on 3 November 2024 at NUS University Town (UTown), NUS’ University Campus Infrastructure (UCI) organised the inaugural Iceberg Series comprising two panel discussions to engage the NUS community on conversations relating to environmental sustainability.

In a spirit akin to uncovering an iceberg’s submerged mass, the Iceberg Series brought together researchers, experts and policymakers to dive deep into how plastic recyclables at the end of their life cycle can be responsibly managed while maximising their environmental sustainability as part of climate action; and how campus greening on Kent Ridge campus has contributed to the global fight against climate change.

Closing the plastic loop on responsible waste management

Speaking on the panel “Where do our plastic recyclables end up? Closing the plastic waste loop”, Senior Minister of State for Sustainability and the Environment Dr Amy Khor shared about Singapore’s strategy for tackling plastic waste through the nation’s Zero Waste Masterplan. These included regulatory measures such as the Beverage Container Return Scheme, which is designed to increase the recycling of beverage containers and reduce waste disposed at incineration plants. She emphasised, however, that government regulation is not the only solution to improving recycling and must instead be supported with public education and industry innovation.

The panel featured other speakers including Dr Jovan Tan, Lecturer at the NUS College of Design and Engineering (CDE); Mr Loo Deliang, Head (Sustainability Strategy Unit) at UCI; Dr Adrian Ang, Director (Group Sustainability & New Business) at Chye Thiam Maintenance; and Gracia Goh, Co-President of NUS Students’ Association for Visions of the Earth (SAVE).

Recognising the importance of traceability in waste management, the NUS Zero Waste Taskforce facilitated a student-driven initiative to place trackers in NUS’ plastic containers to track their journey. It was discovered that recyclables were sent to Malaysia and likely processed in facilities with inadequate pollution controls.

Highlighting the negative impact of inadequate end-of-life management of recyclables, Mr Loo pointed out that its implications extend beyond geographical boundaries, making it essential to tackle the issue from the root. He shared that NUS is exploring options to reduce packaging materials upstream and is sending clean PET-1 (polyethylene terephthalate) plastic bottles, which are commonly used in the production of beverage containers, to an established processing facility in Johor, Malaysia, to be turned into recycled PET resins, closing the plastic waste loop.

To encourage youths to take action, Gracia who is a Year 4 undergraduate from the Faculty of Arts and Social Sciences, suggested that youths can contribute by sparking conversations to rally actions or share their views to inform the regulatory environment.

Adopting an evidence-based approach to campus greening

During the panel on “Campus as a real-world living laboratory to tackle climate change”, NUS Vice-President of Campus Infrastructure Mr Koh Yan Leng, who also heads UCI, highlighted that the University is one of the first in Singapore to intensify campus greening efforts to build climate-resilience.

Taking an evidence-based approach, 49 weather stations and microclimate sensors have been installed across the Kent Ridge campus since March 2024 – the densest network in a local campus, to track how the University’s greening strategies have impacted the microclimate over time.

Mr Koh was joined by other speakers including Mr Steve Teo, Climate and Ecosystem Scientist at the NUS Centre for Nature-based Climate Solutions; Dr Marcel Ignatius, Senior Research Fellow at CDE; and Nadya Heryanto, Co-President of NUS SAVE. The panel discussion was moderated by Dr Sean Shin, Senior Lecturer of Accounting at NUS Business School.

Dr Ignatius, the co-principal investigator of the CoolNUS-BEAM initiative, shared that tree planting efforts on campus have resulted in a significant increase in tree canopy coverage from 36 per cent in 2019 to 60 per cent in 2024. As temperatures continue to rise with climate change, having more than half the campus grounds covered in trees will help cool the environment through shade and evapotranspiration. Mr Teo noted the positive impact of strategic urban reforestation on campus for health and well-being, yielding restorative effects that can help alleviate stress and encourage community interactions.

Nadya, a Year 3 undergraduate from NUS Business School, reflected on how tree-planting ignited in her, a deeper appreciation of nature and taking a stake in protecting the environment. “Once you realise how hard it is to plant a tree, you will think harder about the implications of ‘killing’ one (tree).”

Milestone planting of the 50,000th tree on campus

CGS Day 2024 also saw the planting of the 50,000th tree on campus. This marked the halfway point of the University’s pledge to plant 100,000 trees by 2030, in support of the National Parks Board’s OneMillionTrees movement. More than 100 NUS staff and students joined hands to plant a total of 50 trees at the event.

Since 2015, the University has been organising annual tree planting activities to augment its commitment to build a Campus in a Tropical Rainforest – one of the goals outlined in NUS’ Campus Sustainability Roadmap 2030.

Year 3 Life Science undergraduate Ahmad Musa was one of the students who participated in this meaningful cause. The avid tree planter said, “I do enjoy tree planting because it helps to restore our native forest and bring back the rich biodiversity that was lost many years ago. It is an investment for current and future generations to enjoy. Ultimately, I hope that through greening (the) campus, we can play a small yet important role in addressing and mitigating the effects of climate change one tree at a time.”

 

By University Campus Infrastructure

The right outcome for Income? Not a merger with Allianz

November 27th 2024 at 12:51 pm

By Emeritus Prof Tommy Koh from the Faculty of Law and Special Adviser to the Institute of Policy Studies at the Lee Kuan Yew School of Public Policy at NUS, and Mr Tan Suee Chieh, past CEO of NTUC Income and past Group CEO of NTUC Enterprise

Equinix and National University of Singapore partner to explore sustainability and energy solutions for data centres

Equinix, Inc. (Nasdaq: EQIX), the world’s digital infrastructure company®, and the Centre for Energy Research & Technology (CERT) under the National University of Singapore’s College of Design and Engineering (NUS CDE) today announced its plan to set up a Co-Innovation Facility (CIF) in Singapore to accelerate the testing and development of innovative solutions focused on low-carbon energy, high-efficiency cooling, circularity, and energy efficiency optimisation for data centres. Accelerating these innovations will shape the future of digital infrastructure and services in Singapore and other tropical locations, as well as address sustainability goals. 

Singapore’s digital economy has grown at a compound annual growth rate of close to 13% since 2017, contributing 17.3% to its gross domestic product (GDP) in 2022. Furthermore, according to the recent 2024 National Budget, Singapore is strengthening its position as a global business and innovation hub by investing more than $740 million into Artificial Intelligence (AI) over the next five years. As digital demands accelerate, data centres have become the foundation of today’s digital economy. To support digital growth more sustainably, data centres need to explore new ways to reduce energy consumption and implement energy efficiency solutions to cope with increased workloads and processing requirements. 

To be built inside Equinix’s upcoming SG6 International Business ExchangeTM (IBX®) data centre, the CIF aligns with Equinix’s Data Centre of the Future Initiative toward building cleaner, more efficient data centres around the world. This CIF will be an open research hub for leading global technology innovators, data centre technology partners, academia, and customers to co-develop and trial core and edge technologies that deliver reliability, energy efficiency, and cost efficiency. 

With an initial investment of US$4 million from Equinix, the CIF will serve as an incubator to trial innovations such as enabling the integration of clean and renewable energy sources and alternative power generation, with the aim of assessing their ability to operate at scale. Artificial Intelligence (AI) and Machine Learning (ML) will also be utilised by the facility along with other advancements, such as liquid cooling, which is becoming more vital as AI makes data processing more compute intensive. The facility will also trial Cognitive Digital Twin (CDT) capabilities of predictive maintenance and upgrades to address challenges faced by current data centre models. 

Yee May Leong, Managing Director, Singapore, Equinix, said: “The effects of climate change are being felt around the world, and it is becoming increasingly urgent to embed best practices in every aspect of our operations. By replicating our successful Co-Innovation Facility from Ashburn and expanding our collaborative efforts in the Asia-Pacific region, we are reaching a significant milestone in advancing our "Future First" sustainability agenda. It will accelerate the development of cutting-edge technologies and apply real-world solutions to help reduce the carbon footprint of the growing number of data centres worldwide.” 

Professor Lee Poh Seng, Director, Centre for Energy Research & Technology, NUS College of Design and Engineering, said, “The establishment of the Co-Innovation Facility highlights our commitment to forging impactful industry partnerships that translate groundbreaking research into practical applications. Collaborating with Equinix enables us to leverage our expertise in energy innovation and sustainability to address critical challenges faced by data centres in tropical climates. Together, we aim to redefine benchmarks for operational efficiency and sustainability in digital infrastructure, aligning with Singapore's ambitions for sustainable development and technological leadership. This partnership is a powerful step forward in shaping a future where cutting-edge innovation meets environmental responsibility.” 

Key Highlights: 

  • To be opened in Q1 2027, the CIF will trial sustainable innovations for data centres, such as: 
    • Alternative power solutions: Alternative power generation solutions such as fuel cells and battery storage, can provide low-carbon power solutions for data centres, serving as bi-directional grid interfaces and on-site prime and/or backup solutions. 
    • Direct current power distribution system: An electrical power distribution architecture known as medium voltage AC to low-voltage DC (MVAC-LVDC), facilitates the seamless integration of battery energy storage system (BESS), solar photovoltaics (PV) and other renewable energy sources (RES) coupled to the data centre power distribution network, with the potential to enhance grid-side power quality, efficiency, and power density for data centres. 
    • Liquid cooling: This advanced cooling method reduces energy consumption and noise while optimising space. It also increases the potential for waste heat reuse, supporting circular data centre models. 
    • Digital twin capabilities: Data-driven model and machine learning will be utilised to enable predictive maintenance and upgrades. 
  • Equinix and NUS have long supported Singapore’s sustainability agenda and implemented various initiatives to support the growth of sustainable development in the country, including scholarship opportunities in nature-based climate solutions for students at NUS.
  • In 2022, Equinix together with the Department of Electrical and Computer Engineering and CERT, both under NUS CDE, collaborated to explore hydrogen-based green fuel technologies for mission-critical data centre infrastructure. The study compared PEM fuel cells and fuel-flexible linear generators, highlighting their efficiency and potential as backup power solutions, particularly in tropical climates. The results were released in 2023.
  • Equinix operates 268 data centres across 73 metros, providing digital infrastructure for more than 10,000 of the world’s leading businesses. Since 2021, Equinix has been driving toward an approved near-term science-based target (SBT) for emissions reduction by 2030.

  • ✇Harvard Gazette
  • How HIV research has reshaped modern medicine Terry Murphy
    Health How HIV research has reshaped modern medicine  Colorized transmission electron micrograph of an HIV-1 virus particle (yellow/gold) budding from an infected cell. Credit: NIAID/NIH Shafaq Zia HMS Communications November 27, 2024 long read Decades of scientific work turned the tide on a fatal disease and yielded insights into immunity, vaccines, and more In 1981, fresh out of medica
     

How HIV research has reshaped modern medicine 

November 27th 2024 at 11:10 pm
Health

How HIV research has reshaped modern medicine 

A bright circular virus particle shines in the center of an image against a dark background, with the edge of an infected cell seen in one corner.

Colorized transmission electron micrograph of an HIV-1 virus particle (yellow/gold) budding from an infected cell.

Credit: NIAID/NIH

Shafaq Zia

HMS Communications

long read

Decades of scientific work turned the tide on a fatal disease and yielded insights into immunity, vaccines, and more

In 1981, fresh out of medical school, physician-scientist Bruce Walker began his internship at Massachusetts General Hospital. One day, a young patient showed up with an unusual cluster of infections and cancers. Baffled and powerless to treat him, Walker and his colleagues could only watch as the patient quickly succumbed to the mysterious condition.

“I distinctly remember the first case we saw at Mass General,” said Walker, who is the Phillip T. and Susan M. Ragon Professor of Medicine at Harvard Medical School and the director of the Ragon Institute of Mass General, MIT, and Harvard. “The attending physician said that although we didn’t know what this condition was, we probably would never see another case like it.”

Two weeks later, another patient came in with the same set of symptoms. It quickly became clear to Walker and his colleagues that they weren’t dealing with a rare disease — it was the beginning of a new epidemic.

The baffling condition was acquired immunodeficiency syndrome (AIDS) — the most advanced stage of infection with the human immunodeficiency virus (HIV), which attacks and destroys infection-fighting immune cells. By 1993, HIV had become the leading cause of death in Americans aged 25-44 years.

In the 40-plus years since it was identified, scientists have made notable progress against HIV, transforming the infection from a death sentence into a manageable chronic condition, one that affects some 1.2 million people in the United States and nearly 40 million worldwide.

This decades-long quest for a cure for HIV has also yielded broader insights that have implications for the treatment of COVID-19, cancer, and other diseases.

From molecular insights to frontline medicines

Since the identification of HIV as the cause of AIDS, basic science and animal research have played a critical role in illuminating the virus’ complex behavior.

Some of the pivotal studies toward unraveling the structure, biology, and behavior of HIV have emanated from labs across Harvard Medical School. Using a range of imaging techniques, Stephen Harrison’s lab has identified key portions of HIV and studied the evolution of HIV antibodies, which is critical to understanding how the immune system interacts with the virus. The work of Joseph Sodroski, Bing Chen, and Alan Engelman has elucidated how HIV enters host cells and interacts with cell receptors, studying the structure and behavior of the virus’ protein envelope during this process.

This research has illuminated how HIV integrates its genetic material into host cell DNA, a crucial step in the virus’ life cycle. These insights have enhanced vaccine and therapeutic development by revealing how broadly neutralizing antibodies work and guiding the design of new immune-targeting strategies.

Early analyses of patient samples revealed that HIV is a human retrovirus — a type of virus that converts its RNA into DNA upon infecting a host cell. This tricks the host cell into copying the virus’ genetic material into its DNA as part of the cell’s normal replication cycle. The maneuver enables it to use the host cell machinery to make more viruses. HIV specifically goes after CD4 T lymphocytes or so-called helper T cells. These white blood cells coordinate immune response by signaling other immune cells to fight invaders. The virus begins by hijacking the cells’ molecular machinery to assemble thousands of viral particles, which go on to infect other CD4 T cells, spreading the pathogen throughout the body.

Today, the standard treatment for HIV is antiretroviral therapy (ART) — a combination of HIV medications, typically taken daily, that disrupt the virus’ replication cycle. When taken consistently, ART can lower the amount of actively replicating virus in the body — or viral load — to undetectable levels, lowering risk of transmission and allowing people with HIV to live nearly as long as uninfected individuals.

ART has also proved to be useful as a pre-exposure prophylaxis (PrEP) — an approach that can prevent up to 99 percent of sexually transmitted HIV infections from developing after exposure. Notably, a new class of medicines has raised hopes as a game-changer in HIV prevention. Two recent clinical trials of more than 7,500 cisgender men and transgender and nonbinary people showed that twice-a-year injections with the long-lasting drug lenacapavir prevented HIV infections in nearly all participants.

Yet, millions around the world are already infected. Once inside the body, HIV persists because of its remarkable ability to hide within healthy CD4 T cells, where it can lie dormant for years without triggering an immune response, said Daniel Kuritzkes, HMS Harriet Ryan Albee Professor of Medicine and chief of the division of infectious diseases at Brigham and Women’s Hospital.

Although these latent reservoirs of HIV do not actively produce new virus particles, they can reawaken at any time, leading to active HIV infection. This chronic immune activation among infected people — even when the virus is kept at bay — can amplify the risk for several chronic conditions.

“People living with HIV often have elevated markers of inflammation. This chronic immune activation can predispose people to long-term complications, including cardiovascular illness.”

Daniel Kuritzkes/
Daniel Kuritzkes, chief of the division of infectious diseases, BWH

“People living with HIV often have elevated markers of inflammation,” Kuritzkes said. “This chronic immune activation can predispose people to long-term complications, including cardiovascular illness.”

Indeed, research has shown that people with HIV have a somewhat elevated risk for cardiovascular disease, diabetes, kidney disease, and certain types of cancer. Now, the latest research from Advancing Clinical Therapeutics Globally — a global network of experts conducting HIV research — has found that daily use of statins could reduce risk of cardiovascular disease in people living with HIV by 35 percent. This pivotal work was conceived by and led by Steven Grinspoon, HMS professor of medicine and director of the Metabolism Unit at Mass General Hospital.

While this offers a path toward managing HIV-related complications, Kuritzkes emphasizes that the ultimate quest of research efforts remains achieving sterilizing immunity through a vaccine that halts the virus in its tracks, preventing infection from taking hold in the first place.

The roadmap to a vaccine

With some 1.3 million new infections a year, a vaccine remains the best way to end the HIV epidemic, said Dan Barouch, the William Bosworth Castle Professor of Medicine at HMS and director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center.

“We should use all of our prevention and treatment tools, including education and pre-exposure prophylaxis with antiretroviral drugs, to prevent HIV, but to really end the epidemic, we need a vaccine,” Barouch said.

Despite great strides with PrEP, Barouch notes, it will only reach high-risk individuals, and as many as half of new HIV infections occur in people who are not designated as high risk. Thus, Barouch notes, even if PrEP were available for free and accessible to everyone in the world, which is far from reality, it would still invariably reach a ceiling of population efficacy.

Yet, after 40 years of effort, the HIV vaccine field is at a crossroads. Since the dawn of HIV research, there have been hundreds of attempts at vaccine design, and dozens have made it to early-stage clinical trials, but only five have been tested in large-scale clinical trials.

“There is a lot of exciting basic, preclinical, and early clinical research, but currently no vaccine candidate has a clear trajectory for advanced clinical development,” Barouch said.

Why?

First, the ability of the virus to shapeshift within the host and across the population. The virus mutates rapidly, resulting in an astonishing genetic diversity not seen with any other virus.

“With HIV, you are not targeting a single virus, you’re targeting millions of different viruses,” said Barouch.

Another problem is the fact that the virus integrates itself into the host genome quickly — within days following infection — then goes into hiding, establishing a latent reservoir that can reactivate at any time. This means that a vaccine needs to induce rapid immune response that counters viral maneuvers very rapidly. No other virus seeds reservoirs so quickly, and no other vaccine has been capable of inducing such rapid defense.

Finally, the virus is cloaked in an envelope of sugar molecules — or glycans — that render it largely impervious to antibodies. There are only three or four targets on HIV that render it vulnerable to antibodies. Thus, for antibodies to work, they must be hyperprecise to latch on to these hotspots in order to disrupt the viral shield. This, Barouch notes, may be one of the greatest hurdles to developing a potent enough vaccine.

Among the most recent efforts was a vaccine developed by Barouch and Johnson & Johnson that was tested in Africa and in South and North America. The approach used a so-called “mosaic” platform optimized using computational biology to target multiple strains of the virus.

The researchers used computer design to create a mosaic antigen in the lab. The trial, which concluded in 2021, showed the vaccine had great safety but low efficacy — around 14 percent. A vaccine needs to be at least 50 percent effective, but ideally 70 percent or more, Barouch noted, meaning that it would have to prevent at least seven out of 10 infections.

Despite the disappointing results, Barouch said, the findings helped refocus the field of HIV vaccine research on the importance of neutralizing antibodies — the types of immune proteins that are capable of disabling rather than merely recognizing the virus.

To that end, Barouch and team have redoubled their efforts to design vaccines that create precisely such broadly neutralizing antibody response as well as spark a robust T cell response, thus activating both major arms of the immune system.

Lessons from elite controllers

In the early 1990s, researchers noticed a tiny subset of HIV-infected patients who were living healthy and symptom free without medication. These patients, who came to be known as elite controllers, had undetectable viral levels in their bodies. Their immune systems were powerful enough to naturally keep the virus from replicating. Between 0.15 and 1.5 percent of HIV-infected individuals are estimated to be elite controllers.

“In these individuals, the immune system is able to suppress HIV replication,” said Yu, whose lab focuses on the molecular and cellular mechanisms behind this remarkable immune response, with the hope of harnessing these insights to develop new antiretroviral treatments for HIV. “And in a rare subgroup, the immune system may even eliminate all cells infected with replication-competent HIV, curing the infection entirely.”

When Gaurav Gaiha, then a first-year student in the Harvard-MIT Program in Health Sciences and Technology, learned about elite controllers, he was captivated by the concept of using insights from these unique individuals to develop an HIV vaccine.

At that time, a prevailing scientific theory was that elite controllers had an exceptionally powerful T cell response to HIV. However, when Gaiha began comparing the T cell responses in elite controllers to that of people living with progressive HIV, he discovered something surprising: While T cell function in elite controllers was important, there was another important piece to this biological riddle. Gaiha therefore shifted his focus and instead began to zero in on the specific regions of the virus that these T cells were targeting.

In a 2019 study, Gaiha, Walker, and colleagues applied network theory to tackle this question. They treated each amino acid in the viral proteins as a node in a network, allowing them to quantify how central each amino acid was to the protein’s function. Their findings offered a breakthrough: T cells in elite controllers consistently targeted critical regions of the virus protein network — areas that were essential for its survival and losing or mutating them would significantly hinder the virus’ ability to replicate.

“It’s similar to key players in a network,” said Gaiha, now an assistant professor of medicine at HMS and a principal investigator at the Ragon Institute of Mass General, MIT, and Harvard. “Key players keep the network connected, while others may be more on the periphery. If T cells target key player amino acids from these critical regions of viral proteins, you may have a chance to control the virus for a long period of time without therapy.”

These insights, Gaiha noted, have implications beyond HIV — they helped guide COVID-19 vaccine developments that stimulate T cells and induce a robust and long-lasting immune response.

Encouraged by promising results in humanized mice, Gaiha and Walker are now collaborating with two biotech companies to translate these insights into a viable HIV vaccine. The group’s viral vector-based vaccine candidate is set to enter a first in human clinical trial in Zimbabwe and South Africa in early 2025, while a second RNA-based vaccine trial is meant to begin in 2026 at Mass General.

“I am hopeful that we will see good outcomes from these initial vaccine trials,” said Gaiha. “But more importantly, I am looking forward to learning key lessons that will guide us, so we can continue to refine. We’re in this for the long haul.”

Ripple benefits beyond HIV

The search for a cure continues, but the sinuous 40-plus-year journey has fueled advances well beyond HIV.

For starters, many of the successes in the identification, testing, and treatment of SARS-CoV-2, the virus that ignited the COVID-19 pandemic, were built on knowledge and hard-earned experiences with HIV.

“Research on HIV really paved the way for the advances that were made with COVID, by laying the platforms for vaccine development that, in particular, the vectors that were used to generate immune responses, the mechanisms for rapid diagnostics, the understanding of viral pathogenesis — all were really contributed by work that had been done on HIV,” Walker said.

“If it wasn’t for the decades of HIV research, we would not have had the COVID-19 vaccines so rapidly.”

Dan Barouch
Dan Barouch, director of the Center for Virology and Vaccine Research, BIDMC

“If it wasn’t for the decades of HIV research, we would not have had the COVID-19 vaccines so rapidly,” Barouch said.

HIV research also equipped scientists with the tools and know-how to unravel viral structures and monitor the behavior of viruses inside their hosts. This work also led to the development of animal models that allow researchers to study how the body responds to vaccines and treatments and laid the foundation for the modern-day infrastructure needed to conduct clinical trials.

HIV research has catalyzed understanding of immune system function in myriad ways. For example, recent advances in gene therapy and CAR T cells were heavily influenced by research conducted in HIV infection.

“Fundamental mechanisms of how the immune system can recognize, engage, and target virally infected cells were first discovered in the context of HIV infection, and a lot of this progress has subsequently been translated to alternative disease contexts,” said HIV researcher Xu Yu, professor of medicine at HMS and a principal investigator at the Ragon Institute of Mass General, MIT, and Harvard.

For example, gene therapy uses lentiviruses as vectors to deliver therapeutic genes into the target cells.

“These lentiviruses are very similar to HIV, and a deeper understanding of HIV allowed researchers to use lentiviruses for therapeutic gene transfer,” Yu said.

HIV research also helped advanced the field of CAR T-cell therapy, which uses genetically engineered immune cells for the treatment of blood cancers. One of the first CAR T-cell studies was done in the context of treating HIV infection, more than 20 years ago.

“Experience gained with CAR T cells in this setting was instrumental in advancing them for oncologic indications,” Yu said.

  • ✇Harvard Gazette
  • Not so much the form, but the functionChristina Pazzanese
    Campus & Community Not so much the form, but the function Gund Hall on Quincy Street.Photos by Jon Ratner Christina Pazzanese Harvard Staff Writer November 27, 2024 5 min read Gund Hall may look the same but a major renovation has improved its energy efficiency and accessibility. (And, now, hopefully, the roof will stop leaking.) Gund Hall, it is safe to say, was overdue for an updat
     

Not so much the form, but the function

November 27th 2024 at 7:30 pm
Campus & Community

Not so much the form, but the function

Gund Hall renovation exterior.

Gund Hall on Quincy Street.

Photos by Jon Ratner

Christina Pazzanese

Harvard Staff Writer

5 min read

Gund Hall may look the same but a major renovation has improved its energy efficiency and accessibility. (And, now, hopefully, the roof will stop leaking.)

Gund Hall, it is safe to say, was overdue for an update after weathering 50 Cambridge winters.

The iconic Quincy Street home of Harvard Graduate School of Design (GSD) is open after a major renovation this year, its most significant since the building opened in 1972. While the changes may not be readily apparent, the need was.

The hall’s concrete-and-glass stepped exterior, which encloses GSD’s beloved five-story, central studio area known as “the trays,” had badly deteriorated over the years, allowing moisture and cold air to seep in, and heat to escape. The space was so inefficient, it consumed nearly half of the building’s total energy. Before rainstorms, students covered their desks with tarps.

“The main purpose of this work is to get rid of the leaks once and for all. This building, for the 52 years it has been open, has always leaked. When it rains hard, you see the buckets everywhere,” said David Fixler, a lecturer in urban planning and design at GSD who chairs the faculty building committee, which has been advising on this first phase of what will be a multiyear project.

Other improvements include boosting the amount of natural light coming into the trays and making the adjacent outdoor terraces wheelchair-accessible for the first time.

For decades, the building’s unique design, as well as its historic and educational importance to GSD, have presented major obstacles to undertaking any substantive restoration that would fix these persistent problems without compromising the look and feel of the original design by Australian architect John Andrews, March. ’58.

Studio trays in Gund Hall.
The five-story, central studio area known as “the trays.” Nearly all of the original windows were badly degraded and couldn’t be salvaged.

Gund Hall Project Fact Sheet

15,475

Square feet of studio tray glazing area

1,617

Panels of glass

160,830

Total square footage of Gund Hall, excluding terraces

28%

Amount of floor area taken up by studio trays

46%

Building’s total energy consumption attributed to studio trays

“When John Andrews was originally tasked to design a new facility for the Departments of Architecture, Landscape Architecture, and Urban Planning and Design, he surprised his clients with a unique building that was at once solid and transparent and that prioritized the student body, united within an enormous, light-filled, single space,” Sarah M. Whiting, dean and Josep Lluis Sert Professor of Architecture at GSD, said in a statement. “Though much has changed since Gund Hall first opened in 1972, the careful rehabilitation of the structure underscores the school’s commitment to this same priority: our students.”

Gund, like other examples of mid-century Brutalist architecture, was constructed before the 1973 global “oil shock” and widespread awareness of climate change. It features large surfaces of exposed concrete, many windows, and is not well-insulated, all of which make it less than well suited to the harsh climate of New England.

“Philosophically, one of the compelling things about brutalism is the structure is the building. What you see is what it is. There’s nothing hidden,” said Fixler, an architect who specializes in mid-20th century building conservation. That means “sometimes they fail spectacularly, and they’re hard to fix.”

Nearly all of the original windows were badly degraded and couldn’t be salvaged. Above, clerestory windows on the roof were replaced with triple-glazed windows.

The curtain walls on each end of the building now have windows made from custom vacuum-insulated glass, a state-of-the-art material not widely used in North America. They provide energy efficiency and noise reduction comparable to traditional triple-glazed windows without the bulk, allowing the new windows to hew very closely to the original window profiles and glass sizes, while delivering two to four times better energy performance than standard glass. They will yield future savings in both carbon and dollars spent on utilities.

Exterior of Gund Hall.
Gund Hall features large surfaces of exposed concrete and numerous windows.

The project takes an aging facade that “had the problems of its time to a facade that is the best-performing glazing system anywhere,” said project architect George Gard, MAUD ’14, of Bruner/Cott Architects. The firm has restored other mid-century buildings at Harvard, including Smith Campus Center and Peabody Terrace.

With so many Brutalist-era buildings around the country now confronting similar challenges because of age, the School hopes the project serves as a model for others, by identifying innovative technology, techniques, and materials and helping define best practices.

“We see a lot of future potential as it becomes more common. And we hope that, this project being a high-profile building on Harvard’s campus, can be part of a growing acceptance of this technology,” said Gard.

Given the project’s unique complexity, Fixler, a conservation architect for many decades, has been incorporating the renovation into his teaching.

“What I find heartening is that [among] the students, there’s a growing understanding that it’s a really responsible thing to do to recycle old buildings, whether you like them or not, and to use that opportunity to test new ideas to make them more resilient, make them more sustainable,” he said.

Not everyone appreciates Brutalist behemoths like Gund Hall or Boston City Hall, often called one of the country’s ugliest buildings, or thinks they’re worth preserving.

“One of the biggest challenges, frankly, is getting people to understand why these are good, interesting buildings, and getting people to love them — because so many people hate them,” he said.

“There are a lot of people, especially younger people of the generation that I’m teaching now and my kids, [who] think these buildings are cool. But an awful lot of people of my generation just don’t.”

Practice and perseverance pay off for NUS Business School students at international case competitions

Tight deadlines and unexpected curveballs are part and parcel of case competitions, contributing to a thrilling learning experience for the intrepid participants. Two NUS Business School teams fielded by the NUS Case Consulting Group (CCG) at recent competitions share with NUS News how they persevered through challenges to take home the top and second runner-up prizes at their respective competitions last month.

Transforming a bank into a sustainability leader

A team of Bachelor of Business Administration (BBA) students did NUS proud at the Thammasat Undergraduate Business Challenge (TUBC) 2024, with the team emerging champions and their team leader Anastasia Goh Hui Yuan, a Year 3 student, taking home the Best Speaker Award.

This was the first international case competition for the other three members of the team – Chia Jeng Yee, a Year 4 student majoring in Computer Science and Business Administration; third-year BBA student Jocelyn Kelly, and second-year BBA student Thng Kai Liang Darren – making the win even more special.

A case competition with 27 years of history, TUBC is organised by undergraduate students in Thammasat University’s BBA international programme, who invite representatives from leading international business schools to compete.

This year, 20 teams from five Thai universities and 15 international business schools from Europe, North America, and Asia Pacific were set the challenge of helping major Thai financial institution Krungsri Bank to reduce its Scope 3 emissions (emissions produced by indirect sources in a company’s value chains) and recommending how the bank could position itself as a regional leader in sustainability.

The NUS team had 28 hours to analyse the situation, formulate their recommendations, and package their solution in a cohesive, concise, and presentable format. Their final proposals laid out a plan for Krungsri to lead Asean’s transition to net zero by using AI-driven tools to assess their corporate clients’ transition readiness; upskilling their relationship managers on environmental, social, and governance (ESG) topics; and offering transition financing products.

Said Jocelyn: “Our team worked around the clock, running on little rest as we navigated ESG, a topic that was new territory for many of us. But ultimately, the effort was worth it; ESG is such a critical and timely topic and being able to propose solutions that could drive real impact made the experience incredibly rewarding.”

A key to their success was the extensive preparation and training they underwent before the competition. They thoroughly researched Krungsri Bank and the Thai market and used other cases to practise researching, developing, and presenting solutions within 24 hours. CCG seniors and faculty advisor Mr Maurice Tan, along with invited faculty and alumni, gave them constructive feedback and mentorship.

Mr Tan, an adjunct senior lecturer of marketing at the Business School, noted that the team performed well under pressure, demonstrating their preparedness and poise and engaging with the judges confidently. “As faculty team advisors, we entrusted our students to shine, and they exceeded expectations,” he said.

The team also benefitted from the unique mix of skills and backgrounds among its members, ranging from tech and ESG to finance and consulting. Each student drew on fundamental skills picked up in their Business School courses on topics like accounting, business law, and marketing, and exercised their public speaking and presentation skills to confidently articulate their message and recommendations to a large audience.

“Beyond the incredible experiences themselves, it was truly special to share these moments with participants from other teams, creating friendships and memories that we’ll always remember fondly,” Jeng Yee concluded.

Earning a hard-fought win in debut performance

Achieving a placement finish at their very first case competition was an achievement in itself for a team of four NUS students at the Hong Kong University of Science and Technology International Case Competition (HKICC), but their second runner-up prize was especially sweet because of the battles they fought to earn it.

HKICC is a premier business case competition organised by HKUST Business School since 2003, attracting student teams from renowned business schools such as Copenhagen Business School and University of California, Berkeley. The 2024 edition hosted 16 teams, who worked on business challenges faced by the helpdesk department of HSBC Bank.

Kim Eunwoo, a Year 4 Accounting student, shared that her team was excited about the intellectual challenge of their first case competition outing, as such competitions are fast-paced and competitive with a steep learning curve while offering opportunities to interact with talented students from around the world.

“The fact that it was our first experience for all of us helped us to bond, and it also made us discuss our solutions and strategic direction more thoroughly, to be extra certain and confident in what we're doing,” she said.

Besides Eunwoo, the team comprised Year 3 BBA student Griffith Goh and Year 4 BBA students Xinxia Lu and Beverly Wan. Through training and practising together in the CCG club, they learnt to strategise around one another’s strengths and weaknesses. They also received mentorship from Associate Professor Ang Swee Hoon, who shared her extensive case competition experience and guided them to shape their presentation styles individually and as a team.

At the competition, the team was immediately faced with an unexpected complication when one member fell severely ill. However, the entire team would be disqualified if they did not all compete in every round, so the other team members rallied to divide up the work and keep going.

They started strong, topping their division in the first round that involved a five-hour mini case to propose employee retention strategies. But the second round involved a more complex challenge – a 24-hour case requiring them to streamline the helpdesk operations to improve efficiency and service quality for the entire business – and their solution for an automated call routing engine that would also use AI to generate solutions and guidance for helpdesk agents to solve customer issues came second in their division.

This was not enough to automatically move them to the final round. Instead, they got one more chance to secure a place in the finals by competing against the other second-placed teams in a challenge round that took place immediately after the second round.

Pushing through the fatigue from staying awake for more than 24 hours, they spent another hour overhauling their script and presentation approach. Their perseverance paid off when they won the challenge round and progressed to the final round to present their solution for the third time, eventually clinching the second runner-up prize.

Assoc Prof Ang praised the team’s positive fighting attitude, which she observed during the CCG weekend training sessions. “The students were humble, eager to learn and improve, and never once complained about having to come to school and stay the whole day and sometimes overnight for training,” she said.

In addition, the team was smart and agile in competition. She noted: “Because they had to do the extra challenge round, they learnt what their strong points are, based on the questions asked by the judges. They used this to their advantage by adapting their presentation in the challenge and final rounds.”

Despite the gruelling journey, the team does not regret the path they ended up taking.

“The challenge round was a blessing in disguise because it made our presentation so much better and helped us become masters of our solution and think of how to address potential questions or present more effectively,” Eunwoo reflected. “It wasn't really like presenting the same case three times; it was like a different presentation every time because we made consistent changes and improvements at each juncture.”

Climate change alone does not cause mass migration

November 27th 2024 at 9:30 am
People are already being forced to flee the consequences of climate change to an alarming extent in the Global South, says Jan Freihardt. He believes, however, that Europe's fear of mass climate migration is exaggerated, since international migration has other root causes.
  • ✇MIT News
  • Creating innovative health solutions for individuals and populationsAnne Wilson | Department of Mechanical Engineering
    The factors impacting successful patient care are many and varied. Early diagnosis, proper adherence to prescription medication schedules, and effective monitoring and management of chronic disease, for example, all contribute to better outcomes. However, each of these factors can be hindered by outside influences — medication doesn’t work as well if it isn’t taken as prescribed, and disease can be missed or misdiagnosed in early stages if symptoms are mild or not present.Giovanni Traverso, the
     

Creating innovative health solutions for individuals and populations

The factors impacting successful patient care are many and varied. Early diagnosis, proper adherence to prescription medication schedules, and effective monitoring and management of chronic disease, for example, all contribute to better outcomes. However, each of these factors can be hindered by outside influences — medication doesn’t work as well if it isn’t taken as prescribed, and disease can be missed or misdiagnosed in early stages if symptoms are mild or not present.

Giovanni Traverso, the Karl Van Tassel Career Development Professor, an associate professor of mechanical engineering, and a gastroenterologist in the Division of Gastroenterology, Brigham and Women’s Hospital (BWH), is working on a variety of innovative solutions to improve patient care. As a physician and an engineer, he brings a unique perspective.

“Bringing those two domains together is what really can help transform and accelerate our capacity to develop new biomedical devices or new therapies for a range of conditions,” he says. “As physicians, we're extremely fortunate to be able to help individuals. As scientists and engineers, not only can we help individuals … we can help populations.”

Traverso found a passion for this work early in life. His family lived in his father’s native Peru through much of his childhood, but left in the late 1980s at the height of the nation’s political instability, emigrating to Canada, where he began high school.

“In high school, I had the incredible opportunity to actually spend time in a lab,” he says. “I really fell in love with molecular genetics. I loved the lab environment and that ability to investigate a very specific problem, with the hopes that those developments would eventually help people.”

He started medical school immediately after high school, attending the University of Cambridge, but paused his medical training to pursue a PhD in medical sciences at Johns Hopkins University before returning to Cambridge. After completing medical school, he completed internal medicine residency at BWH and his gastroenterology fellowship training at Massachusetts General Hospital, both at Harvard Medical School. For his postdoctoral research, he transitioned to the fields of chemical and biomedical engineering in the laboratory of Professor Robert Langer.

Traverso’s research interests today include biomedical device development, ingestible and implantable robotics, and drug delivery for optimal drug adherence. His academic home at MIT is in the Department of Mechanical Engineering, but his work integrates multiple domains, including mechanical engineering, electrical engineering, material science, and synthetic biology.

“The mechanical engineering department is a tremendous place to engage with students, as well as faculty, towards the development of the next generation of medical devices,” he says. “At the core of many of those medical devices are fundamental mechanical principles.”

Traverso’s team in the Laboratory for Translational Engineering is developing pioneering biomedical devices such as drug delivery systems to enable safe, efficient delivery of therapeutics, and novel diagnostic tests to support early detection of diseases.

The heart of his work, he says, is “about trying to help others. Patients, of course, but also students, to help them see the arc of bench-to-bedside and help stimulate their interest in careers applying engineering to help improve human health.”

© Photo: John Freidah/MechE

Giovanni Traverso is the Karl Van Tassel Career Development Professor and an associate professor of mechanical engineering, and a gastroenterologist in the Division of Gastroenterology, Brigham and Women’s Hospital.
  • ✇NUS - National University of Singapore Newsroom
  • Supporting NUS student-athletes in their sporting excellence
    A highly-committed athlete in university lives a life of careful balance – planning training sessions in tandem with lectures and classes, managing an academic load while preparing for events and competitions, staying healthy in the face of daily physical and mental exertion, and weighing up which of the many responsibilities and commitments should come first in the limited 24 hours of a day.Lucas Chew (Year 2, Environmental Studies) has been an athlete for most of his life, but this balancing a
     

Supporting NUS student-athletes in their sporting excellence

A highly-committed athlete in university lives a life of careful balance – planning training sessions in tandem with lectures and classes, managing an academic load while preparing for events and competitions, staying healthy in the face of daily physical and mental exertion, and weighing up which of the many responsibilities and commitments should come first in the limited 24 hours of a day.

Lucas Chew (Year 2, Environmental Studies) has been an athlete for most of his life, but this balancing act is still a consistent effort, so much so that he quips that his current role as a national finswimming representative feels like he is pursuing a double degree programme instead.

Finswimming is not a common sport in Singapore – so uncommon, in fact, that Lucas is the sole competitive finswimming athlete in the whole of NUS. It is a version of competitive swimming, where athletes don customised fins and snorkelling equipment to traverse the length of the pool at high speed.

“Over the past five years, finswimming has taken over more and more of my life. As a student-athlete, time and energy are always in short supply and require a delicate balance between school, sport, and sleep,” shared Lucas.

While continuing to keep NUS’ flag flying at national competitions as a member of the varsity table tennis team, Year 3 Dentistry undergraduate Janine Chew has also set her sights on widening access to table tennis within the NUS community, and as a means of community outreach beyond the University.

Janine played a central role in organising community events, such as the NUS Racketlon, a two-day multi-sport competition event which aims to promote racket sports in a fun manner, with no minimal skill prerequisites, among the NUS community. The team also recently concluded the Learn-to-Play Table Tennis programme, in collaboration with NUS Office of Student Affairs (OSA) which organises sessions to teach NUS students basic table tennis skills. The programme serves as a stepping stone into the sport for participants who have no prior experience.

The time taken for meticulous planning and execution of these events comes into careful balance alongside schoolwork.  “Key factors that have helped me balance both my sporting and academic commitments would be discipline, time management and having a good support system,” reflected Janine.

“The chance to interact with individuals from diverse sporting backgrounds has broadened my perspective and showed me that there is so much more to sports than just competition; it is also about engaging the community around us. While I might get tired and drained at times, I am reminded of the joy that I feel when I see people enjoying the sport and this helps to push me through the tough times,” she added.

Supporting sporting excellence

Lucas and Janine both credit the NUS Sports Scholarship for helping to even out the scales as they balance their lives as student-athletes.

Every academic year, the University awards up to 20 bond-free sports scholarships to national athletes and outstanding student-athletes, which cover tuition fees and include an annual allowance and on-campus accommodation allowance. Awarded to students pursuing full-time undergraduate programmes at NUS, the scholarship is disbursed in two categories – Sports Excellence for national representatives such as Lucas, and Community Sports for athletes like Janine who have made significant contributions towards promoting active sports participation in NUS.

Janine expressed her appreciation for the NUS Sports Scholarship for helping her to pursue goals in both academics and sports without the constant worry about financial constraints.

“The NUS Community Sports Scholarship has empowered me to channel my enthusiasm for community engagement in sports by spearheading events and initiatives aimed at bringing sports closer to the NUS community. It allowed me to connect and collaborate with some amazing like-minded individuals who share a passion for sports and community engagement,” added Janine. 

Sports support at NUS can also come in the form of subsidies for travel to overseas competitions, such as when Lucas travelled to Colombia recently to represent NUS and Singapore at the Finswimming World University Championship (WUC) 2024, which was subsidised by the U-SPARKS grant for NUS student-athletes who qualify for any World University Championships or Games. Seventy hours of travel time and some amazing local hot chocolate later, Lucas came home with not one, but three new national records for finswimming.

They can also consult the University when alternative arrangements to classes and exams are required, in consideration of overseas competition schedules.

“I’m appreciative of the scholarship for its all-rounded support, clear systems in place for communicating my goals with a sports manager, and the systemic perks of building my academic schedules around my training commitments so that I need not choose one or the other,” explained Lucas.

“We’re all in it together”

The athletic journey in NUS is not one of solitude; TeamNUS athletes are spurred on by the support of friends, family, coaches and teammates. They can also rely on a reliable team of sports managers at OSA, who wear many hats in their role of supporting athletes to pursue their sporting dreams.

Despite being the sole finswimmer in NUS, Lucas has the unwavering support of his sports manager at NUS, Mr Lim Fang Yi, who was himself a student-athlete in the past. “Fang Yi has always had my back administratively in registering for events, such as the recent Finswimming WUC,” said Lucas.

A former national swimmer, Fang Yi recently returned to competitive swimming, clinching three gold medals at the Singapore Masters 2024.

“More importantly, he uses his own experience as a student-athlete and national swimmer to mentor me to develop myself in ways outside of purely sporting performance, but also in community service, leadership, and in balancing my personal commitments, among other things,” Lucas added, emphasising the well-rounded development that comes from stable guidance.

Similar sentiments were also echoed by Janine, as she reflected on her relationship with her sports manager Riley Tan. “I have received a lot of support from the OSA sports managers, especially Riley. I appreciate that they often check in on our well-being and provide us with advice and support, especially when it gets tougher to balance academic and sporting commitments.”

Janine also said, “Riley arranges for regular sessions for catch-ups and updates on our recent developments, providing us with timely feedback where necessary. She also helped to advise me on my future goals and discuss small actionable steps that I can take along the way. The OSA sports managers even helped to guide me in the planning process of my events!”

Recognising excellence, supporting students for future success  

NUS Dean of Students Associate Professor Ho Han Kiat, said, “Co-curricular space is part of the expanded classroom to develop students holistically in preparation for the future of work. Such opportunities allow our students to engage in activities that align with their passion, and to take it to the level in accordance with their motivation. Through such endeavours, students pick up life skills, sharpen their personal effectiveness and become more meaningfully engaged with the community.”

“Besides recognising their accomplishments in different aspects of student life, such as sports, arts and culture, community impact, scholarships are an institutional commitment that we esteem to see our students build themselves towards future success,” Assoc Prof Ho added.

The NUS Sports Scholarship is awarded to students pursuing full-time undergraduate programmes at NUS, excluding Music, and is tenable for the normal candidature period. The next application period opens in June 2025. More information on the NUS Sports Scholarship can be found here:

  • ✇University of Pennsylvania
  • From one gene switch, many possible outcomes
    A team of researchers led by Aman Husbands of the School of Arts Sciences has uncovered surprising ways transcription factors—the genetic switches for genes—regulate plant development, revealing how subtle changes in a lipid-binding region can dramatically alter gene regulation.
     

From one gene switch, many possible outcomes

November 27th 2024 at 1:36 am

A team of researchers led by Aman Husbands of the School of Arts Sciences has uncovered surprising ways transcription factors—the genetic switches for genes—regulate plant development, revealing how subtle changes in a lipid-binding region can dramatically alter gene regulation.

  • ✇MIT News
  • Troy Van Voorhis to step down as department head of chemistrySchool of Science
    Troy Van Voorhis, the Robert T. Haslam and Bradley Dewey Professor of Chemistry, will step down as department head of the Department of Chemistry at the end of this academic year. Van Voorhis has served as department head since 2019, previously serving the department as associate department head since 2015.“Troy has been an invaluable partner and sounding board who could always be counted on for a wonderful mix of wisdom and pragmatism,” says Nergis Mavalvala, the Kathleen and Curtis Marble prof
     

Troy Van Voorhis to step down as department head of chemistry

November 27th 2024 at 1:20 am

Troy Van Voorhis, the Robert T. Haslam and Bradley Dewey Professor of Chemistry, will step down as department head of the Department of Chemistry at the end of this academic year. Van Voorhis has served as department head since 2019, previously serving the department as associate department head since 2015.

“Troy has been an invaluable partner and sounding board who could always be counted on for a wonderful mix of wisdom and pragmatism,” says Nergis Mavalvala, the Kathleen and Curtis Marble professor of astrophysics and dean of the MIT School of Science. “While department head, Troy provided calm guidance during the Covid pandemic, encouraging and financially supporting additional programs to improve his community’s quality of life.”

“I have had the pleasure of serving as head of our department for the past five-plus years. It has been a period of significant upheaval in our world,” says Van Voorhis. “Throughout it all, one of my consistent joys has been the privilege of working within the chemistry department and across the wider MIT community on research, education, and community building.”

Under Van Voorhis’ leadership, the Department of Chemistry implemented a department-wide statement of values that launched the Diversity, Equity, and Inclusion Committee, a Future Faculty Symposium that showcases rising stars in chemistry, and the Creating Bonds in Chemistry program that partners MIT faculty with chemistry faculty at select historically Black colleges and universities and minority-serving institutions.

Van Voorhis also oversaw a time of tremendous faculty growth in the department with the addition of nine new faculty. During his tenure as head, he also guided the department through a period of significant growth of interest in chemistry with the number of undergraduate majors, enrolled students, graduate students, and graduate student yields all up significantly.

Van Voorhis also had the honor of celebrating with the entire Institute for Professor Moungi Bawendi’s Nobel Prize in Chemistry — the department’s first win in 18 years, since Professor Richard R. Schrock’s win in 2005.

In addition to his service to the department within the School of Science, Van Voorhis had also co-chaired the Working Group on Curricula and Degrees for the MIT Stephen A. Schwarzman College of Computing. This service relates to Van Voorhis’ own research interests and programs.

Van Voorhis’ research lies at the nexus of chemistry and computation, and his work has impact on renewable energy and quantum computing. His lab is focused on developing new methods that provide an accurate description of electron dynamics in molecules and materials. Over the years, his research has led to advances in light-emitting diodes, solar cells, and other devices and technologies crucial to addressing 21st-century energy concerns.   

Van Voorhis received his bachelor's degree in chemistry and mathematics from Rice University and his PhD in chemistry from the University of California at Berkeley in 2001. Following a postdoctoral fellowship at Harvard University, he joined the faculty of MIT in 2003 and was promoted to professor of chemistry in 2012.

He has received many honors and awards, including being named an Alfred P. Sloan research fellow, a fellow of the David and Lucille Packard Foundation, and a recipient of a National Science Foundation CAREER award. He has also received the MIT School of Science’s award for excellence in graduate teaching.

© Photo: Justin Knight

Van Voorhis, the Robert T. Haslam and Bradley Dewey Professor of Chemistry, has served as department head since 2019, previously serving the department as associate department head since 2015.

Is there enough land on Earth to fight climate change and feed the world?

Capping global warming at 1.5 degrees Celsius is a tall order. Achieving that goal will not only require a massive reduction in greenhouse gas emissions from human activities, but also a substantial reallocation of land to support that effort and sustain the biosphere, including humans. More land will be needed to accommodate a growing demand for bioenergy and nature-based carbon sequestration while ensuring sufficient acreage for food production and ecological sustainability.

The expanding role of land in a 1.5 C world will be twofold — to remove carbon dioxide from the atmosphere and to produce clean energy. Land-based carbon dioxide removal strategies include bioenergy with carbon capture and storage; direct air capture; and afforestation/reforestation and other nature-based solutions. Land-based clean energy production includes wind and solar farms and sustainable bioenergy cropland. Any decision to allocate more land for climate mitigation must also address competing needs for long-term food security and ecosystem health.

Land-based climate mitigation choices vary in terms of costs — amount of land required, implications for food security, impact on biodiversity and other ecosystem services — and benefits — potential for sequestering greenhouse gases and producing clean energy.

Now a study in the journal Frontiers in Environmental Science provides the most comprehensive analysis to date of competing land-use and technology options to limit global warming to 1.5 C. Led by researchers at the MIT Center for Sustainability Science and Strategy (CS3), the study applies the MIT Integrated Global System Modeling (IGSM) framework to evaluate costs and benefits of different land-based climate mitigation options in Sky2050, a 1.5 C climate-stabilization scenario developed by Shell.

Under this scenario, demand for bioenergy and natural carbon sinks increase along with the need for sustainable farming and food production. To determine if there’s enough land to meet all these growing demands, the research team uses the global hectare (gha) — an area of 10,000 square meters, or 2.471 acres — as the standard unit of measurement, and current estimates of the Earth’s total habitable land area (about 10 gha) and land area used for food production and bioenergy (5 gha).

The team finds that with transformative changes in policy, land management practices, and consumption patterns, global land is sufficient to provide a sustainable supply of food and ecosystem services throughout this century while also reducing greenhouse gas emissions in alignment with the 1.5 C goal. These transformative changes include policies to protect natural ecosystems; stop deforestation and accelerate reforestation and afforestation; promote advances in sustainable agriculture technology and practice; reduce agricultural and food waste; and incentivize consumers to purchase sustainably produced goods.

If such changes are implemented, 2.5–3.5 gha of land would be used for NBS practices to sequester 3–6 gigatonnes (Gt) of CO2 per year, and 0.4–0.6 gha of land would be allocated for energy production — 0.2–0.3 gha for bioenergy and 0.2–0.35 gha for wind and solar power generation.

“Our scenario shows that there is enough land to support a 1.5 degree C future as long as effective policies at national and global levels are in place,” says CS3 Principal Research Scientist Angelo Gurgel, the study’s lead author. “These policies must not only promote efficient use of land for food, energy, and nature, but also be supported by long-term commitments from government and industry decision-makers.”

© Photo courtesy of the U.S. Department of Energy.

A study led by MIT Center for Sustainability Science and Strategy researchers shows that there is enough land to support efforts to cap global warming at 1.5 degrees Celsius while addressing competing needs for long-term food security and ecosystem health.

Is there enough land on Earth to fight climate change and feed the world?

Capping global warming at 1.5 degrees Celsius is a tall order. Achieving that goal will not only require a massive reduction in greenhouse gas emissions from human activities, but also a substantial reallocation of land to support that effort and sustain the biosphere, including humans. More land will be needed to accommodate a growing demand for bioenergy and nature-based carbon sequestration while ensuring sufficient acreage for food production and ecological sustainability.

The expanding role of land in a 1.5 C world will be twofold — to remove carbon dioxide from the atmosphere and to produce clean energy. Land-based carbon dioxide removal strategies include bioenergy with carbon capture and storage; direct air capture; and afforestation/reforestation and other nature-based solutions. Land-based clean energy production includes wind and solar farms and sustainable bioenergy cropland. Any decision to allocate more land for climate mitigation must also address competing needs for long-term food security and ecosystem health.

Land-based climate mitigation choices vary in terms of costs — amount of land required, implications for food security, impact on biodiversity and other ecosystem services — and benefits — potential for sequestering greenhouse gases and producing clean energy.

Now a study in the journal Frontiers in Environmental Science provides the most comprehensive analysis to date of competing land-use and technology options to limit global warming to 1.5 C. Led by researchers at the MIT Center for Sustainability Science and Strategy (CS3), the study applies the MIT Integrated Global System Modeling (IGSM) framework to evaluate costs and benefits of different land-based climate mitigation options in Sky2050, a 1.5 C climate-stabilization scenario developed by Shell.

Under this scenario, demand for bioenergy and natural carbon sinks increase along with the need for sustainable farming and food production. To determine if there’s enough land to meet all these growing demands, the research team uses the global hectare (gha) — an area of 10,000 square meters, or 2.471 acres — as the standard unit of measurement, and current estimates of the Earth’s total habitable land area (about 10 gha) and land area used for food production and bioenergy (5 gha).

The team finds that with transformative changes in policy, land management practices, and consumption patterns, global land is sufficient to provide a sustainable supply of food and ecosystem services throughout this century while also reducing greenhouse gas emissions in alignment with the 1.5 C goal. These transformative changes include policies to protect natural ecosystems; stop deforestation and accelerate reforestation and afforestation; promote advances in sustainable agriculture technology and practice; reduce agricultural and food waste; and incentivize consumers to purchase sustainably produced goods.

If such changes are implemented, 2.5–3.5 gha of land would be used for NBS practices to sequester 3–6 gigatonnes (Gt) of CO2 per year, and 0.4–0.6 gha of land would be allocated for energy production — 0.2–0.3 gha for bioenergy and 0.2–0.35 gha for wind and solar power generation.

“Our scenario shows that there is enough land to support a 1.5 degree C future as long as effective policies at national and global levels are in place,” says CS3 Principal Research Scientist Angelo Gurgel, the study’s lead author. “These policies must not only promote efficient use of land for food, energy, and nature, but also be supported by long-term commitments from government and industry decision-makers.”

© Photo courtesy of the U.S. Department of Energy.

A study led by MIT Center for Sustainability Science and Strategy researchers shows that there is enough land to support efforts to cap global warming at 1.5 degrees Celsius while addressing competing needs for long-term food security and ecosystem health.
  • ✇Harvard Gazette
  • Ever wonder why your dog does this?Al Powell
    Science & Tech Ever wonder why your dog does this? Study decodes neural mechanism that causes hairy mammals to shake their fur when wet Alvin Powell Harvard Staff Writer November 26, 2024 6 min read It’s a regular occurrence when taking our canine pals for drizzly walks and summer swims. But until recently, the biology behind the water-flinging, human-drenching, muzzle-distorting “we
     

Ever wonder why your dog does this?

By: Al Powell
November 27th 2024 at 12:12 am
Science & Tech

Ever wonder why your dog does this?

Study decodes neural mechanism that causes hairy mammals to shake their fur when wet

Alvin Powell

Harvard Staff Writer

6 min read

It’s a regular occurrence when taking our canine pals for drizzly walks and summer swims. But until recently, the biology behind the water-flinging, human-drenching, muzzle-distorting “wet dog shake” has mystified scientists working to decode the sense of touch.

Last month, researchers in the lab of David Ginty, the Edward R. and Anne G. Lefler Professor of Neurobiology and chair of Harvard Medical School’s Neurobiology Department, reported in work published in the journal Science that they’d used cutting-edge techniques to track sensory signals that underlie wet dog shakes from receptors on the skin to a part of the brain called the parabrachial nucleus.

Using tools — many developed in the Ginty lab — that allow researchers to isolate and trace single neurons and stimulate or block them using light, the researchers determined that the shaking behavior can be evoked by activating a class of sensory neurons called C-LTMRs and, conversely, the number of wet dog shakes evoked by mechanical stimuli decreases when C-LTMRs and the parabrachial nucleus are muted.

The researchers determined that the shaking behavior can be evoked by activating a class of sensory neurons called C-LTMRs.

Though unseen in humans, the motion is universal among fur-bearing mammals, serving as something of an early warning system that insects, dirt, water, and other substances are about to come into contact with the skin. Occurring in everything from grizzly bears to dogs and cats to lab mice, the response is innate, Ginty said, meaning that, though reflexive, it can be controlled by the animal. In humans, Ginty compared it to feeling a bug landing on your arm: You may jerk your arm or flick at it with your other hand with little thought, but it can be controlled if desired. In Ginty’s lab, researchers used droplets of sunflower oil applied to the upper back to trigger the response in mice who’d been genetically engineered so that specific neurons could be stimulated or blocked using light.

“One thing we’ve done over the last 15 to 20 years is generate genetic tools that allow us to study each of the sensory neurons that associate with the skin in isolation and that’s been incredibly powerful,” Ginty said.

The skin has approximately 20 different types of sensory receptors, including those that detect hot, cold, itch, and touch. Twelve or so receptors detect different types of touch, from a quick stab of pain to vibration to steady pressure to a soft caress. The signal triggering the “wet dog shake” starts in C-LTMRs, or C-fiber low threshold mechanoreceptors, which wrap around the base of a hair follicle. The receptor is one of the body’s most sensitive and can pick up the slightest movement of the hair or a depression of the skin around the hair’s base.

From the receptor, the signal travels along nerve cells into the spine, where it joins with the spinal cord. The signals then emerge from the spinal cord and travel to the brain stem and the parabrachial nucleus. Beyond enhancing our understanding of a basic and familiar mammalian behavior, Ginty said that the techniques developed have allowed researchers to overcome a major hurdle — understanding what’s going on inside the spinal cord.

“We understand the logic of organization of the neural circuitry that underlies visual information processing and sound information processing,” said Ginty, whose lab has been focused on unravelling the neurobiology of touch for decades. “For touch — for somatosensory information processing — we’re kind of in a black box trying to understand it because it’s been so challenging to access and record neural activity in the spinal cord.”

Though they’ve tracked the signal to a specific location in the brain, Ginty said many questions remain. An important one is understanding whether the pathway they identified accounts for all the wet dog shake response or, given the limitations of their functional manipulations, if there’s more going on than they were able to see.

“We’re struggling to answer that question, because the tools we typically use are rarely 100 percent effective in blocking one of these steps,” Ginty said. “So, you never know if a residual 10 percent underlies the remaining behavior or if there’s another pathway or another cell type that you’re missing. In this case, I guess it’s the latter, but we can’t be sure.”

Another important question in the work, supported by the National Institutes of Health and the Lefler Center for the Study of Neurodegenerative Disorders, is why, if C-LTMR receptors are located all over the body, do only those on the upper middle back trigger the response?

“It’s a very exciting time to understand brain-body physiology: how the body is represented in the brain and how the brain, in turn, controls organ systems of the body.”

David Ginty

From a behavioral standpoint, the answer is clear — that part of the body is out of reach of claws and paws and hooves for swatting or scratching — but that doesn’t explain how nerve signals from that part of the body trigger the wet dog shake while other signals that begin in the same type of receptor and go to the same part of the brain do not. Perhaps, Ginty said, the signals emanating from the nerves originating on the upper middle back propagate to unique regions of the parabrachial nucleus from those originating elsewhere on the body. Another possibility, he said, is that the signal from the upper back is somehow amplified in the spinal cord before reaching the brain.

Though Ginty is a dog lover, he said the work began not out of an appreciation for dogs but by accident. Dawei Zhang, then a graduate student in Ginty’s lab, was using optical tools to activate the then-mysterious pathway beginning with C-LTMR and noticed that every time he did, the mouse would give itself a shake. When Zhang and Ginty saw the reaction, they immediately realized what it was.

“It’s a very exciting time to understand brain-body physiology: how the body is represented in the brain and how the brain, in turn, controls organ systems of the body,” Ginty said. “Some of the new tools coming online are really powerful for helping us unravel these circuits.”

  • ✇University of Cambridge
  • Scientists warn of ‘invisible threat’ of microplastics as global treaty nears completionsc604
    Even if global production and pollution of new plastic is drastically reduced, scientists, writing in the journal Nature Communications, say that legacy plastics, the billions of tonnes of waste already in the environment, will continue to break down into tiny particles called microplastics for decades or centuries. These fragments contaminate oceans, land, and the air we breathe, posing risks to marine life, food production and human health. The researchers – from the University of Cambridge,
     

Scientists warn of ‘invisible threat’ of microplastics as global treaty nears completion

By: sc604
November 26th 2024 at 2:20 pm
Researcher holding small pieces of micro plastic pollution washed up on a beach

Even if global production and pollution of new plastic is drastically reduced, scientists, writing in the journal Nature Communications, say that legacy plastics, the billions of tonnes of waste already in the environment, will continue to break down into tiny particles called microplastics for decades or centuries.

These fragments contaminate oceans, land, and the air we breathe, posing risks to marine life, food production and human health.

The researchers – from the University of Cambridge, GNS Science in New Zealand and The Ocean Cleanup in The Netherlands – say the problem lies in a gap between ambition and action, called the fragmentation gap.

At a meeting this week in Busan, South Korea, the Intergovernmental Negotiating Committee on Plastic Pollution is meeting to finalise the Global Plastics Treaty, the first legally binding treaty to tackle plastic pollution.

While the treaty’s initial discussions highlight prevention of plastic pollution, the researchers say it largely overlooks the need to remove existing waste. This omission means microplastics will continue to accumulate, even if plastic pollution slows.

“The treaty is aiming to eliminate plastic pollution by 2040, but this goal is unlikely without stronger action,” said co-author Zhenna Azimrayat-Andrews, a PhD student at Cambridge’s Department of Earth Sciences. “Even with a sharp reduction in plastic entering the ocean, existing debris will split into smaller pieces and persist for centuries.”

These microplastics have already infiltrated marine ecosystems and are harming marine ecosystems, degrading commercial seafood quality, and disrupting critical ocean processes.

The researchers argue that plastic clean-up efforts must be prioritised alongside reduction targets. Strategies to remove plastics from terrestrial and marine environments, such as those targeting pollution in beaches and rivers, could help prevent microplastics from forming. In fact, a 3% annual removal of legacy plastic, combined with aggressive reduction measures, could significantly curb future contamination, they say.

Without action to address legacy plastic, the treaty risks leaving behind a long-lasting problem for marine life and future generations. Experts are calling for clean-up efforts to become an equal pillar of the treaty, alongside prevention and recycling.

As world leaders gather to negotiate the treaty this week, the spotlight is on their ability to craft a comprehensive plan that doesn't just slow pollution but also begins to reverse the damage that has already been done.

Reference:
Karin Kvale, Zhenna Azimrayat Andrews & Matthias Egger. ‘Mind the fragmentation gap.’ Nature Communications (2024). DOI: 10.1038/s41467-024-53962-3

As the UN meets this week to finalise the Global Plastics Treaty, researchers warn that the agreement could fail to address one of the biggest threats to marine environments—microplastics.

Researcher holding small pieces of micro plastic pollution washed up on a beach

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A sense of mattering: Pioneer House Master Prahlad Vadakkepat on fostering care, connection and belonging

November 26th 2024 at 10:30 am

Home away from home icon-Final


In this series, NUS News profiles the personalities shaping vibrant residential life and culture on campus, and how they craft a holistic residential experience that brings out the best in student residents.

 

When his son graduated from university in 2016, Associate Professor Prahlad Vadakkepat felt a sudden void in his life. Over the years, he had taken on the role of a mentor, learning about the younger generation’s challenges and perspectives as he supported his child through his academic journey.

But as his son prepared to enter the working world, their topics of conversation shifted, and Assoc Prof Prahlad was struck by a sense of loss. “There was a vacuum, like there was something I was missing out on,” he said.

Then came the serendipitous email in early 2017. It detailed an opening for Master of a new hostel at Prince George’s Park Residences at NUS. Without hesitation, he applied for it.

“(It) turned out to be one of the best decisions of my life,” the professor, who hails from the Department of Electrical and Computer Engineering at the NUS College of Design and Engineering, said. “I truly enjoy serving as the Master of Pioneer House.”

He was a mentor once more, this time to hundreds of students as Master of Pioneer House.

Pioneer House’s journey began in 2017, when the Office of Student Affairs proposed a fourth model of student housing in NUS. Initially dubbed PGP House, it was renamed Pioneer House in 2022, when NUS officially recognised the “House” model.

Pioneer House lives up to its name, being the first hostel on campus to merge NUS’ three existing housing models. It balances the vibrancy of halls and residential colleges with the quiet freedom of residences. In short, the House model balances residents’ involvement while maintaining a lively student residence.

Pioneer House also features Dining with Master sessions, where Assoc Prof Prahlad and the students gather for a weekly chat over dinner.

It currently houses over 600 residents, who can participate in interest groups, find peer mentors for support, and rely on Pastoral Care Teams (PCTs) comprising student leaders and staff when they need help.

NUS sits down with Assoc Prof Prahlad as he shares his journey in making Pioneer House the caring home it is for students today.

This interview has been edited for length and clarity.

 

Q: What’s a typical day like for you?

In the morning, I check various Telegram channels for any messages that need attention, and we start the day with warm greetings. Evenings often involve student activities in the House, ranging from cultural events, sports, and training to various meetings.

Living in a hostel surrounded by familiar faces is both comforting and reassuring. It creates a sense of belonging, like being part of a family. Every time I pass a resident or colleague, we exchange smiles and waves and engage in small conversations. These small interactions make a big difference – I truly enjoy interacting with young minds and fellow residents.

Q: What’s buzzing at Pioneer House?

We have all kinds of student life activities for residents to choose from, allowing them to explore and destress after a long day of classes. Before COVID-19, we had something called “Chill and Chat”, where we came together, went outside, and sat in a space between the blocks. There, we would chat and dine – an under-the-stars kind of thing.

We had an event for Deepavali as well! There was Indian food, Indian dancing, and people wore traditional costumes. There was also henna and floral decoration (using) flowers or powders. And once night fell, sparklers were lit.

We also celebrate birthdays. When we have a Dining with Master or Cluster event, a PCT event, or a meeting with student leaders, we celebrate the birthdays of students as well as the management team with a cake. I'm a vegetarian, and the students will buy me a cake without eggs. There’s the sense that you belong and matter in Pioneer House. They feel that I matter to them, and they feel that they matter to me, and they care about the food I eat.

Q: Tell us about the theme of “Frugality and Sustainability” at Pioneer House. How did that come about?

During my childhood, my grandmother would make sure we never wasted even a single grain of rice. As I grew older, I began to realise how much we waste while many communities struggle for a better life. This awareness led me to delve deeper into the concepts of frugality and sustainability.

At Pioneer House, we integrate the principles of frugality and sustainability into our daily practices, whether it's managing resources, nurturing plants, or fostering leadership.

Pioneer House has a community garden where residents cultivate and harvest their own vegetables. It is equivalent to the size of about two master bedrooms. We grow sweet potatoes, lady's fingers, and other leafy vegetables, then we harvest them. We go to the barbecue pit nearby, cook, and we share.

By weaving these values into every aspect of our operations, we foster a culture that respects resources, promotes sustainability, and nurtures growth in all forms.

Q: What are the most rewarding and challenging parts of being a Master?

The most rewarding aspect is the opportunity to connect with a diverse group of people and work collaboratively to provide the best experience for our students. Here, we create a sense of belonging and mattering; it’s really important.

Once, after a break, a student from Pioneer House sat next to me on the bus. I asked her, “Did you go home (during the break)?” She told me she did, and that she was in tears on the flight back to Singapore from her home country. I had also just come back from India, and I told her: “I cried too.” It is these authentic conversations – I was happy that she could share that with me, and that I could share that with her. Again, a sense of mattering. We care, and we do things genuinely.

The challenge was establishing a completely new hostel model in 2017. We didn’t have a specific model to follow; the closest existing framework was the Hall model. We had extensive discussions and empowered ourselves through research, exploring frameworks that would help us build a community grounded in care and support. I had previously helped a community in India and developed a social enterprise, uniting around 900 individuals from varied backgrounds for the project and honing my ability to form personal human connections. My entrepreneurial background, combined with my experience in brainstorming and design thinking, helped me navigate these uncharted waters.

Concepts like a sense of belonging and mattering, inclusive leadership, frugality, and sustainability became central to our approach. We integrated the principles of belonging into our programmes and events, fostering a community where students could work together, while also feeling free to be themselves. One such example is PHamigo—creatively named to reflect its affiliation and mission, it is a group formed by residents which leverages the "Design-Your-Own-Course" academic scheme to foster inclusiveness by engaging the international student community. The support from student leaders was instrumental in weaving these values into the very fabric of Pioneer House.

Q: What makes Pioneer House home for you?

Colleagues and residents share a strong bond and support each other wholeheartedly. During the COVID-19 period, my family was in India – that was the first time I lived alone. The community really helped me, such as my House colleagues who would bring me fruits and homemade food. Though I am a strict vegetarian, I also made sure to source specially cooked chicken for my colleagues as a gesture of appreciation.

Residents often greet us warmly, waving whenever we cross paths, whether in the House, on the shuttle bus, or on the MRT. This deep sense of belonging fosters a familial community atmosphere. During the Dining with Master sessions, I often share stories about my family, and the residents frequently ask about how we’re doing. Pioneer House truly feels like home.

 

MORE IN THIS SERIES

The power of a blank canvas: House Master Lee Kooi Cheng of Helix House on creating a home from scratch

Old is gold: KEVII Hall’s Master Kuldip Singh is proud of its long history and traditions

Unity from diversity: Prince George’s Park Residence Master Lee Chian Chau welcomes you to a customised hostel experience 

Do what you enjoy: RC4’s Master Peter Pang wants students to ‘chill’ and stay connected

Find refuge, recharge and rest: LightHouse Master Chen Zhi Xiong sheds light on what makes his hostel a haven

A legacy of excellence: Celebrating 95 years of research and educational innovation at the NUS Faculty of Arts and Social Sciences

More than 350 distinguished guests comprising university and faculty members, donors, cherished alumni, students and friends came together to celebrate the NUS Faculty of Arts and Social Sciences’ (FASS) legacy of education and research excellence at a gala dinner held at One Farrer Hotel on 22 November 2024.

From humble beginnings to a world-class faculty

FASS boasts a rich and illustrious history that spans close to a century.

The Faculty began by offering diploma courses in the four disciplines of English, History, Geography and Economics in 1929. Over the years, in response to the nation’s growth and local and international needs, other departments such as Social Work (1952), Philosophy (1954), Political Science (1961), Communications and New Media (2005), and many others were formed.

Today, the Faculty is one of the largest faculties at NUS boasting 16 different departments and programmes and academic offerings in the fields of humanities, social sciences, Asian studies, and language studies that cover a rich and diverse array of disciplines ranging from Southeast Asian Studies and Psychology to Theatre Studies, and Sociology and Anthropology.

From just fewer than 40 students taking its classes in 1929, FASS welcomed about 4,400 undergraduates and more than 1,500 postgraduates in the current academic year. The Faculty also has a strong international outlook, offering students diverse opportunities to study abroad and engage with global perspectives through joint degree programmes, exchange programmes, internships and collaborations with top universities worldwide such as King’s College London and the University of North Carolina – Chapel Hill. In the last academic year alone, the Faculty received more than 800 exchange students from 34 countries, a testament to its global appeal and multicultural campus environment.  

Reflecting on FASS’ legacy at the dinner, Dean of FASS and FASS alumnus Professor Lionel Wee noted that the Faculty has never wavered in its mission to advance knowledge and learning in the humanities and social sciences. He said, “Over the decades, while the world around us has changed, this mission has remained steadfast – the guiding of generations of students to become thoughtful leaders and engaged citizens who make a difference in Singapore and beyond.”  

FASS alumni have gone on to excel on the national and global stages – playing leading roles in shaping global and public policy, trailblazing business initiatives in the private sector, advancing cultural initiatives and driving social change. Eminent alumni include former President of Singapore Mr S R Nathan; Former Under-Secretary-General of the United Nations and social scientist Dr Noeleen Heyzer; influential Asian historian and NUS Emeritus Professor Wang Gungwu, as well as prominent business entrepreneur and Founder of Banyan Tree Holdings, Mr Ho Kwon Ping.

Over the years, the Faculty has continuously spearheaded fresh educational strategies – demonstrating its keen understanding of evolving societal trends. In 2019, it introduced the FASS 2.0 Industry Tracks initiative that provides undergraduates industry-relevant training to complement the FASS education. A year later, the Faculty and the NUS Faculty of Science launched the NUS College of Humanities and Sciences with interdisciplinary education as its focus.

Indeed, initiatives such as CHS, said Prof Wee, demonstrate FASS’ dedication to equip students to meet the demands of an interconnected and rapidly changing world. “This interdisciplinary approach helps prepare them to view challenges from multiple perspectives, positioning them as well-rounded leaders and changemakers.”

Echoing similar sentiments was guest-of-honour, Prof Aaron Thean, NUS Deputy President (Academic Affairs) and Provost, who noted that CHS also offers more opportunities for NUS academics as it encourages groundbreaking interdisciplinary research partnerships between FASS and faculties across NUS. FASS, he stressed, “has been, and will continue to be, a cornerstone of our university and a place where intellectual exploration and a sense of community can be found.”

FASS alumni: Memories of FASS and the value of a FASS education

The gala dinner was an opportunity for alumni to reconnect and recall fond memories of their time at FASS.

Reminiscing about her university days, Ms Nichol Ng, CEO of food and beverage business X-Inc Group and Co-founder of the Food Bank Singapore, shared that her best memories were of studying on the steps of the Forum near the Central Library and climbing the hills to get to class.

The rigour and diversity of experiences offered by the Faculty proved invaluable in the FASS Economics and Japanese Studies alumna’s career. “The diversity of people whom I have met in FASS also allowed me to work with peers from different backgrounds and passions, establishing the people skills that I have today,” she added.

Another alumna, Ms Nur Diyana shared that the academic rigour and emphasis on critical inquiry during her time at the Department of Malay Studies sharpened her analytical thinking and nurtured a deep curiosity. “This has been instrumental in my graduate studies and continues to influence my work as a research librarian at NUS Libraries, where I draw upon those same skills to navigate complex information and contribute meaningfully to my field.”

Professor Robbie Goh, former FASS Dean and Provost at the Singapore University of Social Sciences observed how far FASS has come, with international university counterparts now lining up to seek potential collaborations with FASS – a far cry from the situation he witnessed as a young FASS academic in the 1990s. FASS, he added, had made a profound impact on his professional and personal lives.

He said, “FASS is my alma mater as well as my intellectual home and where I spent 33 years as an academic.  It’s where I met my wife when we were undergraduates together. Without the opportunities and encouragement that FASS gave me, I simply would not have had the resources and wherewithal to become an academic.”

Looking ahead – A FASS that continues to nurture young changemakers, with a strong social ethos

To mark the Faculty’s 95th birthday, FASSCares, an annual community engagement programme that started in 2018, held a fundraising initiative for Club Rainbow – a charity that supports children with chronic illnesses and their families. FASS had chosen to partner with Club Rainbow given a shared commitment to social responsibility and community support. A special outing was also organised for 22 children from Club Rainbow and their families at Jewel Changi Airport’s Canopy Park in September, where FASS staff, students and alumni spent the afternoon playing with the children and their families on the slides and bouncing nets, and bonded over lunch.

Close to S$66,000 was raised at this fundraising initiative through donations from staff, students and alumni and ticket sales for the gala dinner.

Thanking FASS for its efforts at the dinner, Mr Teo Siang Loong, Executive Director of Club Rainbow said, “We are currently serving close to 5,000 individuals in Club Rainbow including 1,200 children with chronic illnesses, many of whom have special needs and disabilities. In this year of an uncertain economic climate and inflationary environment, our donations have decreased overall. All the support garnered will have a direct impact on the children in need and on the vulnerable families.”

FASS also launched the new 95th FASS Distinguished Speaker Series with the aim to inspire FASS students towards excellence through meaningful engagements with alumni about their achievements. The series’ inaugural speaker, Ms Denise Phua, Member of Parliament for Jalan Besar GRC and Mayor for Central Singapore District, engaged students in September on the leadership lessons she learnt from her careers in the private, public and social sectors.

As FASS enters its centennial, Prof Wee stressed that the Faculty will focus on building on the work of past FASS cohorts to advance an interdisciplinary education that has both breadth and depth. It will continue to nurture adaptable, empathetic and innovative problem-solvers with a strong social ethos.

The Faculty, he added, is also committed to enhancing impact through research that spans disciplines and connects with real-world issues, “from urban studies to public policy, from heritage conservation to digital humanities.”

When asked for his views on the role FASS will take in shaping contemporary society, Dr Maliki Osman, an alumnus and Minister in the Prime Minister’s Office and Second Minister for Education and Foreign Affairs, summed it up succinctly. “In today's world where issues are becoming increasingly complex and require a multi-disciplinary approach to solve, the humanities and social sciences continue to play an important role…I am confident that FASS will continue to scale new heights and nurture tomorrow’s citizens – people who are creative, collaborative and compassionate.”

  • ✇University of Pennsylvania
  • A semester of community on campus
    Penn’s fall semester officially began in August, as many students returned to campus. While staff, faculty, and postdocs are largely in West Philadelphia year-round, the fall marks a reset and starting point for many. The late summer and mild fall weather brings the natural beauty of campus to life.
     

A semester of community on campus

November 26th 2024 at 3:36 am

Penn’s fall semester officially began in August, as many students returned to campus. While staff, faculty, and postdocs are largely in West Philadelphia year-round, the fall marks a reset and starting point for many. The late summer and mild fall weather brings the natural beauty of campus to life.

  • ✇MIT News
  • The MIT Press releases report on the future of open access publishing and policyMIT Press
    The MIT Press has released a comprehensive report that addresses how open access policies shape research and what is needed to maximize their positive impact on the research ecosystem.The report, entitled “Access to Science and Scholarship 2024: Building an Evidence Base to Support the Future of Open Research Policy,” is the outcome of a National Science Foundation-funded workshop held at the Washington headquarters of the American Association for the Advancement of Science on Sept. 20.While ope
     

The MIT Press releases report on the future of open access publishing and policy

By: MIT Press
November 26th 2024 at 2:00 am

The MIT Press has released a comprehensive report that addresses how open access policies shape research and what is needed to maximize their positive impact on the research ecosystem.

The report, entitled “Access to Science and Scholarship 2024: Building an Evidence Base to Support the Future of Open Research Policy,” is the outcome of a National Science Foundation-funded workshop held at the Washington headquarters of the American Association for the Advancement of Science on Sept. 20.

While open access aims to democratize knowledge, its implementation has been a factor in the consolidation of the academic publishing industry, an explosion in published articles with inconsistent review and quality control, and new costs that may be hard for researchers and universities to bear, with less-affluent schools and regions facing the greatest risk. The workshop examined how open access and other open science policies may affect research and researchers in the future, how to measure their impact, and how to address emerging challenges.

The event brought together leading experts to discuss critical issues in open scientific and scholarly publishing. These issues include:

  • the impact of open access policies on the research ecosystem;
  • the enduring role of peer review in ensuring research quality;
  • the challenges and opportunities of data sharing and curation; and
  • the evolving landscape of scholarly communications infrastructure.

The report identifies key research questions in order to advance open science and scholarship. These include:

  • How can we better model and anticipate the consequences of government policies on public access to science and scholarship?
  • How can research funders support experimentation with new and more equitable business models for scientific publishing? and
  • If the dissemination of scholarship is decoupled from peer review and evaluation, who is best suited to perform that evaluation, and how should that process be managed and funded?

“This workshop report is a crucial step in building a data-driven roadmap for the future of open science publishing and policy,” says Phillip Sharp, Institute Professor and professor of biology emeritus at MIT, and faculty lead of the working group behind the workshop and the report. “By identifying key research questions around infrastructure, training, technology, and business models, we aim to ensure that open science practices are sustainable and that they contribute to the highest quality research.”

The full report is available for download, along with video recordings of the workshop.

The MIT Press is a leading academic publisher committed to advancing knowledge and innovation. It publishes significant books and journals across a wide range of disciplines spanning science, technology, design, humanities, and social science.

© Image courtesy of The MIT Press.

A recent workshop and its subsequent report examined how open access and other open science policies may affect research and researchers in the future, how to measure their impact, and how to address emerging challenges.
  • ✇MIT News
  • The MIT Press releases report on the future of open access publishing and policyMIT Press
    The MIT Press has released a comprehensive report that addresses how open access policies shape research and what is needed to maximize their positive impact on the research ecosystem.The report, entitled “Access to Science and Scholarship 2024: Building an Evidence Base to Support the Future of Open Research Policy,” is the outcome of a National Science Foundation-funded workshop held at the Washington headquarters of the American Association for the Advancement of Science on Sept. 20.While ope
     

The MIT Press releases report on the future of open access publishing and policy

By: MIT Press
November 26th 2024 at 2:00 am

The MIT Press has released a comprehensive report that addresses how open access policies shape research and what is needed to maximize their positive impact on the research ecosystem.

The report, entitled “Access to Science and Scholarship 2024: Building an Evidence Base to Support the Future of Open Research Policy,” is the outcome of a National Science Foundation-funded workshop held at the Washington headquarters of the American Association for the Advancement of Science on Sept. 20.

While open access aims to democratize knowledge, its implementation has been a factor in the consolidation of the academic publishing industry, an explosion in published articles with inconsistent review and quality control, and new costs that may be hard for researchers and universities to bear, with less-affluent schools and regions facing the greatest risk. The workshop examined how open access and other open science policies may affect research and researchers in the future, how to measure their impact, and how to address emerging challenges.

The event brought together leading experts to discuss critical issues in open scientific and scholarly publishing. These issues include:

  • the impact of open access policies on the research ecosystem;
  • the enduring role of peer review in ensuring research quality;
  • the challenges and opportunities of data sharing and curation; and
  • the evolving landscape of scholarly communications infrastructure.

The report identifies key research questions in order to advance open science and scholarship. These include:

  • How can we better model and anticipate the consequences of government policies on public access to science and scholarship?
  • How can research funders support experimentation with new and more equitable business models for scientific publishing? and
  • If the dissemination of scholarship is decoupled from peer review and evaluation, who is best suited to perform that evaluation, and how should that process be managed and funded?

“This workshop report is a crucial step in building a data-driven roadmap for the future of open science publishing and policy,” says Phillip Sharp, Institute Professor and professor of biology emeritus at MIT, and faculty lead of the working group behind the workshop and the report. “By identifying key research questions around infrastructure, training, technology, and business models, we aim to ensure that open science practices are sustainable and that they contribute to the highest quality research.”

The full report is available for download, along with video recordings of the workshop.

The MIT Press is a leading academic publisher committed to advancing knowledge and innovation. It publishes significant books and journals across a wide range of disciplines spanning science, technology, design, humanities, and social science.

© Image courtesy of The MIT Press.

A recent workshop and its subsequent report examined how open access and other open science policies may affect research and researchers in the future, how to measure their impact, and how to address emerging challenges.
  • ✇MIT News
  • A blueprint for better cancer immunotherapiesBendta Schroeder | Koch Institute
    Immune checkpoint blockade (ICB) therapies can be very effective against some cancers by helping the immune system recognize cancer cells that are masquerading as healthy cells. T cells are built to recognize specific pathogens or cancer cells, which they identify from the short fragments of proteins presented on their surface. These fragments are often referred to as antigens. Healthy cells will will not have the same short fragments or antigens on their surface, and thus will be spared from at
     

A blueprint for better cancer immunotherapies

November 26th 2024 at 1:45 am

Immune checkpoint blockade (ICB) therapies can be very effective against some cancers by helping the immune system recognize cancer cells that are masquerading as healthy cells. 

T cells are built to recognize specific pathogens or cancer cells, which they identify from the short fragments of proteins presented on their surface. These fragments are often referred to as antigens. Healthy cells will will not have the same short fragments or antigens on their surface, and thus will be spared from attack. 

Even with cancer-associated antigens studding their surfaces, tumor cells can still escape attack by presenting a checkpoint protein, which is built to turn off the T cell. Immune checkpoint blockade therapies bind to these “off-switch” proteins and allow the T cell to attack.

Researchers have established that how cancer-associated antigens are distributed throughout a tumor determines how it will respond to checkpoint therapies. Tumors with the same antigen signal across most of its cells respond well, but heterogeneous tumors with subpopulations of cells that each have different antigens, do not. The overwhelming majority of tumors fall into the latter category and are characterized by heterogenous antigen expression. Because the mechanisms behind antigen distribution and tumor response are poorly understood, efforts to improve ICB therapy response in heterogenous tumors have been hindered.

In a new study, MIT researchers analyzed antigen expression patterns and associated T cell responses to better understand why patients with heterogenous tumors respond poorly to ICB therapies. In addition to identifying specific antigen architectures that determine how immune systems respond to tumors, the team developed an RNA-based vaccine that, when combined with ICB therapies, was effective at controlling tumors in mouse models of lung cancer.

Stefani Spranger, associate professor of biology and member of MIT’s Koch Institute for Integrative Cancer Research, is the senior author of the study, appearing recently in the Journal for Immunotherapy of Cancer. Other contributors include Koch Institute colleague Forest White, the Ned C. (1949) and Janet Bemis Rice Professor and professor of biological engineering at MIT, and Darrell Irvine, professor of immunology and microbiology at Scripps Research Institute and a former member of the Koch Institute.

While RNA vaccines are being evaluated in clinical trials, current practice of antigen selection is based on the predicted stability of antigens on the surface of tumor cells. 

“It’s not so black-and-white,” says Spranger. “Even antigens that don’t make the numerical cut-off could be really valuable targets. Instead of just focusing on the numbers, we need to look inside the complex interplays between antigen hierarchies to uncover new and important therapeutic strategies.”

Spranger and her team created mouse models of lung cancer with a number of different and well-defined expression patterns of cancer-associated antigens in order to analyze how each antigen impacts T cell response. They created both “clonal” tumors, with the same antigen expression pattern across cells, and “subclonal” tumors that represent a heterogenous mix of tumor cell subpopulations expressing different antigens. In each type of tumor, they tested different combinations of antigens with strong or weak binding affinity to MHC.

The researchers found that the keys to immune response were how widespread an antigen is expressed across a tumor, what other antigens are expressed at the same time, and the relative binding strength and other characteristics of antigens expressed by multiple cell populations in the tumor

As expected, mouse models with clonal tumors were able to mount an immune response sufficient to control tumor growth when treated with ICB therapy, no matter which combinations of weak or strong antigens were present. However, the team discovered that the relative strength of antigens present resulted in dynamics of competition and synergy between T cell populations, mediated by immune recognition specialists called cross-presenting dendritic cells in tumor-draining lymph nodes. In pairings of two weak or two strong antigens, one resulting T cell population would be reduced through competition. In pairings of weak and strong antigens, overall T cell response was enhanced. 

In subclonal tumors, with different cell populations emitting different antigen signals, competition rather than synergy was the rule, regardless of antigen combination. Tumors with a subclonal cell population expressing a strong antigen would be well-controlled under ICB treatment at first, but eventually parts of the tumor lacking the strong antigen began to grow and developed the ability evade immune attack and resist ICB therapy.

Incorporating these insights, the researchers then designed an RNA-based vaccine to be delivered in combination with ICB treatment with the goal of strengthening immune responses suppressed by antigen-driven dynamics. Strikingly, they found that no matter the binding affinity or other characteristics of the antigen targeted, the vaccine-ICB therapy combination was able to control tumors in mouse models. The widespread availability of an antigen across tumor cells determined the vaccine’s success, even if that antigen was associated with weak immune response.

Analysis of clinical data across tumor types showed that the vaccine-ICB therapy combination may be an effective strategy for treating patients with tumors with high heterogeneity. Patterns of antigen architectures in patient tumors correlated with T cell synergy or competition in mice models and determined responsiveness to ICB in cancer patients. In future work with the Irvine laboratory at the Scripps Research Institute, the Spranger laboratory will further optimize the vaccine with the aim of testing the therapy strategy in the clinic. 

© Image: Elen Torres/Koch Institute

A heterogeneous lung tumor, with different subpopulations of cells depicted in red and and blue. After treatment with a checkpoint blockade, T cells (white) attack some populations (blue) but not others (red) — a sign that checkpoint blockade therapies might be ineffective for this tumor. A new vaccine from the Spranger Lab may help checkpoint blockades attack all cell populations and effectively treat the tumor.
  • ✇MIT News
  • A blueprint for better cancer immunotherapiesBendta Schroeder | Koch Institute
    Immune checkpoint blockade (ICB) therapies can be very effective against some cancers by helping the immune system recognize cancer cells that are masquerading as healthy cells. T cells are built to recognize specific pathogens or cancer cells, which they identify from the short fragments of proteins presented on their surface. These fragments are often referred to as antigens. Healthy cells will will not have the same short fragments or antigens on their surface, and thus will be spared from at
     

A blueprint for better cancer immunotherapies

November 26th 2024 at 1:45 am

Immune checkpoint blockade (ICB) therapies can be very effective against some cancers by helping the immune system recognize cancer cells that are masquerading as healthy cells. 

T cells are built to recognize specific pathogens or cancer cells, which they identify from the short fragments of proteins presented on their surface. These fragments are often referred to as antigens. Healthy cells will will not have the same short fragments or antigens on their surface, and thus will be spared from attack. 

Even with cancer-associated antigens studding their surfaces, tumor cells can still escape attack by presenting a checkpoint protein, which is built to turn off the T cell. Immune checkpoint blockade therapies bind to these “off-switch” proteins and allow the T cell to attack.

Researchers have established that how cancer-associated antigens are distributed throughout a tumor determines how it will respond to checkpoint therapies. Tumors with the same antigen signal across most of its cells respond well, but heterogeneous tumors with subpopulations of cells that each have different antigens, do not. The overwhelming majority of tumors fall into the latter category and are characterized by heterogenous antigen expression. Because the mechanisms behind antigen distribution and tumor response are poorly understood, efforts to improve ICB therapy response in heterogenous tumors have been hindered.

In a new study, MIT researchers analyzed antigen expression patterns and associated T cell responses to better understand why patients with heterogenous tumors respond poorly to ICB therapies. In addition to identifying specific antigen architectures that determine how immune systems respond to tumors, the team developed an RNA-based vaccine that, when combined with ICB therapies, was effective at controlling tumors in mouse models of lung cancer.

Stefani Spranger, associate professor of biology and member of MIT’s Koch Institute for Integrative Cancer Research, is the senior author of the study, appearing recently in the Journal for Immunotherapy of Cancer. Other contributors include Koch Institute colleague Forest White, the Ned C. (1949) and Janet Bemis Rice Professor and professor of biological engineering at MIT, and Darrell Irvine, professor of immunology and microbiology at Scripps Research Institute and a former member of the Koch Institute.

While RNA vaccines are being evaluated in clinical trials, current practice of antigen selection is based on the predicted stability of antigens on the surface of tumor cells. 

“It’s not so black-and-white,” says Spranger. “Even antigens that don’t make the numerical cut-off could be really valuable targets. Instead of just focusing on the numbers, we need to look inside the complex interplays between antigen hierarchies to uncover new and important therapeutic strategies.”

Spranger and her team created mouse models of lung cancer with a number of different and well-defined expression patterns of cancer-associated antigens in order to analyze how each antigen impacts T cell response. They created both “clonal” tumors, with the same antigen expression pattern across cells, and “subclonal” tumors that represent a heterogenous mix of tumor cell subpopulations expressing different antigens. In each type of tumor, they tested different combinations of antigens with strong or weak binding affinity to MHC.

The researchers found that the keys to immune response were how widespread an antigen is expressed across a tumor, what other antigens are expressed at the same time, and the relative binding strength and other characteristics of antigens expressed by multiple cell populations in the tumor

As expected, mouse models with clonal tumors were able to mount an immune response sufficient to control tumor growth when treated with ICB therapy, no matter which combinations of weak or strong antigens were present. However, the team discovered that the relative strength of antigens present resulted in dynamics of competition and synergy between T cell populations, mediated by immune recognition specialists called cross-presenting dendritic cells in tumor-draining lymph nodes. In pairings of two weak or two strong antigens, one resulting T cell population would be reduced through competition. In pairings of weak and strong antigens, overall T cell response was enhanced. 

In subclonal tumors, with different cell populations emitting different antigen signals, competition rather than synergy was the rule, regardless of antigen combination. Tumors with a subclonal cell population expressing a strong antigen would be well-controlled under ICB treatment at first, but eventually parts of the tumor lacking the strong antigen began to grow and developed the ability evade immune attack and resist ICB therapy.

Incorporating these insights, the researchers then designed an RNA-based vaccine to be delivered in combination with ICB treatment with the goal of strengthening immune responses suppressed by antigen-driven dynamics. Strikingly, they found that no matter the binding affinity or other characteristics of the antigen targeted, the vaccine-ICB therapy combination was able to control tumors in mouse models. The widespread availability of an antigen across tumor cells determined the vaccine’s success, even if that antigen was associated with weak immune response.

Analysis of clinical data across tumor types showed that the vaccine-ICB therapy combination may be an effective strategy for treating patients with tumors with high heterogeneity. Patterns of antigen architectures in patient tumors correlated with T cell synergy or competition in mice models and determined responsiveness to ICB in cancer patients. In future work with the Irvine laboratory at the Scripps Research Institute, the Spranger laboratory will further optimize the vaccine with the aim of testing the therapy strategy in the clinic. 

© Image: Elen Torres/Koch Institute

A heterogeneous lung tumor, with different subpopulations of cells depicted in red and and blue. After treatment with a checkpoint blockade, T cells (white) attack some populations (blue) but not others (red) — a sign that checkpoint blockade therapies might be ineffective for this tumor. A new vaccine from the Spranger Lab may help checkpoint blockades attack all cell populations and effectively treat the tumor.
  • ✇MIT News
  • Improving health, one machine learning system at a timeMichaela Jarvis | Laboratory for Information and Decision Systems
    Captivated as a child by video games and puzzles, Marzyeh Ghassemi was also fascinated at an early age in health. Luckily, she found a path where she could combine the two interests. “Although I had considered a career in health care, the pull of computer science and engineering was stronger,” says Ghassemi, an associate professor in MIT’s Department of Electrical Engineering and Computer Science and the Institute for Medical Engineering and Science (IMES) and principal investigator at the Labor
     

Improving health, one machine learning system at a time

Captivated as a child by video games and puzzles, Marzyeh Ghassemi was also fascinated at an early age in health. Luckily, she found a path where she could combine the two interests. 

“Although I had considered a career in health care, the pull of computer science and engineering was stronger,” says Ghassemi, an associate professor in MIT’s Department of Electrical Engineering and Computer Science and the Institute for Medical Engineering and Science (IMES) and principal investigator at the Laboratory for Information and Decision Systems (LIDS). “When I found that computer science broadly, and AI/ML specifically, could be applied to health care, it was a convergence of interests.”

Today, Ghassemi and her Healthy ML research group at LIDS work on the deep study of how machine learning (ML) can be made more robust, and be subsequently applied to improve safety and equity in health.

Growing up in Texas and New Mexico in an engineering-oriented Iranian-American family, Ghassemi had role models to follow into a STEM career. While she loved puzzle-based video games — “Solving puzzles to unlock other levels or progress further was a very attractive challenge” — her mother also engaged her in more advanced math early on, enticing her toward seeing math as more than arithmetic.

“Adding or multiplying are basic skills emphasized for good reason, but the focus can obscure the idea that much of higher-level math and science are more about logic and puzzles,” Ghassemi says. “Because of my mom’s encouragement, I knew there were fun things ahead.”

Ghassemi says that in addition to her mother, many others supported her intellectual development. As she earned her undergraduate degree at New Mexico State University, the director of the Honors College and a former Marshall Scholar — Jason Ackelson, now a senior advisor to the U.S. Department of Homeland Security — helped her to apply for a Marshall Scholarship that took her to Oxford University, where she earned a master’s degree in 2011 and first became interested in the new and rapidly evolving field of machine learning. During her PhD work at MIT, Ghassemi says she received support “from professors and peers alike,” adding, “That environment of openness and acceptance is something I try to replicate for my students.”

While working on her PhD, Ghassemi also encountered her first clue that biases in health data can hide in machine learning models.

She had trained models to predict outcomes using health data, “and the mindset at the time was to use all available data. In neural networks for images, we had seen that the right features would be learned for good performance, eliminating the need to hand-engineer specific features.”

During a meeting with Leo Celi, principal research scientist at the MIT Laboratory for Computational Physiology and IMES and a member of Ghassemi’s thesis committee, Celi asked if Ghassemi had checked how well the models performed on patients of different genders, insurance types, and self-reported races.

Ghassemi did check, and there were gaps. “We now have almost a decade of work showing that these model gaps are hard to address — they stem from existing biases in health data and default technical practices. Unless you think carefully about them, models will naively reproduce and extend biases,” she says.

Ghassemi has been exploring such issues ever since.

Her favorite breakthrough in the work she has done came about in several parts. First, she and her research group showed that learning models could recognize a patient’s race from medical images like chest X-rays, which radiologists are unable to do. The group then found that models optimized to perform well “on average” did not perform as well for women and minorities. This past summer, her group combined these findings to show that the more a model learned to predict a patient’s race or gender from a medical image, the worse its performance gap would be for subgroups in those demographics. Ghassemi and her team found that the problem could be mitigated if a model was trained to account for demographic differences, instead of being focused on overall average performance — but this process has to be performed at every site where a model is deployed.

“We are emphasizing that models trained to optimize performance (balancing overall performance with lowest fairness gap) in one hospital setting are not optimal in other settings. This has an important impact on how models are developed for human use,” Ghassemi says. “One hospital might have the resources to train a model, and then be able to demonstrate that it performs well, possibly even with specific fairness constraints. However, our research shows that these performance guarantees do not hold in new settings. A model that is well-balanced in one site may not function effectively in a different environment. This impacts the utility of models in practice, and it’s essential that we work to address this issue for those who develop and deploy models.”

Ghassemi’s work is informed by her identity.

“I am a visibly Muslim woman and a mother — both have helped to shape how I see the world, which informs my research interests,” she says. “I work on the robustness of machine learning models, and how a lack of robustness can combine with existing biases. That interest is not a coincidence.”

Regarding her thought process, Ghassemi says inspiration often strikes when she is outdoors — bike-riding in New Mexico as an undergraduate, rowing at Oxford, running as a PhD student at MIT, and these days walking by the Cambridge Esplanade. She also says she has found it helpful when approaching a complicated problem to think about the parts of the larger problem and try to understand how her assumptions about each part might be incorrect.

“In my experience, the most limiting factor for new solutions is what you think you know,” she says. “Sometimes it’s hard to get past your own (partial) knowledge about something until you dig really deeply into a model, system, etc., and realize that you didn’t understand a subpart correctly or fully.”

As passionate as Ghassemi is about her work, she intentionally keeps track of life’s bigger picture.

“When you love your research, it can be hard to stop that from becoming your identity — it’s something that I think a lot of academics have to be aware of,” she says. “I try to make sure that I have interests (and knowledge) beyond my own technical expertise.

“One of the best ways to help prioritize a balance is with good people. If you have family, friends, or colleagues who encourage you to be a full person, hold on to them!”

Having won many awards and much recognition for the work that encompasses two early passions — computer science and health — Ghassemi professes a faith in seeing life as a journey.

“There’s a quote by the Persian poet Rumi that is translated as, ‘You are what you are looking for,’” she says. “At every stage of your life, you have to reinvest in finding who you are, and nudging that towards who you want to be.”

© Photo: Qudus Shittu

Marzyeh Ghassemi and her Healthy Machine Learning research group at the MIT Laboratory for Information and Decision Systems work on the deep study of how machine learning can be made more robust and subsequently applied to improve safety and equity in health.
  • ✇Harvard Gazette
  • Polaroid gave her a shot. She helped revolutionize photography.Elizabeth Zonarich
    Images courtesy of Baker Library Special Collections; Ansel Adams test photos. © The Ansel Adams Publishing Rights Trust; photo illustration by Liz Zonarich/Harvard Staff Arts & Culture Polaroid gave her a shot. She helped revolutionize photography. HBS Communications November 25, 2024 4 min read Meroë Morse — focus of Baker Library exhibition — led company’s researchers during innovative era 
     

Polaroid gave her a shot. She helped revolutionize photography.

November 25th 2024 at 11:05 pm

Images courtesy of Baker Library Special Collections; Ansel Adams test photos. © The Ansel Adams Publishing Rights Trust; photo illustration by Liz Zonarich/Harvard Staff

Arts & Culture

Polaroid gave her a shot. She helped revolutionize photography.

HBS Communications

4 min read

Meroë Morse — focus of Baker Library exhibition — led company’s researchers during innovative era 

Meroë Morse had no formal background in business or science when she started at Polaroid in 1945, but within a few years she rose to become manager of black-and-white photographic research and later to director of special photographic research, a notable achievement for a woman in the 1950s and ’60s.

A new exhibition at the Business School’s Baker Library is putting the focus on Morse and her contributions to the development of instant photography — launched commercially by Polaroid in 1948. The collection, “From Concept to Product: Meroë Morse and Polaroid’s Culture of Art and Innovation, 1945–1969,” on view in Baker’s north lobby through April 18, draws on the library’s extensive holdings of the Polaroid Corporation Collection.


“The function of industry is not just the making of goods, the function of industry is the development of people.”

-Edwin Land, the founder of Polaroid

Meroë Morse.

A culture of innovation

Edwin H. Land, Polaroid’s founder, cultivated a creative culture within his research and manufacturing enterprise, building an interdisciplinary community devoted to technical and artistic excellence. 

Morse, an art history graduate of Smith College, found exceptional opportunities for women in the post-war era at Polaroid. She oversaw round-the-clock shifts of researchers conducting thousands of experiments in the company’s Cambridge laboratory, and met increasing demands for new Polaroid films as the popularity of instant photography soared. 

Meroë Morse and three male colleagues.
Morse’s affable and commanding presence among her male colleagues. 

Instant photography is launched

The first instant film and camera sold for $1.75 and $89.75 respectively on Nov. 26, 1948, in Boston’s Jordan Marsh department store. The camera measured 10½ by 4½ by 2½ inches and weighed four pounds, two ounces. It featured an optical foldout viewfinder, a three-element 135-mm f/11 lens, and shutter speeds from 1/8 to 1/60 of a second. All 56 cameras sold out that day.

Polaroid camera patent from October 6, 1945.
Morse is holding a hand-made wheel with the names of some of the developing chemicals used in the instant photography system. 

Morse holds a hand-made wheel containing names of some of the developing chemicals used in instant photography.

Edwin Land.

Early Polaroid test photograph of Edwin Land in November 1945.

Edwin Land in a test photo.

The first Polaroid film, Type 40, produced sepia-toned prints with a limited tonal range.

Two young girls embrace as they pose for a photo.

Children pose for a test photo.

Two children on a bicycle.

In 1950, the company introduced black-and-white film Type 41.

Research in black and white

In 1948, Morse became the laboratory supervisor responsible for photographic materials. The earliest Polaroid film, Type 40, produced sepia-toned prints that had limited tonal range. Morse and her lab looked to produce black-and-white images that exhibited greater detail and a color palette more familiar and appealing to consumers. In 1950, after two years of intensive work, the company introduced black-and-white film Type 41. The film produced prints that exhibited finer detail and, as U.S. Camera enthused, created “pictures-in-a-minute of exceptional tonal values.” The Detroit Free Press reported that Land credited Morse with “valuable assistance in research that led to the new film.”

Meroë Morse poses for Polaroid test photos. One photo is her posing with a large white hat. And the other photo is her standing elegantly with a pearl necklace.
Meroë Morse poses for Polaroid test photos.

Ansel Adams and Polaroid

Morse also served as chief liaison to Ansel Adams, the renowned landscape photographer. A principal consultant for Polaroid from 1948 until his death in 1984, Adams tested the company’s prototype cameras and film. He reviewed technical and design aspects of Polaroid prototypes, from the wording of instruction manuals to the tonal values of finished prints.

Photo by Ansel Adams of an older woman.

Ansel Adams Polaroid test photos.

Ansel Adams test photos. © The Ansel Adams Publishing Rights Trust.

Photo by Ansel Adams of Edwin Land.

Portrait of Edwin Land.

Ansel Adams test photos. © The Ansel Adams Publishing Rights Trust.

Photo by Ansel Adams of an animal skull.

Polaroid test photo from the Southwest.

Ansel Adams test photos. © The Ansel Adams Publishing Rights Trust.

Photo by Ansel Adams of a waterfall.

Polaroid test photo from California.

Ansel Adams test photos. © The Ansel Adams Publishing Rights Trust.

The exhibition was organized by Baker Library Special Collections and Archives, with support from the de Gaspé Beaubien Family Endowment. This text is drawn from the exhibition catalog. Find more information at the Baker Library website.

  • ✇MIT News
  • To design better water filters, MIT engineers look to manta raysJennifer Chu | MIT News
    Filter feeders are everywhere in the animal world, from tiny crustaceans and certain types of coral and krill, to various molluscs, barnacles, and even massive basking sharks and baleen whales. Now, MIT engineers have found that one filter feeder has evolved to sift food in ways that could improve the design of industrial water filters.In a paper appearing this week in the Proceedings of the National Academy of Sciences, the team characterizes the filter-feeding mechanism of the mobula ray — a f
     

To design better water filters, MIT engineers look to manta rays

November 25th 2024 at 11:30 pm

Filter feeders are everywhere in the animal world, from tiny crustaceans and certain types of coral and krill, to various molluscs, barnacles, and even massive basking sharks and baleen whales. Now, MIT engineers have found that one filter feeder has evolved to sift food in ways that could improve the design of industrial water filters.

In a paper appearing this week in the Proceedings of the National Academy of Sciences, the team characterizes the filter-feeding mechanism of the mobula ray — a family of aquatic rays that includes two manta species and seven devil rays. Mobula rays feed by swimming open-mouthed through plankton-rich regions of the ocean and filtering plankton particles into their gullet as water streams into their mouths and out through their gills.

The floor of the mobula ray’s mouth is lined on either side with parallel, comb-like structures, called plates, that siphon water into the ray’s gills. The MIT team has shown that the dimensions of these plates may allow for incoming plankton to bounce all the way across the plates and further into the ray’s cavity, rather than out through the gills. What’s more, the ray’s gills absorb oxygen from the outflowing water, helping the ray to simultaneously breathe while feeding.

“We show that the mobula ray has evolved the geometry of these plates to be the perfect size to balance feeding and breathing,” says study author Anette “Peko” Hosoi, the Pappalardo Professor of Mechanical Engineering at MIT.

The engineers fabricated a simple water filter modeled after the mobula ray’s plankton-filtering features. They studied how water flowed through the filter when it was fitted with 3D-printed plate-like structures. The team took the results of these experiments and drew up a blueprint, which they say designers can use to optimize industrial cross-flow filters, which are broadly similar in configuration to that of the mobula ray.

“We want to expand the design space of traditional cross-flow filtration with new knowledge from the manta ray,” says lead author and MIT postdoc Xinyu Mao PhD ’24. “People can choose a parameter regime of the mobula ray so they could potentially improve overall filter performance.”

Hosoi and Mao co-authored the new study with Irmgard Bischofberger, associate professor of mechanical engineering at MIT.

A better trade-off

The new study grew out of the group’s focus on filtration during the height of the Covid pandemic, when the researchers were designing face masks to filter out the virus. Since then, Mao has shifted focus to study filtration in animals and how certain filter-feeding mechanisms might improve filters used in industry, such as in water treatment plants.

Mao observed that any industrial filter must strike a balance between permeability (how easily fluid can flow through a filter), and selectivity (how successful a filter is at keeping out particles of a target size). For instance, a membrane that is studded with large holes might be highly permeable, meaning a lot of water can be pumped through using very little energy. However, the membrane’s large holes would let many particles through, making it very low in selectivity. Likewise, a membrane with much smaller pores would be more selective yet also require more energy to pump the water through the smaller openings.

“We asked ourselves, how do we do better with this tradeoff between permeability and selectivity?” Hosoi says.

As Mao looked into filter-feeding animals, he found that the mobula ray has struck an ideal balance between permeability and selectivity: The ray is highly permeable, in that it can let water into its mouth and out through its gills quickly enough to capture oxygen to breathe. At the same time, it is highly selective, filtering and feeding on plankton rather than letting the particles stream out through the gills.

The researchers realized that the ray’s filtering features are broadly similar to that of industrial cross-flow filters. These filters are designed such that fluid flows across a permeable membrane that lets through most of the fluid, while any polluting particles continue flowing across the membrane and eventually out into a reservoir of waste.

The team wondered whether the mobula ray might inspire design improvements to industrial cross-flow filters. For that, they took a deeper dive into the dynamics of mobula ray filtration.

A vortex key

As part of their new study, the team fabricated a simple filter inspired by the mobula ray. The filter’s design is what engineers refer to as a “leaky channel” — effectively, a pipe with holes along its sides. In this case, the team’s “channel” consists of two flat, transparent acrylic plates that are glued together at the edges, with a slight opening between the plates through which fluid can be pumped. At one end of the channel, the researchers inserted 3D-printed structures resembling the grooved plates that run along the floor of the mobula ray’s mouth.

The team then pumped water through the channel at various rates, along with colored dye to visualize the flow. They took images across the channel and observed an interesting transition: At slow pumping rates, the flow was “very peaceful,” and fluid easily slipped through the grooves in the printed plates and out into a reservoir. When the researchers increased the pumping rate, the faster-flowing fluid did not slip through, but appeared to swirl at the mouth of each groove, creating a vortex, similar to a small knot of hair between the tips of a comb’s teeth.

“This vortex is not blocking water, but it is blocking particles,” Hosoi explains. “Whereas in a slower flow, particles go through the filter with the water, at higher flow rates, particles try to get through the filter but are blocked by this vortex and are shot down the channel instead. The vortex is helpful because it prevents particles from flowing out.”

The team surmised that vortices are the key to mobula rays’ filter-feeding ability. The ray is able to swim at just the right speed that water, streaming into its mouth, can form vortices between the grooved plates. These vortices effectively block any plankton particles — even those that are smaller than the space between plates. The particles then bounce across the plates and head further into the ray’s cavity, while the rest of the water can still flow between the plates and out through the gills.

The researchers used the results of their experiments, along with dimensions of the filtering features of mobula rays, to develop a blueprint for cross-flow filtration.

“We have provided practical guidance on how to actually filter as the mobula ray does,” Mao offers.

“You want to design a filter such that you’re in the regime where you generate vortices,” Hosoi says. “Our guidelines tell you: If you want your plant to pump at a certain rate, then your filter has to have a particular pore diameter and spacing to generate vortices that will filter out particles of this size. The mobula ray is giving us a really nice rule of thumb for rational design.”

This work was supported, in part, by the U.S. National Institutes of Health, and the Harvey P. Greenspan Fellowship Fund. 

© Photo: Jennifer Chu

Engineers fabricated a simple water filter modeled after the mobula ray’s plankton-filtering features. Pictured are pieces of the filter.

Professor Emeritus James Harris, a scholar of Spanish language, dies at 92

James Wesley “Jim” Harris PhD ’67, professor emeritus of Spanish and linguistics, passed away on Nov. 10. He was 92.

Harris attended the University of Georgia, the Instituto Tecnológico de Estudios Superiores de Monterrey, and the Universidad Nacional Autónoma de México. He later earned a master’s degree in linguistics from Louisiana State University and a PhD in linguistics from MIT.

Harris joined the MIT faculty as an assistant professor in 1967, where he remained until his retirement in 1996. During his tenure, he served as head of what was then called the Department of Foreign Languages and Literatures.

“I met Jim when I came to MIT in 1977 as department head of the neonatal Department of Linguistics and Philosophy,” says Samuel Jay Keyser, MIT professor emeritus of linguistics. “Throughout his career in the department, he never relinquished his connection to the unit that first employed him at MIT.”

In his early days at MIT, when French, German, and Russian dominated as elite “languages of science and world literature,” Harris championed, over some opposition, the introduction of Spanish language and literature courses.

He later oversaw the inclusion of Japanese and Chinese courses as language offerings at MIT. He promoted undergraduate courses in linguistics, leading to a full undergraduate degree program and later broadening the focus of the prestigious PhD program. 

His research in linguistics centered on theoretical phonology and morphology. His books, presentations at professional meetings, and articles in peer-reviewed journals were among the most discussed — in both positive and negative assessments, as he noted — by prominent scholars in the field. The ability to teach complex technical material comfortably in Spanish, plus the status of an MIT professorship, resulted in invitations to teach at universities across Spain and Latin America. He was also highly valued as a member of the editorial boards of several professional journals.

“I remember Jim most of all for being the consummate scholar,” Keyser says. “His articles were models of argumentation. They were assembled with all the precision of an Inca wall and all the beauty of a Faberge Egg. You couldn’t slip a credit card through any of its arguments, they were so superbly sculpted.”

Having achieved national recognition as an English-Spanish bilingual teacher and teacher-trainer, Harris was engaged as a writer at the Modern Language Materials Development Center in New York. Later, he co-authored, with Guillermo Segreda, a series of popular college-level Spanish textbooks.

“Harris belonged to Noam Chomsky and Morris Halle’s first generation of graduate students,” says MIT linguist Michael John Kenstowicz. “Together they overturned the distributionalist model of the structuralists in favor of ordered generative rules.”

After retiring from MIT, he remained internationally recognized as a highly influential figure in the area of Romance linguistics, and “el decano” (“the dean”) of Spanish phonology.

Harris was married to Florence Warshawsky Harris for 50 years until her passing in 2020. In 2011, in celebration of the program’s 50th anniversary, they partnered to prepare and publish a detailed history of the linguistics program’s origins. Warshawsky Harris, formerly an MIT graduate student, also edited Chomsky and Halle’s influential "The Sound Pattern on English" and numerous other important linguistic texts.

Harris’ scholarship was widely recognized in a diverse group of scholarly articles and textbooks he authored, co-authored, edited, and published.

Harris was born outside Atlanta, Georgia, in 1932. During the Korean War, he performed his military service as the clarinet and saxophone instructor at the U.S. Naval School of Music in Washington. After his discharge, he directed the band at the Charlotte Hall School in Maryland, where he also taught Spanish, French, and Latin.

Harris is survived by ​​his daughter, Lynn Corinne Harris, his son-in-law, Rabbi David Adelson, and his grandchildren, Bee Adelson and Sam Harris.

© Photo: Lynn Harris

Professor Emeritus James Harris was a scholar of Spanish language whose research centered on theoretical phonology and morphology.
  • ✇Harvard Gazette
  • Updating their 3-word biosStephanie Mitchell
    Passing through an autumn campus at Harvard University.Photos by Stephanie Mitchell/Harvard Staff Photographer Campus & Community Updating their 3-word bios Stephanie Mitchell Harvard Staff Photographer November 25, 2024 8 min read Juniors who talked to us when they first arrived here — and again as sophomores — reflect on how they’ve changed Gazette photographer Stephanie Mitchell h
     

Updating their 3-word bios

November 25th 2024 at 9:40 pm
View outside Littauer Building.

Passing through an autumn campus at Harvard University.

Photos by Stephanie Mitchell/Harvard Staff Photographer

Campus & Community

Updating their 3-word bios

Stephanie Mitchell

Harvard Staff Photographer

8 min read

Juniors who talked to us when they first arrived here — and again as sophomores — reflect on how they’ve changed

Gazette photographer Stephanie Mitchell has been conducting a bit of an experiment inspired by her own college years — specifically the address by Nora Ephron to Wellesley’s Class of 1996 expressing, “You are not going to be you, fixed and immutable you, forever.” She met with a group of Harvard students during their first year and sophomore year, photographed them, and asked them to describe themselves in three words. The students, now juniors, participated in the exercise once again. The three words they chose appear below in gray (2022), dark gray (2023), and black (2024).


Free. Independent. Friendly.

Independent. Free. Possibility.

Free. Independent. Creativity.

Sofia Chavez.
First Year
Sofia Chavez is pictured.
Sophomore Year
Sofia Chavez.
Junior Year

Sofia Chavez

Currier House

When we first spoke to Chavez in 2022, the student from Hidalgo, Mexico, noted that she was “learning how to be independent for the first time, leaving home and my country.”

This year, she said: “I’m growing. I’m an adult. I have the freedom of choosing my own path, making decisions, making mistakes, and learning from them.”

In all three of her interviews, Chavez described herself as “free” and independent.” She added a new descriptor this year: creativity. “It gives you the tools to solve problems, not only academically, but in your life.”

As a first-year, she listed women’s and gender studies and sociology as academic interests. By the fall of her sophomore year, she was leaning toward a government concentration in the law and justice track with a secondary in economics. Chavez has since declared a government concentration with a language citation in French. She is considering a senior thesis in political theory and a career in law.

“As a perfectionist or overachiever, you always want to have things in control,” said Chavez, but lately she is happier because “I don’t think about those expectations anymore, only my own.”


God-loving. Adventurous. Passionate.

God-loving. Adventurous. Kind.

God-loving. Grateful. Composed.

Bradley Chinhara.
First Year
Bradley Chinhara.
Sophomore Year
Bradley Chinhara.
Junior Year

Bradley Chinhara

Lowell House

Two years ago, Zimbabwe native Chinhara characterized himself as an “adventurous” person with “diverse interests,” from electrical engineering to rugby to playing the marimba. He credited Christianity and love of family as guiding forces.

“I still pray every day. I still love my religion,” said Chinhara. He’s added two new descriptors this year.

“Grateful, because I wake up every day, and I realize that I go to Harvard, which was one of my biggest dreams growing up. … Grateful for my mom. She passed away, but she lived a beautiful life. … And then composed, because I’m a junior now. I know how things work. I’ve made mistakes, and I’ve learned from them. I’m now at a point where I know what I want. I know how to pursue it.”

Chinhara’s interest in computer science hasn’t wavered as he tilts toward tech entrepreneurship and product management. In 2023, he launched a software development startup. He said he will declare a secondary in economics and is considering business school.

Last spring, he “started reaching out more, talking to more people, going to office hours.”

“It dramatically improved my academic life, my social life, my mental health.”


Fun. Kind. Excited.

Grateful. Motivated. Hopeful.

Energized. Grateful. Inspired.

Myra Bhathena.
First Year
Myra Bhathena.
Sophomore Year
Myra Bhathena ’26.
Junior Year

Myra Bhathena

Pforzheimer House

“Building relationships is the most important thing to me,” said Bhathena in her first-year interview. That theme continues today. She feels energized, she said, “reflecting on the people who have gotten me here.”

“It brings me back to my family — my grandparents, my parents, my siblings. I was lucky to spend the end of the summer with a lot of them, and they always ground me.”

Bhathena has completed many foundational requirements for her economics concentration and is turning to her secondary in global health and health policy. Interning at Boston Children’s Hospital doing research this past summer has only reaffirmed her pre-med track. “I am really excited to dedicate my career to medicine and to caring for people.”

She has moved into mentorship roles in clubs and the classroom, for example serving as a Teaching Fellow for EC10. “I love teaching, and I’m excited to meet new freshmen in the class who are just as nervous and scared as I was.”

This year, “I am a more balanced person,” Bhathena said. “Time has given me more freedom to just be myself and take some deep breaths and enjoy my last two years here.”


Friendly. Excitable. Ambitious.

Approachable. Adaptable. Vibrant.

Evolving. Ambitious. Present.

Dara Omoloja.
First Year
Dara Omoloja.
Sophomore Year
Dara Omoloja.
Junior Year

Dara Omoloja

Leverett House

Omoloja spent the summer back home in Wisconsin. “I had a lot of time to think and contemplate my priorities. There’s so much I need to do and that I want to do in this life.”

In her first Gazette interview Omoloja said she was most looking forward to “immense personal discovery that everyone mentions when thinking about college.”

Now a junior cognizant of how quickly time is passing, she said, “In the past, I spent so much time looking down, be that at my phone, or as I walk, looking at the floor, because I’m thinking about how all these people are seeing me. But now, I really want to pay attention, to be present. Every time I look around, I think, ‘Wow, this world is so pretty, and I want to just take that in more.’”

Reflecting on last year, Omoloja said, “I learned to advocate for myself more. … My biggest lesson was although it is important to show kindness and to have community, it shouldn’t go at the expense of your personal comfort and happiness. … I’m more comfortable in my identity this year. I’m very happy to be me.”

“Ambitious,” a word she used to define herself in 2022, re-emerged as she studies for the MCAT and takes the courses “Medicine and Health in America” and “Therapeutic Rationalities,” concrete steps toward becoming a doctor.


Adventurous. Ambitious. Authentic.

Excited. Fun. Adventurous.

Excited. Relaxed. Melancholy.

Austin Wang.
First Year
Austin Wang.
Sophomore Year
Austin Wang.
Junior Year

Austin Wang

Lowell House

Wang describes himself as both excited and relaxed this year. “I think believing in yourself and having confidence is really important,” and when things become hectic “it’s good to be relaxed and Zen.”

Rejuvenated from a summer of seeing friends and family, doing genetic computational research at the Medical School, and volunteering at the Harvard Square Homeless Shelter, Wang also feels a bit melancholic.

“I looked down at my Pset, and I look up, and it’s already junior year. It went by really quickly … I’m looking forward to the second half.”

Since his last interview, the Canada native has declared his concentration in chemical and physical biology with a secondary in computer science and has continued to find ways to break out of his comfort zone, a goal he emphasized in previous years.

Ringing the Lowell House bells every Sunday has been “super fun.” He shares the recruitment joke for the bells, known for waking up students at the bright hour of 1 p.m. on Sundays: “If you feel like you’re too well liked, feel free to join!”


Creative. Passionate. Fun.

Enthusiastic. Creative/Artistic. Natural.

Creative. Mellow. Open.

Nali Gone.
First Year
Nali Gone.
Sophomore Year
Nali Gone.
Junior Year

Nali Gone

Eliot House

Creativity has been a constant for Gone over the past three years. “It’s a great way for me to engage with the world and understand what people think and feel.”

This year, “I’m not as worried about what’s going to happen. I’m just living in the moment. I am really trying to put myself out there and try new things. Now is such a formative time in my life.”

Gone has declared a concentration in women, gender, and sexuality with a secondary in psychology, and is currently taking a history class about the relationship between guns, property, and power, as well as a First Amendment seminar. “I’m in my amendment era, one might say.”

Last year Gone helped stage-manage for the Harvard-Radcliffe Dramatic Club musical “Jekyll and Hyde” and the musical comedy “The 25th Annual Putnam County Spelling Bee,” and continues this year with the musical “Pippin.”

A key lesson from sophomore year: how to find balance and take breaks between time commitments.


Excited. Determined. Outgoing

Excited. Passionate. Ambitious.

Growth. Excited. Passionate.

Riley Flynn.
First Year
Riley Flynn.
Sophomore Year
Riley Flynn.
Junior Year

Riley Flynn

Eliot House

Softball continues to be a focus for Flynn, a rise ball and curveball pitcher who was named Ivy League Rookie of the Year in 2023. While athletics can be time-consuming, she enjoys the camaraderie while traveling the country with her teammates.

Last season, Flynn underwent elbow surgery. “I’m finding my way, working through rehab, and my team has been great through all of that, supporting me and helping me. I should be able to play in the spring.”

What else has changed? “My first years were definitely more about exploring, and this year, I have found things that I am passionate about, whether it’s making friends, playing sports, what I’m studying, and I’m definitely going to go deeper into that in the next two years.”

She’s delving into her concentration in human developmental and regenerative biology with a neuroscience secondary, taking courses in organic chemistry and psychopharmacology.

“I feel that I’ve found my place here and now it’s more about growing in order to continue finding people and places that I love.”

  • ✇MIT News
  • New solar projects will grow renewable energy generation for four major campus buildingsMIT Office of Sustainability
    In the latest step to implement commitments made in MIT’s Fast Forward climate action plan, staff from the Department of Facilities; Office of Sustainability; and Environment, Health and Safety Office are advancing new solar panel installations this fall and winter on four major campus buildings: The Stratton Student Center (W20), the Dewey Library building (E53), and two newer buildings, New Vassar (W46) and the Theater Arts building (W97).These four new installations, in addition to existing r
     

New solar projects will grow renewable energy generation for four major campus buildings

November 25th 2024 at 9:30 pm

In the latest step to implement commitments made in MIT’s Fast Forward climate action plan, staff from the Department of Facilities; Office of Sustainability; and Environment, Health and Safety Office are advancing new solar panel installations this fall and winter on four major campus buildings: The Stratton Student Center (W20), the Dewey Library building (E53), and two newer buildings, New Vassar (W46) and the Theater Arts building (W97).

These four new installations, in addition to existing rooftop solar installations on campus, are “just one part of our broader strategy to reduce MIT’s carbon footprint and transition to clean energy,” says Joe Higgins, vice president for campus services and stewardship.

The installations will not only meet but exceed the target set for total solar energy production on campus in the Fast Forward climate action plan that was issued in 2021. With an initial target of 500 kilowatts of installed solar capacity on campus, the new installations, along with those already in place, will bring the total output to roughly 650 kW, exceeding the goal. The solar installations are an important facet of MIT’s approach to eliminating all direct campus emissions by 2050.

The process of advancing to the stage of placing solar panels on campus rooftops is much more complex than just getting them installed on an ordinary house. The process began with a detailed assessment of the potential for reducing the campus greenhouse gas footprint. A first cut eliminated rooftops that were too shaded by trees or other buildings. Then, the schedule for regular replacement of roofs had to be taken into account — it’s better to put new solar panels on top of a roof that will not need replacement in a few years. Other roofs, especially lab buildings, simply had too much existing equipment on them to allow a large area of space for solar panels.

Randa Ghattas, senior sustainability project manager, and Taya Dixon, assistant director for capital budgets and contracts within the Department of Facilities, spearheaded the project. Their initial assessment showed that there were many buildings identified with significant solar potential, and it took the impetus of the Fast Forward plan to kick things into action. 

Even after winnowing down the list of campus buildings based on shading and the life cycle of roof replacements, there were still many other factors to consider. Some buildings that had ample roof space were of older construction that couldn’t bear the loads of a full solar installation without significant reconstruction. “That actually has proved trickier than we thought,” Ghattas says. For example, one building that seemed a good candidate, and already had some solar panels on it, proved unable to sustain the greater weight and wind loads of a full solar installation. Structural capacity, she says, turned out to be “probably the most important” factor in this case.

The roofs on the Student Center and on the Dewey Library building were replaced in the last few years with the intention of the later addition of solar panels. And the two newer buildings were designed from the beginning with solar in mind, even though the solar panels were not part of the initial construction. “The designs were built into them to accommodate solar,” Dixon says, “so those were easy options for us because we knew the buildings were solar-ready and could support solar being integrated into their systems, both the electrical system and the structural system of the roof.”

But there were also other considerations. The Student Center is considered a historically significant building, so the installation had to be designed so that it was invisible from street level, even including a safety railing that had to be built around the solar array. But that was not a problem. “It was fine for this building,” Ghattas says, because it turned out that the geometry of the building and the roofs hid the safety railing from view below.

Each installation will connect directly to the building’s electrical system, and thus into the campus grid. The power they produce will be used in the buildings they are on, though none will be sufficient to fully power its building. Overall, the new installations, in addition to the existing ones on the MIT Sloan School of Management building (E62) and the Alumni Pool (57) and the planned array on the new Graduate Junction dorm (W87-W88), will be enough to power 5 to 10 percent of the buildings’ electric needs, and offset about 190 metric tons of carbon dioxide emissions each year, Ghattas says. This is equivalent to the electricity use of 35 homes annually.

Each building installation is expected to take just a couple of weeks. “We’re hopeful that we’re going to have everything installed and operational by the end of this calendar year,” she says.

Other buildings could be added in coming years, as their roof replacement cycles come around. With the lessons learned along the way in getting to this point, Ghattas says, “now that we have a system in place, hopefully it’s going to be much easier in the future.”

Higgins adds that “in parallel with the solar projects, we’re working on expanding electric vehicle charging stations and the electric vehicle fleet and reducing energy consumption in campus buildings.”

Besides the on-campus improvements, he says, “MIT is focused on both the local and the global.” In addition to solar installations on campus buildings, which can only mitigate a small portion of campus emissions, “large-scale aggregation partnerships are key to moving the actual market landscape for adding cleaner energy generation to power grids,” which must ultimately lead to zero emissions, he says. “We are spurring the development of new utility-grade renewable energy facilities in regions with high carbon-intensive electrical grids. These projects have an immediate and significant impact in the urgently needed decarbonization of regional power grids.”

MIT is also making more advances to accelerate renewable energy generation and electricity grid decarbonization at the local and state level. The Institute has recently concluded an agreement through the Solar Massachusetts Renewable Target program that supports the Commonwealth of Massachusetts’ state solar power development goals by enabling the construction of a new 5-megawatt solar energy facility on Cape Cod. The new solar energy system is integral to supporting a new net-zero emissions development that includes affordable housing, while also providing additional resiliency to the local grid.

Higgins says that other technologies, strategies, and practices are being evaluated for heating, cooling, and power for the campus, “with zero carbon emissions by 2050, utilizing cleaner energy sources.” He adds that these campus initiatives “are part of MIT’s larger Climate Project, aiming to drive progress both on campus and beyond, advancing broader partnerships, new market models, and informing approaches to climate policy.” 

New solar panels are installed on the roof of MIT Building W46.
  • ✇MIT News
  • New AI tool generates realistic satellite images of future floodingJennifer Chu | MIT News
    Visualizing the potential impacts of a hurricane on people’s homes before it hits can help residents prepare and decide whether to evacuate.MIT scientists have developed a method that generates satellite imagery from the future to depict how a region would look after a potential flooding event. The method combines a generative artificial intelligence model with a physics-based flood model to create realistic, birds-eye-view images of a region, showing where flooding is likely to occur given the
     

New AI tool generates realistic satellite images of future flooding

November 25th 2024 at 7:50 pm

Visualizing the potential impacts of a hurricane on people’s homes before it hits can help residents prepare and decide whether to evacuate.

MIT scientists have developed a method that generates satellite imagery from the future to depict how a region would look after a potential flooding event. The method combines a generative artificial intelligence model with a physics-based flood model to create realistic, birds-eye-view images of a region, showing where flooding is likely to occur given the strength of an oncoming storm.

As a test case, the team applied the method to Houston and generated satellite images depicting what certain locations around the city would look like after a storm comparable to Hurricane Harvey, which hit the region in 2017. The team compared these generated images with actual satellite images taken of the same regions after Harvey hit. They also compared AI-generated images that did not include a physics-based flood model.

The team’s physics-reinforced method generated satellite images of future flooding that were more realistic and accurate. The AI-only method, in contrast, generated images of flooding in places where flooding is not physically possible.

The team’s method is a proof-of-concept, meant to demonstrate a case in which generative AI models can generate realistic, trustworthy content when paired with a physics-based model. In order to apply the method to other regions to depict flooding from future storms, it will need to be trained on many more satellite images to learn how flooding would look in other regions.

“The idea is: One day, we could use this before a hurricane, where it provides an additional visualization layer for the public,” says Björn Lütjens, a postdoc in MIT’s Department of Earth, Atmospheric and Planetary Sciences, who led the research while he was a doctoral student in MIT’s Department of Aeronautics and Astronautics (AeroAstro). “One of the biggest challenges is encouraging people to evacuate when they are at risk. Maybe this could be another visualization to help increase that readiness.”

To illustrate the potential of the new method, which they have dubbed the “Earth Intelligence Engine,” the team has made it available as an online resource for others to try.

The researchers report their results today in the journal IEEE Transactions on Geoscience and Remote Sensing. The study’s MIT co-authors include Brandon Leshchinskiy; Aruna Sankaranarayanan; and Dava Newman, professor of AeroAstro and director of the MIT Media Lab; along with collaborators from multiple institutions.

Generative adversarial images

The new study is an extension of the team’s efforts to apply generative AI tools to visualize future climate scenarios.

“Providing a hyper-local perspective of climate seems to be the most effective way to communicate our scientific results,” says Newman, the study’s senior author. “People relate to their own zip code, their local environment where their family and friends live. Providing local climate simulations becomes intuitive, personal, and relatable.”

For this study, the authors use a conditional generative adversarial network, or GAN, a type of machine learning method that can generate realistic images using two competing, or “adversarial,” neural networks. The first “generator” network is trained on pairs of real data, such as satellite images before and after a hurricane. The second “discriminator” network is then trained to distinguish between the real satellite imagery and the one synthesized by the first network.

Each network automatically improves its performance based on feedback from the other network. The idea, then, is that such an adversarial push and pull should ultimately produce synthetic images that are indistinguishable from the real thing. Nevertheless, GANs can still produce “hallucinations,” or factually incorrect features in an otherwise realistic image that shouldn’t be there.

“Hallucinations can mislead viewers,” says Lütjens, who began to wonder whether such hallucinations could be avoided, such that generative AI tools can be trusted to help inform people, particularly in risk-sensitive scenarios. “We were thinking: How can we use these generative AI models in a climate-impact setting, where having trusted data sources is so important?”

Flood hallucinations

In their new work, the researchers considered a risk-sensitive scenario in which generative AI is tasked with creating satellite images of future flooding that could be trustworthy enough to inform decisions of how to prepare and potentially evacuate people out of harm’s way.

Typically, policymakers can get an idea of where flooding might occur based on visualizations in the form of color-coded maps. These maps are the final product of a pipeline of physical models that usually begins with a hurricane track model, which then feeds into a wind model that simulates the pattern and strength of winds over a local region. This is combined with a flood or storm surge model that forecasts how wind might push any nearby body of water onto land. A hydraulic model then maps out where flooding will occur based on the local flood infrastructure and generates a visual, color-coded map of flood elevations over a particular region.

“The question is: Can visualizations of satellite imagery add another level to this, that is a bit more tangible and emotionally engaging than a color-coded map of reds, yellows, and blues, while still being trustworthy?” Lütjens says.

The team first tested how generative AI alone would produce satellite images of future flooding. They trained a GAN on actual satellite images taken by satellites as they passed over Houston before and after Hurricane Harvey. When they tasked the generator to produce new flood images of the same regions, they found that the images resembled typical satellite imagery, but a closer look revealed hallucinations in some images, in the form of floods where flooding should not be possible (for instance, in locations at higher elevation).

To reduce hallucinations and increase the trustworthiness of the AI-generated images, the team paired the GAN with a physics-based flood model that incorporates real, physical parameters and phenomena, such as an approaching hurricane’s trajectory, storm surge, and flood patterns. With this physics-reinforced method, the team generated satellite images around Houston that depict the same flood extent, pixel by pixel, as forecasted by the flood model.

“We show a tangible way to combine machine learning with physics for a use case that’s risk-sensitive, which requires us to analyze the complexity of Earth’s systems and project future actions and possible scenarios to keep people out of harm’s way,” Newman says. “We can’t wait to get our generative AI tools into the hands of decision-makers at the local community level, which could make a significant difference and perhaps save lives.”

The research was supported, in part, by the MIT Portugal Program, the DAF-MIT Artificial Intelligence Accelerator, NASA, and Google Cloud.

© Credit: Pre-flood images from Maxar Open Data Program via Gupta et al., CVPR Workshop Proceedings. Generated images from Lütjen et al., IEEE TGRS.

A generative AI model visualizes how floods in Texas would look like in satellite imagery. The original photo is on the left, and the AI generated image is in on the right.
  • ✇University of Cambridge
  • Professor Lord Colin Renfrew – 1937-2024Anonymous
    The Department of Archaeology and McDonald Institute for Archaeological Research at the University of Cambridge mourn the death and celebrate the extraordinary life of Professor Colin Renfrew, Lord Renfrew of Kaimsthorn, formerly tenth Disney Professor of Archaeology, the McDonald’s founding Director, and Master of Jesus College. Colin was, and will always remain, one of the titans of modern archaeology, a distinguished public figure, and a fine friend and colleague to innumerable archaeologis
     

Professor Lord Colin Renfrew – 1937-2024

By: Anonymous
November 25th 2024 at 3:47 pm
Professor Colin Renfrew, Lord Renfrew of Kaimsthorn


The Department of Archaeology and McDonald Institute for Archaeological Research at the University of Cambridge mourn the death and celebrate the extraordinary life of Professor Colin Renfrew, Lord Renfrew of Kaimsthorn, formerly tenth Disney Professor of Archaeology, the McDonald’s founding Director, and Master of Jesus College.

Colin was, and will always remain, one of the titans of modern archaeology, a distinguished public figure, and a fine friend and colleague to innumerable archaeologists around the world. This loss makes the world of archaeology a poorer place intellectually, as well as in terms of the sheer energy and optimism that he brought to everything he did.

From his first years as one of the brave new archaeologists of the 1960s, Colin stood out as an exceptional mind, and as a spirit of profound, exciting and rigorous change. He pioneered new, theoretically informed ways of thinking about the explanation of social and political change in the past, within and then far beyond his first enduring regional love for the prehistoric Aegean, while advocating scientific techniques of dating and provenance as an integral part of archaeological endeavour. From this perspective, he was one of the first to appreciate the significance of the calibration of radiocarbon dates for the understanding of European prehistory. 

He went on to ask equally fresh questions about the link between language evolution and archaeology and, as the first Director of the McDonald Institute for Archaeological Research, championed some of the earliest applications of archaeogenetics, as well as a critical and investigative approach to the illicit antiquities market. His fieldwork expanded to Orkney, and latterly returned to the more southerly isles of the Cyclades, subject of his doctoral research, and to remarkable discoveries on the island of Keros. To the very end, he remained engaged with the forefront of archaeological developments, attending and clearly relishing the 36th Annual McDonald Lecture on the Wednesday before he left us.

As those who knew him will amply testify, there was far, far more to Colin than the world-leading and much honoured archaeologist. He took on the mantle of a working peer in the House of Lords, where he spoke up for matters of heritage and archaeological legislation with the customary eloquence and lapidary reasoning of a one-time President of the Cambridge Union.

He was a passionate and knowledgeable expert and collector of modern art, by which Jesus College under his care remains permanently graced. Social events under his hospitality became unforgettable and often hugely convivial gatherings of brilliant minds from the widespread fields that he drew together, and under the right circumstances often culminated in demonstrations of Colin’s skills as a dancer. Last but far from least, he was a much-loved husband to his wife Jane, and father to Helena, Alban and Magnus.

Colin passed away peacefully in his sleep during the night of Saturday 23 to Sunday 24 November 2024. All of us at Cambridge extend our heartfelt condolences and profound respects to his family and to all those who loved and knew him.

Professor Cyprian Broodbank remembers Professor Lord Colin Renfrew, founding Director of the McDonald Institute for Archaeological Research and former Master of Jesus College, who passed away at the weekend aged 87.  

Professor Colin Renfrew, Lord Renfrew of Kaimsthorn

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The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

PSA and NUS launch supply chain living lab facilitating efficient and sustainable supply chain growth

November 25th 2024 at 12:30 pm

PSA International (PSA) and National University of Singapore (NUS) announced today the launch of the PSA-NUS Supply Chain Living Lab. Recognising the growing need for integrated solutions that extend beyond container handling within ports, PSA has in recent years, expanded its role as a leading global port operator to also encompass complementary services in the broader supply chain sphere. In line with its overall strategy, PSA will be supporting the initiative with funds totalling up to S$10 million.

The PSA-NUS Supply Chain Living Lab will strengthen collaboration between industry and academic expertise to address critical supply chain challenges. The Lab will provide a sandbox to foster the development of community-centric solutions for supply chain optimisation together with industry stakeholders, with a focus on enhancing agility, resilience and sustainability for supply chain operations both regionally and globally.

Mr Ong Kim Pong, Group CEO of PSA International, said, "As we navigate the rapidly evolving landscape of global trade, it has become essential for PSA Group to continually adapt and refine our business strategy. We will continue to look for new areas of expansion whilst enhancing our presence in key locations, and connecting these strategic nodes to form a cohesive and integrated network across the globe. This collaboration with NUS also marks a significant step in our journey towards strengthening PSA’s position as a leading global port operator and supply chain services provider, capable of delivering supply chain efficiency and resilience across the world.”

Professor Tan Eng Chye, NUS President, said, “The establishment of the PSA-NUS Supply Chain Living Lab marks a significant milestone in our collaborative efforts to advance supply chain innovation. This initiative exemplifies the synergy between academia and industry, leveraging our combined strengths to address complex challenges such as optimising logistical efficiency, enhancing data-driven decision-making, and integrating sustainable practices across supply chain operations. By fostering a dynamic ecosystem for research and development, we aim to drive transformative solutions that enhance the resilience and efficiency of supply chain operations, ultimately benefitting communities and economies worldwide.”

The launch of the Supply Chain Living Lab follows the recent groundbreaking of the upcoming PSA Supply Chain Hub (PSCH), which is an integral part of PSA’s strategic expansion of Singapore’s Tuas Port Ecosystem. The state-of-the-art PSCH facility is scheduled to be ready by 2027 and will seamlessly integrate with Singapore’s extensive supply chain ecosystem, offering unparalleled connectivity and supply chain synergies.

  • ✇University of Cambridge
  • Wildlife monitoring technologies used to intimidate and spy on women, study findsjg533
    Remotely operated camera traps, sound recorders and drones are increasingly being used in conservation science to monitor wildlife and natural habitats, and to keep watch on protected natural areas. But Cambridge researchers studying a forest in northern India have found that the technologies are being deliberately misused by local government and male villagers to keep watch on women without their consent. Cambridge researcher Dr Trishant Simlai spent 14 months interviewing 270 locals living a
     

Wildlife monitoring technologies used to intimidate and spy on women, study finds

By: jg533
November 25th 2024 at 3:31 am
Researcher interviewing a local woman in India

Remotely operated camera traps, sound recorders and drones are increasingly being used in conservation science to monitor wildlife and natural habitats, and to keep watch on protected natural areas.

But Cambridge researchers studying a forest in northern India have found that the technologies are being deliberately misused by local government and male villagers to keep watch on women without their consent.

Cambridge researcher Dr Trishant Simlai spent 14 months interviewing 270 locals living around the Corbett Tiger Reserve, a national park in northern India, including many women from nearby villages.

His report, published today in the journal Environment and Planning F, reveals how forest rangers in the national park deliberately fly drones over local women to frighten them out of the forest, and stop them collecting natural resources despite it being their legal right to do so.

The women, who previously found sanctuary in the forest away from their male-dominated villages, told Simlai they feel watched and inhibited by camera traps, so talk and sing much more quietly. This increases the chance of surprise encounters with potentially dangerous wildlife like elephants and tigers. One woman he interviewed has since been killed in a tiger attack.

The study reveals a worst-case scenario of deliberate human monitoring and intimidation. But the researchers say people are being unintentionally recorded by wildlife monitoring devices without their knowledge in many other places - even national parks in the UK. 

“Nobody could have realised that camera traps put in the Indian forest to monitor mammals actually have a profoundly negative impact on the mental health of local women who use these spaces,” said Dr Trishant Simlai, a researcher in the University of Cambridge’s Department of Sociology and lead author of the report.

“These findings have caused quite a stir amongst the conservation community. It’s very common for projects to use these technologies to monitor wildlife, but this highlights that we really need to be sure they’re not causing unintended harm,” said Professor Chris Sandbrook, Director of the University of Cambridge’s Masters in Conservation Leadership programme, who was also involved in the report.

He added: “Surveillance technologies that are supposed to be tracking animals can easily be used to watch people instead – invading their privacy and altering the way they behave.”

Many areas of conservation importance overlap with areas of human use. The researchers call for conservationists to think carefully about the social implications of using remote monitoring technologies – and whether less invasive methods like surveys could provide the information they need instead.

Intimidation and deliberate humiliation

The women living near India’s Corbett Tiger Reserve use the forest daily in ways that are central to their lives: from gathering firewood and herbs to sharing life’s difficulties through traditional songs.

Domestic violence and alcoholism are widespread problems in this rural region and many women spend long hours in forest spaces to escape difficult home situations.

The women told Simlai that new technologies, deployed under the guise of wildlife monitoring projects, are being used to intimidate and exert power over them - by monitoring them too. 

“A photograph of a woman going to the toilet in the forest – captured on a camera trap supposedly for wildlife monitoring - was circulated on local Facebook and WhatsApp groups as a means of deliberate harassment,” said Simlai. 

He added: “I discovered that local women form strong bonds while working together in the forest, and they sing while collecting firewood to deter attacks by elephants and tigers. When they see camera traps they feel inhibited because they don’t know who’s watching or listening to them – and as a result they behave differently - often being much quieter, which puts them in danger.”

In places like northern India, the identity of local women is closely linked to their daily activities and social roles within the forest. The researchers say that understanding the various ways local women use forests is vital for effective forest management strategies.

Reference: Simlai, T. et al: ‘The Gendered Forest: Digital Surveillance Technologies for Conservation and Gender-Environment relationships.’ November 2024. DOI:10.17863/CAM.111664
 

Camera traps and drones deployed by government authorities to monitor a forest in India are infringing on the privacy and rights of local women.

Nobody could have realised that camera traps put in the Indian forest to monitor mammals actually have a profoundly negative impact on the mental health of local women who use these spaces.
Trishant Simlai
Researcher interviewing a local woman in India

Creative Commons License.
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes
  • ✇NUS - National University of Singapore Newsroom
  • Decoding the secrets of evolution to tackle today’s greatest challenges
    Evolution Day is observed on 24 November each year, marking the anniversary of the publication of Charles Darwin’s groundbreaking work, On the Origin of Species, in 1859. This day commemorates not just a book but a seismic shift in our understanding of life — a theory that connects all living organisms in a vast, intricate web of shared ancestry.This year, to commemorate Evolution Day, we shine the spotlight on researchers from the Department of Biological Sciences at the NUS Faculty of Science
     

Decoding the secrets of evolution to tackle today’s greatest challenges

Evolution Day is observed on 24 November each year, marking the anniversary of the publication of Charles Darwin’s groundbreaking work, On the Origin of Species, in 1859. This day commemorates not just a book but a seismic shift in our understanding of life — a theory that connects all living organisms in a vast, intricate web of shared ancestry.

This year, to commemorate Evolution Day, we shine the spotlight on researchers from the Department of Biological Sciences at the NUS Faculty of Science who are building on Darwin’s legacy, exploring the mechanisms of evolution and its impact on biodiversity in the region and beyond. Their work underscores the enduring relevance of evolutionary theory in addressing modern challenges, from conservation to climate change.

Learning from insects: Understanding biodiversity through reproductive evolution research

Evolution is often synonymous with the phrase ‘survival of the fittest,’ but in evolutionary biology, ‘fitness’ refers to an organism’s ability to survive, reproduce and pass on its genes to the next generation. Reproductive evolution, which focuses on how mating behaviours and reproductive strategies evolve across species, plays a crucial role in shaping population dynamics, speciation, and biodiversity.

Assistant Professor Nalini Puniamoorthy from the Department of Biological Sciences at the NUS Faculty of Science, together with her team at the Reproductive Evolution Lab (ReproLab), are exploring how sexual selection – a mechanism of natural selection – affects reproductive traits and influences population differentiation and speciation, the process by which new species emerge.

“Since reproductive processes directly influence a species’ adaptation and resilience to environmental variability, studying reproductive evolution can support biodiversity conservation by shedding light on how species evolve and adapt to changes to their habitats, especially in the face of climate change and habitat loss,” said Asst Prof Nalini.

The ReproLab studies micro- and macro-evolutionary processes of various insects: From ecosystem service providers like dung beetles, disease vectors like mosquitoes, and even to food waste recyclers like black soldier flies.

For instance, a recent study published by Asst Prof Nalini’s team in Ecology and Evolution, investigated how resource constraints affect dung beetle fitness in secondary rainforests. Dung beetles are important for nutrient recycling and forest health but are often sensitive to habitat changes and resource variations. Asst. Prof. Nalini’s team found that parental provisioning is crucial and that there was a trade-off between early offspring fitness and resource quality. This discovery documents genotype by environment interactions that are relevant for understanding dung beetle ecology in the face of climatic and environmental changes.

Seeking sustainable solutions to challenges

The ReproLab also investigates the interactions between insects and their bacterial symbionts, like gut microbes in black soldier flies that aid in breaking down food waste as well as the reproductive bacteria Wolbachia in mosquitoes. Their study on Aedes albopictus documented that the dispersal of this secondary dengue vector was not limited to green spaces, and that urban and forest populations of Ae. albopictus are naturally infected with more than one strain of Wolbachia. “Untangling these interactions has implications for vector management and combating disease transmission in a city with heterogenous landscapes like Singapore,” explained Asst Prof Nalini.

Shaping biodiversity of tropical ecosystems: The role of fruit-eating animals

In tropical ecosystems, plant-frugivore interactions — where animals help disperse seeds of fruiting plants — play a critical role in maintaining biodiversity. Approximately 90 per cent of woody plant species in tropical forests rely on animals to disperse their seeds. Assistant Professor Lim Jun Ying and his team from the NUS Department of Biological Sciences are investigating how these interactions shape plant biodiversity and ecosystem dynamics. This is especially pertinent as human activities such as habitat loss and hunting are threatening these crucial relationships.

“The loss of fruit-eating animals or frugivores can disrupt plant populations, preventing them from migrating to new areas in response to climate change. Understanding how plant-frugivore interactions evolve is important for quantifying the long-term effects of human activities on tropical ecosystems,” said Asst Prof Lim.

In a recent study published in Global Ecology and Conservation, Asst Prof Lim and his team studied large-bodied birds known as hornbills, which are essential for dispersing large-fruited plants. Many of these birds are under threat from habitat loss and hunting. As the gapes – mouth-openings – of these hornbills are larger than most birds, plants with large fruits and seeds depend on them for seed dispersal.

Asst Prof Lim noted, “Evolution in fruits is shaped by a complex web of interactions with various animals and other factors, suggesting that co-evolution between plants and frugivores must be understood at a community level. This broader perspective is essential for grasping the full complexity of ecological evolution in tropical forests and helping to conserve their biodiversity.”

Understanding fungi: From a billion-year evolutionary journey to addressing environmental challenges

Fungi represent one of the most diverse and ancient groups of organisms on Earth, with an evolutionary history spanning over a billion years. Despite their widespread presence and ecological importance, our understanding of fungal diversity is still limited.

“Less than 10 per cent of the estimated fungal diversity has been documented. The challenge lies in the fact that many fungi remain microscopic throughout their life stages, and a vast majority cannot be cultured in laboratories, hindering direct observation and experimentation,” said Assistant Professor Chang Ying from the NUS Department of Biological Sciences.

At Asst Prof Chang’s lab, her team is dedicated to finding the hidden diversity of fungi, with a focus on marine and coastal environments. Their research tackles two key aspects of fungal ecology: reconstructing the evolutionary history of fungal adaptations using genomic tools, and exploring fungal diversity in natural habitats through metagenomics. By studying the genetic, structural, and ecological traits of existing fungal species, Asst Prof Chang and her team are able to infer a fungi’s common ancestor and understand the traits that allowed ancestral fungi to diversify and adapt to a range of ecological and environmental conditions.

An ongoing project by Asst Prof Chang and her team, in collaboration with the One Thousand Fungal Genomes (1KFG) consortium, investigates the evolution of digestive enzymes across the fungal kingdom. This study could help to predict the ecological capabilities of unknown or newly discovered fungi, as well as entire fungal communities.

“Insights from this research also has practical applications, particularly in the field of bioremediation, where fungi are increasingly valued for their potential to break down environmental pollutants,” added Asst Prof Chang.

By analysing the distribution of hydrocarbon-degrading enzymes across a large set of fungal genomes and mapping their evolutionary trajectories, NUS researchers could identify fungal groups that are especially suited to utilising petroleum hydrocarbons as nutrient sources, making them strong candidates for bioremediation strategies.

  • ✇Harvard Gazette
  • Rhodes scholars share their Oxford ambitions  Elizabeth Zonarich
    From left top row Aneesh Muppidi, Sofia Corona, Thomas Barone, Laura Wegner; second row, Matthew Anzarouth, Ayush Noori, Lena Ashooh, Shahmir Aziz.Photos by Stephanie Mitchell and Niles Singer/Harvard Staff Photographers; photo illustration by Liz Zonarich/Harvard Staff Campus & Community Rhodes scholars share their Oxford ambitions   Anne J. Manning and Eileen O’Grady  Harvard Staff Writers  November 22, 2024
     

Rhodes scholars share their Oxford ambitions  

November 23rd 2024 at 1:29 am
From left top row Aneesh Muppidi, Sofia Corona, Thomas Barone, Laura Wegner; second row,
Matthew Anzarouth, Ayush Noori, Lena Ashooh, Shahmir Aziz.

From left top row Aneesh Muppidi, Sofia Corona, Thomas Barone, Laura Wegner; second row, Matthew Anzarouth, Ayush Noori, Lena Ashooh, Shahmir Aziz.

Photos by Stephanie Mitchell and Niles Singer/Harvard Staff Photographers; photo illustration by Liz Zonarich/Harvard Staff

Campus & Community

Rhodes scholars share their Oxford ambitions  

Anne J. Manning and Eileen O’Grady 

Harvard Staff Writers 

long read

8 students to pursue social, political, computational sciences 

Whether examining animal ethics, combating AI bias, or weighing the values essential to a functioning democracy, Harvard’s newest Rhodes Scholars have made their mark across a wide expanse of disciplines. These eight seniors, representing four countries and several U.S. states, will continue their academic pursuits at the University of Oxford next year. They shared their plans, accomplishments, and what it was like to receive the news of their award.   


Matthew Anzarouth

Matthew Anzarouth.

Niles Singer/Harvard Staff Photographer

Matthew Anzarouth

Montreal, Canada

Concentration: Social studies

Matthew Anzarouth was at home with family in Montreal when he got the phone call that he had won a Rhodes Scholarship for Canada. Anzarouth was one of two recipients from the region that includes Ontario, Quebec, and the Maritime provinces.

“I felt a mix of shock, excitement, and profound gratitude,” Anzarouth said. “This opportunity is an extraordinary privilege, and I’m really keen to make the most of it.”

Anzarouth is currently writing a thesis on Canadian federalism and multiculturalism, with an emphasis on language policy in Quebec and Indigenous self-determination. The Mather House resident is using political theory to examine the challenge of reconciling universal individual rights with group rights specific to Canada’s national minorities.

“I’m using political theory as a way of understanding — and hopefully better resolving — the challenge of coexistence in a culturally diverse federation,” Anzarouth said. “The thesis work has helped me stay engaged with my country’s politics and reflect on how I want to contribute.”

On campus, Anzarouth is an undergraduate research fellow at the Weatherhead Center for International Affairs, and an editor and podcast host for the Harvard Political Review

At Oxford, he hopes to continue his studies of political theory, focusing on questions of how to balance competing claims for cultural preservation and how to balance power between legislative and judicial bodies of government. He hopes to eventually attend law school.


Lena Ashooh

Lena Ashooh.

Stephanie Mitchell/Harvard Staff Photographer

Lena Ashooh

Shelburne, Vermont

Concentration: Special concentration in animal studies

The summer after her first year on campus, Lena Ashooh worked as a research assistant in Puerto Rico, studying the impacts of natural disaster and trauma on the behavior of a colony of free-ranging macaque monkeys. It was a pivotal moment for the Kirkland House resident, who said it felt like observing an “extremely sophisticated society of individuals.”

“That was where I initially had the idea that, were the conditions that animals are in to change completely, they might behave in ways that we never imagined,” Ashooh said. “This led me, in philosophy, to working out how we might wrong animals in the beliefs we have about them and to be interested in how we’re managing land, the decisions we’re making about who has access to land, and who should be involved in the decision-making process.”

Ashooh designed a special concentration in animal studies, combining political philosophy, government, and animal psychology. She is an undergraduate fellow at the Edmond and Lily Safra Center for Ethics, has written for the Harvard Review of Philosophy, and co-founded Harvard College Animal Advocates. Off-campus, she works as a lab manager in animal cognition scientist Irene Pepperberg’s parrot lab at Boston University.

“I say that to study animal studies is to study social injustice and gives us a new way of understanding how oppression and violence occurs, and how moral complacency and inaction occur,” said Ashooh, who is planning to eventually attend law school. “One of the key questions that animal studies allows us to address is: How is it that people can be led to look at suffering and decide not to act on it?”

Ashooh hopes to study philosophy next year, focusing on the question of what it means to treat and respect an animal as an individual.


Shahmir Aziz

Shahmir Aziz.

Stephanie Mitchell/Harvard Staff Photographer

Shahmir Aziz 

Lahore, Pakistan 

Concentration: Biomedical engineering and mathematics, secondary in computer science, language citation in French 

As an undergraduate researcher in different Harvard labs, Shahmir Aziz has analyzed the impact of physical exertion on the glycolytic levels of diabetes patients and has investigated nano-lipids as potential drug delivery vesicles. As an intern at Novo Nordisk, he has focused on optimization of drug-delivery processes. 

He wants to keep working on the cutting edges of biotechnology, and he wants to help others do so as well, in his native Pakistan. 

“In the long run, I hope to help start a culture of startups and biotech in Pakistan, so that students and other innovators can grow out their ideas,” said the Adams House resident named one of two Rhodes Scholars for Pakistan.  

A first-year course in quantitative physiology taught by Linsey Moyer solidified Aziz’ chosen field of study. He also took courses in government and political philosophy, feeding an equal passion for international relations. 

At Oxford, Aziz plans to pursue a master’s in bioengineering, followed by a second degree in diplomacy and global governance — arenas in which he’s also made meaningful contributions on campus.

A member of the leadership team of Harvard’s International Relations Council, Aziz helped the University’s Model United Nations team win two major intercollegiate competitions. “The opportunity I have cherished most at Harvard has been to interact with students from all extremes and opposites of background, pursuing all nature of subjects, and dreaming all ranges of noble dreams,” Aziz wrote in his scholarship application. 

Some of those interactions have come in his four years playing Harvard Club Tennis, as a sports editor with The Harvard Crimson, and as a course assistant in the Department of Mathematics. 


Tommy Barone

Thomas Barone.

Niles Singer/Harvard Staff Photographer

Tommy Barone

Little Falls, New Jersey

Concentration: Social studies

Tommy Barone wants to understand what people believe, and why.

Barone currently is studying what he calls a “crisis of liberalism,” or the philosophical values essential to healthy democracy. In particular he’s interested in how best to understand the beliefs of people engaging in illiberalism in democratic societies.

“It’s so easy to create a narrative about why something important or worrying or disruptive in society is happening that serves your ends,” Barone said. “I think it’s a civic obligation that we listen to what people have to say and try to understand them. If you are trying to theorize something that involves people without speaking and listening to the people who are part of that phenomenon, you’re going to be missing something.”

Barone said that when he learned he had been named a Rhodes Scholar, all he could do was start “breathing heavily.”

“I didn’t cry until I called my parents,” Barone recalled. “Then I cried. Then I had to get it together to talk to the judges afterward.” 

The Currier House resident, who hopes to pursue journalism in the future, is co-chair for the editorial board at The Crimson. Their coverage won first place for editorial writing in collegiate journalism in the Society of Professional Journalists’ 2023 Mark of Excellence Awards.

“I’ve had the unique challenge, but also the really educational, enriching experience, of being tasked with bringing people together to have difficult discussions in one of the most challenging years on campus in decades,” said Barone, who plans to study history at Oxford. “I’ve had the privilege to publish a really broad diversity of perspectives on a range of important issues on campus.”


Sofia Corona

Sofia Corona.

Stephanie Mitchell/Harvard Staff Photographer

Sofia Corona

Miami, Florida, and Pereira, Colombia    

Concentration: Applied mathematics and economics, secondary in government 

From watching her mother commute several hours a day for work in Maryland to biking throughout her community, Sofia Corona learned early on that how people move is fundamental to the human experience. 

Helping people get where they need to go — within cities, towns, and systems that benefit all — has become her life’s work. “I’m interested in how communities are engaged in infrastructure planning, especially when the benefits of that infrastructure are collective and widespread, but the burdens are localized,” said Corona, a Currier House resident graduating in December. 

Corona, who hopes to work in the transportation sector, thinks seismic shifts toward sustainable modes of transportation are possible. “At the same time, our transportation networks are often superimposed on inherited, segregated landscapes, both racially and socioeconomically,” she said. “We can’t be agnostic to that.” 

At Oxford, Corona’s master’s coursework will contextualize mobility systems within broader economic development and sustainability frameworks. At Harvard, she worked in the Allen Lab for Democracy Renovation, conducting research on inclusive decision-making in renewable energy projects. She also spent time in the MIT Transit Lab. Her professional experience includes internships at Uber, BMW, the U.S. Department of Transportation, and McKinsey & Co. 

Her interests have taken her all over the world, from working on carbon dioxide pricing for the Chilean Ministry of Finance to collaborating with researchers at the Technical University of Munich on a tool that advises local transit agencies. 

The Colombian American was a walk-on on Harvard’s varsity sailing team and is an avid mountaineer with the summits of Denali and Kilimanjaro among her feats, and she has run the Boston, New York, and Berlin marathons. Among her most cherished moments at Harvard have been as a dog-walker to Currier House dogs Huckleberry and Ari.  


Aneesh Muppidi 

Aneesh Muppidi.

Niles Singer/Harvard Staff Photographer

Aneesh Muppidi 

Schenectady, New York 

Concentration: Computer science and neuroscience, concurrent master’s in computer science 

Waiting in a room with other Rhodes Scholar finalists, Aneesh Muppidi did a homework problem set and chatted about South Asian politics, having already made peace with not winning. 

“In my head I thought, ‘This has been an amazing process, but now it’s time to go back to the real world,’” the Lowell House resident said. 

Then, he heard his name.   

“I called my little brother first,” he said, followed by his parents and two best friends. 

Muppidi has spent time mulling the question Alan Turing famously posed in 1950: Can machines think? He’s come to believe that understanding human intelligence — and computationally scaling up that intelligence — can solve some of the world’s biggest problems, such as diagnosing complex medical conditions or giving personalized tutors to every child in every classroom. 

At Harvard, he’s immersed himself in the power and promise of artificial intelligence through projects on deep reinforcement learning in Assistant Professor Heng Yang’s Computational Robotics Lab; particle filter machine learning algorithms with the Fiete Lab at MIT; and autonomous agent detection with Professor Sam Gershman’s Computational Cognitive Neuroscience Lab.

Outside the lab, Muppidi is equally passionate about AI policy and ethics. Ensuring technologies are developed safely is a cornerstone of Muppidi’s research, which he plans to continue while pursuing master’s coursework in computer science and public policy at Oxford. 

Muppidi served as president of Harvard Dharma and as president of the Harvard Computational Neuroscience Undergraduate Society. He includes among his mentors Sanskrit instructor Nell Shapiro Hawley, now at Vassar College, with whom he took two years of the ancient language of India. “How she taught had a very beautiful effect on my life, in the sense that I was able to get closer to my spiritual identity, who I am as a person, and what I believe in.” 


Ayush Noori.

Stephanie Mitchell/Harvard Staff Photographer

Ayush Noori

Bellevue, Washington 

Concentration: Computer science and neuroscience, concurrent master’s in computer science 

When Ayush Noori was 7, his grandmother, Munira Brooks, was diagnosed with progressive supranuclear palsy, a rare neurodegenerative disease that slowly robbed her of the ability to speak, move, or breathe. Assisting in her care and witnessing her long struggle inspired Noori to pursue science and medicine. “My mission is to give people with neurological disease more time with their loved ones,” said Noori.

Noori has championed this mission for nearly a decade. Since the age of 12, working or volunteering in various labs, he has conducted research at the intersection of neuroscience, artificial intelligence, and precision medicine, seeking to develop new AI-enabled diagnostic and treatment options for patients with neurological disorders.

As an undergraduate, Noori has authored 25 peer-reviewed publications — including seven as first author — in scientific journals including CellNature NeuroscienceNature Machine IntelligenceNature AgingAlzheimer’s & Dementia, and NBD, and his work has been featured at more than a dozen international conferences. He has been advised by professors including Marinka Zitnik at Harvard Medical School; George Church at the Wyss Institute for Biologically Inspired Materials; and Sudeshna Das, Alberto Serrano-Pozo, and Bradley T. Hyman in the Department of Neurology at Massachusetts General Hospital. He plans to do graduate study in clinical neurosciences at Oxford next year. 

The recipient of more than a dozen fellowships at Harvard and a Roberts Family Fellow at Harvard Business School, the Goldwater Scholar and Adams House resident is also devoted to teaching and mentorship as co-founder of the Harvard Undergraduate OpenBio Laboratory and as a peer adviser at Harvard College.

“I have an immense debt of gratitude toward Harvard because I’ve studied and trained here since I was a teenager,” he said. “The College, SEAS, MGH, and Harvard Medical School have enabled me to contribute to the global fight against neurological disease and given me hope for a healthier future, for my loved ones, and for the world.”


Laura Wegner

Laura Wegner.

Photo courtesy of Laura Wegner

Laura Wegner

Walsrode, Germany

Concentration: Economics, secondary in computer science 

Laura Wegner, Currier House resident and Germany Rhodes Scholarship recipient, wants to address patients’ fragmented medical records and revolutionize healthcare technology to improve patient outcomes.

It’s a cause driven by personal experience. While in high school, Wegner, formerly a competitive swimmer, had to undergo surgery for a knee injury. Doctors used the “wrong surgical method,” Wegner said, due to not having access to her full medical history, including information about a pre-existing health condition, leaving her unable to continue swimming.

“That was a personal experience where I thought, ‘Wow, parts of my patient data are stored in so many different places, and I wish they were together somehow.’”

To improve experiences for future patients, Wegner co-founded the startup Mii in 2022, a patient healthcare passport that securely stores patient data so patients can bring their medical history from doctor to doctor, around the world. 

Wegner has taken Harvard courses in health economics, privacy and technology, and entrepreneurship, and has worked as a fellow with the Lemann Program on Creativity and Entrepreneurship. Eager for global perspectives, Wegner has studied digital healthcare systems in the U.S., Germany, and Australia, and she is writing her thesis on systems in Estonia and Lithuania.

Looking forward to improving her technical skills at Oxford with the hope of continuing her work in healthcare technology, Wegner says she loves both the creative and technical sides of entrepreneurship.

“It’s just about having an idea and then immediately being able to build a prototype, test it out, and see where it goes. It’s an amazing opportunity to bring any idea to life, and hopefully have it improve people’s lives.” 

Consortium led by MIT, Harvard University, and Mass General Brigham spurs development of 408 MW of renewable energy

November 22nd 2024 at 9:00 pm

MIT is co-leading an effort to enable the development of two new large-scale renewable energy projects in regions with carbon-intensive electrical grids: Big Elm Solar in Bell County, Texas, came online this year, and the Bowman Wind Project in Bowman County, North Dakota, is expected to be operational in 2026. Together, they will add a combined 408 megawatts (MW) of new renewable energy capacity to the power grid. This work is a critical part of MIT’s strategy to achieve its goal of net-zero carbon emissions by 2026.

The Consortium for Climate Solutions, which includes MIT and 10 other Massachusetts organizations, seeks to eliminate close to 1 million metric tons of greenhouse gases each year — more than five times the annual direct emissions from MIT’s campus — by committing to purchase an estimated 1.3-million-megawatt hours of new solar and wind electricity generation annually.

“MIT has mobilized on multiple fronts to expedite solutions to climate change,” says Glen Shor, executive vice president and treasurer. “Catalyzing these large-scale renewable projects is an important part of our comprehensive efforts to reduce carbon emissions from generating energy. We are pleased to work in partnership with other local enterprises and organizations to amplify the impact we could achieve individually.”

The two new projects complement MIT’s existing 25-year power purchase agreement established with Summit Farms in 2016, which enabled the construction of a roughly 650-acre, 60 MW solar farm on farmland in North Carolina, leading to the early retirement of a coal-fired plant nearby. Its success has inspired other institutions to implement similar aggregation models.

A collective approach to enable global impact

MIT, Harvard University, and Mass General Brigham formed the consortium in 2020 to provide a structure to accelerate global emissions reductions through the development of large-scale renewable energy projects — accelerating and expanding the impact of each institution’s greenhouse gas reduction initiatives. As the project’s anchors, they collectively procured the largest volume of energy through the aggregation.  

The consortium engaged with PowerOptions, a nonprofit energy-buying consortium, which offered its members the opportunity to participate in the projects. The City of Cambridge, Beth Israel Lahey, Boston Children’s Hospital, Dana-Farber Cancer Institute, Tufts University, the Mass Convention Center Authority, the Museum of Fine Arts, and GBH later joined the consortium through PowerOptions. 
 
The consortium vetted over 125 potential projects against its rigorous project evaluation criteria. With faculty and MIT stakeholder input on a short list of the highest-ranking projects, it ultimately chose Bowman Wind and Big Elm Solar. Collectively, these two projects will achieve large greenhouse gas emissions reductions in two of the most carbon-intensive electrical grid regions in the United States and create clean energy generation sources to reduce negative health impacts.

“Enabling these projects in regions where the grids are most carbon-intensive allows them to have the greatest impact. We anticipate these projects will prevent two times more emissions per unit of generated electricity than would a similar-scale project in New England,” explains Vice President for Campus Services and Stewardship Joe Higgins.

By all consortium institutions making significant 15-to-20-year financial commitments to buy electricity, the developer was able to obtain critical external project financing to build the projects. Owned and operated by Apex Clean Energy, the projects will add new renewable electricity to the grid equivalent to powering 130,000 households annually, displacing over 950,000 metric tons of greenhouse gas emissions each year from highly carbon-intensive power plants in the region. 

Complementary decarbonization work underway 

In addition to investing in offsite renewable energy projects, many consortium members have developed strategies to reduce and eliminate their own direct emissions. At MIT, accomplishing this requires transformative change in how energy is generated, distributed, and used on campus. Efforts underway include the installation of solar panels on campus rooftops that will increase renewable energy generation four-fold by 2026; continuing to transition our heat distribution infrastructure from steam-based to hot water-based; utilizing design and construction that minimizes emissions and increases energy efficiency; employing AI-enabled sensors to optimize temperature set points and reduce energy use in buildings; and converting MIT’s vehicle fleet to all-electric vehicles while adding more electric car charging stations.

The Institute has also upgraded the Central Utilities Plant, which uses advanced co-generation technology to produce power that is up to 20 percent less carbon-intensive than that from the regional power grid. MIT is charting the course toward a next-generation district energy system, with a comprehensive planning initiative to revolutionize its campus energy infrastructure. The effort is exploring leading-edge technology, including industrial-scale heat pumps, geothermal exchange, micro-reactors, bio-based fuels, and green hydrogen derived from renewable sources as solutions to achieve full decarbonization of campus operations by 2050.

“At MIT, we are focused on decarbonizing our own campus as well as the role we can play in solving climate at the largest of scales, including supporting a cleaner grid in line with the call to triple renewables globally by 2030. By enabling these large-scale renewable projects, we can have an immediate and significant impact of reducing emissions through the urgently needed decarbonization of regional power grids,” says Julie Newman, MIT’s director of sustainability.  

© Photo courtesy of Apex Clean Energy.

Big Elm Solar in Bell County, Texas, a 200 MW renewable energy facility, is now operational.

NUS Science raises over S$1.2 million for student bursaries in celebration of its 95th Anniversary

The National University of Singapore’s Faculty of Science (NUS Science) concluded a year of celebratory events marking its 95th Anniversary with a Charity Golf event, raising a record of over S$1.2 million for its 95th Anniversary Bursary Fund - the largest amount raised in the history of the NUS Charity Golf series since 2012.

The Bursary Fund will support over 40 bursaries each year, starting from 2026. The bursaries will benefit undergraduates at the Faculty who are facing financial challenges, providing them with the resources they need to focus on their studies, pursue their passions and achieve their academic and professional aspirations.

In partnership with the NUS Alumni Student Advancement Committee, benefactors who contributed S$25,000 or more to the Bursary Fund had the opportunity to sub-name their bursaries under the NUS Science 95th Anniversary Bursary Fund. Professors rallied former PhD students and members of their research groups in NUS Science to pool donations, resulting in bursaries sub-named after these groups. Former students, colleagues and friends contributed collectively to honour professors, both past and present, while corporate partners and individual benefactors also made independent contributions to this initiative. The Department of Physics, for example, led efforts to gather contributions from colleagues, alumni and friends to sub-name a bursary in honour of Emeritus Professor Bernard Tan Tiong Gie, the longest serving Dean of Science (1985-1997).

Making the announcement at the Faculty’s 95th Anniversary Gala Dinner on 22 November 2024, Dean of NUS Science Professor Sun Yeneng said, “I am deeply grateful for the support and generosity of our community. Your collective commitment will make a lasting impact on the lives of our students, giving them the opportunity to realise their full potential, regardless of their circumstances.”  

95 years of excellence in science education and research

NUS President Professor Tan Eng Chye, who was the Guest-of-Honour at the Gala Dinner, commended the Faculty’s progress and achievements. “Science research in Singapore started off small and unknown in the academic research space, but we have since made immense and very visible progress. From fundamental science, such as the development of advanced materials to translational innovations like nature-based climate solutions, the Faculty has been timely and relevant in addressing pressing challenges of the day.”

He added, “We have built up global credibility and repute for our research; this has enabled us to draw top minds from across the world to build their careers and research aspirations here.”

At the Gala Dinner, the Faculty also presented awards to 16 Science alumni from industries such as healthcare, financial services, manufacturing, technology, sustainability-related sectors, data analytics and Artificial Intelligence, to name a few. Prof Tan presented the Distinguished Science Alumni Award to three alumni who have distinguished themselves in national leadership, service, research excellence, or the betterment and promotion of science.

Another 13 alumni received the Outstanding Science Alumni Award (OSA) from Prof Sun. The OSA recognised the recipients’ leadership and contributions to their professions, industries and disciplines, service to the nation or community, entrepreneurship, research, as well as other noteworthy endeavours.

“Our students do not just excel academically - their accomplishments extend beyond the classroom in service of diverse communities. Many of them go on to pursue distinguished careers; some have founded successful enterprises, contributing to society and making meaningful advancements in fields ranging from environmental sustainability to technology and healthcare,” lauded Prof Tan.

Year-long celebration

The Gala Dinner was the culminating event in a series of specially-curated activities celebrating the Faculty of Science’s 95th Anniversary this year.  These other events included the Achieving Gender Diversity in STEM conference in March 2024, which highlighted leadership in STEM and insights from our female alumni; a Homecoming for Alumni programme at both Bukit Timah and Kent Ridge Campuses in May 2024; the launch of a mural wall to commemorate the former Deans of Science in September 2024, and the Faculty of Science Symposium in September 2024 where researchers, educators, alumni and entrepreneurs, as well as students, came together to share their experiences in scientific developments, educational advancements, career journeys and student advocacy respectively.

Spark Award 2024: procedure for recycling rare earth metals receives award

November 22nd 2024 at 9:30 am
The prize for the most promising invention of the past year goes to Marie Amélie Perrin and Victor Mougel. They have developed a method that enables rare earth elements to be efficiently recovered from electrical waste.
  • ✇MIT News
  • MIT researchers develop an efficient way to train more reliable AI agentsAdam Zewe | MIT News
    Fields ranging from robotics to medicine to political science are attempting to train AI systems to make meaningful decisions of all kinds. For example, using an AI system to intelligently control traffic in a congested city could help motorists reach their destinations faster, while improving safety or sustainability.Unfortunately, teaching an AI system to make good decisions is no easy task.Reinforcement learning models, which underlie these AI decision-making systems, still often fail when fa
     

MIT researchers develop an efficient way to train more reliable AI agents

November 22nd 2024 at 8:30 am

Fields ranging from robotics to medicine to political science are attempting to train AI systems to make meaningful decisions of all kinds. For example, using an AI system to intelligently control traffic in a congested city could help motorists reach their destinations faster, while improving safety or sustainability.

Unfortunately, teaching an AI system to make good decisions is no easy task.

Reinforcement learning models, which underlie these AI decision-making systems, still often fail when faced with even small variations in the tasks they are trained to perform. In the case of traffic, a model might struggle to control a set of intersections with different speed limits, numbers of lanes, or traffic patterns.

To boost the reliability of reinforcement learning models for complex tasks with variability, MIT researchers have introduced a more efficient algorithm for training them.

The algorithm strategically selects the best tasks for training an AI agent so it can effectively perform all tasks in a collection of related tasks. In the case of traffic signal control, each task could be one intersection in a task space that includes all intersections in the city.

By focusing on a smaller number of intersections that contribute the most to the algorithm’s overall effectiveness, this method maximizes performance while keeping the training cost low.

The researchers found that their technique was between five and 50 times more efficient than standard approaches on an array of simulated tasks. This gain in efficiency helps the algorithm learn a better solution in a faster manner, ultimately improving the performance of the AI agent.

“We were able to see incredible performance improvements, with a very simple algorithm, by thinking outside the box. An algorithm that is not very complicated stands a better chance of being adopted by the community because it is easier to implement and easier for others to understand,” says senior author Cathy Wu, the Thomas D. and Virginia W. Cabot Career Development Associate Professor in Civil and Environmental Engineering (CEE) and the Institute for Data, Systems, and Society (IDSS), and a member of the Laboratory for Information and Decision Systems (LIDS).

She is joined on the paper by lead author Jung-Hoon Cho, a CEE graduate student; Vindula Jayawardana, a graduate student in the Department of Electrical Engineering and Computer Science (EECS); and Sirui Li, an IDSS graduate student. The research will be presented at the Conference on Neural Information Processing Systems.

Finding a middle ground

To train an algorithm to control traffic lights at many intersections in a city, an engineer would typically choose between two main approaches. She can train one algorithm for each intersection independently, using only that intersection’s data, or train a larger algorithm using data from all intersections and then apply it to each one.

But each approach comes with its share of downsides. Training a separate algorithm for each task (such as a given intersection) is a time-consuming process that requires an enormous amount of data and computation, while training one algorithm for all tasks often leads to subpar performance.

Wu and her collaborators sought a sweet spot between these two approaches.

For their method, they choose a subset of tasks and train one algorithm for each task independently. Importantly, they strategically select individual tasks which are most likely to improve the algorithm’s overall performance on all tasks.

They leverage a common trick from the reinforcement learning field called zero-shot transfer learning, in which an already trained model is applied to a new task without being further trained. With transfer learning, the model often performs remarkably well on the new neighbor task.

“We know it would be ideal to train on all the tasks, but we wondered if we could get away with training on a subset of those tasks, apply the result to all the tasks, and still see a performance increase,” Wu says.

To identify which tasks they should select to maximize expected performance, the researchers developed an algorithm called Model-Based Transfer Learning (MBTL).

The MBTL algorithm has two pieces. For one, it models how well each algorithm would perform if it were trained independently on one task. Then it models how much each algorithm’s performance would degrade if it were transferred to each other task, a concept known as generalization performance.

Explicitly modeling generalization performance allows MBTL to estimate the value of training on a new task.

MBTL does this sequentially, choosing the task which leads to the highest performance gain first, then selecting additional tasks that provide the biggest subsequent marginal improvements to overall performance.

Since MBTL only focuses on the most promising tasks, it can dramatically improve the efficiency of the training process.

Reducing training costs

When the researchers tested this technique on simulated tasks, including controlling traffic signals, managing real-time speed advisories, and executing several classic control tasks, it was five to 50 times more efficient than other methods.

This means they could arrive at the same solution by training on far less data. For instance, with a 50x efficiency boost, the MBTL algorithm could train on just two tasks and achieve the same performance as a standard method which uses data from 100 tasks.

“From the perspective of the two main approaches, that means data from the other 98 tasks was not necessary or that training on all 100 tasks is confusing to the algorithm, so the performance ends up worse than ours,” Wu says.

With MBTL, adding even a small amount of additional training time could lead to much better performance.

In the future, the researchers plan to design MBTL algorithms that can extend to more complex problems, such as high-dimensional task spaces. They are also interested in applying their approach to real-world problems, especially in next-generation mobility systems.

The research is funded, in part, by a National Science Foundation CAREER Award, the Kwanjeong Educational Foundation PhD Scholarship Program, and an Amazon Robotics PhD Fellowship.

© Image: MIT News; iStock

MIT researchers develop an efficient approach for training more reliable reinforcement learning models, focusing on complex tasks that involve variability.

Award-winning broadcaster Hannah Fry joins Cambridge as Professor of the Public Understanding of Mathematics

By: sc604
November 22nd 2024 at 3:34 am
Hannah Fry.

Fry brings outstanding experience to the role of communicating to diverse audiences, including with people not previously interested in maths. She will follow in the footsteps of giants of public engagement with mathematics, including David Spiegelhalter and the late Stephen Hawking as she joins the Department of Applied Mathematics and Theoretical Physics (DAMTP).

“I’m really looking forward to joining the Cambridge community,” said Fry, “to those chance encounters and interactions that end up sparking new ideas and collaborations: it’s so exciting to be in an environment where every single person you speak to is working on something absolutely fascinating.”

Fry won the Christopher Zeeman Medal for promoting mathematics in 2018 and the Royal Society David Attenborough Award in 2024, and is the current President of the Institute of Mathematics and its Applications.

She is currently Professor of the Mathematics of Cities at UCL, where she works with physicists, mathematicians, computer scientists, architects and geographers to study patterns in human behaviour – particularly in an urban setting. Her research applies to a wide range of social problems and questions, from shopping and transport to urban crime, riots and terrorism, and she has applied this research by advising and working alongside governments, police forces, supermarkets and health analysts.

“When you create a mathematical model, it doesn’t really matter how beautifully crafted your equations are, or how accurate your simulations are,” said Fry. “You have to think about how the work you’ve created is going to be seen and perceived by other people and how it’s going to be understood or misunderstood.”

The new professorship builds on Cambridge’s long track record in sharing maths. DAMTP is also the home of the largest subject-specific outreach and engagement project in the University – the Millennium Mathematics Project (MMP).

Fry says she plans for her work at Cambridge to follow on from Spiegelhalter's extensive public communication work, which she sees as a vital part of the research process.

“Communication is not an optional extra: if you are creating something that is used by, or interacts with members of the public or the world in general, then I think it’s genuinely your moral duty to engage the people affected by it,” she said. “I’d love to build and grow a community around excellence in mathematical communication at Cambridge – so that we’re really researching the best possible methods to communicate with people.”

“Hannah is an outstanding mathematician and researcher, and one of the UK’s best maths communicators,” said Professor Colm-cille Caulfield, Head of DAMTP. “Mathematics affects so many aspects of our everyday lives in interesting and exciting ways, and Hannah will strengthen the excellent work already being done at Cambridge in this area. We in DAMTP and our Faculty of Mathematics colleagues in the Department of Pure Mathematics and Mathematical Statistics are so excited to have her join us.”

Professor Fry announced her appointment at an event yesterday (21 November) organised by the MMP in collaboration with the Newton Gateway to Mathematics at the Isaac Newton Institute in Cambridge. The event – Communicating mathematical and data sciences – what does success look like? – explored evidence for effectively communicating mathematical and data science research to policymakers, mainstream media and the wider public.

“Professor Fry is one of the most exciting voices in science and mathematics today,” said Professor Nigel Peake, Head of the School of the Physical Sciences. “Her deep commitment to sharing the excitement of maths with people of all ages and backgrounds, at a time when mathematical literacy has never been so important, will be an enormous benefit to Cambridge, and the UK as a whole.”

Professor Hannah Fry, mathematician, best-selling author, award-winning science presenter and host of popular podcasts and television shows, will join the University of Cambridge as the first Professor of the Public Understanding of Mathematics on 1 January.

Hannah Fry

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RVRC marks 10 years of fostering sustainability education and workplace readiness in students

Nestled against the lush backdrop of Kent Ridge Forest, Ridge View Residential College (RVRC) is the University’s first and only residential college located outside NUS University Town. Founded on the integrated themes of sustainability and workplace readiness, the College started as a one-year living-learning programme in 2014, expanding into a two-year programme in 2017 and evolving further in 2021 to align with the enhanced NUS General Education Curriculum.

This year, RVRC celebrates its 10th anniversary, a milestone that has seen learning at the residential college transcend the boundaries of the classroom, and its students playing an active role in contributing towards sustainability efforts in NUS and the community.

In line with its sustainability theme, many of the courses offered at RVRC incorporate the United Nations Sustainable Development Goals, allowing students to explore sustainability initiatives that help shape a future that is more sustainable and equitable for all. This is done through a multifaceted learning approach that focuses on experiential outdoor learning and collaboration with industry partners. In line with its workplace readiness theme, students are also encouraged to participate in meaningful college activities beyond coursework that diversify their interests and skillsets to help develop them into better versions of their current selves.

“Place, Programme, and People are the elements that make for memorable university experiences, and these are the elements that make for a memorable RV10,” said RVRC College Master Associate Professor Sim Tick Ngee, outlining the focus of the year-long celebration in his congratulatory message.

As part of RV10, the College’s initiative to encapsulate the anniversary celebrations, a series of commemorative events were held to strengthen the college culture and collective sense of community among its students, alumni, and staff. Here are three of the events that showcased the different but integrated aspects of life at RVRC – namely academic, student and residential life.

RVRC Symposium: Living and learning for a shared future – the RVRC way

For the first time this year, students led the planning and organising of the annual RVRC Symposium held on 24 February 2024. Some 145 participants comprising students, educators and community partners attended the Symposium which showcased the best of student and alumni achievements through panel discussions, oral presentations, and poster sessions.

Guest-of-Honour Associate Professor Adrian Loo from the NUS Department of Biological Sciences shared about the importance of education and community stewardship for youth, drawing on his extensive experience in his previous role as National Parks Board’s Group Director for Wildlife Management and Senior Director for Community Projects. Participants also gleaned insights from RVRC alumnus, Founder and CEO of Hatch Mr Victor Zhu (Science '20), who shared about his journey in building his start-up with a social mission of providing digital skills and employability programmes whilst still a student at RVRC.

The day’s programme was segmented into three key themes, namely Edu-venture, Adventure, and Venturing Beyond. Edu-venture showcased RVRC’s approach towards fostering a learning ecosystem that has addressed societal and environmental challenges, as well as student projects on real-world issues. Adventure highlighted the importance of various co-curricular and student life activities, which has helped hone students’ soft skills and provided them an avenue to give back to society. Lastly, Venturing Beyond challenged students to build meaningful initiatives that go beyond the walls of the College and beyond their time at NUS, encouraging them to champion lasting environmental and societal changes through innovative means. 

Co-Chair of the Symposium’s organising committee and RVRC Senior Jason Qiu, a Year 4 undergraduate from the School of Computing, said, “It was the insightful questions posed during the presentations along with the meaningful tea break discussions that brought home the value of the engagement for the RVRC community which truly represented the vibrant learning spirit that the College embodies.”

Gala Dinner: Celebrating a decade of shared memories, experiences and achievements

The RVRC 10th Anniversary Gala Dinner on 30 August 2024 saw past and present members of the College celebrate the journey that has shaped RVRC into the unique, dynamic community it is today.

The evening began with a commemorative speech by College Master Assoc Prof Sim, who reflected on the College's decade of achievements. RVRC Rector Dr Noeleen Heyzer and RVRC’s first Director of Studies Associate Professor Lee Kooi Cheng shared about the College's indelible impact over the years while founding RVRC College Master Professor Adekunle Adeyeye recounted the strong foundation upon which the college was built, in a special video message.

Guests were also treated to a night of engaging performances, including song items by RVRC’s Jukebox and the winners of the RV10 songwriting competition, as well as an electrifying dance performance by the NUS Dance Ensemble.

A highlight at the gala dinner was the commemorative video created by RVRC students which showcased RVRC’s key milestones since its inception, evoking a deep sense of nostalgia amongst alumni, faculty and staff, both past and present, who had an enjoyable time reconnecting and reminiscing about the pivotal moments that defined their time at the College.

RVRC alumnus Zhang Xiangyu Oliver (Business ‘24), said, “It was great to reconnect with the people who made my four-year journey in RVRC memorable, and celebrate together the countless milestones of the college since inception. I’m confident that RVRC will continue to inspire the next generation in the upcoming decade and beyond!”

RVRC Day: Building bridges, strengthening bonds

Apart from sustainability, the RVRC community is also passionate about giving back to society, a cornerstone of NUS' ethos. The theme of RVRC Day Building Bridges, Strengthening Bonds underscored the importance of community building, not just amongst the RVRC community of students and staff, but just as importantly, with the wider community and the less privileged.

In the early morning hours of 26 October 2024, the RVRC community gathered at the Harbourfront area for Walk for Rice, a long-running signature event at RVRC to support vulnerable families. In partnership with a charity organisation, for every 300 meters walked, food donations were made to support vulnerable families, turning each step into a meaningful act of kindness. With the support of 52 RVRC students and staff, a total of 520 kilometres were clocked, making possible a donation of 1,733 packets of rice and oatmeal.

Following the charity walk, the event continued with a second segment focused on community engagement. Titled OutRidge, this initiative aimed to raise awareness for persons with disabilities (PWDs), foster inclusivity and inspire participants to take active steps toward building a more inclusive society. In addition to having the opportunity to interact with PWDs on their lived experiences and challenges, the event held at the College also featured a fireside chat with two invited speakers Year 4 NUS student Kimberly Quek, a Deaflympic athlete who won numerous medals at international bowling competitions, and Joan Hung, a visually impaired para athlete with Team Singapore.

Additionally, participants had the opportunity to engage in interactive games at several informative booths designed by RVRC students to raise awareness about the daily challenges faced by PWDs. They also lent their support through their patronage of the food stalls set up by social enterprises that advocate for the PWD community.

RVRC Senior and Year 3 Computing undergraduate Soh Zheng Yang, Marcus, reflected, “I found the fireside chat to be eye-opening, especially when the two speakers shared about how they strive to overcome the challenges they face in pursuing their dreams. The interactive booths made me realise how adaptable PWDs have to be, to overcome the limitations of living in a society that does not primarily cater to their special needs or circumstances. I was happy to see the RVRC community come together to empower PWDs through active participation and enhanced awareness.”

As the celebrations come to a close, College Master Assoc Prof Sim, said, “The conclusion of the year-long activities held in conjunction with RV10 has brought a renewed understanding of what has shaped the College into what it is today. With this reflection comes a strong sense of optimism for the future—one where the College continues to evolve, striving towards becoming a better place that offers a more robust RVRC programme with a more united and inclusive RVRC community.”

  • ✇Harvard Gazette
  • What Trump got rightChristina Pazzanese
    Nation & World What Trump got right Setti Warren and Kellyanne Conway.Photos by Niles Singer/Harvard Staff Photographer Christina Pazzanese Harvard Staff Writer November 21, 2024 3 min read Kellyanne Conway, president-elect’s 2016 campaign manager and former senior adviser, discusses recent election, what comes next The Democrats got it wrong. It wasn’t threats to national securit
     

What Trump got right

November 22nd 2024 at 1:15 am
Nation & World

What Trump got right

Setti Warren and Kellyanne Conway.

Setti Warren and Kellyanne Conway.

Photos by Niles Singer/Harvard Staff Photographer

Christina Pazzanese

Harvard Staff Writer

3 min read

Kellyanne Conway, president-elect’s 2016 campaign manager and former senior adviser, discusses recent election, what comes next

The Democrats got it wrong.

It wasn’t threats to national security or democracy, and it wasn’t the U.S. Supreme Court’s undoing of Roe v. Wade. What voters cared most about this election was “safety, affordability, fairness, and education,” said Republican operative Kellyanne Conway during a sometimes testy 90-minute talk at the JFK Jr. Forum about the 2024 election and what to expect from the incoming Trump administration. 

That’s why ads and other messaging about crime, inflation, immigration, student loan forgiveness, and school choice proved so effective in the campaigns of President-elect Donald Trump and several other Republican candidates, she told Setti Warren, director of the Institute of Politics at Harvard Kennedy School. 

Trump won by running up the numbers of voters already predisposed to vote for him and “peeling off” some support among “core Democratic” Party constituencies, including African Americans, Hispanic Americans, union households, Jewish, and younger voters, improving on his own 2016 and 2020 numbers, said Conway, who managed the final months of Trump’s 2016 campaign and served as an adviser during his first term.

Conway said she thinks Democrats underestimated how motivating the issue of K-12 education was to many across the political spectrum, particularly women, who did not support Harris as robustly as they had Presidents Joe Biden and Barack Obama.

Trump was seen as “authentic” and a proven commodity who had already done the job and ran a “joyful” and “forward-looking” campaign, she said, pointing to Trump’s visit to a McDonald’s franchise, rallies at concert venues, and his garbage truck ride. 

Kellyanne Conway.

Conway credited the campaign’s embrace of “new, new media” like TikTok, podcasts, and social media influencers, as a strategic move that paid real dividends in the final weeks reaching young men and low propensity voters. Also important was the campaign’s under-reported effort to educate disengaged voters about the many ways they could cast a ballot before Election Day, which also helped the former president prevail. 

Over the past two weeks, Trump has announced more than two dozen nominees for White House and Cabinet positions, primarily top campaign staffers and high-profile business executives.

“What they all have in common is they know him; he knows them; and they are fluent in the America First agenda, meaning: This is what we’ve been elected to do,” Conway said. “So he’s got people who are willing to work with alacrity and energy to get that agenda through.”

At times, Conway flashed the quick and cutting fast-talk that has made her a polarizing figure on the left, sparring with student questioners.

She called for students to try to bring their friends who suffer from “Trump derangement syndrome” back to their senses.

“You all know someone afflicted by it. … It wrecks the nervous system. It addles the brain. There is no vaccine, cure, or therapeutic, but you all have a role to play in helping people at least unwind a little bit from it” by not canceling those who have a different point of view. 

“I certainly hope that the new government that’s forming can rely upon, if not all of you right away, most of you along the way, to help in any way, shape, or form that you possibly can,” she said.

  • ✇MIT News
  • Advancing urban tree monitoring with AI-powered digital twinsRachel Gordon | MIT CSAIL
    The Irish philosopher George Berkely, best known for his theory of immaterialism, once famously mused, “If a tree falls in a forest and no one is around to hear it, does it make a sound?”What about AI-generated trees? They probably wouldn’t make a sound, but they will be critical nonetheless for applications such as adaptation of urban flora to climate change. To that end, the novel “Tree-D Fusion” system developed by researchers at the MIT Computer Science and Artificial Intelligence Laboratory
     

Advancing urban tree monitoring with AI-powered digital twins

November 22nd 2024 at 12:45 am

The Irish philosopher George Berkely, best known for his theory of immaterialism, once famously mused, “If a tree falls in a forest and no one is around to hear it, does it make a sound?”

What about AI-generated trees? They probably wouldn’t make a sound, but they will be critical nonetheless for applications such as adaptation of urban flora to climate change. To that end, the novel “Tree-D Fusion” system developed by researchers at the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL), Google, and Purdue University merges AI and tree-growth models with Google's Auto Arborist data to create accurate 3D models of existing urban trees. The project has produced the first-ever large-scale database of 600,000 environmentally aware, simulation-ready tree models across North America.

“We’re bridging decades of forestry science with modern AI capabilities,” says Sara Beery, MIT electrical engineering and computer science (EECS) assistant professor, MIT CSAIL principal investigator, and a co-author on a new paper about Tree-D Fusion. “This allows us to not just identify trees in cities, but to predict how they’ll grow and impact their surroundings over time. We’re not ignoring the past 30 years of work in understanding how to build these 3D synthetic models; instead, we’re using AI to make this existing knowledge more useful across a broader set of individual trees in cities around North America, and eventually the globe.”

Tree-D Fusion builds on previous urban forest monitoring efforts that used Google Street View data, but branches it forward by generating complete 3D models from single images. While earlier attempts at tree modeling were limited to specific neighborhoods, or struggled with accuracy at scale, Tree-D Fusion can create detailed models that include typically hidden features, such as the back side of trees that aren’t visible in street-view photos.

The technology’s practical applications extend far beyond mere observation. City planners could use Tree-D Fusion to one day peer into the future, anticipating where growing branches might tangle with power lines, or identifying neighborhoods where strategic tree placement could maximize cooling effects and air quality improvements. These predictive capabilities, the team says, could change urban forest management from reactive maintenance to proactive planning.

A tree grows in Brooklyn (and many other places)

The researchers took a hybrid approach to their method, using deep learning to create a 3D envelope of each tree’s shape, then using traditional procedural models to simulate realistic branch and leaf patterns based on the tree’s genus. This combo helped the model predict how trees would grow under different environmental conditions and climate scenarios, such as different possible local temperatures and varying access to groundwater.

Now, as cities worldwide grapple with rising temperatures, this research offers a new window into the future of urban forests. In a collaboration with MIT’s Senseable City Lab, the Purdue University and Google team is embarking on a global study that re-imagines trees as living climate shields. Their digital modeling system captures the intricate dance of shade patterns throughout the seasons, revealing how strategic urban forestry could hopefully change sweltering city blocks into more naturally cooled neighborhoods.

“Every time a street mapping vehicle passes through a city now, we’re not just taking snapshots — we’re watching these urban forests evolve in real-time,” says Beery. “This continuous monitoring creates a living digital forest that mirrors its physical counterpart, offering cities a powerful lens to observe how environmental stresses shape tree health and growth patterns across their urban landscape.”

AI-based tree modeling has emerged as an ally in the quest for environmental justice: By mapping urban tree canopy in unprecedented detail, a sister project from the Google AI for Nature team has helped uncover disparities in green space access across different socioeconomic areas. “We’re not just studying urban forests — we’re trying to cultivate more equity,” says Beery. The team is now working closely with ecologists and tree health experts to refine these models, ensuring that as cities expand their green canopies, the benefits branch out to all residents equally.

It’s a breeze

While Tree-D fusion marks some major “growth” in the field, trees can be uniquely challenging for computer vision systems. Unlike the rigid structures of buildings or vehicles that current 3D modeling techniques handle well, trees are nature’s shape-shifters — swaying in the wind, interweaving branches with neighbors, and constantly changing their form as they grow. The Tree-D fusion models are “simulation-ready” in that they can estimate the shape of the trees in the future, depending on the environmental conditions.

“What makes this work exciting is how it pushes us to rethink fundamental assumptions in computer vision,” says Beery. “While 3D scene understanding techniques like photogrammetry or NeRF [neural radiance fields] excel at capturing static objects, trees demand new approaches that can account for their dynamic nature, where even a gentle breeze can dramatically alter their structure from moment to moment.”

The team’s approach of creating rough structural envelopes that approximate each tree’s form has proven remarkably effective, but certain issues remain unsolved. Perhaps the most vexing is the “entangled tree problem;” when neighboring trees grow into each other, their intertwined branches create a puzzle that no current AI system can fully unravel.

The scientists see their dataset as a springboard for future innovations in computer vision, and they’re already exploring applications beyond street view imagery, looking to extend their approach to platforms like iNaturalist and wildlife camera traps.

“This marks just the beginning for Tree-D Fusion,” says Jae Joong Lee, a Purdue University PhD student who developed, implemented and deployed the Tree-D-Fusion algorithm. “Together with my collaborators, I envision expanding the platform’s capabilities to a planetary scale. Our goal is to use AI-driven insights in service of natural ecosystems — supporting biodiversity, promoting global sustainability, and ultimately, benefiting the health of our entire planet.”

Beery and Lee’s co-authors are Jonathan Huang, Scaled Foundations head of AI (formerly of Google); and four others from Purdue University: PhD students Jae Joong Lee and Bosheng Li, Professor and Dean's Chair of Remote Sensing Songlin Fei, Assistant Professor Raymond Yeh, and Professor and Associate Head of Computer Science Bedrich Benes. Their work is based on efforts supported by the United States Department of Agriculture’s (USDA) Natural Resources Conservation Service and is directly supported by the USDA’s National Institute of Food and Agriculture. The researchers presented their findings at the European Conference on Computer Vision this month. 

© Image: Alex Shipps/MIT CSAIL with background image via Pixabay.

MIT Assistant Professor Sara Beery contributed to the new Tree D-fusion system, which can generate a simulation-ready 3D model of a real tree from images such as those found on Google Street View. The system leverages a tree shape generated using species- and environment-specific data to create realistic, lifelike tree models.
  • ✇MIT News
  • Advancing urban tree monitoring with AI-powered digital twinsRachel Gordon | MIT CSAIL
    The Irish philosopher George Berkely, best known for his theory of immaterialism, once famously mused, “If a tree falls in a forest and no one is around to hear it, does it make a sound?”What about AI-generated trees? They probably wouldn’t make a sound, but they will be critical nonetheless for applications such as adaptation of urban flora to climate change. To that end, the novel “Tree-D Fusion” system developed by researchers at the MIT Computer Science and Artificial Intelligence Laboratory
     

Advancing urban tree monitoring with AI-powered digital twins

November 22nd 2024 at 12:45 am

The Irish philosopher George Berkely, best known for his theory of immaterialism, once famously mused, “If a tree falls in a forest and no one is around to hear it, does it make a sound?”

What about AI-generated trees? They probably wouldn’t make a sound, but they will be critical nonetheless for applications such as adaptation of urban flora to climate change. To that end, the novel “Tree-D Fusion” system developed by researchers at the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL), Google, and Purdue University merges AI and tree-growth models with Google's Auto Arborist data to create accurate 3D models of existing urban trees. The project has produced the first-ever large-scale database of 600,000 environmentally aware, simulation-ready tree models across North America.

“We’re bridging decades of forestry science with modern AI capabilities,” says Sara Beery, MIT electrical engineering and computer science (EECS) assistant professor, MIT CSAIL principal investigator, and a co-author on a new paper about Tree-D Fusion. “This allows us to not just identify trees in cities, but to predict how they’ll grow and impact their surroundings over time. We’re not ignoring the past 30 years of work in understanding how to build these 3D synthetic models; instead, we’re using AI to make this existing knowledge more useful across a broader set of individual trees in cities around North America, and eventually the globe.”

Tree-D Fusion builds on previous urban forest monitoring efforts that used Google Street View data, but branches it forward by generating complete 3D models from single images. While earlier attempts at tree modeling were limited to specific neighborhoods, or struggled with accuracy at scale, Tree-D Fusion can create detailed models that include typically hidden features, such as the back side of trees that aren’t visible in street-view photos.

The technology’s practical applications extend far beyond mere observation. City planners could use Tree-D Fusion to one day peer into the future, anticipating where growing branches might tangle with power lines, or identifying neighborhoods where strategic tree placement could maximize cooling effects and air quality improvements. These predictive capabilities, the team says, could change urban forest management from reactive maintenance to proactive planning.

A tree grows in Brooklyn (and many other places)

The researchers took a hybrid approach to their method, using deep learning to create a 3D envelope of each tree’s shape, then using traditional procedural models to simulate realistic branch and leaf patterns based on the tree’s genus. This combo helped the model predict how trees would grow under different environmental conditions and climate scenarios, such as different possible local temperatures and varying access to groundwater.

Now, as cities worldwide grapple with rising temperatures, this research offers a new window into the future of urban forests. In a collaboration with MIT’s Senseable City Lab, the Purdue University and Google team is embarking on a global study that re-imagines trees as living climate shields. Their digital modeling system captures the intricate dance of shade patterns throughout the seasons, revealing how strategic urban forestry could hopefully change sweltering city blocks into more naturally cooled neighborhoods.

“Every time a street mapping vehicle passes through a city now, we’re not just taking snapshots — we’re watching these urban forests evolve in real-time,” says Beery. “This continuous monitoring creates a living digital forest that mirrors its physical counterpart, offering cities a powerful lens to observe how environmental stresses shape tree health and growth patterns across their urban landscape.”

AI-based tree modeling has emerged as an ally in the quest for environmental justice: By mapping urban tree canopy in unprecedented detail, a sister project from the Google AI for Nature team has helped uncover disparities in green space access across different socioeconomic areas. “We’re not just studying urban forests — we’re trying to cultivate more equity,” says Beery. The team is now working closely with ecologists and tree health experts to refine these models, ensuring that as cities expand their green canopies, the benefits branch out to all residents equally.

It’s a breeze

While Tree-D fusion marks some major “growth” in the field, trees can be uniquely challenging for computer vision systems. Unlike the rigid structures of buildings or vehicles that current 3D modeling techniques handle well, trees are nature’s shape-shifters — swaying in the wind, interweaving branches with neighbors, and constantly changing their form as they grow. The Tree-D fusion models are “simulation-ready” in that they can estimate the shape of the trees in the future, depending on the environmental conditions.

“What makes this work exciting is how it pushes us to rethink fundamental assumptions in computer vision,” says Beery. “While 3D scene understanding techniques like photogrammetry or NeRF [neural radiance fields] excel at capturing static objects, trees demand new approaches that can account for their dynamic nature, where even a gentle breeze can dramatically alter their structure from moment to moment.”

The team’s approach of creating rough structural envelopes that approximate each tree’s form has proven remarkably effective, but certain issues remain unsolved. Perhaps the most vexing is the “entangled tree problem;” when neighboring trees grow into each other, their intertwined branches create a puzzle that no current AI system can fully unravel.

The scientists see their dataset as a springboard for future innovations in computer vision, and they’re already exploring applications beyond street view imagery, looking to extend their approach to platforms like iNaturalist and wildlife camera traps.

“This marks just the beginning for Tree-D Fusion,” says Jae Joong Lee, a Purdue University PhD student who developed, implemented and deployed the Tree-D-Fusion algorithm. “Together with my collaborators, I envision expanding the platform’s capabilities to a planetary scale. Our goal is to use AI-driven insights in service of natural ecosystems — supporting biodiversity, promoting global sustainability, and ultimately, benefiting the health of our entire planet.”

Beery and Lee’s co-authors are Jonathan Huang, Scaled Foundations head of AI (formerly of Google); and four others from Purdue University: PhD students Jae Joong Lee and Bosheng Li, Professor and Dean's Chair of Remote Sensing Songlin Fei, Assistant Professor Raymond Yeh, and Professor and Associate Head of Computer Science Bedrich Benes. Their work is based on efforts supported by the United States Department of Agriculture’s (USDA) Natural Resources Conservation Service and is directly supported by the USDA’s National Institute of Food and Agriculture. The researchers presented their findings at the European Conference on Computer Vision this month. 

© Image: Alex Shipps/MIT CSAIL with background image via Pixabay.

MIT Assistant Professor Sara Beery contributed to the new Tree D-fusion system, which can generate a simulation-ready 3D model of a real tree from images such as those found on Google Street View. The system leverages a tree shape generated using species- and environment-specific data to create realistic, lifelike tree models.
  • ✇Harvard Gazette
  • Use of new diet drugs likely to mushroomTerry Murphy
    Health Use of new diet drugs likely to mushroom Study estimates over half of Americans eligible to take them based on diagoses, underscoring need to ensure equity of access. BIDMC Communications November 21, 2024 4 min read In a new analysis of national data, an estimated 137 million U.S. adults, more than half of the adult population, would qualify for the anti-obesity drug semagludtide. “Thes
     

Use of new diet drugs likely to mushroom

November 22nd 2024 at 12:16 am
Two packages of 5 dosing pens each of semiglutin .
Health

Use of new diet drugs likely to mushroom

Study estimates over half of Americans eligible to take them based on diagoses, underscoring need to ensure equity of access.

BIDMC Communications

4 min read

In a new analysis of national data, an estimated 137 million U.S. adults, more than half of the adult population, would qualify for the anti-obesity drug semagludtide.

“These staggering numbers mean that we are likely to see large increases in spending on semaglutide and related medications in years to come,” said corresponding author Dhruv S. Kazi, associate director of the Richard A. and Susan F. Smith Center for Outcomes Research at Beth Israel Deaconess Medical Center. “Ensuring equitable access to these effective but high-cost medications, as well as supporting individuals so that they can stay on the therapy long-term, should be a priority for our clinicians and policymakers.”

The findings, which were presented at the American Heart Association Scientific Sessions and simultaneously published in JAMA Cardiology, underscore the need to increase equitable access to this new class of pharmaceuticals.

Semaglutide belongs to a class of drugs known as GLP-1 receptor agonists. It is currently approved to manage diabetes, treat overweight or obesity, and of recurrent cardiovascular disease. About 15 million adults take semaglutide, which stimulates the pancreas to produce insulin and reduces the hunger hormone ghrelin, decreasing the appetite and slowing down the rate of stomach emptying. As a result, semaglutide helps lower blood sugar levels and promotes weight loss.

Semaglutide is found to improve symptoms in sleep apnea and in some types of heart failure, and slows the progression of chronic kidney disease.

In 2023, it was the top-selling drug in the U.S. in terms of total pharmaceutical spending. But rapidly emerging data about its effectiveness for other health conditions is likely to further expand its use in future years. For instance, semaglutide is found to improve symptoms in sleep apnea and in some types of heart failure, and slows the progression of chronic kidney disease. Semaglutide and others in its class are currently being evaluated for treatment of liver and kidney diseases, substance use disorders, and dementia.

Ivy Shi, who is a resident in internal medicine at BIDMC, worked with Kazi to produce the analysis. They used five years’ worth of recent data from the National Health and Nutrition Examination Survey, a long-running survey of the U.S. population run by the U.S. Department of Health and Human Services, to identify U.S. adults aged 18 years or older who would be eligible for semaglutide treatment based on currently approved indications. They analyzed information about 25,531 survey participants gathered through in-person interviews, physical examinations, and laboratory testing.

They found that of the 136.8 million U.S. adults who qualified for semaglutide, 35 million would administer it for diabetes management, 129.2 million for weight loss, and 8.9 million for secondary prevention of cardiovascular disease. The semaglutide-eligible population includes 26.8 million adults covered by Medicare, 13.8 million covered by Medicaid, and 61.1 million covered by commercial insurance.

“The large number of U.S. adults eligible for semaglutide highlights its potential transformative impact on population health,” said Shi. “Prior studies have shown that more than half of the individuals who have taken these medications state the therapy was difficult to afford. Interventions to reduce economic barriers to access are urgently needed.”

Co-authors: Ivy Shi, Robert W. Yeh, Jennifer E. Ho, and Issa Dahabreh of BIDMC; and Sadiya S. Khan of Feinberg School of Medicine, Northwestern University.

Disclosures: Sadiya S. Khan reported grants from the National Heart, Lung, and Blood Institute outside the submitted work. Jennifer E. Ho reported grants from the National Institutes of Health during the conduct of the study. Issa Dahabreh reported a contract with the Patient-Centered Outcomes Research Institute and grants from the National Institutes of Health during the conduct of the study. Kazi reported grants from the National Heart, Lung, and Blood Institute, American Heart Institute, Agency for Healthcare Research and Quality, Patient-Centered Outcomes Research Institute, and Institute for Clinical and Economic Research outside the submitted work. No other disclosures were reported.

Funding/support: Dahabreh is supported by grants from the National Library of Medicine (R01 LM013616), the National Heart, Lung, and Blood Institute (R01 HL136708), and the Patient-Centered Outcomes Research Institute (ME-2021C2-22365).

  • ✇Harvard Gazette
  • He didn’t come all this way to lose to YaleChristy DeSmith
    Campus & Community He didn’t come all this way to lose to Yale Harvard coach Andrew Aurich answers questions from the media. Niles Singer/Harvard Staff Photographer Christy DeSmith Harvard Staff Writer November 21, 2024 5 min read Dream job and a winning season for Aurich, but one big test remains: The Game. For many Crimson football fans, devotion can be measured by consecutive year
     

He didn’t come all this way to lose to Yale

November 21st 2024 at 11:28 pm
Campus & Community

He didn’t come all this way to lose to Yale

Andrew Aurich (pictured) answers questions from the media. Photos

Harvard coach Andrew Aurich answers questions from the media.

Niles Singer/Harvard Staff Photographer

Christy DeSmith

Harvard Staff Writer

5 min read

Dream job and a winning season for Aurich, but one big test remains: The Game.

For many Crimson football fans, devotion can be measured by consecutive years of attendance at the Harvard-Yale game. But Saturday’s showdown will be a first for the man who now leads their beloved program.

“All the time I was playing at Princeton, and coaching at Princeton, I was kind of jealous of Harvard-Yale,” said Andrew Aurich, Thomas Stephenson Family Head Coach for Harvard Football. “I’m really excited to experience it.”

The first-time head coach, who came to Harvard from Rutgers University, has led the Crimson to an impressive 8-1 record. The team clinched at least a share of the Ivy League title with a dramatic win over the University of Pennsylvania last weekend, making Aurich the first head football coach in Harvard history to win a league title in his first season.

We caught up with Aurich to learn more about preparations for one of the biggest dates on the Crimson calendar. The interview has been edited for length and clarity.


The Crimson are having a great season under your leadership. To what do you attribute your early success?  

Former head coach Tim Murphy played a big part in what’s happening this year. When I got here, it was very clear these players were already training to win a championship. They are very tough mentally. We’ve had some close games where our ability to focus at the end, and really execute, has allowed us to win.

Tell me about your leadership style.

One of the core parts of our culture is 100 percent honesty; the players are always going to get 100 percent honesty from me. Whether or not they like what they hear, they should know it’s coming from a good place. I expect the same from them. If there’s a better way to do something, I want to find a way to do that.

Andrew Aurich on sidelines during Stetson game.

Aurich on the sidelines during the Harvard-Stetson game in September.

Credit: Harvard Athletics

What changes have you brought to the program?

My plan all along was to get an Ivy League head coaching job. But my experiences outside the league helped me see there were opportunities to help these young men become better players and a better team overall. If you ask them, they’ll say there’s a little more emphasis on sports science, whether it’s in the weight room or the emphasis we’re putting on nutrition, hydration, and sleep.

You said something interesting just now — that you always wanted to be a head coach in the Ivy League. Say more about that.

I knew I wanted to get into coaching when I was playing at Princeton. My dad had been my high school football coach, so I went back to St. Paul, Minnesota, and coached with him for a year and confirmed that I loved it. I ended up at a small Division 3 school in Pennsylvania for two years, and then I got the opportunity to go to Rutgers for my first stint as a defensive assistant.

From there I got the running backs coaching job at Princeton. My experience with the student-athletes there was so enjoyable. They’re just so driven and fun to be around. The next year I went to the Tampa Bay Buccaneers with my former boss at Rutgers, coach Greg Schiano. But as soon I got to the NFL, I immediately thought: “The Ivy League is where it’s at, I’ve got to do everything I can to become an Ivy League head football coach.”

What happened next?

I ended up back at Princeton. I was there for a long time, but saw that I needed something more than just Ivy League experience. When coach Schiano got the head coaching job at Rutgers again, I knew that working for him would help prepare me for success.

Landing the top job at Harvard must have felt like a dream fulfilled.

I was on the road recruiting with coach Schiano as the whole hiring process was underway. He doesn’t know the Ivy League all that well, so he was trying to get some perspective. “What is it like?” he wanted to know. I told him: “Coach, this is like being at Ohio State or [University of] Michigan in the Big Ten.” The entire time I was at Princeton — whether I was a player or a coach — I saw Harvard as top dog in the Ivy League.

How are you preparing for Yale?

Well, there’s definitely a different kind of energy right now. My job is to make sure our players are going about their business the same way they have been for the last nine weeks. This game means a lot to a lot of people. Even the level of the interest from the outside, including the number of media requests, is completely different from previous weeks. But ultimately, I can’t get caught up in it. Because if I am, I know the players are.

The Crimson fell to the Bulldogs in 2022 and ’23, but you’re the favorite this year. What do you hope to see on the field Saturday?

I want to see a team that is protecting the football on offense, that is taking the ball away in defense. I want to see a team that is executing 11 guys every play. I want to see a team that’s on the attack every single play. That’s how we define ourselves as a football program.

Will you get to participate in any of the fun stuff this weekend?

Hopefully the fun stuff I’ll be doing is celebrating a win.

Previously unknown compound in chloraminated drinking water identified

November 21st 2024 at 10:30 pm
Since the 1980s, it’s been known that a mysterious contaminant forms in chloraminated drinking water, but only now has a Swiss-American research team been able to identify the unknown product in US drinking water systems.
  • ✇MIT News
  • Your child, the sophisticated language learnerPeter Dizikes | MIT News
    As young children, how do we build our vocabulary? Even by age 1, many infants seem to think that if they hear a new word, it means something different from the words they already know. But why they think so has remained subject to inquiry among scholars for the last 40 years.A new study carried out at the MIT Language Acquisition Lab offers a novel insight into the matter: Sentences contain subtle hints in their grammar that tell young children about the meaning of new words. The finding, based
     

Your child, the sophisticated language learner

November 21st 2024 at 7:30 pm

As young children, how do we build our vocabulary? Even by age 1, many infants seem to think that if they hear a new word, it means something different from the words they already know. But why they think so has remained subject to inquiry among scholars for the last 40 years.

A new study carried out at the MIT Language Acquisition Lab offers a novel insight into the matter: Sentences contain subtle hints in their grammar that tell young children about the meaning of new words. The finding, based on experiments with 2-year-olds, suggests that even very young kids are capable of absorbing grammatical cues from language and leveraging that information to acquire new words.

“Even at a surprisingly young age, kids have sophisticated knowledge of the grammar of sentences and can use that to learn the meanings of new words,” says Athulya Aravind, an associate professor of linguistics at MIT.

The new insight stands in contrast to a prior explanation for how children build vocabulary: that they rely on the concept of “mutual exclusivity,” meaning they treat each new word as corresponding to a new object or category. Instead, the new research shows how extensively children respond directly to grammatical information when interpreting words.

“For us it’s very exciting because it’s a very simple idea that explains so much about how children understand language,” says Gabor Brody, a postdoc at Brown University, who is the first author of the paper.

The paper is titled, “Why Do Children Think Words Are Mutually Exclusive?” It is published in advance online form in Psychological Science. The authors are Brody; Roman Feiman, the Thomas J. and Alice M. Tisch Assistant Professor of Cognitive and Psychological Sciences and Linguistics at Brown; and Aravind, the Alfred Henry and Jean Morrison Hayes Career Development Associate Professor in MIT’s Department of Linguistics and Philosophy.

Focusing on focus

Many scholars have thought that young children, when learning new words, have an innate bias toward mutual exclusivity, which could explain how children learn some of their new words. However, the concept of mutual exclusivity has never been airtight: Words like “bat” refer to multiple kinds of objects, while any object can be described using countlessly many words. For instance a rabbit can be called not only a “rabbit” or a “bunny,” but also an “animal,” or a “beauty,” and in some contexts even a “delicacy.” Despite this lack of perfect one-to-one mapping between words and objects, mutual exclusivity has still been posited as a strong tendency in children’s word learning.

What Aravind, Brody, and Fieman propose is that children have no such tendency, and instead rely on so-called “focus” signals to decide what a new word means. Linguists use the term “focus” to refer to the way we emphasize or stress certain words to signal some kind of contrast. Depending on what is focused, the same sentence can have different implications. “Carlos gave Lewis a Ferrari” implies contrast with other possible cars — he could have given Lewis a Mercedes. But “Carlos gave Lewis a Ferrari” implies contrast with other people — he could have given Alexandra a Ferrari.

The researchers’ experiments manipulated focus in three experiments with a total of 106 children. The participants watched videos of a cartoon fox who asked them to point to different objects.

The first experiment established how focus influences kids’ choice between two objects when they hear a label, like “toy,” that could, in principle, correspond to either of the two. After giving a name to one of the two objects (“Look, I am pointing to the blicket”), the fox told the child, “Now you point to the toy!” Children were divided into two groups. One group heard “toy” without emphasis, while the other heard it with emphasis.

In the first version, “blicket” and “toy” plausibly refer to the same object. But in the second version, the added focus, through intonation, implies that “toy” contrasts with the previously discussed “blicket.” Without focus, only 24 percent of the respondents thought the words were mutually exclusive, whereas with the focus created by emphasizing “toy,” 89 percent of participants thought “blicket” and “toy” referred to different objects.

The second and third experiments showed that focus is not just key when it comes to words like “toy,” but it also affects the interpretation of new words children have never encountered before, like “wug” or “dax.” If a new word was said without focus, children thought the word meant the previously named object 71 percent of the time. But when hearing the new word spoken with focus, they thought it must refer to a new object 87 percent of the time.

“Even though they know nothing about this new word, when it was focused, that still told them something: Focus communicated to children the presence of a contrasting alternative, and they correspondingly understood the noun to refer to an object that had not previously been labeled,” Aravind explains.

She adds: “The particular claim we’re making is that there is no inherent bias in children toward mutual exclusivity. The only reason we make the corresponding inference is because focus tells you that the word means something different from another word. When focus goes away, children don’t draw those exclusivity inferences any more.”

The researchers believe the full set of experiments sheds new light on the issue.

“Earlier explanations of mutual exclusivity introduced a whole new problem,” Feiman says. “If kids assume words are mutually exclusive, how do they learn words that are not? After all, you can call the same animal either a rabbit or a bunny, and kids have to learn both of those at some point. Our finding explains why this isn't actually a problem. Kids won’t think the new word is mutually exclusive with the old word by default, unless adults tell them that it is — all adults have to do if the new word is not mutually exclusive is just say it without focusing it, and they’ll naturally do that if they're thinking about it as compatible.”

Learning language from language

The experiment, the researchers note, is the result of interdisciplinary research bridging psychology and linguistics — in this case, mobilizing the linguistics concept of focus to address an issue of interest in both fields.

“We are hopeful this will be a paper that shows that small, simple theories have a place in psychology,” Brody says. “It is a very small theory, not a huge model of the mind, but it completely flips the switch on some phenomena we thought we understood.”

If the new hypothesis is correct, the researchers may have developed a more robust explanation about how children correctly apply new words.

“An influential idea in language development is that children can use their existing knowledge of language to learn more language,” Aravind says. “We’re in a sense building on that idea, and saying that even in the simplest cases, aspects of language that children already know, in this case an understanding of focus, help them grasp the meanings of unknown words.”

The scholars acknowledge that more studies could further advance our knowledge about the issue. Future research, they note in the paper, could reexamine prior studies about mutual exclusivity, record and study naturalistic interactions between parents and children to see how focus is used, and examine the issue in other languages, especially those marking focus in alternate ways, such as word order.

The research was supported, in part, by a Jacobs Foundation Fellowship awarded to Feiman.

© Image: Jose-Luis Olivares, MIT; iStock

The researchers’ experiments manipulated focus in three experiments with a total of 106 children. The participants watched videos of a cartoon fox who asked them to point to different objects, like a “toy” or “blicket.”

Ground rules for ethical AI use needed to be successful innovation hub

November 15th 2024 at 11:45 am

By Professor Julian Savulescu, Chen Su Lan Centennial Professor of Medical Ethics and Director, and Associate Professor Brian D. Earp, both from the Centre for Biomedical Ethics at the Yong Loo Lin School of Medicine at NUS, together with Dr Sebastian Porsdam Mann, a Visiting Research Fellow at the University of Oxford

  • ✇Harvard Gazette
  • Ketanji Brown Jackson? Present!Christy DeSmith
    Campus & Community Ketanji Brown Jackson? Present! Supreme Court Justice Ketanji Brown Jackson (left) with Michael Sandel and Margaret Marshall, former chief justice of the Supreme Judicial Court of Massachusetts.Photo by Grace DuVal Christy DeSmith Harvard Staff Writer November 20, 2024 3 min read Supreme Court justice revisits Michael Sandel’s class, which left her with lessons that lasted l
     

Ketanji Brown Jackson? Present!

November 21st 2024 at 1:31 am
Campus & Community

Ketanji Brown Jackson? Present!

Supreme Court Justice Ketanji Brown Jackson (left) speaks with Michael J. Sandel and Massachusetts Supreme Court Judge Margaret Marshall d

Supreme Court Justice Ketanji Brown Jackson (left) with Michael Sandel and Margaret Marshall, former chief justice of the Supreme Judicial Court of Massachusetts.

Photo by Grace DuVal

Christy DeSmith

Harvard Staff Writer

3 min read

Supreme Court justice revisits Michael Sandel’s class, which left her with lessons that lasted long beyond her time in it as first-year

In a passage from “Lovely One,” Supreme Court Justice Ketanji Brown Jackson ’92, J.D. ’96, is a Harvard College first-year drawing a smiley face in her notes for the course “Justice.”

“I want to laugh at the way my mind spins as I listen to the opinions being expressed,” she writes in a College essay excerpted in the new memoir. “I want to know the answers. I glimpse that there are no answers. Yet to wonder is not enough. We must never stop asking the questions.”

On Tuesday, Jackson was met by 800-plus smiles — and a standing ovation — as she returned to visit a course that proved influential in her life. Welcoming her at Sanders Theatre was Michael J. Sandel, the Anne T. and Robert M. Bass Professor of Government, who has taught “Justice” since 1980. Jackson credits Sandel’s Gen Ed offering with building her confidence while instilling a passion for healthy debate.

“I felt myself expanding and growing more visible to myself as I engaged the great philosophical conundrums,” she writes in the book. “The animated discussions about open-ended ethical dilemmas made me come completely alive.”

Seated with Jackson under the bright stage lights, Sandel invited students to engage with the issue of affirmative action while drawing on insights from influential philosophers, ancient and modern. Primary readings this semester include works from Aristotle, Immanuel Kant, and John Rawls. But the syllabus also features the 2022 U.S. Supreme Court decision rejecting affirmative-action policies at Harvard College and the University of North Carolina.

Some students lined up to share responses to Jackson’s dissent in the UNC case. (She recused herself in the case of Harvard, having served on its Board of Overseers.) Jackson may have been a quiet participant in “Justice” three decades ago, as she notes in the book. But she was much less so on her return to the two-hour lecture as she laid out her legal and moral reasoning on affirmative action. The whole exchange was off the record.

Taking the stage to address the class for the final 45 minutes of the session was Margaret Marshall, Ed.M. ’69, former chief justice of the Supreme Judicial Court of Massachusetts. Sandel assigned students to read her 2003 opinion in Goodridge v. Department of Public Health, which established the right to same-sex marriage for the first time in U.S. history. Sandel said that Marshall’s opinion is a rare piece of legal writing with the resonance of prayer. It has found second life as a popular reading at weddings nationwide.

  • ✇NUS - National University of Singapore Newsroom
  • Philosophy, AI, and mental health: Perspectives on World Philosophy Day
    Each year on World Philosophy Day on 21 November, people around the globe are invited to reflect on the role philosophy plays in shaping our understanding of the world.Philosophy, meaning ‘love of wisdom’, is interpreted differently by different people, and this diversity of interpretation is one of its most enduring strengths. For some, it’s an intellectual pursuit, a way of seeking deep truths about existence, morality, and knowledge. For others, it’s simply a practical guide to living more me
     

Philosophy, AI, and mental health: Perspectives on World Philosophy Day

Each year on World Philosophy Day on 21 November, people around the globe are invited to reflect on the role philosophy plays in shaping our understanding of the world.

Philosophy, meaning ‘love of wisdom’, is interpreted differently by different people, and this diversity of interpretation is one of its most enduring strengths. For some, it’s an intellectual pursuit, a way of seeking deep truths about existence, morality, and knowledge. For others, it’s simply a practical guide to living more meaningfully.

“Philosophy is an attempt to make sense of life, the universe, and everything, through human reason,” says Associate Professor Loy Hui Chieh from the Department of Philosophy at the NUS Faculty of Arts and Social Sciences.

For final-year Philosophy major Christopher Chin, the understanding of philosophy challenges our norms and forces us to grow, while final-year History and Philosophy double major Sofia Marliini Heikkonen believes it offers the privilege of interrogating life.

Dr Daryl Ooi, a lecturer at the Department of Philosophy agrees, saying that, “Philosophy is one of the activities humans practice when we’re trying to figure out how to relate and orientate ourselves to this exciting, complex and confusing world we live in.”

Fundamentally, however, philosophy is a way of thinking that cuts to the heart of what it means to be human.

‘Confucius says…’

The foundational ideas established by many great thinkers and philosophers like Socrates, Plato, and Aristotle have shaped our understanding of the world. These renowned philosophers pioneered the use of reason and logic to explore the workings of the universe while delving into the complexities of human morality.

Although Confucius lived around 500 BC, some 2,500 years ago, today he remains synonymous with wisdom and insights into life. The expression ‘Confucius says...’ is often cited when imparting general wisdom, exemplifying how philosophy transcends time and generations.

In the context of retaliation, for example – whether in war or conflict – one might consider Confucius’ wise words before determining a course of action: ‘Before you embark on a journey of revenge, dig two graves.’

“A common misunderstanding about philosophy is that it’s purely abstract and impractical, dealing only with questions that have no real-world impact. In reality, many of the questions discussed in philosophy have significant real-world implications,” said the Department’s Assistant Professor Song Moonyoung.

A compass for the modern world

Some may question the relevance of philosophical thinking today given the proliferation of science and technology that comes with the promise to simplify our lives and even make decisions on our behalf. Philosophers, however, agree that as the world changes rapidly through technology and social upheaval, the role of philosophy will only grow in importance.

Dr Ooi believes that as long as humans continue to ask big and narrow questions about the world today and attempt to make sense of their beliefs, values, emotions and ideas, philosophy will continue to endure.

Likewise, Asst Prof Song believes philosophy is even more relevant in a time when science and technology are at the forefront. “Philosophy encourages us to consider the ethical implications of technological advancements, such as artificial intelligence (AI) and genetic engineering, and guides us in making thoughtful, responsible choices about their development and use,” she says.

Assoc Prof Loy views philosophy as one part of a much larger repertoire now available to modern humanity. Its strength stems not from disregarding developments in other fields and domains, but from working in tandem with them. “Take artificial intelligence or AI for example. I have been drawn to research projects that look into how AI will affect education because it involves contributions from social science, data science, computer science and many others,” he says.  

Related to that is the complex task of developing a practical governing framework for the development of AI and, even more critically, the ethics of its application. Dr Ooi, himself a former student of Assoc Prof Loy, says that the intricacy of such tasks is precisely the reason we recognise the value of interdisciplinary education.

He explains, “We need specialists from different disciplines to work together – and philosophers certainly have much to contribute towards the development or shaping of any kind of moral framework that would support the development and application of AI. Get a philosopher in the room to ask questions about ethics and morality, or even what it means to be human. This will trigger some incredibly meaningful and important conversations, and sometimes, you may even get something like an answer!”

Assoc Prof Loy, who is also Vice Dean (Academic Affairs) for NUS College, adds that he sees philosophers as some of the most interested and equipped people to discuss complex issues, not necessarily by supplying any ready-made “moral framework”, but simply by being people who are keen on thinking very carefully and working with experts from other technical disciplines.

Expanding on this perspective, Asst Prof Song, who specialises in the philosophy of art, notes that the increasing integration of AI into our lives invites us to reflect on what truly defines humanity. The answer may not lie in what we can do better than AI. Instead, what makes us special may indeed be our limitations, such as the fact that humans have physical bodies that inevitably age and perish.

She adds, “These limitations give human achievements – such as artwork – a completely different meaning, even if, on the surface, they may look similar to AI-created products.”

In recent years, mental health has become another area where philosophy provides a unique lens through which we can understand and address psychological well-being. Commenting on the role of philosophy or philosophical ideas in mental health treatment or in helping people cope with mental health challenges, Dr Ooi highlights the increasing attention given to the therapeutic value of philosophical ideas.

He says, “The idea of ‘care for the soul’ and ‘care for the self’ is a historically important one that is of immense relevance for us today, and there are many important philosophical questions that we can ask that are highly relevant to issues surrounding mental health today. For instance, how do we understand the obligations individuals have to care for one another, should education systems have an ethical responsibility to ensure that students do not suffer certain harms, or how can individuals and societies understand values such as ‘respect’ and ‘dignity’ so that those values shape the way humans treat each other?”

Many of the tools employed in philosophy and the intellectual dispositions it nurtures have broad applications – particularly in instances where careful reasoning is needed or when navigating any situations without any clear precedents. This intellectual rigour is what has drawn some undergraduates to take up Philosophy to complement other fields of study, recognising the value of the discipline’s critical thinking and reasoning skills.  

Joan Lim, a final-year Philosophy and Life Sciences double degree student, was first introduced to Philosophy in secondary school.

Joan was part of the pioneering batch at the College of Humanities and Sciences and says she jumped at the opportunity to take two contrasting degrees, believing in the importance of an interdisciplinary education to gain a deeper understanding of our increasingly complex and interconnected world. 

“I feel that the disciplines are complementary because science needs to be ethically applied, and the humanities benefit from the real-world grounding from the sciences.  Fields such as AI and sustainability consider the best ways to apply science and technology such that harm may be reduced; a purely scientific approach may lack that moral analysis.”

Armed with the insights gained from her philosophy studies, Joan is looking for a career that will allow her to contribute to the field of sustainability, another existential challenge for mankind. “I hope to provide an ethical and logical lens for analysing complex issues such as sustainability and AI, but also in the vein of the philosophical training that I have received here at NUS, one which is empathetic and kind,” she says.

Marliini, who has always felt very strongly about diversity, representation and inclusivity, is looking for opportunities to build bridges within the communities around her. “I'm still discovering what exactly my career will look like post-graduation, and what excites me is the prospect of fostering environments where people feel empowered, accepted and connected.”

Beyond its influence on society, Christopher believes that philosophy’s teachings have made an impact on his personal relationships.

“The clarity and discernment that philosophy teaches us should be channelled towards goodness. It reminds us to be compassionate because as (Chinese Confucian philosopher) Mengzi suggests, all humans have the heart of compassion. Whatever the psychological pain, I believe being compassionate, empathetic, and present should be our first response,” says Christopher, reflecting on the wisdom drawn from philosophy when dealing with friends and loved ones in need.

Enduring influence in shaping humanity

From artificial intelligence to mental health, philosophy offers a powerful lens for understanding and navigating the complexities of contemporary life. Whether for those immersed in academic inquiry or individuals looking for clarity in a fast-paced world, philosophy provides a space for thoughtful reflection, grounded in the search for truth and meaning.

Assoc Prof Loy has noted how students get to have a lot of intellectual fun reading philosophy while giving them leverage for other intellectual pursuits.

“Everyone stands to gain from the process of philosophical inquiry,” says Marliini. “The skills we learn are beneficial far beyond academics because philosophy at its core teaches us how to hold space for different perspectives while maintaining the rigour to examine and articulate our own.”

In the words of Peter Singer, one of the most highly regarded modern philosophers alive today, “Philosophy ought to question the basic assumptions of the age. Thinking through, critically and carefully, what most of us take for granted is, I believe, the chief task of philosophy, and the task that makes philosophy a worthwhile activity.”

  • ✇MIT News
  • Tunable ultrasound propagation in microscale metamaterialsAnne Wilson | Department of Mechanical Engineering
    Acoustic metamaterials — architected materials that have tailored geometries designed to control the propagation of acoustic or elastic waves through a medium — have been studied extensively through computational and theoretical methods. Physical realizations of these materials to date have been restricted to large sizes and low frequencies.“The multifunctionality of metamaterials — being simultaneously lightweight and strong while having tunable acoustic properties — make them great candidates
     

Tunable ultrasound propagation in microscale metamaterials

Acoustic metamaterials — architected materials that have tailored geometries designed to control the propagation of acoustic or elastic waves through a medium — have been studied extensively through computational and theoretical methods. Physical realizations of these materials to date have been restricted to large sizes and low frequencies.

“The multifunctionality of metamaterials — being simultaneously lightweight and strong while having tunable acoustic properties — make them great candidates for use in extreme-condition engineering applications,” explains Carlos Portela, the Robert N. Noyce Career Development Chair and assistant professor of mechanical engineering at MIT. “But challenges in miniaturizing and characterizing acoustic metamaterials at high frequencies have hindered progress towards realizing advanced materials that have ultrasonic-wave control capabilities.”

A new study coauthored by Portela; Rachel Sun, Jet Lem, and Yun Kai of the MIT Department of Mechanical Engineering (MechE); and Washington DeLima of the U.S. Department of Energy Kansas City National Security Campus presents a design framework for controlling ultrasound wave propagation in microscopic acoustic metamaterials. A paper on the work, “Tailored Ultrasound Propagation in Microscale Metamaterials via Inertia Design,” was recently published in the journal Science Advances. 

“Our work proposes a design framework based on precisely positioning microscale spheres to tune how ultrasound waves travel through 3D microscale metamaterials,” says Portela. “Specifically, we investigate how placing microscopic spherical masses within a metamaterial lattice affect how fast ultrasound waves travel throughout, ultimately leading to wave guiding or focusing responses.”

Through nondestructive, high-throughput laser-ultrasonics characterization, the team experimentally demonstrates tunable elastic-wave velocities within microscale materials. They use the varied wave velocities to spatially and temporally tune wave propagation in microscale materials, also demonstrating an acoustic demultiplexer (a device that separates one acoustic signal into multiple output signals). The work paves the way for microscale devices and components that could be useful for ultrasound imaging or information transmission via ultrasound.

“Using simple geometrical changes, this design framework expands the tunable dynamic property space of metamaterials, enabling straightforward design and fabrication of microscale acoustic metamaterials and devices,” says Portela.

The research also advances experimental capabilities, including fabrication and characterization, of microscale acoustic metamaterials toward application in medical ultrasound and mechanical computing applications, and underscores the underlying mechanics of ultrasound wave propagation in metamaterials, tuning dynamic properties via simple geometric changes and describing these changes as a function of changes in mass and stiffness. More importantly, the framework is amenable to other fabrication techniques beyond the microscale, requiring merely a single constituent material and one base 3D geometry to attain largely tunable properties.

“The beauty of this framework is that it fundamentally links physical material properties to geometric features. By placing spherical masses on a spring-like lattice scaffold, we could create direct analogies for how mass affects quasi-static stiffness and dynamic wave velocity,” says Sun, first author of the study. “I realized that we could obtain hundreds of different designs and corresponding material properties regardless of whether we vibrated or slowly compressed the materials.”

This work was carried out, in part, through the use of MIT.nano facilities.

© Image courtesy of the researchers.

A new study presents a design framework for controlling ultrasound wave propagation in microscopic acoustic metamaterials. The researchers focused on cubic lattice with braces comprising a “braced-cubic” design.
  • ✇MIT News
  • Tunable ultrasound propagation in microscale metamaterialsAnne Wilson | Department of Mechanical Engineering
    Acoustic metamaterials — architected materials that have tailored geometries designed to control the propagation of acoustic or elastic waves through a medium — have been studied extensively through computational and theoretical methods. Physical realizations of these materials to date have been restricted to large sizes and low frequencies.“The multifunctionality of metamaterials — being simultaneously lightweight and strong while having tunable acoustic properties — make them great candidates
     

Tunable ultrasound propagation in microscale metamaterials

Acoustic metamaterials — architected materials that have tailored geometries designed to control the propagation of acoustic or elastic waves through a medium — have been studied extensively through computational and theoretical methods. Physical realizations of these materials to date have been restricted to large sizes and low frequencies.

“The multifunctionality of metamaterials — being simultaneously lightweight and strong while having tunable acoustic properties — make them great candidates for use in extreme-condition engineering applications,” explains Carlos Portela, the Robert N. Noyce Career Development Chair and assistant professor of mechanical engineering at MIT. “But challenges in miniaturizing and characterizing acoustic metamaterials at high frequencies have hindered progress towards realizing advanced materials that have ultrasonic-wave control capabilities.”

A new study coauthored by Portela; Rachel Sun, Jet Lem, and Yun Kai of the MIT Department of Mechanical Engineering (MechE); and Washington DeLima of the U.S. Department of Energy Kansas City National Security Campus presents a design framework for controlling ultrasound wave propagation in microscopic acoustic metamaterials. A paper on the work, “Tailored Ultrasound Propagation in Microscale Metamaterials via Inertia Design,” was recently published in the journal Science Advances. 

“Our work proposes a design framework based on precisely positioning microscale spheres to tune how ultrasound waves travel through 3D microscale metamaterials,” says Portela. “Specifically, we investigate how placing microscopic spherical masses within a metamaterial lattice affect how fast ultrasound waves travel throughout, ultimately leading to wave guiding or focusing responses.”

Through nondestructive, high-throughput laser-ultrasonics characterization, the team experimentally demonstrates tunable elastic-wave velocities within microscale materials. They use the varied wave velocities to spatially and temporally tune wave propagation in microscale materials, also demonstrating an acoustic demultiplexer (a device that separates one acoustic signal into multiple output signals). The work paves the way for microscale devices and components that could be useful for ultrasound imaging or information transmission via ultrasound.

“Using simple geometrical changes, this design framework expands the tunable dynamic property space of metamaterials, enabling straightforward design and fabrication of microscale acoustic metamaterials and devices,” says Portela.

The research also advances experimental capabilities, including fabrication and characterization, of microscale acoustic metamaterials toward application in medical ultrasound and mechanical computing applications, and underscores the underlying mechanics of ultrasound wave propagation in metamaterials, tuning dynamic properties via simple geometric changes and describing these changes as a function of changes in mass and stiffness. More importantly, the framework is amenable to other fabrication techniques beyond the microscale, requiring merely a single constituent material and one base 3D geometry to attain largely tunable properties.

“The beauty of this framework is that it fundamentally links physical material properties to geometric features. By placing spherical masses on a spring-like lattice scaffold, we could create direct analogies for how mass affects quasi-static stiffness and dynamic wave velocity,” says Sun, first author of the study. “I realized that we could obtain hundreds of different designs and corresponding material properties regardless of whether we vibrated or slowly compressed the materials.”

This work was carried out, in part, through the use of MIT.nano facilities.

© Image courtesy of the researchers.

A new study presents a design framework for controlling ultrasound wave propagation in microscopic acoustic metamaterials. The researchers focused on cubic lattice with braces comprising a “braced-cubic” design.
  • ✇MIT News
  • Reality check on technologies to remove carbon dioxide from the airNancy W. Stauffer | MIT Energy Initiative
    In 2015, 195 nations plus the European Union signed the Paris Agreement and pledged to undertake plans designed to limit the global temperature increase to 1.5 degrees Celsius. Yet in 2023, the world exceeded that target for most, if not all of, the year — calling into question the long-term feasibility of achieving that target.To do so, the world must reduce the levels of greenhouse gases in the atmosphere, and strategies for achieving levels that will “stabilize the climate” have been both pro
     

Reality check on technologies to remove carbon dioxide from the air

November 21st 2024 at 1:20 am

In 2015, 195 nations plus the European Union signed the Paris Agreement and pledged to undertake plans designed to limit the global temperature increase to 1.5 degrees Celsius. Yet in 2023, the world exceeded that target for most, if not all of, the year — calling into question the long-term feasibility of achieving that target.

To do so, the world must reduce the levels of greenhouse gases in the atmosphere, and strategies for achieving levels that will “stabilize the climate” have been both proposed and adopted. Many of those strategies combine dramatic cuts in carbon dioxide (CO2) emissions with the use of direct air capture (DAC), a technology that removes CO2 from the ambient air. As a reality check, a team of researchers in the MIT Energy Initiative (MITEI) examined those strategies, and what they found was alarming: The strategies rely on overly optimistic — indeed, unrealistic — assumptions about how much CO2 could be removed by DAC. As a result, the strategies won’t perform as predicted. Nevertheless, the MITEI team recommends that work to develop the DAC technology continue so that it’s ready to help with the energy transition — even if it’s not the silver bullet that solves the world’s decarbonization challenge.

DAC: The promise and the reality

Including DAC in plans to stabilize the climate makes sense. Much work is now under way to develop DAC systems, and the technology looks promising. While companies may never run their own DAC systems, they can already buy “carbon credits” based on DAC. Today, a multibillion-dollar market exists on which entities or individuals that face high costs or excessive disruptions to reduce their own carbon emissions can pay others to take emissions-reducing actions on their behalf. Those actions can involve undertaking new renewable energy projects or “carbon-removal” initiatives such as DAC or afforestation/reforestation (planting trees in areas that have never been forested or that were forested in the past). 

DAC-based credits are especially appealing for several reasons, explains Howard Herzog, a senior research engineer at MITEI. With DAC, measuring and verifying the amount of carbon removed is straightforward; the removal is immediate, unlike with planting forests, which may take decades to have an impact; and when DAC is coupled with CO2 storage in geologic formations, the CO2 is kept out of the atmosphere essentially permanently — in contrast to, for example, sequestering it in trees, which may one day burn and release the stored CO2.

Will current plans that rely on DAC be effective in stabilizing the climate in the coming years? To find out, Herzog and his colleagues Jennifer Morris and Angelo Gurgel, both MITEI principal research scientists, and Sergey Paltsev, a MITEI senior research scientist — all affiliated with the MIT Center for Sustainability Science and Strategy (CS3) — took a close look at the modeling studies on which those plans are based.

Their investigation identified three unavoidable engineering challenges that together lead to a fourth challenge — high costs for removing a single ton of CO2 from the atmosphere. The details of their findings are reported in a paper published in the journal One Earth on Sept. 20.

Challenge 1: Scaling up

When it comes to removing CO2 from the air, nature presents “a major, non-negotiable challenge,” notes the MITEI team: The concentration of CO2 in the air is extremely low — just 420 parts per million, or roughly 0.04 percent. In contrast, the CO2 concentration in flue gases emitted by power plants and industrial processes ranges from 3 percent to 20 percent. Companies now use various carbon capture and sequestration (CCS) technologies to capture CO2 from their flue gases, but capturing CO2 from the air is much more difficult. To explain, the researchers offer the following analogy: “The difference is akin to needing to find 10 red marbles in a jar of 25,000 marbles of which 24,990 are blue [the task representing DAC] versus needing to find about 10 red marbles in a jar of 100 marbles of which 90 are blue [the task for CCS].”

Given that low concentration, removing a single metric ton (tonne) of CO2 from air requires processing about 1.8 million cubic meters of air, which is roughly equivalent to the volume of 720 Olympic-sized swimming pools. And all that air must be moved across a CO2-capturing sorbent — a feat requiring large equipment. For example, one recently proposed design for capturing 1 million tonnes of CO2 per year would require an “air contactor” equivalent in size to a structure about three stories high and three miles long.

Recent modeling studies project DAC deployment on the scale of 5 to 40 gigatonnes of CO2 removed per year. (A gigatonne equals 1 billion metric tonnes.) But in their paper, the researchers conclude that the likelihood of deploying DAC at the gigatonne scale is “highly uncertain.”

Challenge 2: Energy requirement

Given the low concentration of CO2 in the air and the need to move large quantities of air to capture it, it’s no surprise that even the best DAC processes proposed today would consume large amounts of energy — energy that’s generally supplied by a combination of electricity and heat. Including the energy needed to compress the captured CO2 for transportation and storage, most proposed processes require an equivalent of at least 1.2 megawatt-hours of electricity for each tonne of CO2 removed.

The source of that electricity is critical. For example, using coal-based electricity to drive an all-electric DAC process would generate 1.2 tonnes of CO2 for each tonne of CO2 captured. The result would be a net increase in emissions, defeating the whole purpose of the DAC. So clearly, the energy requirement must be satisfied using either low-carbon electricity or electricity generated using fossil fuels with CCS. All-electric DAC deployed at large scale — say, 10 gigatonnes of CO2 removed annually — would require 12,000 terawatt-hours of electricity, which is more than 40 percent of total global electricity generation today.

Electricity consumption is expected to grow due to increasing overall electrification of the world economy, so low-carbon electricity will be in high demand for many competing uses — for example, in power generation, transportation, industry, and building operations. Using clean electricity for DAC instead of for reducing CO2 emissions in other critical areas raises concerns about the best uses of clean electricity.

Many studies assume that a DAC unit could also get energy from “waste heat” generated by some industrial process or facility nearby. In the MITEI researchers’ opinion, “that may be more wishful thinking than reality.” The heat source would need to be within a few miles of the DAC plant for transporting the heat to be economical; given its high capital cost, the DAC plant would need to run nonstop, requiring constant heat delivery; and heat at the temperature required by the DAC plant would have competing uses, for example, for heating buildings. Finally, if DAC is deployed at the gigatonne per year scale, waste heat will likely be able to provide only a small fraction of the needed energy.

Challenge 3: Siting

Some analysts have asserted that, because air is everywhere, DAC units can be located anywhere. But in reality, siting a DAC plant involves many complex issues. As noted above, DAC plants require significant amounts of energy, so having access to enough low-carbon energy is critical. Likewise, having nearby options for storing the removed CO2 is also critical. If storage sites or pipelines to such sites don’t exist, major new infrastructure will need to be built, and building new infrastructure of any kind is expensive and complicated, involving issues related to permitting, environmental justice, and public acceptability — issues that are, in the words of the researchers, “commonly underestimated in the real world and neglected in models.”

Two more siting needs must be considered. First, meteorological conditions must be acceptable. By definition, any DAC unit will be exposed to the elements, and factors like temperature and humidity will affect process performance and process availability. And second, a DAC plant will require some dedicated land — though how much is unclear, as the optimal spacing of units is as yet unresolved. Like wind turbines, DAC units need to be properly spaced to ensure maximum performance such that one unit is not sucking in CO2-depleted air from another unit.

Challenge 4: Cost

Considering the first three challenges, the final challenge is clear: the cost per tonne of CO2 removed is inevitably high. Recent modeling studies assume DAC costs as low as $100 to $200 per ton of CO2 removed. But the researchers found evidence suggesting far higher costs.

To start, they cite typical costs for power plants and industrial sites that now use CCS to remove CO2 from their flue gases. The cost of CCS in such applications is estimated to be in the range of $50 to $150 per ton of CO2 removed. As explained above, the far lower concentration of CO2 in the air will lead to substantially higher costs.

As explained under Challenge 1, the DAC units needed to capture the required amount of air are massive. The capital cost of building them will be high, given labor, materials, permitting costs, and so on. Some estimates in the literature exceed $5,000 per tonne captured per year.

Then there are the ongoing costs of energy. As noted under Challenge 2, removing 1 tonne of CO2 requires the equivalent of 1.2 megawatt-hours of electricity. If that electricity costs $0.10 per kilowatt-hour, the cost of just the electricity needed to remove 1 tonne of CO2 is $120. The researchers point out that assuming such a low price is “questionable,” given the expected increase in electricity demand, future competition for clean energy, and higher costs on a system dominated by renewable — but intermittent — energy sources.

Then there’s the cost of storage, which is ignored in many DAC cost estimates.

Clearly, many considerations show that prices of $100 to $200 per tonne are unrealistic, and assuming such low prices will distort assessments of strategies, leading them to underperform going forward.

The bottom line

In their paper, the MITEI team calls DAC a “very seductive concept.” Using DAC to suck CO2 out of the air and generate high-quality carbon-removal credits can offset reduction requirements for industries that have hard-to-abate emissions. By doing so, DAC would minimize disruptions to key parts of the world’s economy, including air travel, certain carbon-intensive industries, and agriculture. However, the world would need to generate billions of tonnes of CO2 credits at an affordable price. That prospect doesn’t look likely. The largest DAC plant in operation today removes just 4,000 tonnes of CO2 per year, and the price to buy the company’s carbon-removal credits on the market today is $1,500 per tonne.

The researchers recognize that there is room for energy efficiency improvements in the future, but DAC units will always be subject to higher work requirements than CCS applied to power plant or industrial flue gases, and there is not a clear pathway to reducing work requirements much below the levels of current DAC technologies.

Nevertheless, the researchers recommend that work to develop DAC continue “because it may be needed for meeting net-zero emissions goals, especially given the current pace of emissions.” But their paper concludes with this warning: “Given the high stakes of climate change, it is foolhardy to rely on DAC to be the hero that comes to our rescue.”

© Photo courtesy of Climeworks.

Pictured are two of the four absorber units at Climeworks’ direct air capture and storage plant, Orca, in Hellisheidi, Iceland. Each absorber unit can remove about 1,000 tons of carbon dioxide per year.
  • ✇MIT News
  • Reality check on technologies to remove carbon dioxide from the airNancy W. Stauffer | MIT Energy Initiative
    In 2015, 195 nations plus the European Union signed the Paris Agreement and pledged to undertake plans designed to limit the global temperature increase to 1.5 degrees Celsius. Yet in 2023, the world exceeded that target for most, if not all of, the year — calling into question the long-term feasibility of achieving that target.To do so, the world must reduce the levels of greenhouse gases in the atmosphere, and strategies for achieving levels that will “stabilize the climate” have been both pro
     

Reality check on technologies to remove carbon dioxide from the air

November 21st 2024 at 1:20 am

In 2015, 195 nations plus the European Union signed the Paris Agreement and pledged to undertake plans designed to limit the global temperature increase to 1.5 degrees Celsius. Yet in 2023, the world exceeded that target for most, if not all of, the year — calling into question the long-term feasibility of achieving that target.

To do so, the world must reduce the levels of greenhouse gases in the atmosphere, and strategies for achieving levels that will “stabilize the climate” have been both proposed and adopted. Many of those strategies combine dramatic cuts in carbon dioxide (CO2) emissions with the use of direct air capture (DAC), a technology that removes CO2 from the ambient air. As a reality check, a team of researchers in the MIT Energy Initiative (MITEI) examined those strategies, and what they found was alarming: The strategies rely on overly optimistic — indeed, unrealistic — assumptions about how much CO2 could be removed by DAC. As a result, the strategies won’t perform as predicted. Nevertheless, the MITEI team recommends that work to develop the DAC technology continue so that it’s ready to help with the energy transition — even if it’s not the silver bullet that solves the world’s decarbonization challenge.

DAC: The promise and the reality

Including DAC in plans to stabilize the climate makes sense. Much work is now under way to develop DAC systems, and the technology looks promising. While companies may never run their own DAC systems, they can already buy “carbon credits” based on DAC. Today, a multibillion-dollar market exists on which entities or individuals that face high costs or excessive disruptions to reduce their own carbon emissions can pay others to take emissions-reducing actions on their behalf. Those actions can involve undertaking new renewable energy projects or “carbon-removal” initiatives such as DAC or afforestation/reforestation (planting trees in areas that have never been forested or that were forested in the past). 

DAC-based credits are especially appealing for several reasons, explains Howard Herzog, a senior research engineer at MITEI. With DAC, measuring and verifying the amount of carbon removed is straightforward; the removal is immediate, unlike with planting forests, which may take decades to have an impact; and when DAC is coupled with CO2 storage in geologic formations, the CO2 is kept out of the atmosphere essentially permanently — in contrast to, for example, sequestering it in trees, which may one day burn and release the stored CO2.

Will current plans that rely on DAC be effective in stabilizing the climate in the coming years? To find out, Herzog and his colleagues Jennifer Morris and Angelo Gurgel, both MITEI principal research scientists, and Sergey Paltsev, a MITEI senior research scientist — all affiliated with the MIT Center for Sustainability Science and Strategy (CS3) — took a close look at the modeling studies on which those plans are based.

Their investigation identified three unavoidable engineering challenges that together lead to a fourth challenge — high costs for removing a single ton of CO2 from the atmosphere. The details of their findings are reported in a paper published in the journal One Earth on Sept. 20.

Challenge 1: Scaling up

When it comes to removing CO2 from the air, nature presents “a major, non-negotiable challenge,” notes the MITEI team: The concentration of CO2 in the air is extremely low — just 420 parts per million, or roughly 0.04 percent. In contrast, the CO2 concentration in flue gases emitted by power plants and industrial processes ranges from 3 percent to 20 percent. Companies now use various carbon capture and sequestration (CCS) technologies to capture CO2 from their flue gases, but capturing CO2 from the air is much more difficult. To explain, the researchers offer the following analogy: “The difference is akin to needing to find 10 red marbles in a jar of 25,000 marbles of which 24,990 are blue [the task representing DAC] versus needing to find about 10 red marbles in a jar of 100 marbles of which 90 are blue [the task for CCS].”

Given that low concentration, removing a single metric ton (tonne) of CO2 from air requires processing about 1.8 million cubic meters of air, which is roughly equivalent to the volume of 720 Olympic-sized swimming pools. And all that air must be moved across a CO2-capturing sorbent — a feat requiring large equipment. For example, one recently proposed design for capturing 1 million tonnes of CO2 per year would require an “air contactor” equivalent in size to a structure about three stories high and three miles long.

Recent modeling studies project DAC deployment on the scale of 5 to 40 gigatonnes of CO2 removed per year. (A gigatonne equals 1 billion metric tonnes.) But in their paper, the researchers conclude that the likelihood of deploying DAC at the gigatonne scale is “highly uncertain.”

Challenge 2: Energy requirement

Given the low concentration of CO2 in the air and the need to move large quantities of air to capture it, it’s no surprise that even the best DAC processes proposed today would consume large amounts of energy — energy that’s generally supplied by a combination of electricity and heat. Including the energy needed to compress the captured CO2 for transportation and storage, most proposed processes require an equivalent of at least 1.2 megawatt-hours of electricity for each tonne of CO2 removed.

The source of that electricity is critical. For example, using coal-based electricity to drive an all-electric DAC process would generate 1.2 tonnes of CO2 for each tonne of CO2 captured. The result would be a net increase in emissions, defeating the whole purpose of the DAC. So clearly, the energy requirement must be satisfied using either low-carbon electricity or electricity generated using fossil fuels with CCS. All-electric DAC deployed at large scale — say, 10 gigatonnes of CO2 removed annually — would require 12,000 terawatt-hours of electricity, which is more than 40 percent of total global electricity generation today.

Electricity consumption is expected to grow due to increasing overall electrification of the world economy, so low-carbon electricity will be in high demand for many competing uses — for example, in power generation, transportation, industry, and building operations. Using clean electricity for DAC instead of for reducing CO2 emissions in other critical areas raises concerns about the best uses of clean electricity.

Many studies assume that a DAC unit could also get energy from “waste heat” generated by some industrial process or facility nearby. In the MITEI researchers’ opinion, “that may be more wishful thinking than reality.” The heat source would need to be within a few miles of the DAC plant for transporting the heat to be economical; given its high capital cost, the DAC plant would need to run nonstop, requiring constant heat delivery; and heat at the temperature required by the DAC plant would have competing uses, for example, for heating buildings. Finally, if DAC is deployed at the gigatonne per year scale, waste heat will likely be able to provide only a small fraction of the needed energy.

Challenge 3: Siting

Some analysts have asserted that, because air is everywhere, DAC units can be located anywhere. But in reality, siting a DAC plant involves many complex issues. As noted above, DAC plants require significant amounts of energy, so having access to enough low-carbon energy is critical. Likewise, having nearby options for storing the removed CO2 is also critical. If storage sites or pipelines to such sites don’t exist, major new infrastructure will need to be built, and building new infrastructure of any kind is expensive and complicated, involving issues related to permitting, environmental justice, and public acceptability — issues that are, in the words of the researchers, “commonly underestimated in the real world and neglected in models.”

Two more siting needs must be considered. First, meteorological conditions must be acceptable. By definition, any DAC unit will be exposed to the elements, and factors like temperature and humidity will affect process performance and process availability. And second, a DAC plant will require some dedicated land — though how much is unclear, as the optimal spacing of units is as yet unresolved. Like wind turbines, DAC units need to be properly spaced to ensure maximum performance such that one unit is not sucking in CO2-depleted air from another unit.

Challenge 4: Cost

Considering the first three challenges, the final challenge is clear: the cost per tonne of CO2 removed is inevitably high. Recent modeling studies assume DAC costs as low as $100 to $200 per ton of CO2 removed. But the researchers found evidence suggesting far higher costs.

To start, they cite typical costs for power plants and industrial sites that now use CCS to remove CO2 from their flue gases. The cost of CCS in such applications is estimated to be in the range of $50 to $150 per ton of CO2 removed. As explained above, the far lower concentration of CO2 in the air will lead to substantially higher costs.

As explained under Challenge 1, the DAC units needed to capture the required amount of air are massive. The capital cost of building them will be high, given labor, materials, permitting costs, and so on. Some estimates in the literature exceed $5,000 per tonne captured per year.

Then there are the ongoing costs of energy. As noted under Challenge 2, removing 1 tonne of CO2 requires the equivalent of 1.2 megawatt-hours of electricity. If that electricity costs $0.10 per kilowatt-hour, the cost of just the electricity needed to remove 1 tonne of CO2 is $120. The researchers point out that assuming such a low price is “questionable,” given the expected increase in electricity demand, future competition for clean energy, and higher costs on a system dominated by renewable — but intermittent — energy sources.

Then there’s the cost of storage, which is ignored in many DAC cost estimates.

Clearly, many considerations show that prices of $100 to $200 per tonne are unrealistic, and assuming such low prices will distort assessments of strategies, leading them to underperform going forward.

The bottom line

In their paper, the MITEI team calls DAC a “very seductive concept.” Using DAC to suck CO2 out of the air and generate high-quality carbon-removal credits can offset reduction requirements for industries that have hard-to-abate emissions. By doing so, DAC would minimize disruptions to key parts of the world’s economy, including air travel, certain carbon-intensive industries, and agriculture. However, the world would need to generate billions of tonnes of CO2 credits at an affordable price. That prospect doesn’t look likely. The largest DAC plant in operation today removes just 4,000 tonnes of CO2 per year, and the price to buy the company’s carbon-removal credits on the market today is $1,500 per tonne.

The researchers recognize that there is room for energy efficiency improvements in the future, but DAC units will always be subject to higher work requirements than CCS applied to power plant or industrial flue gases, and there is not a clear pathway to reducing work requirements much below the levels of current DAC technologies.

Nevertheless, the researchers recommend that work to develop DAC continue “because it may be needed for meeting net-zero emissions goals, especially given the current pace of emissions.” But their paper concludes with this warning: “Given the high stakes of climate change, it is foolhardy to rely on DAC to be the hero that comes to our rescue.”

© Photo courtesy of Climeworks.

Pictured are two of the four absorber units at Climeworks’ direct air capture and storage plant, Orca, in Hellisheidi, Iceland. Each absorber unit can remove about 1,000 tons of carbon dioxide per year.
  • ✇Harvard Gazette
  • Harvard, MIT, Mass General form renewable energy collaborationAmy Kamosa
    Campus & Community Harvard, MIT, Mass General form renewable energy collaboration Group will include higher education, healthcare, and cultural institutions, seek to leverage buying power to advance cost-effective projects Amy Kamosa Harvard Correspondent November 20, 2024 4 min read The Big Elm Solar Project located in Bell County, Texas, came online this year.Credit: Apex Energy Har
     

Harvard, MIT, Mass General form renewable energy collaboration

November 20th 2024 at 11:24 pm
Campus & Community

Harvard, MIT, Mass General form renewable energy collaboration

Group will include higher education, healthcare, and cultural institutions, seek to leverage buying power to advance cost-effective projects

Amy Kamosa

Harvard Correspondent

4 min read
The Big Elm Solar Project located in Bell County, Texas, came online in 2024.

The Big Elm Solar Project located in Bell County, Texas, came online this year.

Credit: Apex Energy

Harvard announced on Wednesday the formation of the Consortium for Climate Solutions, a first-of-its-kind renewable energy collaboration of higher education, healthcare, and cultural institutions, as well as state and local government entities, led by Harvard, Mass General Brigham (MGB), and the Massachusetts Institute of Technology (MIT). 

The consortium will leverage its members’ collective purchasing power to overcome market conditions that serve as barriers to development of projects that advance cost-effective renewable energy and allow for larger-scale investment.

“With these new utility-scale renewable electricity projects, Harvard will purchase the equivalent of 100 percent of its electricity from renewable sources, fulfilling a key component of our approach to meet our goal to be fossil fuel-neutral by 2026.”

Heather Henriksen.
Heather Henriksen, chief sustainability officer

“Investing in new, large-scale renewables marks a significant step forward for Harvard in its commitment to a clean energy future,” said Meredith Weenick, executive vice president. “By founding the consortium with MIT and MGB, we are not only catalyzing the transition to a cleaner grid but also demonstrating a collaboration model that will enable a variety of nonprofit organizations and municipalities to work together to address the urgent challenges of climate change.”

The consortium recently finalized negotiations that will result in the development of 408 megawatts of new renewable energy through two large-scale, utility-grade projects — the Big Elm Solar in Bell County, Texas, and the Bowman Wind Project in Bowman County, North Dakota. The 200-megawatt Big Elm Solar project came online earlier this year, and the 208-megawatt Bowman Wind project is expected to come online in 2026. Collectively these projects will generate clean power equal to the electricity use of 130,000 U.S. homes annually.

“With these new utility-scale renewable electricity projects, Harvard will purchase the equivalent of 100 percent of its electricity from renewable sources, fulfilling a key component of our approach to meet our goal to be fossil fuel-neutral by 2026, while we simultaneously work on the longer-term effort to decarbonize our historic and urban campus,” explained Heather Henriksen, Harvard’s chief sustainability officer. 

Achieving fossil-fuel neutrality by 2026 is a bridging strategy to mitigate the negative impact of fossil fuels on emission levels and air pollution while the University develops longer-term technology and infrastructure changes to eliminate its use of fossil fuels by 2050. In addition to purchasing electricity from renewable sources, the University looks to seek greater energy efficiency and heat recovery on campus, replace fossil-fuel equipment at the end of life, increase its electric vehicle fleet, and find other reductions of fossil-fuel use.

“There is plenty of scientific evidence that fossil fuels are negatively impacting health, community stability, and ecosystems around the world. As Harvard continues on its path to become a fossil fuel-free campus, it is critical that the University not only conduct research on how to drive down global emissions and bolster adaptation, but to use our purchasing power to help produce cost-effective renewable energy solutions at scale,” said Mike Toffel, the Senator John Heinz Professor of Environmental Management at Harvard Business School, faculty chair of the Business and Environment Initiative at HBS, and co-chair of the Presidential Committee on Sustainability. “The consortium is an excellent example of engaging with the renewable electricity markets to expand their scale and impact.” 

The consortium founding members, Harvard, MGB, and MIT, sought opportunities to collaborate with smaller nonprofits and municipalities. This resulted in the partnership with PowerOptions, a nonprofit energy-buying organization, enabling the city of Cambridge, Beth Israel Lahey, Boston Children’s Hospital, Dana-Farber Cancer Institute, Tufts University, the Mass. Convention Center Authority, the Museum of Fine Arts, and WGBH to join under the PowerOptions umbrella. The consortium is providing PowerOptions members with access to affordable, large-scale renewable energy purchases that would typically be out of reach for individual buyers. 

The creation of the consortium, supported by Harvard’s leadership, was led by the Office for Sustainability working with faculty and other key stakeholders. The projects chosen for investment align with the recommendations and criteria set forth by the Fossil Fuel-Neutral by 2026 Subcommittee of the University’s Presidential Committee on Sustainability. The consortium vetted more than 100 potential projects, ultimately choosing the Big Elm Solar and Bowman Wind projects from developer Apex Clean Energy.

Locally, the consortium’s power-purchase agreements with the Big Elm and Bowman projects will enable its members to accelerate progress toward their individual sustainability goals consistent with local emissions-reduction regulatory targets, while simultaneously reducing fossil fuel emissions at a national scale. 

“The locations and scale of each project, in two of the most carbon-intensive electrical grid regions in the United States, mean that the potential positive impact is significant, creating a more robust and cleaner grid,” explained Henriksen.

  • ✇Harvard Gazette
  • Rapid relief for the severely depressed? There’s a catch.Liz Mineo
    Health Rapid relief for the severely depressed? There’s a catch. Liz Mineo Harvard Staff Writer November 20, 2024 6 min read Ketamine carries risks, say researchers. Yet for some patients, it’s ‘the only thing that works.’  At the Ketamine Clinic for Depression at Massachusetts General Hospital, patients make their way each day to receive intravenous infusions of the powerful anesthetic
     

Rapid relief for the severely depressed? There’s a catch.

By: Liz Mineo
November 20th 2024 at 9:12 pm
Health

Rapid relief for the severely depressed? There’s a catch.

woman sitting on bed alone

Liz Mineo

Harvard Staff Writer

6 min read

Ketamine carries risks, say researchers. Yet for some patients, it’s ‘the only thing that works.’ 

At the Ketamine Clinic for Depression at Massachusetts General Hospital, patients make their way each day to receive intravenous infusions of the powerful anesthetic that has become an alternative therapy for treatment-resistant depression. 

Many of the clinic’s patients have not been helped by traditional treatments, including psychological counseling, antidepressant medication, transcranial magnetic stimulation, and electroconvulsive therapy. With its rapid antidepressant effects, ketamine is sometimes the only option that provides relief, said clinic founder and director Cristina Cusin, who has been researching depression and mood disorders for the past 25 years.  

“We don’t have good weapons to treat some severe forms of depression, just like we don’t have treatments for advanced-stage cancer,” said Cusin, who is also an associate professor in psychiatry at Harvard Medical School. “We’re always looking for the next thing so that we can continue to offer hope to patients who don’t respond to standard treatments.”

In 2000, after a study reported that small doses of IV ketamine rapidly reversed symptoms of depression while standard antidepressants often took several weeks to have an effect, ketamine became the next new thing. In 2019, based on years of research, the FDA approved a nasal spray medication, derived from ketamine, to be administered under medical supervision.

Depression is a mental health disorder characterized by feelings of sadness and hopelessness, that affects 18 percent of Americans. One-third of those diagnosed with depression don’t respond to standard treatments, with acute consequences to their personal and professional lives. The stigma associated with depression makes it harder for people to seek treatment, said Cusin. 

“There are some forms of depression that have a strong biological component; there are neurocircuits in the brain that are not functioning right. In many cases, it’s not for lack of trying.” 

Cristina Cusin

“In our society, if you suffer from depression, you may be told to ‘try harder,’ ‘stop complaining,’ ‘pick yourself up by your bootstraps,’ and so on,” Cusin said. “But there are some forms of depression that have a strong biological component; there are neurocircuits in the brain that are not functioning right. In many cases, it’s not for lack of trying.” 

Patients follow a strict protocol to be admitted to the MGH Ketamine Clinic; not only do they have to be referred by their primary prescribers, but also prior treatments for depression must have failed. Ketamine therapy is integrated with other treatments and is done in the clinic under medical supervision and in coordination with patients’ primary medical teams. The clinic doesn’t admit self-referred patients or those with active substance use disorders or a history of psychosis. Ketamine produces hallucinogenic effects and dissociation, which can exacerbate psychotic symptoms. 

Other risks associated with ketamine are the possibility of developing addiction and a host of medical problems, but for patients who experience rapid relief from their symptoms of depression after treatment, ketamine is a game-changer, said Cusin. “Our patients have failed other treatments, so they don’t have a lot of other options,” she said. “If this is the only thing that works, they keep coming.” 

Scientists continue researching ketamine’s antidepressant effects on treatment-resistant depression. A recent clinical trial found that ketamine was as effective for non-psychotic treatment-resistant depression as electroconvulsive therapy (ECT), which has long been the gold standard for hard-to-treat depression.

Conducted by Amit Anand, professor of psychiatry at Harvard Medical School, the study found that 55 percent of those receiving ketamine and 41 percent of those receiving ECT had at least a 50 percent improvement in their self-reported depression symptoms. Anand co-authored the pivotal 2000 study that revealed the rapid antidepressant effects of ketamine.

Encouraged by his recent study’s results, Anand is conducting a follow-up clinical trial comparing ketamine and ECT treatments among patients with suicidal depression. If ketamine can affect suicidal thoughts, it could be lifesaving. “What we’re trying to see is that if ketamine can cause a very rapid reversal of the troubling kind of depression leading to suicidality,” he said. “People are suffering, and even if it is for a short time, it is beneficial to provide a rapid change.”

“What we’re trying to see is that if ketamine can cause a very rapid reversal of the troubling kind of depression leading to suicidality.”

Amit Anand

Even though doctors and researchers are hopeful regarding the promise of ketamine, there is growing concern about the proliferation of private ketamine clinics, which began to crop up around the country after restrictions on telemedicine relaxed during the pandemic. These clinics offer IV ketamine infusions, with prices ranging from $600 to $800 per infusion. 

Most ketamine private clinics operate in a gray zone, with almost no oversight, and function as for-profit businesses, said Peter Grinspoon, a primary care physician, educator, and cannabis specialist at MGH. 

“The end result is that now our population has broad access to ketamine, and it’s a little bit of an uncontrolled experiment,” said Grinspoon. “Whether it’s going to alleviate many people’s depression or whether it’s going to get a lot of people addicted to ketamine is going to be an open question. We don’t know how much it is going to help or harm things.”

Ketamine is not nearly as addictive as alcohol or opioids, but its use as a recreational drug poses serious risks. Actor Matthew Perry died last year of “acute effects of ketamine.” His autopsy also found opioids in his blood, but the level of ketamine found was equivalent to the amount that would be used during general anesthesia. 

The other troubling issue for Grinspoon is affordability. “I work as a primary care doctor in an inner-city clinic,” he said. “None of my patients can afford six $800 injections. … The last thing we need is for ketamine to be another treatment for just the well to-do. … This has got to be affordable.”

At the MGH clinic, patients receive low doses of ketamine in long intervals and have mixed experiences. While some report feeling relaxed, others find it unpleasant, but most said their symptoms of depression improve and don’t interfere with day-to-day functioning. Still, 

Cusin warns that ketamine should not be a first-option treatment for depression. 

“If someone is depressed or suicidal, there are alternatives out there,” said Cusin. “There are 50, 80 different treatments to consider. It’s rare that somebody has tried everything. Usually, there are entire classes of medications or treatments that have not been considered. There is always hope.”

  • ✇Harvard Gazette
  • Culture Lab Innovation Fund grants awarded to 12 projectsLaurie Rodriguez
    Campus & Community Culture Lab Innovation Fund grants awarded to 12 projects Grant recipients foster a culture of innovation and belonging on Harvard campus Laurie Rodriguez Harvard Correspondent November 20, 2024 6 min read The Lighting for Diverse Skin Tones project holding an in-person lighting master class for Harvard media professionals. Photo by Julia King Twelve projects have r
     

Culture Lab Innovation Fund grants awarded to 12 projects

November 20th 2024 at 7:30 pm
Campus & Community

Culture Lab Innovation Fund grants awarded to 12 projects

Grant recipients foster a culture of innovation and belonging on Harvard campus

Laurie Rodriguez

Harvard Correspondent

6 min read
The Lighting for Diverse Skin Tones project holding an in-person lighting master class for Harvard media professionals.

The Lighting for Diverse Skin Tones project holding an in-person lighting master class for Harvard media professionals.

Photo by Julia King

Twelve projects have recently been awarded grants from the Harvard Culture Lab Innovation Fund (HCLIF) for the 2024–2025 cycle. Harvard students, faculty, staff, postdoctoral researchers, and fellows submitted grant proposals for projects aimed at fostering an inclusive environment at the University. Each project aligns with HCLIF’s mission to “encourage experimentation, build a culture of inclusion, and grow a network of equity, diversity, inclusion, and belonging innovators at Harvard,” while also supporting the University’s goal of achieving inclusive excellence. Funded by the Office of the President and administered by the Office for Equity, Diversity, Inclusion, and Belonging, these grants range from $5,000 to $15,000.

“Harvard is committed to continuing its investment in innovative ideas that promote a campus culture of inclusion and belonging,” said Sherri Charleston, chief diversity and inclusion officer. “These grassroots projects unite community members at all levels of the University — researchers, students, faculty, postdocs, and staff — who identify pressing campus needs and apply their expertise to develop solutions. From a series exploring faith and justice to a project creating inclusive medical illustrations, the HCLIF projects are transforming ideas into action and making a significant impact.”

“From a series exploring faith and justice to a project creating inclusive medical illustrations, the HCLIF projects are transforming ideas into action and making a significant impact.”

Sherri Charleston
Sherri Charleston, chief diversity and inclusion officer
 

This year’s project teams showcase cross-University collaboration, with members representing Schools and units from across Harvard.

The awardees include the Lighting for Diverse Skin Tones project, a second-year grant recipient. It is a University-wide training resource that educates video producers and media professionals at Harvard on how to create lighting that captures a variety of skin tones effectively in photography, especially skin tones previously overlooked in photography and film training. With additional funding, they will work to identify a host site for the project and complete editing of previously recorded videos. “This project started with the intention of honing media producers’ skills in the craft of inclusive cinema lighting, but we ended by finding the time and space to really see people and understand how they want to be represented,” said Julia King, creative video producer at the Harvard T.H. Chan School of Public Health, and Jacob Beizer, senior digital content producer and strategist at the Harvard Kennedy School in a statement. “We are excited to provide this resource to the entire Harvard community.”

The Inclusive Anatomical Images project stems from collaborations between Harvard Medical School, Harvard Art Museums, and the University of Global Health Equity based in Rwanda. The project seeks to ensure diverse patients have a higher chance of being better served and aims to improve patient outcomes by creating more inclusive educational medical literature. It creates materials reflecting a diversity of bodies — including various sizes, ancestries, genders, and skin tones — to better serve a wide diversity of patients. With this year’s funding, the team will expand their reach by making their resources more accessible to institutions, researchers, and health professionals beyond Harvard, while expanding their team to meet the demand for their expertise and images. Martha Ellen Katz, a faculty member of the Harvard Medical School, said, “Our project has the potential to validate the life experience of historically excluded patients, physicians, dentists, and student learners at HMS, and curricula worldwide. Our equitable work culture, which strives to be as non-hierarchical as possible, also encourages student leadership and acknowledges the essential contributions of all team members, collaborators, and supporters.”

The Connecting Community Through Food project celebrates Harvard’s student body through food. By collaborating with Harvard College students, student organizations, and employees, the Harvard University Dining Services team aims to develop recipes and menus authored by Harvard undergraduates from a diversity of backgrounds. These meals will be served more regularly in dining halls. Smitha Haneef, executive director of the Harvard University Dining Services, explained, “We want students to experience the dining halls as welcoming, comforting places, hopefully like their home kitchens. For this to happen, the menus must feel like home. This project helps us realize that vision for more community members.”

Additional 2024 HCLIF Recipients

  • Community Project on Faith and Justice cultivates inclusivity and engagement centered on faith by hosting speaker series and community events where affiliates can explore the influence of faith in their lives.
  • Disability Awareness Series aims to increase awareness about the resources available for, and challenges faced by, those with disability and accessibility needs at Harvard. It engages Harvard College students, staff, researchers, and faculty through an awareness campaign and series of events.
  • Disability in Health Professions Mentorship Program cultivates a supportive community for current and future health professionals living with disabilities and chronic illness, fostering a greater sense of belonging at Harvard.
  • Emerging Scientists Program connects high school students from Cambridge and Boston with Harvard graduate students, postdoctoral researchers, and staff, providing meaningful and accessible life sciences research experiences.
  • Harvard Career Capsule empowers graduate students by providing professional attire and equipment to support their career development.
  • Harvard University Peer Coaching Initiative aims to reduce loneliness and enhance interpersonal skills by pairing Harvard students and researchers. Participants engage in weekly sessions over the course of a semester to practice effective listening with one another.
  • Justice-Impacted Inclusion seeks to make Harvard more inclusive of formerly incarcerated people and others impacted by the justice system. The initiative consults with formerly incarcerated policy experts and creates resources, such as a guide on inclusive language and practices.
  • LifeSaveHer develops trainings to address misconceptions regarding performing CPR on women, including modifying male CPR mannequins to represent female bodies, ultimately aiming to reduce cardiac arrest survival disparities for women.
  • Trans+ Community Celebration at Harvard seeks to uplift the trans+ community by creating inclusive spaces within the University.

Applications for the 2025-2026 funding term of Harvard Culture Lab Innovation Fund grants are now open to Harvard students, faculty, staff, postdoctoral researchers, and academic personnel. Harvard community members interested in participating as judges for the 2025-2026 HCLIF grant applications can now sign up.

  • ✇Harvard Gazette
  • New frontiers in cancer careSamantha Perfas
    Getty Images Health ‘Harvard Thinking’: New frontiers in cancer care In podcast, experts discuss breakthroughs in treatment, from genomic sequencing to AI, and how close we are to personalized vaccines Samantha Laine Perfas Harvard Staff Writer November 20, 2024 long read Cancer kills nearly 10 million people worldwide every year, but advances in genomic sequencing, artificial intelligenc
     

New frontiers in cancer care

November 20th 2024 at 6:58 pm
Illustration of a target over a cancerous cell.

Getty Images

Health

‘Harvard Thinking’: New frontiers in cancer care

In podcast, experts discuss breakthroughs in treatment, from genomic sequencing to AI, and how close we are to personalized vaccines

Samantha Laine Perfas

Harvard Staff Writer

long read

Cancer kills nearly 10 million people worldwide every year, but advances in genomic sequencing, artificial intelligence, and other technologies are ushering in a new era of treatment.

Alumnus Levi Garraway, who runs late-stage drug development at the biotech company Roche and previously worked at the Dana-Farber Cancer Institute, said the field has come a long way.

“Although cancers may look the same under the microscope, they can be very different when you look at the DNA,” Garraway said. That’s why the pillars of cancer treatment — surgery, radiotherapy, and chemotherapy — are so limited in their applications. Moving to more personalized treatments based on a patient’s genetics has revolutionized the field. “[Genetic sequencing] was one of the first breakthroughs that allowed cancer treatment to start to become a bit more personalized.”

Connie Lehman, a professor of radiology at Harvard Medical School and a breast imaging specialist at Mass General Brigham, said artificial intelligence has shown remarkable promise in detecting breast cancer, with success rates that far exceed what the human eye can detect alone. “What [other industries] are doing in computer vision is just unbelievable. And bringing that into healthcare to improve the lives of our patients is incredibly exciting.”

Treatment and prevention will only become more personalized and effective as researchers continue to explore the human genome and genetic structure of cancers, said Catherine Wu, a professor of medicine and chief of the Division of Stem Cell Transplantation and Cellular Therapies at the Dana-Farber Cancer Institute. One question that drives some of her research: Is it possible to vaccinate against cancer?

“That’s the vision,” said Wu, a recent recipient of the Sjöberg Prize for cancer research. “Can we, for example, make cancer vaccines as available as, say, the COVID vaccine was? That was a huge rollout given to all citizens of our country. How were we able to roll that out quickly and safely?”

In this episode of “Harvard Thinking,” host Samantha Laine Perfas talks with Garraway, Lehman, and Wu about some of their most cutting-edge cancer research — and what hope lies on the horizon.

Transcript

Levi Garraway: And now all of a sudden, it’s not quite such a blunt instrument. You’re able to get a much more selective killing effect of the cancer. Now you have a way to tell in advance who might respond to this treatment. That was one of the first breakthroughs that allowed cancer treatment to start to become a bit more personalized.

Samantha Laine Perfas: Advances in technologies like genomic sequencing and artificial intelligence have ushered in a new era in the fight against cancer, which kills nearly 10 million people worldwide every year. Researchers are now working on therapies that can be genetically tailored to individual patients and they’re also working on methods for discovering cancers at much earlier stages. Someday, we might even have vaccines that can prevent the disease altogether.

How close are we to turning a corner on cancer?

Welcome to “Harvard Thinking,” a podcast where the life of the mind meets everyday life. Today, we’re joined by:

Garraway: Levi Garraway. I run late-stage drug development at Roche, which in the U.S. is known as Genentech.

Laine Perfas: Levi attended Harvard as an undergraduate, graduate, and medical student. He also worked at the Dana-Farber Cancer Institute for 11 years. Then:

Connie Lehman: Connie Lehman. I’m a professor of radiology at Harvard Medical School and I’m a breast imaging specialist at Mass General Brigham.

Laine Perfas: She’s also a founding partner at Clairity, which uses the power of artificial intelligence to better inform precision care. And finally:

Cathy Wu: Cathy Wu. I am a professor of medicine and division chief for transplant and cellular therapies at Dana-Farber Cancer Institute.

Laine Perfas: She was an undergraduate at Harvard and completed her clinical training at the University. Recently she received the Sjöberg Prize for cancer research.

And I’m Samantha Laine Perfas, your host and a writer for The Harvard Gazette. This episode looks at the future of cancer treatment.

Historically, how have we approached cancer treatment and how has that shifted in recent years?

Garraway: Historically you had surgery, you had radiotherapy, and you had chemotherapy. I put historically in quotes because these are all in wide use today, and they’re probably not going anywhere anytime soon. And the reason why they’re not going anywhere is because they actually can be effective in treating many cancers, even curing some cancers, but there are well-known limitations. And of course, I think for all of us who went into this field, it was in part to try to counter those limitations. And one is that there’s a whole lot of cancers that can’t be cured with those therapies, and the other is that these are all blunt instruments. I mean, often you get damage to normal or adjacent cells and tissues as well as cancer cells. And that’s a big problem. You often can’t tell in advance who’s going to respond or who’s not going to respond, for example, to chemotherapy. So it’s a vexing issue when you have a patient and you know they need treatment, but you can’t tell them that they’re going to benefit from a potentially toxic treatment.

Wu: Yeah. I agree with Levi. I think we were taught that the pillars of cancer care have been chemotherapy, radiotherapy, and surgery. I think what’s been exciting in the lifetime that we are going through our training and treating our patients is that we’ve seen so much evolved that there are actually new pillars that have been coming up and so I think that one of the things that kind of worldwide that we’re excited about is immunotherapy because this has emerged as a fourth pillar that is touching on all the different disease types and has proven to be really important.

Lehman: It is really exciting to see this transition to more targeted and more personalized treatment. Also at the other end of the spectrum is, can we actually even prevent cancers? Like, are there domains where we don’t need to wait until they’re so far advanced that cure is really elusive even with the most advanced therapies? So in my part of the sandbox, we’re really focused on early detection and also accurate risk assessment so we can have the right interventions to prevent the cancer from developing. It’s so interesting to look at the changes in how breast cancer presents. You can have women moving from one country to another, to adopting different diets, different lifestyles, and their breast cancer risk goes up within their lifetime. So there are these correlations between modifiable risk factors and lifestyle, diet, exercise, environmental, carcinogens, and how can we be better at identifying those and really stopping the cancer from occurring?

Laine Perfas: Treatment has become a lot more personalized in many ways. The historical treatment, if this is accurate, it seems like it was very much one-size-fits-all. What were some of the problems of that approach and why did that need to change?

Garraway: One major recognition that happened over time is that you could have two women with breast cancer, they’re both called breast cancer, but they behave very differently. They may show up very differently. They respond differently to treatment. There’s now a lot more understanding about why that is. And one big reason is that although cancers may look the same under the microscope, they can be very different when you look at the DNA, the genomes of those cancers. They’ve acquired mutations of various types. Some of them are completely random and they don’t matter to the cancer, but others are critical. They become what we call drivers of the cancer. So when we talk about what made cancer become more personalized, it was the recognition that some of those mutations, they occur over again in certain subsets of cancer, but you can design medicines against the resulting mutated proteins that drive the cancer. And those medicines are now much more selective. Now all of a sudden, it’s not quite such a blunt instrument. You’re able to get a much more selective killing effect of the cancer. Now you have a way to tell in advance who might respond to this treatment. That was one of the first breakthroughs that allowed cancer treatment to start to become a bit more personalized.

Wu: A lot of innovation follows technology. So I think that it’s always been recognized that you can try to do one-size-fits-all. But the reality is that not everyone responds and patients do or do not have toxicities. So I think the kind of technology that has brought so much insight has been through unraveling the molecular secrets of cancer cells through sequencing. I think that very, perhaps, simple technological advance has meant the world to what we understand about cancer now. And at some level, I think that the personalization is what is fighting fire with fire. You’re confronting that heterogeneity up front. You’re not trying to hide from it. You’re acknowledging that it exists and that it actually mandates that we become more selective in terms of how and what we can offer to our patients.

Lehman: I really like how both Levi and Cathy talk about [how] this personalized domain is about getting the fit with the patient and that patient’s tumor and the treatment. We see that in other domains of medicine. So, for example, we can look back at old studies and there was a drug therapy that people were very excited about, and the results were mediocre and everyone abandoned and moved on. But there were some patients that responded really well. So you want to go back and say, it wasn’t necessarily a bad treatment. It was a bad selection of the patients that could benefit. If we can be more tailored and more personalized and more targeted, will there be a lot of drugs that had been like, this isn’t a great way to approach treating quote, breast cancer, which is far too broad of a term to use. Exactly the same analogy happens in the imaging sciences and radiology. We had a boon in developing new technology for breast imaging from old film screen to digital mammography to tomosynthesis to contrast-enhanced mammography to MRI to nuclear medicine scans to ultrasound. Everyone’s really excited, and we were trying to use these in screening, and some of them give orders that, well, we can’t screen with ultrasound, there are too many false positives, we can’t screen with MRI, it’s too expensive and we can’t afford it and the value proposition isn’t there. But what we needed to do was to say, what if you targeted the right population, that, one, is disadvantaged with mammography and, two, is really at high risk for having a cancer aggressively grow and fail to be detected by mammography? And if you targeted those high-risk patients, all of a sudden these technologies look a lot better, look a lot more powerful.

Laine Perfas: Cathy, one of the things you mentioned that I wanted to ask about was genetic sequencing. I believe it just was so time-consuming and expensive in the past that it wasn’t really a practical thing that could be done on a patient-by-patient basis. How has that changed and what doors has that opened with research?

Wu: It’s been huge. In short, I think the big change happened around 2008-09, more or less, where suddenly from the exorbitantly expensive experience of running the Human Genome Project, there was new technology available that suddenly made it possible to sequence on the order of hundreds to low thousands, which still sounds like a lot. That was back then. Now we’re coming down to the low hundreds per sample. We are already testing the waters, but I really do think it’s a reality that in the not-too-distant future that this should be a diagnostic test that can be offered that is a standard part of your cancer workup. As we as a community gain more experience, this experience can be aggregated and we can look for patterns and we can look for opportunities that can at one level afford personal opportunities, but also at a population level find perhaps therapies that can benefit another population that may share those kind of genetic characteristics.

Garraway: I’ll add a couple of points. One is that what Sam described, the laborious nature of sequencing, the unlock, as you point out, that happened coming close to two decades ago, was the ability to sequence at scale. So this technology called Massively Parallel Sequencing came on the scene, and now all of a sudden, where it used to be so laborious to even sequence one gene, and there are 20,000 genes in the genome and there are many hundreds that are critical in cancer, now all of a sudden you can sequence dozens or hundreds of genes at a time. Eventually, as Cathy mentioned, it’s become possible to sequence whole genomes routinely and many times over. So the expansion of technology has been remarkable. The other thing that it is enabling is possibly a new generation of what Cathy mentioned: immune therapy. It may be that in the fullness of time, the same sequencing technologies will figure out mutations that actually now cause a tumor to look more foreign. There can be new ways to target the immune system with that information, but that’s also very personalized information. Each tumor will have a different set of mutations or changes like that. So this is a direction that immunotherapy is taking. It’s early days but it looks very intriguing.

Laine Perfas: Is it accurate to say that there could be a future where we might be able to vaccinate against cancer or treat people with personalized vaccines for their specific case?

Wu: That’s the vision. I think that if we are going to be able to offer sequencing as a routine test, then the information content that is provided by that test not only allows you to understand maybe some of the origins of where that kind of cancer came from, what were the steps that made it into the cancer that it was, but it also provides you with different therapeutic opportunities. That gets into another interesting topic, which is, how can we, for example, make cancer vaccines as available as, say, the COVID vaccine was, right? So that was a huge rollout given to all citizens of our country. How were we able to roll that out quickly and safely? A cancer vaccine is far more complicated. Some of the principles, though, are very similar. But because of the scale of that difference in the personalization, it is more complex. On the other hand, the ingredients to make that type of vaccine are contained within the sequencing information that I think we would all envision would be a routine test in the not-too-distant future.

Lehman: I also think it’s exciting, and we’re becoming more and more sophisticated and not thinking of the multitude of cancers as cancer. So a vaccine against cancer is almost like thinking, will we have a vaccine against a virus? And so we have areas that have been incredibly exciting during my career where I certainly didn’t think when I was a medical school student and learning about cervical cancer that we would have a vaccine to prevent HPV infection and that would eradicate a very large percentage of cervical cancers in patients that are vaccinated and that also can reduce the occurrence of prostate cancer. So there’s a whole domain that you can actually stop the trigger for the cancer to be able to develop rather than wait and then see that there’s circulating cancer cells and now let’s come in and let’s try to have the body help fight away those cancer cells.

Laine Perfas: Connie, early detection is an area that you’re really passionate about. And actually in the work you’ve been doing, you’ve been using AI. I would love to hear more about that and how AI is being used to detect breast cancer sooner.

Lehman: Part of the different changing face of breast cancer has been mammography screening. Mammography is a very imperfect tool, but it did change the spectrum of patients presenting with breast cancer. We shifted historically from women coming forward when they noticed that there was a lump in their breast, or a doctor noticed that, and we could find cancers preclinical before that happened, and we really saw a shift in both the morbidity of the treatment, but also the survival.

That was a big win, but as I said it’s limited, and we have women presenting with advanced cancer despite routine screening. We have the costs and the false positives and the challenges of using mammography effectively. So I think that what I’m most excited about is changing the paradigm of how we screen and moving away from a very archaic age-based approach and moving into a risk-based approach.

Everyone has seen over the years the arguments about screening mammography. In Europe they tend to start at 50 and screen every two to three years. In the U.S. we constantly battle about whether you start at 40 or 50 and it’s every year or every two years. That argument is so limited. It’s almost unbelievable to me that we’re still having a basic argument about 40 or 50 or every year or every two years when there’s such a diversity of the risk profiles of women within their 40s, within their 30s, within their 50s, and we ignore that. Now one of the reasons why we’ve ignored it is our traditional risk models are inadequate. So the area I’m most excited about with artificial intelligence is using computer vision, not to look for cancer currently on the mammogram, but to predict whether that woman will develop cancer within the coming five years. So if you can look out into the future, is there something about this tissue that is putting this woman at increased risk? And our research to date shows that the AI applied to the basic regular mammogram can predict future breast cancer at a level that we just haven’t seen before.

It also eliminates the really unfortunate racial biases in our traditional risk models, which were built largely on European Caucasian women, and just don’t perform for us in Black, Hispanic, and Asian women. There’s a whole other domain, too, of having the computers learn how to read the mammograms, because one of the limitations of mammography is you need these highly specialized humans to read them, which really reduces the impact of screening mammography globally, because we just don’t have enough highly specialized radiologists to interpret the mammograms. So I think we’ll also see that shift.

Garraway: We could have a whole conversation, of course, on AI in medicine, and what Connie described in radiology is so exciting. It’s really going to be revolutionary. I’ll just say at a high level that AI is already changing every component of the research and development of new medicines, starting all the way from the very beginning, where you can use AI to conduct a lot of the compound screening or chemical screening in a computer. Where it used to be, you have to have lots of expensive chemical libraries and iterative screening of things. A lot of that can be done in silico, as we call it, because of AI, and even design of therapeutic antibodies from scratch, using AI-first principles. Then when you get into the clinic, the ability to synthesize all kinds of patient data to predict the kinds of patients that one should study so that you’re not fooled either in the positive or the negative way about whether a medicine is working. So it’s hard to come up with a component of the research and discovery of medicines that’s not being impacted by AI.

Laine Perfas: A lot of Connie’s work involves using AI for mammography and then Levi, you mentioned really every area of medicine is being revolutionized. Are there other emerging technologies that are really changing the landscape of cancer detection, treatment, and lowering morbidity rates?

Wu: I think there’s a lot of exciting technologies that are among us right now. It’s not for nothing that we’re in the age of human biomedicine that we actually can learn directly from human biospecimens as opposed to fruit flies, worms, and mice, which is really how we gained our insights in the past. Along the lines of some of the AI work, there’s a tremendous interest, not only unlocking the secrets one cell at a time, looking at the DNA, the RNA, the protein expression, but also looking to see how all of these cells in, for example, tumor tissue, are patterned, are organized in space. These patterns on the one hand are teaching us how the cells are interacting with each other and allowing us to relate that to patient characteristics. So for patients who are destined to respond or not respond to a particular therapy, what were the patterns that were seen? And what does that tell us about the biology that happened? A lot of that information can also be fed into AI-related algorithms so that we can become better at pattern recognition.

Lehman: Yeah, Cathy, I like how you’re presenting that because it is where, again with these multidisciplinary approaches, the more I interact with specialists in computer science and artificial intelligence, the more I realize how much we really need their expertise just infusing healthcare. Because what we deal with is, we’ve had this incredible renaissance where we have so much technology that can collect so much data and in the imaging sciences alone. I think about, when I started, the kinds of images I would look at with plain films and a chest X-ray and a mammogram and then the complexity of the way that we can image the human body and the data that results from that. But the technology to collect that information, to create those patterns, just far exceeds our ability as humans. From the military, from the auto industry, I mean, what they’re doing in computer vision is just unbelievable. And bringing that into healthcare to improve the lives of our patients is incredibly exciting.

Garraway: Sam, you asked the question about other kinds of technologies. Of course, as Connie’s mentioning, AI pervades all of them, but I will mention there are technologies that are also allowing new kinds of cancer treatments to emerge. There are now what we call treatment modalities, which are different than were possible in the past. I’ll just mention a couple of them.

One is what we call cellular therapy. So this is a technology platform. You basically collect certain kinds of immune cells from an individual and then you expand them in the laboratory. You engineer them so that they can destroy tumor cells very effectively and then you give them back to patients. And so, the first generation of cell therapy, you would collect those cells from a patient with, let’s say a blood cancer, and then you engineer them and you give them back to the same patients. That actually often works remarkably well. You can get very profound clinical benefit in patients who otherwise weren’t going to benefit at all. But as you might imagine it’s logistically challenging to do this for every patient, and in every center and every context. So not as many patients have access to cell therapy as one might like.

So there’s now a new kind of emerging generation of cell therapy. The technical term is allogeneic cell therapy. In that setting, what you do is you collect immune cells from completely unrelated donors, and you expand them and you engineer them, just like we talked about, but then you can store them so that in the future, you have, like, an off-the-shelf way of leveraging this cell therapy. You don’t have to do the whole start-to-finish process on every single patient, every single time. We think this is potentially a really exciting, future promise. Then the other platform I’ll just mention very briefly, it’s called bispecific antibodies. Traditionally one kind of therapy we call a therapeutic antibody, it’s a mimic of the immune system but it allows you to design an antibody that binds a particular disease target very tightly. But bispecific antibodies work by binding not just one target, but two targets. So if one target is on the tumor cell and the other target is on the immune cell, the bispecific antibody can bring the immune cell to the tumor cell and activate the immune cell and kill the tumor cell. So I just want to bring up that we talked a lot about AI as it’s revolutionizing everything, but there are other kinds of platforms that we use more and more in the pharmaceutical arena to try to develop new kinds of medicines that can bring new kinds of benefits.

Laine Perfas: Hearing about all these emerging therapies is so exciting and amazing and miraculous-seeming, especially as someone who is not a cancer researcher. But I also want to acknowledge that there’s still challenges there, you know, there’s costs, resources, still limitations on technology. A lot of it is just a lot of work.

Wu: We know. Oh, we know.

Laine Perfas: So what keeps you all hopeful with the current trajectory and where do you see us being or hope we’ll be 10 years from now, 20 years from now?

Wu: I think the hope comes from all the progress that we see. It is incremental. I think all of us know the challenges but experience the positive signals that kind of give us hope and tell us that we’re on the right track, and you’ve got to have the focus and the vision to get you through the finish line.

Garraway: Yeah, Sam, I think it’s a really prescient question because I know that both Connie and Cathy are part of outstanding institutions where unfortunately, the waiting rooms are still all too full with patients, some of whom are benefiting from these approaches, but others are not benefiting enough, or even at all from these approaches. So the unmet need is still quite considerable, and sometimes it feels like the pace of advance, it’s almost like, there’s a concept of how evolution happens, which is punctuated equilibrium: There’s a bunch of evolution, and then it plateaus, and there’s a bunch more, and then it plateaus. Cancer research and drug development can be like that. So you have this flurry of activity that led to targeted therapies, and then you have this flurry of activity that established immunotherapies, but all the while, you can be in these plateau phases also, where it’s like, “Oh, it’s not happening fast enough.” But the fact that these advances have happened and that we’ve been fortunate enough in our careers to either witness or, in some cases, participate in those advances, it doesn’t get old. You don’t forget those moments of impact, those opportunities to bring the advances. That’s what motivates you to bring more of those. I know for me, that’s what wakes me up in the morning.

Lehman: I actually think our strongest energy is around what we know needs to be done and the technology we have to make that happen. So we need to have the right people agree that this is the direction we have to go in. You can be in those domains where dogma, and this is the way we’ve always done it, and politics, can slow down the implementation and the progress. And so that’s really in the domain that I’m working the most in. The early detection-prevention side is to change the guidelines, to change the approach, to change how we think about how we screen to detect breast cancer early.

COVID was such a horrible period for so many, but one of the silver linings was we realized that we can be both safe and fast in certain domains of healthcare. I had been struggling with how many barriers there were to telehealth and to providing services to women in rural areas and in healthcare deserts. All of a sudden, all those barriers with COVID, it’s like, we can probably do these things that we used to always say weren’t safe, weren’t OK. But now that we need to do it, we can do it. I think it gave people new vision in what can be accomplished. That is something that’s going to be exciting as we continue to move forward in the next few years.

Laine Perfas: Thank you for this wonderful conversation.

Thanks for listening. To find a transcript of this episode and links to all of our other episodes, visit harvard.edu/thinking. This episode was hosted and produced by me, Samantha Laine Perfas. It was edited by Ryan Mulcahy, Simona Covel, and Paul Makishima with additional editing and production support from Sarah Lamodi. Original music and sound designed by Noel Flatt. Produced by Harvard University, copyright 2024.



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  • ✇MIT News
  • A bioinspired capsule can pump drugs directly into the walls of the GI tractAnne Trafton | MIT News
    Inspired by the way that squids use jets to propel themselves through the ocean and shoot ink clouds, researchers from MIT and Novo Nordisk have developed an ingestible capsule that releases a burst of drugs directly into the wall of the stomach or other organs of the digestive tract.This capsule could offer an alternative way to deliver drugs that normally have to be injected, such as insulin and other large proteins, including antibodies. This needle-free strategy could also be used to deliver
     

A bioinspired capsule can pump drugs directly into the walls of the GI tract

November 20th 2024 at 7:30 pm

Inspired by the way that squids use jets to propel themselves through the ocean and shoot ink clouds, researchers from MIT and Novo Nordisk have developed an ingestible capsule that releases a burst of drugs directly into the wall of the stomach or other organs of the digestive tract.

This capsule could offer an alternative way to deliver drugs that normally have to be injected, such as insulin and other large proteins, including antibodies. This needle-free strategy could also be used to deliver RNA, either as a vaccine or a therapeutic molecule to treat diabetes, obesity, and other metabolic disorders.

“One of the longstanding challenges that we’ve been exploring is the development of systems that enable the oral delivery of macromolecules that usually require an injection to be administered. This work represents one of the next major advances in that progression,” says Giovanni Traverso, director of the Laboratory for Translational Engineering and an associate professor of mechanical engineering at MIT, a gastroenterologist at Brigham and Women’s Hospital, an associate member of the Broad Institute, and the senior author of the study.

Traverso and his students at MIT developed the new capsule along with researchers at Brigham and Women’s Hospital and Novo Nordisk. Graham Arrick SM ’20 and Novo Nordisk scientists Drago Sticker and Aghiad Ghazal are the lead authors of the paper, which appears today in Nature.

Inspired by cephalopods

Drugs that consist of large proteins or RNA typically can’t be taken orally because they are easily broken down in the digestive tract. For several years, Traverso’s lab has been working on ways to deliver such drugs orally by encapsulating them in small devices that protect the drugs from degradation and then inject them directly into the lining of the digestive tract.

Most of these capsules use a small needle or set of microneedles to deliver drugs once the device arrives in the digestive tract. In the new study, Traverso and his colleagues wanted to explore ways to deliver these molecules without any kind of needle, which could reduce the possibility of any damage to the tissue.

To achieve that, they took inspiration from cephalopods. Squids and octopuses can propel themselves by filling their mantle cavity with water, then rapidly expelling it through their siphon. By changing the force of water expulsion and pointing the siphon in different directions, the animals can control their speed and direction of travel. The siphon organ also allows cephalopods to shoot jets of ink, forming decoy clouds to distract predators.

The researchers came up with two ways to mimic this jetting action, using compressed carbon dioxide or tightly coiled springs to generate the force needed to propel liquid drugs out of the capsule. The gas or spring is kept in a compressed state by a carbohydrate trigger, which is designed to dissolve when exposed to humidity or an acidic environment such as the stomach. When the trigger dissolves, the gas or spring is allowed to expand, propelling a jet of drugs out of the capsule.

In a series of experiments using tissue from the digestive tract, the researchers calculated the pressures needed to expel the drugs with enough force that they would penetrate the submucosal tissue and accumulate there, creating a depot that would then release drugs into the tissue.

“Aside from the elimination of sharps, another potential advantage of high-velocity columnated jets is their robustness to localization issues. In contrast to a small needle, which needs to have intimate contact with the tissue, our experiments indicated that a jet may be able to deliver most of the dose from a distance or at a slight angle,” Arrick says.

The researchers also designed the capsules so that they can target different parts of the digestive tract. One version of the capsule, which has a flat bottom and a high dome, can sit on a surface, such as the lining of the stomach, and eject drug downward into the tissue. This capsule, which was inspired by previous research from Traverso’s lab on self-orienting capsules, is about the size of a blueberry and can carry 80 microliters of drug.

The second version has a tube-like shape that allows it to align itself within a long tubular organ such as the esophagus or small intestine. In that case, the drug is ejected out toward the side wall, rather than downward. This version can deliver 200 microliters of drug.

Made of metal and plastic, the capsules can pass through the digestive tract and are excreted after releasing their drug payload.

Needle-free drug delivery

In tests in animals, the researchers showed that they could use these capsules to deliver insulin, a GLP-1 receptor agonist similar to the diabetes drug Ozempic, and a type of RNA called short interfering RNA (siRNA). This type of RNA can be used to silence genes, making it potentially useful in treating many genetic disorders.

They also showed that the concentration of the drugs in the animals’ bloodstream reached levels on the same order of magnitude as those seen when the drugs were injected with a syringe, and they did not detect any tissue damage.

The researchers envision that the ingestible capsule could be used at home by patients who need to take insulin or other injected drugs frequently. In addition to making it easier to administer drugs, especially for patients who don’t like needles, this approach also eliminates the need to dispose of sharp needles. The researchers also created and tested a version of the device that could be attached to an endoscope, allowing doctors to use it in an endoscopy suite or operating room to deliver drugs to a patient.

“This technology is a significant leap forward in oral drug delivery of macromolecule drugs like insulin and GLP-1 agonists. While many approaches for oral drug delivery have been attempted in the past, they tend to be poorly efficient in achieving high bioavailability. Here, the researchers demonstrate the ability to deliver bioavailability in animal models with high efficiency. This is an exciting approach which could be impactful for many biologics which are currently administered through injections or intravascular infusions,” says Omid Veiseh, a professor of bioengineering at Rice University, who was not involved in the research.

The researchers now plan to further develop the capsules, in hopes of testing them in humans.

The research was funded by Novo Nordisk, the Natural Sciences and Engineering Research Council of Canada, the MIT Department of Mechanical Engineering, Brigham and Women’s Hospital, and the U.S. Advanced Research Projects Agency for Health.

© Credit: Courtesy of the researchers

The researchers designed the capsules so that they can target different parts of the digestive tract. A second version has a tube-like shape that allows it to align itself within a long tubular organ. Another version of the device could be attached to an endoscope.

Arm donates £3.5 million for Cambridge PhD students to study computer architecture and semiconductor design

By: skbf2
November 20th 2024 at 4:35 pm
computer chip

The first three students to be supported by the Arm donation will begin their studies at the new research centre in the autumn of 2025. They will be followed by another three students each year for the following four years.  

Arm – the company building the future of computing with its global headquarters in Cambridge – is the first organisation to donate to the new CASCADE Research Centre, part of the Department of Computer Science and Technology.

“We’re very grateful to them for their generous support,” said Professor Timothy Jones, Director of the Centre. “As well as funding 15 PhD students over the next five years, Arm’s involvement is helping us realise our vision of a centre where research into addressing key challenges in this field is informed and supported by our industrial partners.This is extremely valuable to us as we work to make the Centre a destination for collaboration between companies, generating pre-competitive open-source artefacts and driving development of novel computer architectures.”

Richard Grisenthwaite, executive vice president and chief architect, Arm said: “Our long-standing commitment to the University of Cambridge through this latest CASCADE funding highlights the vital collaboration between academia and industry as we embark on ground-breaking intent-based programming work to realize the future promise of AI through the next generation of processor designs."

“The Centre has the potential to enable further technology innovation within the semiconductor industry and is an important part of Arm’s mission to build the future of computing.” 

Jones added: "Computer architecture is a critical area of computing. It underpins today’s technologies and drives the next generation of computing systems. Here in the Department of Computer Science and Technology, we’re proud of our research and innovation in this area. And the recently published National Semiconductor Strategy underlined how vital such work is, showing that the UK is currently a leader in computer architecture."

"But to maintain this leading position, we need to invest in developing the research leaders of tomorrow. That's why we have established the new CASCADE Research Centre to fund PhD students working in this area, through support from industry. It is currently taking applications for its first cohort of students."

The Centre will focus on research that addresses some of the grand challenges in computer architecture, design automation and semiconductors.  

PhD students will work alongside researchers here who have expertise across the breadth of the area, encompassing the design and optimisation of general-purpose microprocessors, specialised accelerators, on-chip interconnect and memory systems, verification, compilation and networking, quantum architecture and resource estimation. This will allow them to explore the areas they are most passionate about, while addressing industry-relevant research.

Students receiving funding from Arm will be working in the general area of intent-based computing, researching systems that communicate what programs will do in the future so that the processor can make better decisions about how to execute them.

Arm was born in Cambridge in 1990 with the goal of changing the computing landscape. Its success since then in designing, architecting, and licensing high-performance, power-efficient CPUs — the 'brain' of all computers and many household and electronic devices — helped fuel the smartphone revolution and has made it a household name.

Arm has long had a research relationship with Cambridge University. Most notably, this has led to the development of new cybersecurity technology, focusing on innovative ways to design the architecture of a computer’s CPU to make software less vulnerable to security breaches.

Adapted from a news release published by the Department of Computer Science and Technology

Arm is donating £3.5 million to enable 15 PhD students over the next five years to study at CASCADE, the University's new Computer Architecture and Semiconductor Design Centre.

Futuristic circuit board and semiconductor

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  • ✇University of Cambridge
  • ‘Manifest’ is Cambridge Dictionary Word of the YearAnonymous
    ‘Manifest’ was looked up almost 130,000 times on the Cambridge Dictionary website, making it one of the most-viewed words of 2024.   The word jumped from use in the self-help community and on social media to being widely used across mainstream media and beyond, as celebrities such as singer Dua Lipa, Olympic sprinter Gabby Thomas and England striker Ollie Watkins spoke of manifesting their success in 2024.  Mentions of it gained traction during the pandemic and have grown in the years since, e
     

‘Manifest’ is Cambridge Dictionary Word of the Year

By: Anonymous
November 20th 2024 at 12:33 pm
A marathon runner celebrates the moment he crosses the marathon finish line

Manifest’ was looked up almost 130,000 times on the Cambridge Dictionary website, making it one of the most-viewed words of 2024.  

The word jumped from use in the self-help community and on social media to being widely used across mainstream media and beyond, as celebrities such as singer Dua Lipa, Olympic sprinter Gabby Thomas and England striker Ollie Watkins spoke of manifesting their success in 2024. 

Mentions of it gained traction during the pandemic and have grown in the years since, especially on TikTok and other social media, where millions of posts and videos used the hashtag #manifest.

They use ‘to manifest’ in the sense of: ‘to imagine achieving something you want, in the belief that doing so will make it more likely to happen’. Yet, manifesting is an unproven idea that grew out of a 100-year-old spiritual philosophy movement.

Wendalyn Nichols, Publishing Manager of the Cambridge Dictionary, said: “When we choose a Cambridge Dictionary Word of the Year, we have three considerations: What word was looked up the most, or spiked? Which one really captures what was happening in that year? And what is interesting about this word from a language point of view?

“‘Manifest’ won this year because it increased notably in lookups, its use widened greatly across all types of media due to events in 2024, and it shows how the meanings of a word can change over time.”

However experts warn that ‘manifesting’ has no scientific validity, despite its popularity. It can lead to risky behaviour or the promotion of false and dangerous beliefs, such as that diseases can be simply wished away.

“Manifesting is what psychologists call ‘magical thinking’ or the general illusion that specific mental rituals can change the world around us," said Cambridge University social psychologist Dr Sander van der Linden, author of The Psychology of Misinformation.

“Manifesting gained tremendous popularity during the pandemic on TikTok with billions of views, including the popular 3-6-9 method which calls for writing down your wishes three times in the morning, six times in the afternoon and nine times before bed. This procedure promotes obsessive and compulsive behaviour with no discernible benefits. But can we really blame people for trying it, when prominent celebrities have been openly ‘manifesting’ their success?  

‘Manifesting’ wealth, love, and power can lead to unrealistic expectations and disappointment. Think of the dangerous idea that you can cure serious diseases simply by wishing them away," said Van der Linden.

“There is good research on the value of positive thinking, self-affirmation, and goal-setting. Believing in yourself, bringing a positive attitude, setting realistic goals, and putting in the effort pays off because people are enacting change in the real world. However, it is crucial to understand the difference between the power of positive thinking and moving reality with your mind – the former is healthy, whereas the latter is pseudoscience.” 

‘Manyfest’, manifest destiny, and manifestos 

The 600-year history of the word “manifest” shows how the meanings of a word can evolve.

The oldest sense – which Geoffrey Chaucer spelled as “manyfest” in the 14th century – is the adjective meaning ‘easily noticed or obvious’.   

In the mid-1800s, this adjective sense was used in American politics in the context of “manifest destiny”, the belief that American settlers were clearly destined to expand across North America.  

Chaucer also used the oldest sense of the verb “manifest”, ‘to show something clearly, through signs or actions’. Shakespeare used manifest as an adjective in The Merchant of Venice: “For it appears, by manifest proceeding, that...thou hast contrived against the very life of the defendant”.  

The verb is still used frequently in this way: for example, people can manifest their dissatisfaction, or symptoms of an illness can manifest themselves. Lack of confidence in a company can manifest itself through a fall in share price.  

The meaning of making something clear is reflected in the related noun “manifesto”: a ‘written statement of the beliefs, aims, and policies of an organization, especially a political party’ – a word that also resonated in 2024 as scores of nations, including the United Kingdom and India, held elections where parties shared manifestos.  

Other words of 2024 

The Cambridge Dictionary is the world’s most popular dictionary for learners of the English language. Increases and spikes in lookups reflect global events and trends. Beyond “manifest”, other popular terms in 2024 included: 

brat: a child, especially one who behaves badly  

“Brat” went viral in the summer of 2024 thanks to pop artist Charli XCX’s album of the same name about nonconformist women who reject a narrow and highly groomed female identity as portrayed on social media. (We weren’t the only dictionary publisher to notice this.) 

demure: quiet and well behaved 

Influencer Jools Lebron’s satirical use of “demure” in a TikTok post mocking stereotypical femininity drove lookups in the Cambridge Dictionary.  After brat summer, we had a demure fall. 

Goldilocks: used to describe a situation in which something is or has to be exactly right  

Financial reporters characterized India’s strong growth and moderate inflation as a Goldilocks economy in early 2024.  

ecotarian: a person who only eats food produced or prepared in a way that does not harm the environment  

This term rose in overall lookups in 2024, reflecting growing interest in environmentally conscious living.  

New words, future entries?   

All year round, Cambridge Dictionary editors track the English language as it changes. Newly emerging words that are being considered for entry are shared every Monday on the Cambridge Dictionary blog, About Words. 

Words Cambridge began tracking in 2024 include: 

quishing: the scam of phishing via QR code. 

resenteeism: to continue doing your job but resent it. This blend of “resent” and “absenteeism” is appearing in business journalism.  

gymfluencer: a social media influencer whose content is focused on fitness or bodybuilding. 

cocktail party problem (also cocktail party effect): the difficulty of focusing on one voice when there are multiple speakers in the room. This term from audiology is now being used with reference to AI. 

vampire: a vampire device or vampire appliance is one which uses energy even when not in use. This is a new, adjective sense of an existing word.  

Adapted from the Cambridge University Press & Assessment website. 

The controversial global trend of manifesting has driven Cambridge Dictionary’s Word of the Year for 2024.

A marathon runner celebrates the moment he crosses the marathon finish line

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The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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Vice President of Research moving from ETH Zurich to Singapore

November 20th 2024 at 11:30 am
Vice President of Research Christian Wolfrum is leaving ETH as of 1 July 2025 to take up a new academic challenge: he is to become Deputy President and Provost responsible for all academic matters at Nanyang Technological University, Singapore (NTU Singapore).
  • ✇University of Cambridge
  • Northerners, Scots and Irish excel at detecting fake accents to guard against outsiders, study suggeststa385
    People from Belfast proved most able to detect someone faking their accent, while people from London, Essex and Bristol were least accurate. The study, published today in Evolutionary Human Sciences found that the ability of participants from Scotland, the north-east of England, Ireland and Northern Ireland to tell whether short recordings of their native accent were real or fake ranged from approximately 65% – 85%. By contrast, for Essex, London and Bristol, success ranged from just over 50%,
     

Northerners, Scots and Irish excel at detecting fake accents to guard against outsiders, study suggests

By: ta385
November 20th 2024 at 10:30 am
Crowds on Newcastle Quayside for the Great North Run in 2013. Photo: Glen Bowman, cc license via Flikr

People from Belfast proved most able to detect someone faking their accent, while people from London, Essex and Bristol were least accurate.

The study, published today in Evolutionary Human Sciences found that the ability of participants from Scotland, the north-east of England, Ireland and Northern Ireland to tell whether short recordings of their native accent were real or fake ranged from approximately 65% – 85%. By contrast, for Essex, London and Bristol, success ranged from just over 50%, barely better than chance, to 65% –75%.

In the biggest study of its kind, drawing on 12,000 responses, the researchers found that participants across all groups were better than chance at detecting fake accents, succeeding just over 60% of the time. Unsurprisingly, participants who spoke naturally in the test accent tended to detect more accurately than non-native listener groups – some of which performed worse than chance – but success varied between regions.

“We found a pretty pronounced difference in accent cheater detection between these areas,” said corresponding author Dr Jonathan R Goodman, from Cambridge’s Department of Archaeology, and Cambridge Public Health.

“We think that the ability to detect fake accents is linked to an area’s cultural homogeneity, the degree to which its people hold similar cultural values.”

The researchers argue that the accents of speakers from Belfast, Glasgow, Dublin, and north-east England have culturally evolved over the past several centuries, during which there have been multiple cases of between-group cultural tension, particularly involving the cultural group making up southeast England, above all London.

This, they suggest, probably caused individuals from areas in Ireland and the northern regions of the United Kingdom to place emphasis on their accents as signals of social identity.

The study argues that greater social cohesion in Belfast, Dublin, Glasgow and the north-east may have resulted in a more prominent fear of cultural dilution by outsiders, which would have encouraged the development of improved accent recognition and mimicry detection.

People from London and Essex proved least able to spot fake accents because, the study suggests, these areas have less strong ‘cultural group boundaries’ and people are more used to hearing different kinds of accents, which could make them less attuned to accent fakery.

The study points out that many speakers of the Essex accent only moved to the area over the past 25 years from London, whereas the accents of people living in Belfast, Glasgow and Dublin have ‘evolved over centuries of cultural tension and violence.’

Some might have expected Bristolians to authenticate recordings of their accent more accurately, but Goodman points out that “cultural heterogeneity has been increasing significantly in the city”. The researchers would also like to obtain more data for Bristol.

An evolved ability

Previous research has shown that when people want to demarcate themselves for cultural reasons, their accents become stronger. In human evolution, the ability to recognise and thwart ‘free riders’ is also thought to have been pivotal in the development of large-scale societies.

Dr Goodman said: “Cultural, political, or even violent conflict are likely to encourage people to strengthen their accents as they try to maintain social cohesion through cultural homogeneity. Even relatively mild tension, for example the intrusion of tourists in the summer, could have this effect.

“I'm interested in the role played by trust in society and how trust forms. One of the first judgments a person will make about another person, and when deciding whether to trust them, is how they speak. How humans learn to trust another person who may be an interloper has been incredibly important over our evolutionary history and it remains critical today.”

Overall, the study found that participants were better than chance at detecting fake accents but is it surprising that so many people failed 40–50% of the time?

The authors point out that participants were only given 2-3 second clips so the fact that some authenticated with 70–85% accuracy is very impressive. If participants had heard a longer clip or been able to interact with someone face-to-face, the researchers would expect success rates to rise but continue to vary by region.

How the tests worked

The researchers constructed a series of sentences designed to elicit phonetic variables distinguishing between 7 accents of interest: north-east England, Belfast, Dublin, Bristol, Glasgow, Essex, and Received Pronunciation (RP), commonly understood as standard British English. The researchers chose these accents to ensure a high number of contrasting phonemes between sentences.

Test sentences included: ‘Hold up those two cooked tea bags’; ‘She kicked the goose hard with her foot’; ‘He thought a bath would make him happy’; ‘Jenny told him to face up to his weight’; and ‘Kit strutted across the room’.

The team initially recruited around 50 participants who spoke in these accents and asked them to record themselves reading the sentences in their natural accent. The same participants were then asked to mimic sentences in the other six accents in which they did not naturally speak, chosen randomly. Females mimicked females, males mimicked males. The researchers selected recordings which they judged came closest to the accents in question based on the reproduction of key phonetic variables.

Finally, the same participants were asked to listen to recordings made by other participants of their own accents, of both genders. Therefore, Belfast accent speakers heard and judged recordings made by native Belfast speakers as well as recordings of fake Belfast accents made by non-native speakers.

Participants were then asked to determine whether the recordings were authentic. All participants were asked to determine whether the speaker was an accent-mimic for each of 12 recordings (six mimics and six genuine speakers, presented in random order). The researchers obtained 618 responses.

In a second phase, the researchers recruited over 900 participants from the United Kingdom and Ireland, regardless of which accent they spoke naturally. This created a control group for comparison and increased the native speaker sample sizes. In the second phase, the researchers collected 11,672 responses.

“The UK is a really interesting place to study,” Dr Goodman said. “The linguistic diversity and cultural history is so rich and you have so many cultural groups that have been roughly in the same location for a really long time. Very specific differences in language, dialect and accents have emerged over time, and that's a fascinating side of language evolution.”

Reference

JR Goodman et al., ‘Evidence that cultural groups differ in their abilities to detect fake accents’, Evolutionary Human Sciences (2024). DOI: 10.1017/ehs.2024.36

People from Glasgow, Belfast, Dublin and the north-east of England are better at detecting someone imitating their accent than people from London and Essex, new research has found.

Cultural, political, or even violent conflict are likely to encourage people to strengthen their accents as they try to maintain social cohesion
Jonathan Goodman
Crowds on Newcastle Quayside for the Great North Run in 2013

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Batik and bonding: Building a warm and inclusive community at Pioneer House through Design-Your-Own-Course

November 20th 2024 at 10:13 am

In developing a familial and inclusive residential community, inclusiveness has been a key theme at Pioneer House (PH) since its inception in 2017 as a new housing model at NUS centred on proactive pastoral care and mentoring. As such, PH adopts various academic approaches to nurture togetherness and warmth amongst its residents – students who hail from different academic years, as well as cultural and ethnic backgrounds.

Since August 2024 (Semester 1, Academic Year 2024/2025), a pioneering group of ten students has taken this theme of fostering inclusiveness a step further by ‘formalising’ their initiatives to engage the international student community at PH. They embarked on a ‘Design-Your-Own-Course’ (DYOC) – an academic scheme at NUS which allows students the opportunities to pursue self-directed learning beyond their disciplines, through avenues such as engaging relevant subject matter experts at the University. While PH has consistently organised programmes and initiatives to engage its international student community, this step marks the first time it has been carried out through a DYOC framework.

Melding academia and application

The idea for a DYOC was mooted by team leader Nikol Goh (Year 2, Psychology), who wanted to do something meaningful in community building. Fueled by the determination to see the idea come to fruition, the initial team of four she pulled together managed to complete a quick recruitment via spreading the word and social media channels, eventually growing to a group of 10. They creatively named themselves PHamigo, tagging PH’s acronym to the word amigo which means ‘friend’ in Spanish.

Together with their mentors, PH Resident Fellows Dr Andi Sudjana Putra, Senior Lecturer at the College of Design and Engineering, and Associate Professor Wilson Tam, Deputy Head (Research) at NUS Nursing, the students formulated the intended learning outcomes through application of Bloom’s Taxonomy, an educational framework which categorises learning outcomes into seven ascending levels of thinking. Of the four intended learning outcomes from DYOC, evaluation of the community development journey required the PHamigo team to apply the sixth of seven levels of higher order learning, stretching the students' thinking.

“I was so proud that the students took charge of their own learning through DYOC. For example, the students themselves proposed the use of Asset Based Community Development (ABCD) in framing their project,” said Dr Andi, referring to the strategy for community development that focuses on identifying and using a community's existing assets to improve the community.

“Many times, the student discussions during the sessions were so rigorous that I did not have to intervene much! It was very heartwarming to witness students being fully immersed in their learning,” Dr Andi enthused.

In terms of activity planning, which was one of the deliverables of DYOC, the students planned for events, tours and hands-on experiences for local and international students alike to explore cultures, cuisines, and landmarks​ of Singapore. During the student-organised tours affectionately called OpenJio, drawing from the colloquial term for an all-inclusive invitation to an activity, the PHamigo team led students on fortnightly visits to events such as the Singapore Light Festival and the Formula 1 Singapore night race, as well as to prominent local landmarks such as Parliament House, the Istana, and the Merlion.

International students also had the chance to experience Singapore’s local childhood games, such as the time-honoured pastime of flipping country erasers. And not to be omitted in a country with an identity rooted in culinary appreciation, students also introduced cuisines from their respective cultures to each other, which they would not have had the chance to try if not for the PHamigo programme.

These activities spanning across the semester were especially valuable in helping international students, most of whom may not have been in Singapore during the orientation season before the start of the academic year, stay plugged into the community.

Elevating community development

To cap off a fulfilling semester of hard work, the PHamigo team also organised a large Batik painting activity on 17 and 19 October 2024. In addition to 40 students, the event also saw the participation of seven members of PH’s housekeeping staff. It was a way for the students to express their gratitude to the staff, who have worked quietly behind the scenes to maintain the cleanliness at PH. It was a serendipitous culmination of many different initiatives which melded together seamlessly – from PHamigo’s framework to elevate community development in their penultimate activity for the semester, to a group of international students who were introduced to batik, to other students who wanted to bring the housekeeping team at PH on an outing.

“We wanted to emphasise the idea that ‘community’ in PH is not only students, but also staff, including the housekeeping team, whom we are grateful for. We wanted to appreciate them as part of PH for all the work that they have done,” Nikol reflected.

“The students originally wanted to bring the housekeeping team on an outing. However, after speaking with them, we realised the challenges in doing so due to their working hours and commitments. Some also had mobility issues, making moving around difficult for them. It was then we learnt that what we think they need, may not be what they actually need,” Nikol added, sharing that this led the team to decide to hold the activity in PH instead.

In additional to its cultural relevance and roots in Southeast Asia, the application of batik creation also tapped on the concept of ABCD that framed the DYOC, such as a group of students keen to introduce it to the community, and the knowledge drawn from previous cluster activities that many fellow students at PH have artistic talents in drawing. The batik workshop was received positively by local and international students, some who found it therapeutic and stress-relieving.

Reflecting on the experience with PHamigo, Nguyen Ky Minh, a first-year international student from Vietnam. “I found PHamigo a very useful and fascinating exercise in cultural exploration. I especially enjoyed the OpenJio walks around Singapore, which helped us learn more about facets of the Singaporean cultural mosaic that we probably would have never encountered on our own. I certainly second the continuation of this initiative, which will undoubtedly complement PH residents’ time in Singapore.”

“I think many students possess theoretical knowledge of community development. However, from its application in PH through DYOC, it was fulfilling to witness how the activities based on the concept were so enthusiastically accepted by the community, and it left me impressed by how many lives the activities have touched,” said Nikol.

Registrations for the next PHamigo DYOC, which will take place next semester, have opened, and the community eagerly looks forward to more activities in their experience of living, learning, and growing together.

By Pioneer House

  • ✇MIT News
  • TBIRD technology could help image black holes’ photon ringsAriana Tantillo | Haley Wahl | MIT Lincoln Laboratory
    In April 2019, a group of astronomers from around the globe stunned the world when they revealed the first image of a black hole — the monstrous accumulation of collapsed stars and gas that lets nothing escape, not even light. The image, which was of the black hole that sits at the core of a galaxy called Messier 87 (M87), revealed glowing gas around the center of the black hole. In March 2021, the same team produced yet another stunning image that showed the polarization of light around the bla
     

TBIRD technology could help image black holes’ photon rings

In April 2019, a group of astronomers from around the globe stunned the world when they revealed the first image of a black hole — the monstrous accumulation of collapsed stars and gas that lets nothing escape, not even light. The image, which was of the black hole that sits at the core of a galaxy called Messier 87 (M87), revealed glowing gas around the center of the black hole. In March 2021, the same team produced yet another stunning image that showed the polarization of light around the black hole, revealing its magnetic field.

The "camera" that took both images is the Event Horizon Telescope (EHT), which is not one singular instrument but rather a collection of radio telescopes situated around the globe that work together to create high-resolution images by combining data from each individual telescope. Now, scientists are looking to extend the EHT into space to get an even sharper look at M87's black hole. But producing the sharpest images in the history of astronomy presents a challenge: transmitting the telescope's massive dataset back to Earth for processing. A small but powerful laser communications (lasercom) payload developed at MIT Lincoln Laboratory operates at the high data rates needed to image the aspects of interest of the black hole.   

Extending baseline distances into space

The EHT created the two existing images of M87's black hole via interferometry — specifically, very long-baseline interferometry. Interferometry works by collecting light in the form of radio waves simultaneously with multiple telescopes in separate places on the globe and then comparing the phase difference of the radio waves at the various locations in order to pinpoint the direction of the source. By taking measurements with different combinations of the telescopes around the planet, the EHT collaboration — which included staff members at the Harvard-Smithsonian Center for Astrophysics (CfA) and MIT Haystack Observatory — essentially created an Earth-sized telescope in order to image the incredibly faint black hole 55 million light-years away from Earth.

With interferometry, the bigger the telescope, the better the resolution of the image. Therefore, in order to focus in on even finer characteristics of these black holes, a bigger instrument is needed. Details that astronomers hope to resolve include the turbulence of the gas falling into a black hole (which drives the accumulation of matter onto the black hole through a process called accretion) and a black hole's shadow (which could be used to help pin down where the jet coming from M87 is drawing its energy from). The ultimate goal is to observe a photon ring (the place where light orbits closest before escaping) around the black hole. Capturing an image of the photon ring would enable scientists to put Albert Einstein's general theory of relativity to the test.

With Earth-based telescopes, the farthest that two telescopes could be from one another is on opposite sides of the Earth, or about 13,000 kilometers apart. In addition to this maximum baseline distance, Earth-based instruments are limited by the atmosphere, which makes observing shorter wavelengths difficult. Earth's atmospheric limitations can be overcome by extending the EHT's baselines and putting at least one of the telescopes in space, which is exactly what the proposed CfA-led Black Hole Explorer (BHEX) mission aims to do.

One of the most significant challenges that comes with this space-based concept is transfer of information. The dataset to produce the first EHT image was so massive (totaling 4 petabytes) that the data had to be put on disks and shipped to a facility for processing. Gathering information from a telescope in orbit would be even more difficult; the team would need a system that can downlink data from the space telescope to Earth at approximately 100 gigabits per second (Gbps) in order to image the desired aspects of the black hole.

Enter TBIRD

Here is where Lincoln Laboratory comes in. In May 2023, the laboratory's TeraByte InfraRed Delivery (TBIRD) lasercom payload achieved the fastest data transfer from space, transmitting at a rate of 200 Gbps — which is 1,000 times faster than typical satellite communication systems — from low Earth orbit (LEO).

"We developed a novel technology for high-volume data transport from space to ground," says Jade Wang, assistant leader of the laboratory's Optical and Quantum Communications Group. "In the process of developing that technology, we looked for collaborations and other potential follow-on missions that could leverage this unprecedented data capability. The BHEX is one such mission. These high data rates will enable scientists to image the photon ring structure of a black hole for the first time."

A lasercom team led by Wang, in partnership with the CfA, is developing the long-distance, high-rate downlink needed for the BHEX mission in middle Earth orbit (MEO).

"Laser communications is completely upending our expectations for what astrophysical discoveries are possible from space," says CfA astrophysicist Michael Johnson, principal investigator for the BHEX mission. "In the next decade, this incredible new technology will bring us to the edge of a black hole, creating a window into the region where our current understanding of physics breaks down."

Though TBIRD is incredibly powerful, the technology needs some modifications to support the higher orbit that BHEX requires for its science mission. The small TBIRD payload (CubeSat) will be upgraded to a larger aperture size and higher transmit power. In addition, the TBIRD automatic request protocol — the error-control mechanism for ensuring data make it to Earth without loss due to atmospheric effects — will be adjusted to account for the longer round-trip times that come with a mission in MEO. Finally, the TBIRD LEO "buffer and burst" architecture for data delivery will shift to a streaming approach.

"With TBIRD and other lasercom missions, we have demonstrated that the lasercom technology for such an impactful science mission is available today," Wang says. "Having the opportunity to contribute to an area of really interesting scientific discovery is an exciting prospect."

The BHEX mission concept has been in development since 2019. Technical and concept studies for BHEX have been supported by the Smithsonian Astrophysical Observatory, the Internal Research and Development program at NASA Goddard Space Flight Center, the University of Arizona, and the ULVAC-Hayashi Seed Fund from the MIT-Japan Program at MIT International Science and Technology Initiatives. BHEX studies of lasercom have been supported by Fred Ehrsam and the Gordon and Betty Moore Foundation. 

© Photos: Event Horizon Telescope; Simulation courtesy of Science Advances, vol. 6, no. 12

Astronomers imaged the black hole at the center of galaxy M87 in 2019 (left) and its magnetic field in 2021 (center). A major goal is to image its photon ring (simulated at right).
  • ✇MIT News
  • Making a mark in the nation’s capitalLeda Zimmerman | MIT Political Science
    Anoushka Bose ’20 spent the summer of 2018 as an MIT Washington program intern, applying her nuclear physics education to arms control research with a D.C. nuclear policy think tank.“It’s crazy how much three months can transform people,” says Bose, now an attorney at the Department of Justice.“Suddenly, I was learning far more than I had expected about treaties, nuclear arms control, and foreign relations,” adds Bose. “But once I was hooked, I couldn’t be stopped as that summer sparked a much b
     

Making a mark in the nation’s capital

November 20th 2024 at 12:25 am

Anoushka Bose ’20 spent the summer of 2018 as an MIT Washington program intern, applying her nuclear physics education to arms control research with a D.C. nuclear policy think tank.

“It’s crazy how much three months can transform people,” says Bose, now an attorney at the Department of Justice.

“Suddenly, I was learning far more than I had expected about treaties, nuclear arms control, and foreign relations,” adds Bose. “But once I was hooked, I couldn’t be stopped as that summer sparked a much broader interest in diplomacy and set me on a different path.”

Bose is one of hundreds of MIT undergraduates whose academic and career trajectories were influenced by their time in the nation’s capital as part of the internship program.

Leah Nichols ’00 is a former D.C. intern, and now executive director of George Mason University’s Institute for a Sustainable Earth. In 1998, Nichols worked in the office of U.S. Senator Max Baucus, D-Mont., developing options for protecting open space on private land.

“I really started to see how science and policy needed to interact in order to solve environmental challenges,” she says. “I’ve actually been working at that interface between science and policy ever since.”

Marking its 30th anniversary this year, the MIT Washington Summer Internship Program has shaped the lives of alumni, and expanded MIT’s capital in the capital city.

Bose believes the MIT Washington summer internship is more vital than ever.

“This program helps steer more technical expertise, analytical thinking, and classic MIT innovation into policy spaces to make them better-informed and better equipped to solve challenges,” she says. With so much at stake, she suggests, it is increasingly important “to invest in bringing the MIT mindset of extreme competence as well as resilience to D.C.”

MIT missionaries

Over the past three decades, students across MIT — whether studying aeronautics or nuclear engineering, management or mathematics, chemistry or computer science — have competed for and won an MIT Washington summer internship. Many describe it as a springboard into high-impact positions in politics, public policy, and the private sector.

The program was launched in 1994 by Charles Stewart III, the Kenan Sahin (1963) Distinguished Professor of Political Science, who still serves as the director.

“The idea 30 years ago was to make this a bit of a missionary program, where we demonstrate to Washington the utility of having MIT students around for things they’re doing,” says Stewart. “MIT’s reputation benefits because our students are unpretentious, down-to-earth, interested in how the world actually works, and dedicated to fixing things that are broken.”

The outlines of the program have remained much the same: A cohort of 15 to 20 students is selected from a pool of fall applicants. With the help of MIT’s Washington office, the students are matched with potential supervisors in search of technical and scientific talent. They travel in the spring to meet potential supervisors and receive a stipend and housing for the summer. In the fall, students take a course that Stewart describes as an “Oxbridge-type tutorial, where they contextualize their experiences and reflect on the political context of the place where they worked.”

Stewart remains as enthusiastic about the internship program as when he started and has notions for building on its foundations. His wish list includes running the program at other times of the year, and for longer durations. “Six months would really change and deepen the experience,” he says. He envisions a real-time tutorial while the students are in Washington. And he would like to draw more students from the data science world. “Part of the goal of this program is to hook non-obvious people into knowledge of the public policy realm,” he says.

Prized in Washington

MIT Vice Provost Philip Khoury, who helped get the program off the ground, praised Stewart’s vision for developing the initial idea.

“Charles understood why science- and technology-oriented students would be great beneficiaries of an experience in Washington and had something to contribute that other internship program students would not be able to do because of their prowess, their prodigious abilities in the technology-engineering-science world,” says Khoury.

Khoury adds that the program has benefited both the host organizations and the students.

“Members of Congress and senior staff who were developing policies prized MIT students, because they were powerful thinkers and workaholics, and students in the program learned that they really mattered to adults in Washington, wherever they went.”

David Goldston, director of the MIT Washington Office, says government is “kind of desperate for people who understand science and technology.” One example: The National Institute of Standards and Technology has launched an artificial intelligence safety division that is “almost begging for students to help conduct research and carry out the ever-expanding mission of worrying about AI issues,” he says.

Holly Krambeck ’06 MST/MCP, program manager of the World Bank Data Lab, can attest to this impact. She hired her first MIT summer intern, Chae Won Lee, in 2013, to analyze road crash data from the Philippines. “Her findings were so striking, we invited her to join the team on a mission to present her work to the government,” says Krambeck.

Subsequent interns have helped the World Bank demonstrate effective, low-cost, transit-fare collection systems; identify houses eligible for hurricane protection retrofits under World Bank loans; and analyze heatwave patterns in the Philippines to inform a lending program for mitigation measures.

“Every year, I’ve been so impressed by the maturity, energy, willingness to learn new skills, and curiosity of the MIT students,” says Krambeck. “At the end of each summer, we ask students to present their projects to World Bank staff, who are invariably amazed to learn that these are undergraduates and not PhD candidates!”

Career springboard

“It absolutely changed my career pathway,” says Samuel Rodarte Jr. ’13, a 2011 program alumnus who interned at the MIT Washington Office, where he tracked congressional hearings related to research at the Institute. Today, he serves as a legislative assistant to Senate Majority Leader Charles E. Schumer. An aerospace engineering and Latin American studies double major, Rodarte says the opportunity to experience policymaking from the inside came “at just the right time, when I was trying to figure out what I really wanted to do post-MIT.”

Miranda Priebe ’03 is director of the Center for Analysis of U.S. Grand Strategy for the Rand Corp. She briefs groups within the Pentagon, the U.S. Department of State, and the National Security Council, among others. “My job is to ask the big question: Does the United States have the right approach in the world in terms of advancing our interests with our capabilities and resources?”

Priebe was a physics major with an evolving interest in political science when she arrived in Washington in 2001 to work in the office of Senator Carl Levin, D-Mich., the chair of the Senate Armed Services Committee. “I was working really hard at MIT, but just hadn’t found my passion until I did this internship,” she says. “Once I came to D.C. I saw all the places I could fit in using my analytical skills — there were a million things I wanted to do — and the internship convinced me that this was the right kind of work for me.”

During her internship in 2022, Anushree Chaudhuri ’24, urban studies and planning and economics major, worked in the U.S. Department of Energy’s Building Technologies Office, where she hoped to experience day-to-day life in a federal agency — with an eye toward a career in high-level policymaking. She developed a web app to help local governments determine which census tracts qualified for environmental justice funds.

“I was pleasantly surprised to see that even as a lower-level civil servant you can make change if you know how to work within the system.” Chaudhuri is now a Marshall Scholar, pursuing a PhD at the University of Oxford on the socioeconomic impacts of energy infrastructure. “I’m pretty sure I want to work in the policy space long term,” she says.

© Photo: Katherine Hoss

Interns from 2022 walk among the cherry blossoms during their Spring Break trip to Washington.
  • ✇MIT News
  • A model of virtuosityNicole Estvanik Taylor | Arts at MIT
    A crowd gathered at the MIT Media Lab in September for a concert by musician Jordan Rudess and two collaborators. One of them, violinist and vocalist Camilla Bäckman, has performed with Rudess before. The other — an artificial intelligence model informally dubbed the jam_bot, which Rudess developed with an MIT team over the preceding several months — was making its public debut as a work in progress.Throughout the show, Rudess and Bäckman exchanged the signals and smiles of experienced musicians
     

A model of virtuosity

November 20th 2024 at 12:00 am

A crowd gathered at the MIT Media Lab in September for a concert by musician Jordan Rudess and two collaborators. One of them, violinist and vocalist Camilla Bäckman, has performed with Rudess before. The other — an artificial intelligence model informally dubbed the jam_bot, which Rudess developed with an MIT team over the preceding several months — was making its public debut as a work in progress.

Throughout the show, Rudess and Bäckman exchanged the signals and smiles of experienced musicians finding a groove together. Rudess’ interactions with the jam_bot suggested a different and unfamiliar kind of exchange. During one duet inspired by Bach, Rudess alternated between playing a few measures and allowing the AI to continue the music in a similar baroque style. Each time the model took its turn, a range of expressions moved across Rudess’ face: bemusement, concentration, curiosity. At the end of the piece, Rudess admitted to the audience, “That is a combination of a whole lot of fun and really, really challenging.”

Rudess is an acclaimed keyboardist — the best of all time, according to one Music Radar magazine poll — known for his work with the platinum-selling, Grammy-winning progressive metal band Dream Theater, which embarks this fall on a 40th anniversary tour. He is also a solo artist whose latest album, “Permission to Fly,” was released on Sept. 6; an educator who shares his skills through detailed online tutorials; and the founder of software company Wizdom Music. His work combines a rigorous classical foundation (he began his piano studies at The Juilliard School at age 9) with a genius for improvisation and an appetite for experimentation.

Last spring, Rudess became a visiting artist with the MIT Center for Art, Science and Technology (CAST), collaborating with the MIT Media Lab’s Responsive Environments research group on the creation of new AI-powered music technology. Rudess’ main collaborators in the enterprise are Media Lab graduate students Lancelot Blanchard, who researches musical applications of generative AI (informed by his own studies in classical piano), and Perry Naseck, an artist and engineer specializing in interactive, kinetic, light- and time-based media. Overseeing the project is Professor Joseph Paradiso, head of the Responsive Environments group and a longtime Rudess fan. Paradiso arrived at the Media Lab in 1994 with a CV in physics and engineering and a sideline designing and building synthesizers to explore his avant-garde musical tastes. His group has a tradition of investigating musical frontiers through novel user interfaces, sensor networks, and unconventional datasets.

The researchers set out to develop a machine learning model channeling Rudess’ distinctive musical style and technique. In a paper published online by MIT Press in September, co-authored with MIT music technology professor Eran Egozy, they articulate their vision for what they call “symbiotic virtuosity:” for human and computer to duet in real-time, learning from each duet they perform together, and making performance-worthy new music in front of a live audience.

Rudess contributed the data on which Blanchard trained the AI model. Rudess also provided continuous testing and feedback, while Naseck experimented with ways of visualizing the technology for the audience.

“Audiences are used to seeing lighting, graphics, and scenic elements at many concerts, so we needed a platform to allow the AI to build its own relationship with the audience,” Naseck says. In early demos, this took the form of a sculptural installation with illumination that shifted each time the AI changed chords. During the concert on Sept. 21, a grid of petal-shaped panels mounted behind Rudess came to life through choreography based on the activity and future generation of the AI model.

“If you see jazz musicians make eye contact and nod at each other, that gives anticipation to the audience of what’s going to happen,” says Naseck. “The AI is effectively generating sheet music and then playing it. How do we show what’s coming next and communicate that?”

Naseck designed and programmed the structure from scratch at the Media Lab with assistance from Brian Mayton (mechanical design) and Carlo Mandolini (fabrication), drawing some of its movements from an experimental machine learning model developed by visiting student Madhav Lavakare that maps music to points moving in space. With the ability to spin and tilt its petals at speeds ranging from subtle to dramatic, the kinetic sculpture distinguished the AI’s contributions during the concert from those of the human performers, while conveying the emotion and energy of its output: swaying gently when Rudess took the lead, for example, or furling and unfurling like a blossom as the AI model generated stately chords for an improvised adagio. The latter was one of Naseck’s favorite moments of the show.

“At the end, Jordan and Camilla left the stage and allowed the AI to fully explore its own direction,” he recalls. “The sculpture made this moment very powerful — it allowed the stage to remain animated and intensified the grandiose nature of the chords the AI played. The audience was clearly captivated by this part, sitting at the edges of their seats.”

“The goal is to create a musical visual experience,” says Rudess, “to show what’s possible and to up the game.”

Musical futures

As the starting point for his model, Blanchard used a music transformer, an open-source neural network architecture developed by MIT Assistant Professor Anna Huang SM ’08, who joined the MIT faculty in September.

“Music transformers work in a similar way as large language models,” Blanchard explains. “The same way that ChatGPT would generate the most probable next word, the model we have would predict the most probable next notes.”

Blanchard fine-tuned the model using Rudess’ own playing of elements from bass lines to chords to melodies, variations of which Rudess recorded in his New York studio. Along the way, Blanchard ensured the AI would be nimble enough to respond in real-time to Rudess’ improvisations.

“We reframed the project,” says Blanchard, “in terms of musical futures that were hypothesized by the model and that were only being realized at the moment based on what Jordan was deciding.”

As Rudess puts it: “How can the AI respond — how can I have a dialogue with it? That’s the cutting-edge part of what we’re doing.”

Another priority emerged: “In the field of generative AI and music, you hear about startups like Suno or Udio that are able to generate music based on text prompts. Those are very interesting, but they lack controllability,” says Blanchard. “It was important for Jordan to be able to anticipate what was going to happen. If he could see the AI was going to make a decision he didn’t want, he could restart the generation or have a kill switch so that he can take control again.”

In addition to giving Rudess a screen previewing the musical decisions of the model, Blanchard built in different modalities the musician could activate as he plays — prompting the AI to generate chords or lead melodies, for example, or initiating a call-and-response pattern.

“Jordan is the mastermind of everything that’s happening,” he says.

What would Jordan do

Though the residency has wrapped up, the collaborators see many paths for continuing the research. For example, Naseck would like to experiment with more ways Rudess could interact directly with his installation, through features like capacitive sensing. “We hope in the future we’ll be able to work with more of his subtle motions and posture,” Naseck says.

While the MIT collaboration focused on how Rudess can use the tool to augment his own performances, it’s easy to imagine other applications. Paradiso recalls an early encounter with the tech: “I played a chord sequence, and Jordan’s model was generating the leads. It was like having a musical ‘bee’ of Jordan Rudess buzzing around the melodic foundation I was laying down, doing something like Jordan would do, but subject to the simple progression I was playing,” he recalls, his face echoing the delight he felt at the time. “You're going to see AI plugins for your favorite musician that you can bring into your own compositions, with some knobs that let you control the particulars,” he posits. “It’s that kind of world we’re opening up with this.”

Rudess is also keen to explore educational uses. Because the samples he recorded to train the model were similar to ear-training exercises he’s used with students, he thinks the model itself could someday be used for teaching. “This work has legs beyond just entertainment value,” he says.

The foray into artificial intelligence is a natural progression for Rudess’ interest in music technology. “This is the next step,” he believes. When he discusses the work with fellow musicians, however, his enthusiasm for AI often meets with resistance. “I can have sympathy or compassion for a musician who feels threatened, I totally get that,” he allows. “But my mission is to be one of the people who moves this technology toward positive things.”

“At the Media Lab, it’s so important to think about how AI and humans come together for the benefit of all,” says Paradiso. “How is AI going to lift us all up? Ideally it will do what so many technologies have done — bring us into another vista where we’re more enabled.”

“Jordan is ahead of the pack,” Paradiso adds. “Once it’s established with him, people will follow.”

Jamming with MIT

The Media Lab first landed on Rudess’ radar before his residency because he wanted to try out the Knitted Keyboard created by another member of Responsive Environments, textile researcher Irmandy Wickasono PhD ’24. From that moment on, “It's been a discovery for me, learning about the cool things that are going on at MIT in the music world,” Rudess says.

During two visits to Cambridge last spring (assisted by his wife, theater and music producer Danielle Rudess), Rudess reviewed final projects in Paradiso’s course on electronic music controllers, the syllabus for which included videos of his own past performances. He brought a new gesture-driven synthesizer called Osmose to a class on interactive music systems taught by Egozy, whose credits include the co-creation of the video game “Guitar Hero.” Rudess also provided tips on improvisation to a composition class; played GeoShred, a touchscreen musical instrument he co-created with Stanford University researchers, with student musicians in the MIT Laptop Ensemble and Arts Scholars program; and experienced immersive audio in the MIT Spatial Sound Lab. During his most recent trip to campus in September, he taught a masterclass for pianists in MIT’s Emerson/Harris Program, which provides a total of 67 scholars and fellows with support for conservatory-level musical instruction.

“I get a kind of rush whenever I come to the university,” Rudess says. “I feel the sense that, wow, all of my musical ideas and inspiration and interests have come together in this really cool way.”

© Photo: Caroline Alden

CAST Visiting Artist Jordan Rudess performs at "Jordan and the jam_bot: a work-in-progress performance" in September.
  • ✇Harvard Gazette
  • Kempner AI cluster named one of world’s fastest ‘green’ supercomputersTerry Murphy
    Science & Tech Kempner AI cluster named one of world’s fastest ‘green’ supercomputers The Kempner Institute AI cluster’s graphics processing units are networked together to allow for incredibly fast parallel processing. Credit: Harvard University Yohan J. John Harvard Correspondent November 19, 2024 long read Computational power can be used to train and run artificial neural networks, creates
     

Kempner AI cluster named one of world’s fastest ‘green’ supercomputers

November 19th 2024 at 11:55 pm
Science & Tech

Kempner AI cluster named one of world’s fastest ‘green’ supercomputers

The Kempner AI cluster’s graphics processing units are networked together to allow for incredibly fast parallel processing.

The Kempner Institute AI cluster’s graphics processing units are networked together to allow for incredibly fast parallel processing.

Credit: Harvard University

Yohan J. John

Harvard Correspondent

long read

Computational power can be used to train and run artificial neural networks, creates key advances in understanding basis of intelligence in natural and artificial systems

Researchers at Harvard now have access to one of the fastest and greenest supercomputers in the world.

Built to support cutting-edge research at the Kempner Institute for the Study of Natural and Artificial Intelligence, and Harvard University more broadly, the Kempner’s AI cluster has just been named the 32nd fastest “green” supercomputer in the world in the Green500, the industry’s premier, independent ranking of the most energy-efficient supercomputers globally. In addition to cracking the top 50 list of green supercomputers, the cluster has been certified as the 85th fastest supercomputer overall in the TOP500, making it one of the fastest and greenest supercomputers on the planet. 

“The Kempner AI cluster’s ranking in the latest Green500 and TOP500 lists positions us squarely among the fastest and most eco-friendly AI clusters in academia and the world,” said Max Shad, Kempner senior director of AI/ML research engineering. “It is no small feat to have built this kind of green high-performance computing power in such a short period of time, enabling cutting-edge research that is innovating in real time, and allowing for truly important advancements at the intersection of artificial intelligence and neuroscience.”

High-performance computing forms the backbone of the massive growth in the field of machine learning, and researchers at the Kempner Institute are leveraging this immense computational power to train and run artificial neural networks, leading to key advances in understanding the basis of intelligence in natural and artificial systems.

The Kempner AI cluster is housed at the Massachusetts Green High Performance Computer Center (MGHPCC) in Holyoke, MA,

The Kempner Institute AI cluster is housed at the Massachusetts Green High Performance Computer Center in Holyoke, Massachusetts, and uses a variety of state-of-the-art techniques to minimize energy usage.

Credit: Harvard University

Measuring green compute power, from flops to gigaflops

The Kempner’s AI cluster opened with an initial pilot installation in spring 2023, and now represents the forefront of Harvard’s growing engagement with state-of-the-art computing resources. Composed of 528 specialized computer processors called graphics processing units (GPUs), which are networked together in parallel with “switches” to enable fast and simultaneous computation, the cluster can run rapid computations on hundreds of research projects at once. 

To gauge the cluster’s green computing power and overall computing power, engineers from Lenovo measured the speed of the cluster’s highest-performing GPUs (called H100s) using the LINPACK Benchmark, which requires solving vast linear algebra problems. This is expressed in terms of floating point operations per second, or “flops.” The system’s efficiency, or “green” computing capacity, depends on how many flops the H100s can perform with a given amount of power, which is expressed as gigaflops per watt of power used. 

The Kempner’s H100s demonstrated the capability to perform 16.29 petaflops, at an efficiency of 48.065 gigaflops per watt of power used.

Just how fast is the Kempner AI cluster? To get a sense of perspective on the Kempner’s 16.29 petaflops of computing power, consider this: The computers aboard Apollo 11, which took Neil Armstrong and Buzz Aldrin to the moon in 1969, were capable of 12,250 flops. That sounds like a lot, but by the 1980s much faster computations were possible: The CRAY-2 supercomputer recorded a performance of 1.9 gigaflops. That’s 1.9 billion flops. And now we have vastly more computing power in our pockets. The iPhone 15 is capable of more than 1,700 gigaflops. And the Kempner’s AI cluster has more than 16 petaflops of computing power — that’s 16 followed by 15 zeros — which is four orders of magnitude greater than the iPhone in your pocket. These numbers suggest that the ability of a Large Language Model (LLM) to produce grammatically correct language and simulate cognition is more computationally intensive than navigating a rocket to the moon — at least for now. 

A supercomputer supporting new research at the Kempner, and across Harvard

With this magnitude of computing power, Kempner researchers are able to train state-of-the-art AI systems like large language models (LLMs), of which ChatGPT is perhaps the best known, quickly and efficiently. For example, the Kempner cluster can train the popular Meta Llama 3.1 8B and Meta Llama 3.1 70B language models in about one week and two months, respectively. Before the Kempner’s cluster was established and operational, training the Llama models on the next-fastest computer system at Harvard would have taken years to complete. 

Beyond using the cluster to create faster models, researchers are also employing the cluster to better understand how and why they work. “With this enhanced computational power, we can delve deeper into how generative models learn to reason and complete tasks with greater efficiency,” says Kempner Institute Research Fellow Binxu Wang. 

In addition to providing researchers with the capacity to train complex models quickly and efficiently, and to understand the mechanisms behind how they learn, the Kempner cluster enables scientists to compare vast numbers of model architectures and learning algorithms in parallel, with important applications in fields ranging from medicine to neuroscience. One example: In research recently published in Nature Medicine, Kempner associate faculty member and Harvard Medical School Assistant Professor Marinka Zitnik and colleagues used the cluster to develop and train TxGNN, an AI system that distills vast amounts of medical data into knowledge graphs, and then uses the graphs to predict the effectiveness of a drug for treating rare diseases. 

The Kempner GPUs form part of Harvard University’s growing computational ecosystem, joining new or soon-to-be-available GPUs supported by Harvard’s Faculty of Arts and Sciences Research Computing (FASRC). More than 5,200 researchers across the University make use of these computing resources in a wide array of scientific and technological applications.  

The power of parallel processing

So what exactly is a cluster? As the name suggests, a computing cluster gathers together multiple devices, each of which can function as a full-fledged computer in its own right. Linking devices together unleashes the power of parallel computing, which leads to massive speed-ups in processing time by performing large numbers of tasks simultaneously. 

Until a few decades ago, most computers were powered by a central processing unit (CPU) that could only perform one computational operation at a time. By the early 2000s, computer scientists had figured out how to create “multicore” CPUs that perform multiple computations in parallel. 

The road to supercomputing clusters like the Kempner’s involved stacking several levels of parallel processing on top of each other. After the introduction of multicore CPUs, the next level of parallelism was enabled by the use of GPUs. Controlling the graphics on a computer screen requires large numbers of very similar computations that can be done simultaneously. For example, displaying a video game requires computing the brightness and color of millions of pixels up to 120 times per second. GPUs perform these numerous yet simple computations in parallel, freeing up the CPU to perform more complex computations.

Computer scientists realized that the capacity of GPUs to perform vast numbers of parallel computations could be repurposed for other tasks, such as machine learning. Running an artificial neural network such as OpenAI’s GPT or DALL-E, for example, involves vast numbers of mathematical operations that can be performed in parallel. But the parallelism doesn’t stop here: Yet another level of parallelism is enabled by linking multiple GPUs together in a network. The Kempner’s network involves hundreds of NVIDIA GPUs — 144 A100s and 384 H100s — that can work in concert. This multilevel parallelism empowers the Kempner’s researchers to perform the dizzyingly intensive computations involved in the study of natural and artificial intelligence and to develop new AI applications in areas such as medicine. 

When it comes to fast and flexible experimentation, iteration, and computationally intensive research, the Kempner AI cluster is, in the words of Boaz Barak, “absolutely instrumental.” Barak, a Kempner associate faculty member and professor at the Harvard John A. Paulson School of Engineering and Applied Sciences, says his lab group “relies on extensive computational experiments using the cluster” to study the mechanisms, capabilities, and limitations of deep learning systems. This, he says, allows his lab group to “hone intuitions and study questions as they arise.”

A powerful supercomputer, built to be green

Intentionally built for optimal energy consumption, the Kempner’s AI cluster is also setting a standard for “green” supercomputing. Modern machine learning has resulted in unprecedented advances in AI, but the methods are increasingly energy-intensive. Lowering the carbon footprint of AI is therefore crucial so that advances in AI do not come at the cost of exacerbating global warming. 

Housed at the Massachusetts Green High Performance Computer Center (MGHPCC) along with other FASRC resources, and located in the town of Holyoke, Massachusetts, the Kempner’s AI cluster uses a variety of state-of-the-art techniques to minimize energy usage and make every megawatt of power count. The center is powered by the Holyoke municipal electric company, which delivers 100 percent carbon-free energy through a hydroelectric power station and several solar arrays that they operate.

As the central computing hub employed by most of the state’s research universities, including Harvard, MIT, UMass, Northeastern and Boston University, the MGHPCC was the first university research data center to achieve LEED Platinum Certification, the highest level awarded by the Green Building Council’s Leadership in Energy and Environmental Design Program. Moving forward, the Kempner’s partnership with MGHPCC will allow it to continue to grow with efficiency in mind, keeping the Kempner’s AI cluster green and efficient even as it grows into an even faster and more powerful tool for advancement in the field. 

“Building an AI cluster that is not just blazing fast but also energy-efficient fits squarely into the Kempner’s mission, both to advance the field of intelligence, and to do so in a way that benefits people,” said Kempner Executive Director Elise Porter. “We have worked closely with MGHPCC to ensure this cluster is built with energy efficiency top of mind, and ranking as the 32nd fastest green supercomputer in the world is a testament to that work.”

Fast, green — and human

While landing a top spot on the TOP500/Green500 list is no small accomplishment, the real power of the Kempner’s work is knowing how to leverage its impressive computing resources to facilitate groundbreaking research. This involves more than building the AI cluster and giving researchers access to it. After all, researchers can’t just copy and paste old code into new machines — certain types of algorithms that work on traditional computers have to be reconceptualized and reformatted to be used with the Kempner’s computing infrastructure. 

To this end, the Kempner has assembled a “full-stack” team of professional research engineers and research scientists with expertise ranging from distributed computing to data architecture to computational neuroscience. This Research & Engineering team develops codebases and standards, working with researchers to enable a seamless pipeline connecting scientific problems to computational solutions. The team also ensures that scientific findings are reproducible by helping students, fellows and faculty adopt industry-tested best practices for coding, testing, and maintenance of open repositories for models and data. 

This human know-how is central to the ability of the Kempner community — and researchers all across Harvard University — to harness the scientific and technological potential of the green supercomputing power now available at its collective fingertips. 

To find out more about the latest Kempner Institute research, check out the Deeper Learning blog.

  • ✇Harvard Gazette
  • How free-market policymakers got it all wrong for decadesChristy DeSmith
    Across history, Republican presidents rarely fell in line with what many today consider GOP economic orthodoxy, said economist Oren Cass.Photo by Beth Pezzoni Work & Economy How free-market policymakers got it all wrong for decades Conservative economist says singular focus on deregulation, unfettered trade failed to deliver for American households Christy DeSmith Harvard Staff Writer November 19, 2024
     

How free-market policymakers got it all wrong for decades

November 19th 2024 at 9:27 pm
Oren Cass giving his presentation.

Across history, Republican presidents rarely fell in line with what many today consider GOP economic orthodoxy, said economist Oren Cass.

Photo by Beth Pezzoni

Work & Economy

How free-market policymakers got it all wrong for decades

Conservative economist says singular focus on deregulation, unfettered trade failed to deliver for American households

Christy DeSmith

Harvard Staff Writer

6 min read

The free-market policymakers of the late 20th and early 21st centuries have “an empirical problem,” said Oren Cass, J.D. ’12, founder and chief economist of the conservative think tank American Compass.

“The stuff they were doing on economics did not work.”

Cass, author of “The Once and Future Worker: A Vision for the Renewal of Work in America” (2018), argued in a talk last week hosted by the Department of Government that the era’s Republicans, with their focus on deregulation and unfettered trade, marked a departure from the party’s longer, more productive traditions of building the economy by bolstering the labor force.

Cass’ ideas, anchored by social conservatism, are gaining traction with a younger set of policymakers on the right. But his pro-worker rhetoric overlaps at times with language used on the left. “Marco Rubio and J.D. Vance on one side and Bernie Sanders and Elizabeth Warren on the other actually see a lot of the same problems in the economy and are willing to say it,” offered Cass, who rang a note of optimism over this “increasing consensus.”

Across U.S. history, he said, Republican presidents rarely fell in line with what many today consider GOP economic orthodoxy. Abraham Lincoln, William McKinley, Teddy Roosevelt Jr., and Richard Nixon all used tariffs to shore up domestic industry and protect the country’s wage earners.

Former President Ronald Reagan, celebrated by conservatives for his embrace of free enterprise, raised taxes at least five times and was far more protectionist than his reputation might suggest. Cass underscored this point by offering background on Reagan’s famous quote: “I’ve always felt the nine most terrifying words in the English language are: I’m from the government, and I’m here to help.”

Reagan uttered these words in 1986 while announcing record-breaking aid to American farmers, including drought assistance and price supports. “One of the very funny things about what we think of as Reaganomics, conservative economics — what I call market fundamentalism — is it’s actually a post-Reagan phenomenon,” Cass said.

How did the market fundamentalism come to dominate politics on the right? Cass, a policy adviser to Mitt Romney’s 2012 presidential campaign, pointed to the distinct interest groups that comprised the famous “three-legged stool” of Reagan’s electoral coalition: social conservatives, economic libertarians, and national security hawks. 

“What do these three groups have in common?” Cass asked. “They all really, really, really hate communists. And in the middle of the Cold War, in the context where the Democratic Party was — let’s be honest — a little squishy on communism, getting together everybody who really, really, really hated communism turned out to be a powerful strategy.”

This coalition collapsed in 1989 with the Berlin Wall, Cass continued. That left the three-legged stool in splinters, with each faction vying for supremacy. “That is the economic libertarians unchained from any actual Cold War just running amok,” he argued. “This is [activist] Grover Norquist getting everybody to agree they will never raise taxes under any circumstances.

“And by the time you get to the 2000s, you have a bunch of [President George W.] Bush tax cuts that bear no relationship to any economic priority and manage to send us back into debt while producing no economic growth whatsoever. You have several massive new wars starting to no apparent effect. And you have social conservatives sort of sitting there, losing on their priorities for the most part.”

For 30 years, that group ceded all territory on economic issues, Cass said. “And then they started to say, ‘Wait a minute. The economy that the economic libertarians are producing does not align with any of the things we actually believe equate to human flourishing.’”

Core to Cass’ critique is the economic libertarian focus on cheap consumer goods over building a labor force where workers can support strong families.

As evidence that the free-market era has failed to deliver for the average American household, Cass showed a series of charts detailing everything from the growing U.S. trade deficit to 50 years of stagnant wage growth even amid rising per-capita GDP. Over the same period, deregulation led to the rise of offshoring, while an increasingly dominant financial sector embraced high-speed trading and speculation over investments in U.S. communities.

Cass also shared a data visualization of America’s growing reliance on government transfers, recently published by a bipartisan Economic Innovation Group associated with Facebook founding president Sean Parker. The display can be read as a “massive victory” by free-market thinkers focused, above all, on individual purchasing power, Cass argued.

But he ventured that most Americans are unsettled by increased dependence on Social Security, veterans’ benefits, and other federal aid programs. “This is not actually a sustainable model for a thriving nation either socially or economically,” he said.

“This is not actually a sustainable model for a thriving nation either socially or economically.”

Oren Cass,
Oren Cass

Conservatives like to approach the market in definitional terms, Cass explained. What is the market, and what is it for? He rejected the terms put forth by former U.S. Senator Pat Toomey during a 2020 talk at the Heritage Foundation.“The market is … really just the name that we assign to the sum total of all the voluntary exchanges that occur every day by free men and women,” Toomey said.

“That’s not a market,” Cass countered. “A market is a much more complex mechanism that allocates labor and capital in response to conditions, rules, and institutions.”

What is the market actually for, in his view? “It’s not just for optimizing consumption,” Cass said. “We need to do a lot more than that, because we don’t want to rely on government to do everything else. We need it to empower workers to support their families. We need it to strengthen the social fabric. We need it to foster domestic investment and innovation.

“And if that’s the case, the role for policymakers isn’t as little as possible,” he concluded. “Their role is to create the rules and support the institutions that will lead to productive applications.”

  • ✇MIT News
  • Can robots learn from machine dreams?Rachel Gordon | MIT CSAIL
    For roboticists, one challenge towers above all others: generalization — the ability to create machines that can adapt to any environment or condition. Since the 1970s, the field has evolved from writing sophisticated programs to using deep learning, teaching robots to learn directly from human behavior. But a critical bottleneck remains: data quality. To improve, robots need to encounter scenarios that push the boundaries of their capabilities, operating at the edge of their mastery. This proce
     

Can robots learn from machine dreams?

November 19th 2024 at 11:20 pm

For roboticists, one challenge towers above all others: generalization — the ability to create machines that can adapt to any environment or condition. Since the 1970s, the field has evolved from writing sophisticated programs to using deep learning, teaching robots to learn directly from human behavior. But a critical bottleneck remains: data quality. To improve, robots need to encounter scenarios that push the boundaries of their capabilities, operating at the edge of their mastery. This process traditionally requires human oversight, with operators carefully challenging robots to expand their abilities. As robots become more sophisticated, this hands-on approach hits a scaling problem: the demand for high-quality training data far outpaces humans’ ability to provide it.

Now, a team of MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers has developed a novel approach to robot training that could significantly accelerate the deployment of adaptable, intelligent machines in real-world environments. The new system, called “LucidSim,” uses recent advances in generative AI and physics simulators to create diverse and realistic virtual training environments, helping robots achieve expert-level performance in difficult tasks without any real-world data.

LucidSim combines physics simulation with generative AI models, addressing one of the most persistent challenges in robotics: transferring skills learned in simulation to the real world. “A fundamental challenge in robot learning has long been the ‘sim-to-real gap’ — the disparity between simulated training environments and the complex, unpredictable real world,” says MIT CSAIL postdoc Ge Yang, a lead researcher on LucidSim. “Previous approaches often relied on depth sensors, which simplified the problem but missed crucial real-world complexities.”

The multipronged system is a blend of different technologies. At its core, LucidSim uses large language models to generate various structured descriptions of environments. These descriptions are then transformed into images using generative models. To ensure that these images reflect real-world physics, an underlying physics simulator is used to guide the generation process.

The birth of an idea: From burritos to breakthroughs

The inspiration for LucidSim came from an unexpected place: a conversation outside Beantown Taqueria in Cambridge, Massachusetts. ​​“We wanted to teach vision-equipped robots how to improve using human feedback. But then, we realized we didn’t have a pure vision-based policy to begin with,” says Alan Yu, an undergraduate student in electrical engineering and computer science (EECS) at MIT and co-lead author on LucidSim. “We kept talking about it as we walked down the street, and then we stopped outside the taqueria for about half-an-hour. That’s where we had our moment.”

To cook up their data, the team generated realistic images by extracting depth maps, which provide geometric information, and semantic masks, which label different parts of an image, from the simulated scene. They quickly realized, however, that with tight control on the composition of the image content, the model would produce similar images that weren’t different from each other using the same prompt. So, they devised a way to source diverse text prompts from ChatGPT.

This approach, however, only resulted in a single image. To make short, coherent videos that serve as little “experiences” for the robot, the scientists hacked together some image magic into another novel technique the team created, called “Dreams In Motion.” The system computes the movements of each pixel between frames, to warp a single generated image into a short, multi-frame video. Dreams In Motion does this by considering the 3D geometry of the scene and the relative changes in the robot’s perspective.

“We outperform domain randomization, a method developed in 2017 that applies random colors and patterns to objects in the environment, which is still considered the go-to method these days,” says Yu. “While this technique generates diverse data, it lacks realism. LucidSim addresses both diversity and realism problems. It’s exciting that even without seeing the real world during training, the robot can recognize and navigate obstacles in real environments.”

The team is particularly excited about the potential of applying LucidSim to domains outside quadruped locomotion and parkour, their main test bed. One example is mobile manipulation, where a mobile robot is tasked to handle objects in an open area; also, color perception is critical. “Today, these robots still learn from real-world demonstrations,” says Yang. “Although collecting demonstrations is easy, scaling a real-world robot teleoperation setup to thousands of skills is challenging because a human has to physically set up each scene. We hope to make this easier, thus qualitatively more scalable, by moving data collection into a virtual environment.”

Who's the real expert?

The team put LucidSim to the test against an alternative, where an expert teacher demonstrates the skill for the robot to learn from. The results were surprising: Robots trained by the expert struggled, succeeding only 15 percent of the time — and even quadrupling the amount of expert training data barely moved the needle. But when robots collected their own training data through LucidSim, the story changed dramatically. Just doubling the dataset size catapulted success rates to 88 percent. “And giving our robot more data monotonically improves its performance — eventually, the student becomes the expert,” says Yang.

“One of the main challenges in sim-to-real transfer for robotics is achieving visual realism in simulated environments,” says Stanford University assistant professor of electrical engineering Shuran Song, who wasn’t involved in the research. “The LucidSim framework provides an elegant solution by using generative models to create diverse, highly realistic visual data for any simulation. This work could significantly accelerate the deployment of robots trained in virtual environments to real-world tasks.”

From the streets of Cambridge to the cutting edge of robotics research, LucidSim is paving the way toward a new generation of intelligent, adaptable machines — ones that learn to navigate our complex world without ever setting foot in it.

Yu and Yang wrote the paper with four fellow CSAIL affiliates: Ran Choi, an MIT postdoc in mechanical engineering; Yajvan Ravan, an MIT undergraduate in EECS; John Leonard, the Samuel C. Collins Professor of Mechanical and Ocean Engineering in the MIT Department of Mechanical Engineering; and Phillip Isola, an MIT associate professor in EECS. Their work was supported, in part, by a Packard Fellowship, a Sloan Research Fellowship, the Office of Naval Research, Singapore’s Defence Science and Technology Agency, Amazon, MIT Lincoln Laboratory, and the National Science Foundation Institute for Artificial Intelligence and Fundamental Interactions. The researchers presented their work at the Conference on Robot Learning (CoRL) in early November.

© Photo: Michael Grimmett/MIT CSAIL

MIT CSAIL researchers (left to right) Alan Yu, an undergraduate in electrical engineering and computer science (EECS); Phillip Isola, associate professor of EECS; and Ge Yang, a postdoctoral associate, developed an AI-powered simulator that generates unlimited, diverse, and realistic training data for robots. Robots trained in this virtual environment can seamlessly transfer their skills to the real world, performing at expert levels without additional fine-tuning.
  • ✇MIT News
  • Can robots learn from machine dreams?Rachel Gordon | MIT CSAIL
    For roboticists, one challenge towers above all others: generalization — the ability to create machines that can adapt to any environment or condition. Since the 1970s, the field has evolved from writing sophisticated programs to using deep learning, teaching robots to learn directly from human behavior. But a critical bottleneck remains: data quality. To improve, robots need to encounter scenarios that push the boundaries of their capabilities, operating at the edge of their mastery. This proce
     

Can robots learn from machine dreams?

November 19th 2024 at 11:20 pm

For roboticists, one challenge towers above all others: generalization — the ability to create machines that can adapt to any environment or condition. Since the 1970s, the field has evolved from writing sophisticated programs to using deep learning, teaching robots to learn directly from human behavior. But a critical bottleneck remains: data quality. To improve, robots need to encounter scenarios that push the boundaries of their capabilities, operating at the edge of their mastery. This process traditionally requires human oversight, with operators carefully challenging robots to expand their abilities. As robots become more sophisticated, this hands-on approach hits a scaling problem: the demand for high-quality training data far outpaces humans’ ability to provide it.

Now, a team of MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers has developed a novel approach to robot training that could significantly accelerate the deployment of adaptable, intelligent machines in real-world environments. The new system, called “LucidSim,” uses recent advances in generative AI and physics simulators to create diverse and realistic virtual training environments, helping robots achieve expert-level performance in difficult tasks without any real-world data.

LucidSim combines physics simulation with generative AI models, addressing one of the most persistent challenges in robotics: transferring skills learned in simulation to the real world. “A fundamental challenge in robot learning has long been the ‘sim-to-real gap’ — the disparity between simulated training environments and the complex, unpredictable real world,” says MIT CSAIL postdoc Ge Yang, a lead researcher on LucidSim. “Previous approaches often relied on depth sensors, which simplified the problem but missed crucial real-world complexities.”

The multipronged system is a blend of different technologies. At its core, LucidSim uses large language models to generate various structured descriptions of environments. These descriptions are then transformed into images using generative models. To ensure that these images reflect real-world physics, an underlying physics simulator is used to guide the generation process.

The birth of an idea: From burritos to breakthroughs

The inspiration for LucidSim came from an unexpected place: a conversation outside Beantown Taqueria in Cambridge, Massachusetts. ​​“We wanted to teach vision-equipped robots how to improve using human feedback. But then, we realized we didn’t have a pure vision-based policy to begin with,” says Alan Yu, an undergraduate student in electrical engineering and computer science (EECS) at MIT and co-lead author on LucidSim. “We kept talking about it as we walked down the street, and then we stopped outside the taqueria for about half-an-hour. That’s where we had our moment.”

To cook up their data, the team generated realistic images by extracting depth maps, which provide geometric information, and semantic masks, which label different parts of an image, from the simulated scene. They quickly realized, however, that with tight control on the composition of the image content, the model would produce similar images that weren’t different from each other using the same prompt. So, they devised a way to source diverse text prompts from ChatGPT.

This approach, however, only resulted in a single image. To make short, coherent videos that serve as little “experiences” for the robot, the scientists hacked together some image magic into another novel technique the team created, called “Dreams In Motion.” The system computes the movements of each pixel between frames, to warp a single generated image into a short, multi-frame video. Dreams In Motion does this by considering the 3D geometry of the scene and the relative changes in the robot’s perspective.

“We outperform domain randomization, a method developed in 2017 that applies random colors and patterns to objects in the environment, which is still considered the go-to method these days,” says Yu. “While this technique generates diverse data, it lacks realism. LucidSim addresses both diversity and realism problems. It’s exciting that even without seeing the real world during training, the robot can recognize and navigate obstacles in real environments.”

The team is particularly excited about the potential of applying LucidSim to domains outside quadruped locomotion and parkour, their main test bed. One example is mobile manipulation, where a mobile robot is tasked to handle objects in an open area; also, color perception is critical. “Today, these robots still learn from real-world demonstrations,” says Yang. “Although collecting demonstrations is easy, scaling a real-world robot teleoperation setup to thousands of skills is challenging because a human has to physically set up each scene. We hope to make this easier, thus qualitatively more scalable, by moving data collection into a virtual environment.”

Who's the real expert?

The team put LucidSim to the test against an alternative, where an expert teacher demonstrates the skill for the robot to learn from. The results were surprising: Robots trained by the expert struggled, succeeding only 15 percent of the time — and even quadrupling the amount of expert training data barely moved the needle. But when robots collected their own training data through LucidSim, the story changed dramatically. Just doubling the dataset size catapulted success rates to 88 percent. “And giving our robot more data monotonically improves its performance — eventually, the student becomes the expert,” says Yang.

“One of the main challenges in sim-to-real transfer for robotics is achieving visual realism in simulated environments,” says Stanford University assistant professor of electrical engineering Shuran Song, who wasn’t involved in the research. “The LucidSim framework provides an elegant solution by using generative models to create diverse, highly realistic visual data for any simulation. This work could significantly accelerate the deployment of robots trained in virtual environments to real-world tasks.”

From the streets of Cambridge to the cutting edge of robotics research, LucidSim is paving the way toward a new generation of intelligent, adaptable machines — ones that learn to navigate our complex world without ever setting foot in it.

Yu and Yang wrote the paper with four fellow CSAIL affiliates: Ran Choi, an MIT postdoc in mechanical engineering; Yajvan Ravan, an MIT undergraduate in EECS; John Leonard, the Samuel C. Collins Professor of Mechanical and Ocean Engineering in the MIT Department of Mechanical Engineering; and Phillip Isola, an MIT associate professor in EECS. Their work was supported, in part, by a Packard Fellowship, a Sloan Research Fellowship, the Office of Naval Research, Singapore’s Defence Science and Technology Agency, Amazon, MIT Lincoln Laboratory, and the National Science Foundation Institute for Artificial Intelligence and Fundamental Interactions. The researchers presented their work at the Conference on Robot Learning (CoRL) in early November.

© Photo: Michael Grimmett/MIT CSAIL

MIT CSAIL researchers (left to right) Alan Yu, an undergraduate in electrical engineering and computer science (EECS); Phillip Isola, associate professor of EECS; and Ge Yang, a postdoctoral associate, developed an AI-powered simulator that generates unlimited, diverse, and realistic training data for robots. Robots trained in this virtual environment can seamlessly transfer their skills to the real world, performing at expert levels without additional fine-tuning.
  • ✇ETH News
  • And it keeps on turningBarbara Vonarburg, freelance author
    The coloured Cube has been around for 50 years. Its inventor, Ernő Rubik, celebrated his 80th birthday this year. At the invitation of the ETH Department of Mathematics, he spent some time in Zurich to discuss the fascination of the Rubik’s Cube with researchers, students and children.
     

And it keeps on turning

November 19th 2024 at 4:30 pm
The coloured Cube has been around for 50 years. Its inventor, Ernő Rubik, celebrated his 80th birthday this year. At the invitation of the ETH Department of Mathematics, he spent some time in Zurich to discuss the fascination of the Rubik’s Cube with researchers, students and children.
  • ✇University of Cambridge
  • A peek inside the box that could help solve a quantum mysterysc604
    Appearing as ‘bumps’ in the data from high-energy experiments, these signals came to be known as short-lived ‘XYZ states.’ They defy the standard picture of particle behaviour and are a problem in contemporary physics, sparking several attempts to understand their mysterious nature. But theorists at the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility in Virginia, with colleagues from the University of Cambridge, suggest the experimental data could be explained with fe
     

A peek inside the box that could help solve a quantum mystery

By: sc604
November 19th 2024 at 6:52 pm
Abstract colourful lines

Appearing as ‘bumps’ in the data from high-energy experiments, these signals came to be known as short-lived ‘XYZ states.’ They defy the standard picture of particle behaviour and are a problem in contemporary physics, sparking several attempts to understand their mysterious nature.

But theorists at the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility in Virginia, with colleagues from the University of Cambridge, suggest the experimental data could be explained with fewer XYZ states, also called resonances, than currently claimed.

The team used a branch of quantum physics to compute the energy levels, or mass, of particles containing a specific ‘flavour’ of the subatomic building blocks known as quarks. Quarks, along with gluons, a force-carrying particle, make up the Strong Force, one of the four fundamental forces of nature.

The researchers found that multiple particle states sharing the same degree of spin – or angular momentum – are coupled, meaning only a single resonance exists at each spin channel. This new interpretation is contrary to several other theoretical and experimental studies.

The researchers have presented their results in a pair of companion papers published for the international Hadron Spectrum Collaboration (HadSpec) in Physical Review Letters and Physical Review D. The work could also provide clues about an enigmatic particle: X(3872).

The charm quark, one of six quark ‘flavours’, was first observed experimentally in 1974. It was discovered alongside its antimatter counterpart, the anticharm, and particles paired this way are part of an energy region called ‘charmonium.’

In 2003, Japanese researchers discovered a new charmonium candidate dubbed X(3872): a short-lived particle state that appears to defy the present quark model.

“X(3872) is now more than 20 years old, and we still haven’t obtained a clear, simple explanation that everyone can get behind,” said lead author Dr David Wilson from Cambridge’s Department of Applied Mathematics and Theoretical Physics (DAMTP).

Thanks to the power of modern particle accelerators, scientists have detected a hodgepodge of exotic charmonium candidate states over the past two decades.

“High-energy experiments started seeing bumps, interpreted as new particles, almost everywhere they looked,” said co-author Professor Jozef Dudek from William & Mary. “And very few of these states agreed with the model that came before.”

But now, by creating a tiny virtual ‘box’ to simulate quark behaviour, the researchers discovered that several supposed XYZ particles might actually be just one particle seen in different ways. This could help simplify the confusing jumble of data scientists have collected over the years.

Despite the tiny volumes they were working with, the team required enormous computing power to simulate all the possible behaviours and masses of quarks.

The researchers used supercomputers at Cambridge and the Jefferson Lab to infer all the possible ways in which mesons – made of a quark and its antimatter counterpart – could decay. To do this, they had to relate the results from their tiny virtual box to what would happen in a nearly infinite volume – that is, the size of the universe.

“In our calculations, unlike experiment, you can't just fire in two particles and measure two particles coming out,” said Wilson. “You have to simultaneously calculate all possible final states, because quantum mechanics will find those for you.”

The results can be understood in terms of just a single short-lived particle whose appearance could differ depending upon which possible decay state it is observed in.

“We're trying to simplify the picture as much as possible, using fundamental theory with the best methods available,” said Wilson. “Our goal is to disentangle what has been seen in experiments.”

Now that the team has proved this type of calculation is feasible, they are ready to apply it to the mysterious particle X(3872).

“The origin of X(3872) is an open question,” said Wilson. “It appears very close to a threshold, which could be accidental or a key part of the story. This is one thing we will look at very soon."

Professor Christopher Thomas, also from DAMTP, is a member of the Hadron Spectrum Collaboration, and is a co-author on the current studies. Wilson’s contribution was made possible in part by an eight-year fellowship with the Royal Society. The research was also supported in part by the Science and Technology Facilities Council (STFC), part of UK Research and Innovation (UKRI). Many of the calculations for this study were carried out with the support of the Cambridge Centre for Data Driven Discovery (CSD3) and DiRAC high-performance computing facilities in Cambridge, managed by Cambridge’s Research Computing Services division.

Reference:
David J. Wilson et al. ‘Scalar and Tensor Charmonium Resonances in Coupled-Channel Scattering from Lattice QCD.’ Physical Review Letters (2024). DOI: 10.1103/PhysRevLett.132.241901

David J. Wilson et al. ‘Charmonium xc0 and xc2 resonances in coupled-channel scattering from lattice QCD.’ Physical Review D (2024). DOI: 10.1103/PhysRevD.109.114503

Adapted from a Jefferson Lab story.

An elusive particle that first formed in the hot, dense early universe has puzzled physicists for decades. Following its discovery in 2003, scientists began observing a slew of other strange objects tied to the millionths of a second after the Big Bang.

Abstract colourful lines

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The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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  • ✇NUS - National University of Singapore Newsroom
  • NUS researchers ranked among the world’s most impactful scholars
    Forty-six NUS researchers have been placed among the world’s most prominent researchers, based on the Highly Cited Researchers 2024 List published by data analytics firm Clarivate. This annual recognition honours researchers who have demonstrated significant and far-reaching influence in their field of research.The Highly Cited Researchers 2024 list features NUS researchers whose publications rank in the top 1 per cent by citations for their respective fields and publication year in the Web of S
     

NUS researchers ranked among the world’s most impactful scholars

November 19th 2024 at 11:31 am

Forty-six NUS researchers have been placed among the world’s most prominent researchers, based on the Highly Cited Researchers 2024 List published by data analytics firm Clarivate. This annual recognition honours researchers who have demonstrated significant and far-reaching influence in their field of research.

The Highly Cited Researchers 2024 list features NUS researchers whose publications rank in the top 1 per cent by citations for their respective fields and publication year in the Web of Science over the past decade. These NUS honourees have made significant contributions to diverse fields including, Chemistry, Clinical Medicine, Computer Science, Economics and Business, Engineering, Immunology, Materials Science, Microbiology, Neuroscience and Behaviour, Pharmacology and Toxicology, Physics, Psychiatry and Psychology and more.

This year, 6,636 researchers from 59 countries and regions have been named Highly Cited Researchers. In the list, 3,560 researchers have been recognised in specific fields and 3,326 researchers for cross-field impact, with 238 researchers being named in two or more fields.

Professor Liu Bin, NUS Deputy President (Research and Technology), said, “NUS is incredibly proud of our exceptional researchers, whose dedication to excellence and groundbreaking discoveries continue to push the frontiers of knowledge. Their meaningful contributions have had a profound impact in addressing real-world issues and paving the way towards a better future for all.”

David Pendlebury, Head of Research Analysis at the Institute for Scientific Information at Clarivate, said, “The Highly Cited Researchers list identifies and celebrates exceptional individual researchers at NUS whose significant and broad influence in their fields translates to impact in their research community. Their pioneering innovations contribute to a healthier, more sustainable and secure world. These researchers’ achievements strengthen the foundation of excellence and innovation that drives societal progress.”

The Institute for Scientific Information (ISI) at Clarivate creates a new list of Highly Cited Researchers each year based on a rolling 11-year window of citation evaluation by applying a rigorous editorial selection process to identify trusted journals in the Web of Science.

The 46 highly cited NUS researchers in their respective fields are:

Chemistry
Professor Chen Xiaoyuan, Shawn            
Clinical Imaging Research Centre, Department of Diagnostic Radiology, NUS Yong Loo Lin School of Medicine &            
Department of Biomedical Engineering, NUS College of Design and Engineering            
[Also listed under Materials Science]            

Professor Jiang Donglin            
Department of Chemistry, NUS Faculty of Science            

Professor Liu Bin            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering            

Professor Xie Jianping            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering &            
Tianjin University-NUS Joint Institute in Fuzhou            

Professor Yan Ning            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering &            
NUS Centre for Hydrogen Innovations
Clinical Medicine
Professor Carolyn Lam         
SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme            

Professor Wong Tien Yin         
Office of Academic Medicine, Duke-NUS Medical School
Computer Science
Professor Zhang Rui            
Department of Electrical and Computer Engineering, NUS College of Design and Engineering
Cross-Field
Emeritus Professor Ang Beng Wah            
NUS Energy Studies Institute &            
Department of Industrial Systems Engineering and Management, NUS College of Design and Engineering            

Professor Antonio Bertoletti            
Signature Research Programme in Emerging Infectious Diseases, Duke-NUS Medical School            

Professor Chen Wei            
Department of Chemistry and Department of Physics, NUS Faculty of Science         

Associate Professor Goki Eda            
Department of Chemistry and Department of Physics, NUS Faculty of Science            

Professor Ge Shuzhi, Sam            
Department of Electrical and Computer Engineering, NUS College of Design and Engineering            

Professor Derek John Hausenloy            
Signature Research Programme in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School        

Professor Ho Ghim Wei            
Department of Electrical and Computer Engineering, NUS College of Design and Engineering            

Assistant Professor Hou Yi            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering            

Assistant Professor Shirin Kalimuddin            
SingHealth Duke-NUS Medicine Academic Clinical Programme, Duke-NUS Medical School            

Associate Professor Sibudjing Kawi            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering             

Associate Professor Lee Chengkuo, Vincent        
Department of Electrical and Computer Engineering, NUS College of Design and Engineering            

Professor Leo Yee Sin            
NUS Saw Swee Hock School of Public Health            

Professor Lin Zhiqun            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering            

Professor Liu Xiaogang            
Department of Chemistry, NUS Faculty of Science            

Professor Loh Kian Ping            
Department of Chemistry, NUS Faculty of Science            

Professor Low Guek Hong, Jenny             
SingHealth Duke-NUS Medicine Academic Clinical Programme, Duke-NUS Medical School            

Visiting Professor Qiang Yujie            
Department of Mechanical Engineering, NUS College of Design and Engineering            

Assistant Professor Sing Swee Leong            
Department of Mechanical Engineering, NUS College of Design and Engineering            

Dr Su Bin            
NUS Energy Studies Institute &            
NUS Centre for Maritime Studies &            
Department of Industrial Systems Engineering and Management,NUS College of Design and Engineering            

Associate Professor Wilson Tam            
Alice Lee Centre for Nursing Studies, NUS Yong Loo Lin School of Medicine            

Assistant Professor Anthony Tanoto Tan        
Signature Research Programme in Emerging Infectious Diseases, Duke-NUS Medical School          

Professor Wang Chi-Hwa        
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering            

Wang Yuxiang        
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering        

Adjunct Associate Professor Wang Xiaonan        
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering        

Associate Professor Zhao Dan            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering
Economics and Business
Professor Jochen Wirtz            
Department of Marketing, NUS Business School
Engineering
Professor Praveen Linga            
Department of Chemical and Biomolecular Engineering, NUS College of Design and Engineering
Immunology
Associate Professor Chen Jinmiao           
Centre for Computational Biology, Duke-NUS Medical School           

Dr Chia Wan Ni (Adjunct)           
Signature Research Programme in Emerging Infectious Diseases, Duke-NUS Medical School
Materials Science
Professor John Wang            
Department of Materials Science and Engineering, NUS College of Design and Engineering
Microbiology
Professor Wang Linfa           
Signature Research Programme in Emerging Infectious Diseases, Duke-NUS Medical School
Neuroscience and Behaviour
Assistant Professor Cyrus Ho            
Department of Psychological Medicine, NUS Yong Loo Lin School of Medicine           

Professor Roger Ho            
Department of Psychological Medicine, NUS Yong Loo Lin School of Medicine           
[Also listed under Psychiatry and Psychology]            

Associate Professor Thomas Yeo Boon Thye           
Department of Electrical and Computer Engineering, NUS College of Design and Engineering &           
Centre for Sleep and Cognition and Centre for Translational MR Research, NUS Yong Loo Lin School of Medicine
Pharmacology and Toxicology
Visiting Research Professor Gerrit Storm           
Department of Surgery, NUS Yong Loo Lin School of Medicine
Physics
Professor Antonio Helio Castro Neto           
NUS Institute for Functional Intelligent Materials &           
NUS Centre for Advanced 2D Materials &           
Department of Physics, NUS Faculty of Science &           
Department of Materials Science and Engineering, NUS College of Design and Engineering           

Professor Sir Konstantin Novoselov           
NUS Institute for Functional Intelligent Materials &           
Department of Materials Science and Engineering, NUS College of Design and Engineering           

Professor Qiu Cheng-Wei           
Department of Electrical and Computer Engineering, NUS College of Design and Engineering &           
Department of Physics, Faculty of Science

University of Melbourne joins $24m project to protect food growers from pests

November 19th 2024 at 9:51 am

A new $24.79 million project is poised to revolutionise pest management for Australian grain and vegetable growers. This initiative is a crucial step in preparing these key food production industries to reduce reliance on broad-spectrum insecticides and implement innovative strategies to manage pest populations and promote beneficial insects.

  • ✇MIT News
  • When a cell protector collaborates with a killerJennifer Michalowski | McGovern Institute for Brain Research
    From early development to old age, cell death is a part of life. Without enough of a critical type of cell death known as apoptosis, animals wind up with too many cells, which can set the stage for cancer or autoimmune disease. But careful control is essential, because when apoptosis eliminates the wrong cells, the effects can be just as dire, helping to drive many kinds of neurodegenerative disease.By studying the microscopic roundworm Caenorhabditis elegans — which was honored with its fourth
     

When a cell protector collaborates with a killer

From early development to old age, cell death is a part of life. Without enough of a critical type of cell death known as apoptosis, animals wind up with too many cells, which can set the stage for cancer or autoimmune disease. But careful control is essential, because when apoptosis eliminates the wrong cells, the effects can be just as dire, helping to drive many kinds of neurodegenerative disease.

By studying the microscopic roundworm Caenorhabditis elegans — which was honored with its fourth Nobel Prize last month — scientists at MIT’s McGovern Institute for Brain Research have begun to unravel a longstanding mystery about the factors that control apoptosis: how a protein capable of preventing programmed cell death can also promote it. Their study, led by Robert Horvitz, the David H. Koch Professor of Biology at MIT, and reported Oct. 9 in the journal Science Advances, sheds light on the process of cell death in both health and disease.

“These findings, by graduate student Nolan Tucker and former graduate student, now MIT faculty colleague, Peter Reddien, have revealed that a protein interaction long thought to block apoptosis in C. elegans likely instead has the opposite effect,” says Horvitz, who is also an investigator at the Howard Hughes Medical Institute and the McGovern Institute. Horvitz shared the 2002 Nobel Prize in Physiology or Medicine for discovering and characterizing the genes controlling cell death in C. elegans.

Mechanisms of cell death

Horvitz, Tucker, Reddien, and colleagues have provided foundational insights in the field of apoptosis by using C. elegans to analyze the mechanisms that drive apoptosis, as well as the mechanisms that determine how cells ensure apoptosis happens when and where it should. Unlike humans and other mammals, which depend on dozens of proteins to control apoptosis, these worms use just a few. And when things go awry, it’s easy to tell: When there’s not enough apoptosis, researchers can see that there are too many cells inside the worms’ translucent bodies. And when there’s too much, the worms lack certain biological functions or, in more extreme cases, can’t reproduce or die during embryonic development.

Work in the Horvitz lab defined the roles of many of the genes and proteins that control apoptosis in worms. These regulators proved to have counterparts in human cells, and for that reason studies of worms have helped reveal how human cells govern cell death and pointed toward potential targets for treating disease.

A protein’s dual role

Three of C. elegans’ primary regulators of apoptosis actively promote cell death, whereas just one, CED-9, reins in the apoptosis-promoting proteins to keep cells alive. As early as the 1990s, however, Horvitz and colleagues recognized that CED-9 was not exclusively a protector of cells. Their experiments indicated that the protector protein also plays a role in promoting cell death. But while researchers thought they knew how CED-9 protected against apoptosis, its pro-apoptotic role was more puzzling.

CED-9’s dual role means that mutations in the gene that encode it can impact apoptosis in multiple ways. Most ced-9 mutations interfere with the protein’s ability to protect against cell death and result in excess cell death. Conversely, mutations that abnormally activate ced-9 cause too little cell death, just like mutations that inactivate any of the three killer genes.

An atypical ced-9 mutation, identified by Reddien when he was a PhD student in Horvitz’s lab, hinted at how CED-9 promotes cell death. That mutation altered the part of the CED-9 protein that interacts with the protein CED-4, which is proapoptotic. Since the mutation specifically leads to a reduction in apoptosis, this suggested that CED-9 might need to interact with CED-4 to promote cell death.

The idea was particularly intriguing because researchers had long thought that CED-9’s interaction with CED-4 had exactly the opposite effect: In the canonical model, CED-9 anchors CED-4 to cells’ mitochondria, sequestering the CED-4 killer protein and preventing it from associating with and activating another key killer, the CED-3 protein — thereby preventing apoptosis.

To test the hypothesis that CED-9’s interactions with the killer CED-4 protein enhance apoptosis, the team needed more evidence. So graduate student Nolan Tucker used CRISPR gene editing tools to create more worms with mutations in CED-9, each one targeting a different spot in the CED-4-binding region. Then he examined the worms. “What I saw with this particular class of mutations was extra cells and viability,” he says — clear signs that the altered CED-9 was still protecting against cell death, but could no longer promote it. “Those observations strongly supported the hypothesis that the ability to bind CED-4 is needed for the pro-apoptotic function of CED-9,” Tucker explains. Their observations also suggested that, contrary to earlier thinking, CED-9 doesn’t need to bind with CED-4 to protect against apoptosis.

When he looked inside the cells of the mutant worms, Tucker found additional evidence that these mutations prevented CED-9’s ability to interact with CED-4. When both CED-9 and CED-4 are intact, CED-4 appears associated with cells’ mitochondria. But in the presence of these mutations, CED-4 was instead at the edge of the cell nucleus. CED-9’s ability to bind CED-4 to mitochondria appeared to be necessary to promote apoptosis, not to protect against it.

Looking ahead

While the team’s findings begin to explain a long-unanswered question about one of the primary regulators of apoptosis, they raise new ones, as well. “I think that this main pathway of apoptosis has been seen by a lot of people as more-or-less settled science. Our findings should change that view,” Tucker says.

The researchers see important parallels between their findings from this study of worms and what’s known about cell death pathways in mammals. The mammalian counterpart to CED-9 is a protein called BCL-2, mutations in which can lead to cancer.  BCL-2, like CED-9, can both promote and protect against apoptosis. As with CED-9, the pro-apoptotic function of BCL-2 has been mysterious. In mammals, too, mitochondria play a key role in activating apoptosis. The Horvitz lab’s discovery opens opportunities to better understand how apoptosis is regulated not only in worms but also in humans, and how dysregulation of apoptosis in humans can lead to such disorders as cancer, autoimmune disease, and neurodegeneration.

© Image: Robert Horvitz

The nematode worm Caenorhabditis elegans has provided answers to many fundamental questions in biology.
  • ✇MIT News
  • When a cell protector collaborates with a killerJennifer Michalowski | McGovern Institute for Brain Research
    From early development to old age, cell death is a part of life. Without enough of a critical type of cell death known as apoptosis, animals wind up with too many cells, which can set the stage for cancer or autoimmune disease. But careful control is essential, because when apoptosis eliminates the wrong cells, the effects can be just as dire, helping to drive many kinds of neurodegenerative disease.By studying the microscopic roundworm Caenorhabditis elegans — which was honored with its fourth
     

When a cell protector collaborates with a killer

From early development to old age, cell death is a part of life. Without enough of a critical type of cell death known as apoptosis, animals wind up with too many cells, which can set the stage for cancer or autoimmune disease. But careful control is essential, because when apoptosis eliminates the wrong cells, the effects can be just as dire, helping to drive many kinds of neurodegenerative disease.

By studying the microscopic roundworm Caenorhabditis elegans — which was honored with its fourth Nobel Prize last month — scientists at MIT’s McGovern Institute for Brain Research have begun to unravel a longstanding mystery about the factors that control apoptosis: how a protein capable of preventing programmed cell death can also promote it. Their study, led by Robert Horvitz, the David H. Koch Professor of Biology at MIT, and reported Oct. 9 in the journal Science Advances, sheds light on the process of cell death in both health and disease.

“These findings, by graduate student Nolan Tucker and former graduate student, now MIT faculty colleague, Peter Reddien, have revealed that a protein interaction long thought to block apoptosis in C. elegans likely instead has the opposite effect,” says Horvitz, who is also an investigator at the Howard Hughes Medical Institute and the McGovern Institute. Horvitz shared the 2002 Nobel Prize in Physiology or Medicine for discovering and characterizing the genes controlling cell death in C. elegans.

Mechanisms of cell death

Horvitz, Tucker, Reddien, and colleagues have provided foundational insights in the field of apoptosis by using C. elegans to analyze the mechanisms that drive apoptosis, as well as the mechanisms that determine how cells ensure apoptosis happens when and where it should. Unlike humans and other mammals, which depend on dozens of proteins to control apoptosis, these worms use just a few. And when things go awry, it’s easy to tell: When there’s not enough apoptosis, researchers can see that there are too many cells inside the worms’ translucent bodies. And when there’s too much, the worms lack certain biological functions or, in more extreme cases, can’t reproduce or die during embryonic development.

Work in the Horvitz lab defined the roles of many of the genes and proteins that control apoptosis in worms. These regulators proved to have counterparts in human cells, and for that reason studies of worms have helped reveal how human cells govern cell death and pointed toward potential targets for treating disease.

A protein’s dual role

Three of C. elegans’ primary regulators of apoptosis actively promote cell death, whereas just one, CED-9, reins in the apoptosis-promoting proteins to keep cells alive. As early as the 1990s, however, Horvitz and colleagues recognized that CED-9 was not exclusively a protector of cells. Their experiments indicated that the protector protein also plays a role in promoting cell death. But while researchers thought they knew how CED-9 protected against apoptosis, its pro-apoptotic role was more puzzling.

CED-9’s dual role means that mutations in the gene that encode it can impact apoptosis in multiple ways. Most ced-9 mutations interfere with the protein’s ability to protect against cell death and result in excess cell death. Conversely, mutations that abnormally activate ced-9 cause too little cell death, just like mutations that inactivate any of the three killer genes.

An atypical ced-9 mutation, identified by Reddien when he was a PhD student in Horvitz’s lab, hinted at how CED-9 promotes cell death. That mutation altered the part of the CED-9 protein that interacts with the protein CED-4, which is proapoptotic. Since the mutation specifically leads to a reduction in apoptosis, this suggested that CED-9 might need to interact with CED-4 to promote cell death.

The idea was particularly intriguing because researchers had long thought that CED-9’s interaction with CED-4 had exactly the opposite effect: In the canonical model, CED-9 anchors CED-4 to cells’ mitochondria, sequestering the CED-4 killer protein and preventing it from associating with and activating another key killer, the CED-3 protein — thereby preventing apoptosis.

To test the hypothesis that CED-9’s interactions with the killer CED-4 protein enhance apoptosis, the team needed more evidence. So graduate student Nolan Tucker used CRISPR gene editing tools to create more worms with mutations in CED-9, each one targeting a different spot in the CED-4-binding region. Then he examined the worms. “What I saw with this particular class of mutations was extra cells and viability,” he says — clear signs that the altered CED-9 was still protecting against cell death, but could no longer promote it. “Those observations strongly supported the hypothesis that the ability to bind CED-4 is needed for the pro-apoptotic function of CED-9,” Tucker explains. Their observations also suggested that, contrary to earlier thinking, CED-9 doesn’t need to bind with CED-4 to protect against apoptosis.

When he looked inside the cells of the mutant worms, Tucker found additional evidence that these mutations prevented CED-9’s ability to interact with CED-4. When both CED-9 and CED-4 are intact, CED-4 appears associated with cells’ mitochondria. But in the presence of these mutations, CED-4 was instead at the edge of the cell nucleus. CED-9’s ability to bind CED-4 to mitochondria appeared to be necessary to promote apoptosis, not to protect against it.

Looking ahead

While the team’s findings begin to explain a long-unanswered question about one of the primary regulators of apoptosis, they raise new ones, as well. “I think that this main pathway of apoptosis has been seen by a lot of people as more-or-less settled science. Our findings should change that view,” Tucker says.

The researchers see important parallels between their findings from this study of worms and what’s known about cell death pathways in mammals. The mammalian counterpart to CED-9 is a protein called BCL-2, mutations in which can lead to cancer.  BCL-2, like CED-9, can both promote and protect against apoptosis. As with CED-9, the pro-apoptotic function of BCL-2 has been mysterious. In mammals, too, mitochondria play a key role in activating apoptosis. The Horvitz lab’s discovery opens opportunities to better understand how apoptosis is regulated not only in worms but also in humans, and how dysregulation of apoptosis in humans can lead to such disorders as cancer, autoimmune disease, and neurodegeneration.

© Image: Robert Horvitz

The nematode worm Caenorhabditis elegans has provided answers to many fundamental questions in biology.

MIT physicists predict exotic form of matter with potential for quantum computing

MIT physicists have shown that it should be possible to create an exotic form of matter that could be manipulated to form the qubit (quantum bit) building blocks of future quantum computers that are even more powerful than the quantum computers in development today.

The work builds on a discovery last year of materials that host electrons that can split into fractions of themselves but, importantly, can do so without the application of a magnetic field. 

The general phenomenon of electron fractionalization was first discovered in 1982 and resulted in a Nobel Prize. That work, however, required the application of a magnetic field. The ability to create the fractionalized electrons without a magnetic field opens new possibilities for basic research and makes the materials hosting them more useful for applications.

When electrons split into fractions of themselves, those fractions are known as anyons. Anyons come in variety of flavors, or classes. The anyons discovered in the 2023 materials are known as Abelian anyons. Now, in a paper reported in the Oct. 17 issue of Physical Review Letters, the MIT team notes that it should be possible to create the most exotic class of anyons, non-Abelian anyons.

“Non-Abelian anyons have the bewildering capacity of ‘remembering’ their spacetime trajectories; this memory effect can be useful for quantum computing,” says Liang Fu, a professor in MIT’s Department of Physics and leader of the work. 

Fu further notes that “the 2023 experiments on electron fractionalization greatly exceeded theoretical expectations. My takeaway is that we theorists should be bolder.”

Fu is also affiliated with the MIT Materials Research Laboratory. His colleagues on the current work are graduate students Aidan P. Reddy and Nisarga Paul, and postdoc Ahmed Abouelkomsan, all of the MIT Department of Phsyics. Reddy and Paul are co-first authors of the Physical Review Letters paper.

The MIT work and two related studies were also featured in an Oct. 17 story in Physics Magazine. “If this prediction is confirmed experimentally, it could lead to more reliable quantum computers that can execute a wider range of tasks … Theorists have already devised ways to harness non-Abelian states as workable qubits and manipulate the excitations of these states to enable robust quantum computation,” writes Ryan Wilkinson.

The current work was guided by recent advances in 2D materials, or those consisting of only one or a few layers of atoms. “The whole world of two-dimensional materials is very interesting because you can stack them and twist them, and sort of play Legos with them to get all sorts of cool sandwich structures with unusual properties,” says Paul. Those sandwich structures, in turn, are called moiré materials.

Anyons can only form in two-dimensional materials. Could they form in moiré materials? The 2023 experiments were the first to show that they can. Soon afterwards, a group led by Long Ju, an MIT assistant professor of physics, reported evidence of anyons in another moiré material. (Fu and Reddy were also involved in the Ju work.)

In the current work, the physicists showed that it should be possible to create non-Abelian anyons in a moiré material composed of atomically thin layers of molybdenum ditelluride. Says Paul, “moiré materials have already revealed fascinating phases of matter in recent years, and our work shows that non-Abelian phases could be added to the list.”

Adds Reddy, “our work shows that when electrons are added at a density of 3/2 or 5/2 per unit cell, they can organize into an intriguing quantum state that hosts non-Abelian anyons.”

The work was exciting, says Reddy, in part because “oftentimes there’s subtlety in interpreting your results and what they are actually telling you. So it was fun to think through our arguments” in support of non-Abelian anyons.

Says Paul, “this project ranged from really concrete numerical calculations to pretty abstract theory and connected the two. I learned a lot from my collaborators about some very interesting topics.”

This work was supported by the U.S. Air Force Office of Scientific Research. The authors also acknowledge the MIT SuperCloud and Lincoln Laboratory Supercomputing Center, the Kavli Institute for Theoretical Physics, the Knut and Alice Wallenberg Foundation, and the Simons Foundation.

© Image courtesy of the Fu Lab.

This illustration represents an emergent magnetic field felt by electrons in atomically thin layers of molybdenum ditelluride in the absence of an external magnetic field. White circles represent fractionally charged non-Abelian anyons exchanging positions. This phenomenon could be exploited to create quantum bits, the building blocks of future quantum computers.

MIT physicists predict exotic form of matter with potential for quantum computing

MIT physicists have shown that it should be possible to create an exotic form of matter that could be manipulated to form the qubit (quantum bit) building blocks of future quantum computers that are even more powerful than the quantum computers in development today.

The work builds on a discovery last year of materials that host electrons that can split into fractions of themselves but, importantly, can do so without the application of a magnetic field. 

The general phenomenon of electron fractionalization was first discovered in 1982 and resulted in a Nobel Prize. That work, however, required the application of a magnetic field. The ability to create the fractionalized electrons without a magnetic field opens new possibilities for basic research and makes the materials hosting them more useful for applications.

When electrons split into fractions of themselves, those fractions are known as anyons. Anyons come in variety of flavors, or classes. The anyons discovered in the 2023 materials are known as Abelian anyons. Now, in a paper reported in the Oct. 17 issue of Physical Review Letters, the MIT team notes that it should be possible to create the most exotic class of anyons, non-Abelian anyons.

“Non-Abelian anyons have the bewildering capacity of ‘remembering’ their spacetime trajectories; this memory effect can be useful for quantum computing,” says Liang Fu, a professor in MIT’s Department of Physics and leader of the work. 

Fu further notes that “the 2023 experiments on electron fractionalization greatly exceeded theoretical expectations. My takeaway is that we theorists should be bolder.”

Fu is also affiliated with the MIT Materials Research Laboratory. His colleagues on the current work are graduate students Aidan P. Reddy and Nisarga Paul, and postdoc Ahmed Abouelkomsan, all of the MIT Department of Phsyics. Reddy and Paul are co-first authors of the Physical Review Letters paper.

The MIT work and two related studies were also featured in an Oct. 17 story in Physics Magazine. “If this prediction is confirmed experimentally, it could lead to more reliable quantum computers that can execute a wider range of tasks … Theorists have already devised ways to harness non-Abelian states as workable qubits and manipulate the excitations of these states to enable robust quantum computation,” writes Ryan Wilkinson.

The current work was guided by recent advances in 2D materials, or those consisting of only one or a few layers of atoms. “The whole world of two-dimensional materials is very interesting because you can stack them and twist them, and sort of play Legos with them to get all sorts of cool sandwich structures with unusual properties,” says Paul. Those sandwich structures, in turn, are called moiré materials.

Anyons can only form in two-dimensional materials. Could they form in moiré materials? The 2023 experiments were the first to show that they can. Soon afterwards, a group led by Long Ju, an MIT assistant professor of physics, reported evidence of anyons in another moiré material. (Fu and Reddy were also involved in the Ju work.)

In the current work, the physicists showed that it should be possible to create non-Abelian anyons in a moiré material composed of atomically thin layers of molybdenum ditelluride. Says Paul, “moiré materials have already revealed fascinating phases of matter in recent years, and our work shows that non-Abelian phases could be added to the list.”

Adds Reddy, “our work shows that when electrons are added at a density of 3/2 or 5/2 per unit cell, they can organize into an intriguing quantum state that hosts non-Abelian anyons.”

The work was exciting, says Reddy, in part because “oftentimes there’s subtlety in interpreting your results and what they are actually telling you. So it was fun to think through our arguments” in support of non-Abelian anyons.

Says Paul, “this project ranged from really concrete numerical calculations to pretty abstract theory and connected the two. I learned a lot from my collaborators about some very interesting topics.”

This work was supported by the U.S. Air Force Office of Scientific Research. The authors also acknowledge the MIT SuperCloud and Lincoln Laboratory Supercomputing Center, the Kavli Institute for Theoretical Physics, the Knut and Alice Wallenberg Foundation, and the Simons Foundation.

© Image courtesy of the Fu Lab.

This illustration represents an emergent magnetic field felt by electrons in atomically thin layers of molybdenum ditelluride in the absence of an external magnetic field. White circles represent fractionally charged non-Abelian anyons exchanging positions. This phenomenon could be exploited to create quantum bits, the building blocks of future quantum computers.
  • ✇Harvard Gazette
  • How humans evolved to be ‘energetically unique’Anne Manning
    Science & Tech How humans evolved to be ‘energetically unique’ Andrew Yegian and Daniel Lieberman.Photo by Dylan Goodman Anne J. Manning  Harvard Staff Writer November 18, 2024 4 min read Metabolic rates outpaced ‘couch potato’ primates thanks to sweat, says new study Humans, it turns out, possess much higher metabolic rates than other mammals, including our close relatives, apes and
     

How humans evolved to be ‘energetically unique’

November 18th 2024 at 11:30 pm
Science & Tech

How humans evolved to be ‘energetically unique’

Andrew Yegian and Daniel Lieberman.

Andrew Yegian and Daniel Lieberman.

Photo by Dylan Goodman

Anne J. Manning 

Harvard Staff Writer

4 min read

Metabolic rates outpaced ‘couch potato’ primates thanks to sweat, says new study

Humans, it turns out, possess much higher metabolic rates than other mammals, including our close relatives, apes and chimpanzees, finds a new Harvard study. Having both high resting and active metabolism, researchers say, enabled our hunter-gatherer ancestors to get all the food they needed while also growing bigger brains, living longer, and increasing their rates of reproduction.

“Humans are off-the-charts different from any creature that we know of so far in terms of how we use energy,” said study co-author and paleoanthropologist Daniel Lieberman, the Edwin M. Lerner Professor of Biological Sciences in the Department of Human Evolutionary Biology.

The paper, published Monday in Proceedings of the National Academy of Sciences, challenges a previous consensus that human and non-human primates’ metabolic rates are either the same or lower than would be expected for their body size. 

 Comparisons of resting, active, and total metabolic quotients among various species and human populations, as defined by the Harvard researchers’ new method.

Comparisons of resting, active, and total metabolic quotients among various species and human populations, as defined by the Harvard researchers’ new method.

Credit: Andrew Yegian

Using a new comparison method that they say better corrects for body size, environmental temperature, and body fat, the researchers found that humans, unlike most mammals including other primates, have evolved to escape a tradeoff between resting and active metabolic rates. 

Animals take in calories through food and, like a bank account, spend them on expenses mostly divided between two broad metabolic categories: resting and physical activity. In other primates, there is a distinct tradeoff between resting and active metabolic rates, which helps explain why chimpanzees, with their large brains, costly reproductive strategies, and lifespans, and thus high resting metabolisms, are “couch potatoes” who spend much of their day eating, said Lieberman. 

Generally, the energy animals spend on metabolism ends up as heat, which is hard to dissipate in warm environments. Because of this tradeoff, animals such as chimpanzees who spend a great deal of energy on their resting metabolism and also inhabit warm, tropical environments, have to have low activity levels.

“Humans have increased not only our resting metabolisms beyond what even chimpanzees and monkeys have, but — thanks to our unique ability to dump heat by sweating — we’ve also been able to increase our physical activity levels without lowering our resting metabolic rates,” said co-author Andrew Yegian, a senior researcher in Lieberman’s lab.

“The result is that we are an energetically unique species.”

“Humans have increased not only our resting metabolisms beyond what even chimpanzees and monkeys have, but — thanks to our unique ability to dump heat by sweating — we’ve also been able to increase our physical activity levels without lowering our resting metabolic rates.”

Andrew Yegian

The team’s analysis shows that monkeys and apes evolved to invest about 30 to 50 percent more calories in their resting metabolic rates than other mammals of the same size, and that humans have taken this to a further extreme, investing 60 percent more calories than similar-sized mammals.

“We started off questioning if it was possible that humans and other primates could have comparatively low total metabolic rates, which other researchers had proposed,” Yegian said. “We tried to come up with a better way to analyze it using quotients. That’s when we hit the accelerator.” 

The research team — which includes collaborators at Louisiana’s Pennington Biomedical Research Center and the University of Kiel in Germany — plans to further investigate metabolic differences among human populations. For example, subsistence farmers who grow all the food they eat without the help of machines have significantly higher physical activity levels than both hunter-gatherers and people in industrial environments like Americans. However, all human populations, regardless of activity levels, spend similar amounts of energy for their body size on their resting metabolic rates.

“What we’re really interested in is variation among humans in metabolic rates, especially in today’s world of increasing technology and lower levels of physical activity,” said Yegian. “Since we evolved to be active, how does having a desk job change our metabolism in ways that affect health?”

  • ✇Harvard Gazette
  • Seeing schools as ‘laboratories of democracy’Liz Mineo
    Host Meira Levinson (clockwise from top left), Carlton Green, Richard Weissbourd, and Kara Pranikoff.Stephanie Mitchell/Harvard Staff Photographer Nation & World Seeing schools as ‘laboratories of democracy’ Encounters with different perspectives are a key part of the learning experience, panelists say Liz Mineo Harvard Staff Writer November 18, 2024 3 min read An Ed School panel high
     

Seeing schools as ‘laboratories of democracy’

By: Liz Mineo
November 18th 2024 at 11:24 pm
Host Meira Levinson (clockwise from top left), Carlton Green, Richard Weissbourd, and Kara Pranikoff speak during the online session.

Host Meira Levinson (clockwise from top left), Carlton Green, Richard Weissbourd, and Kara Pranikoff.

Stephanie Mitchell/Harvard Staff Photographer

Nation & World

Seeing schools as ‘laboratories of democracy’

Encounters with different perspectives are a key part of the learning experience, panelists say

Liz Mineo

Harvard Staff Writer

3 min read

An Ed School panel highlighted the critical role schools can play in helping students learn to listen to different perspectives and have conversations across divides in a webinar on Thursday.

“Schools are one of the places where people with diverse perspectives are often together,” said Richard Weissbourd, senior lecturer on education. “Other settings are often not diverse, or at least they’re contained or bounded in ways that schools are not … Schools can be laboratories of democracy.”

Led by Meira Levinson, Juliana W. and William Foss Thompson Professor of Education and Society, the panel made the case for schools as ideal settings for lessons in compromise and civil disagreement.

“Schools are socializing agents,” said Carlton Green, an assistant clinical professor and co-director of Intergroup Dialogue Training Center at the University of Maryland. “That is where we learn some of the ethic around how to be in community with other people, especially people who are different from us.”

Educators help students learn interpersonal skills and how to navigate conflict, the panelists noted, fostering their social and emotional development. Although that work has been part of education for decades, the concept of “social-emotional learning” has recently come under attack by some conservative activists — and parents — who insist that teachers should focus strictly on academic learning.

Kara Pranikoff, an education consultant and coach, pushed back on that idea.

“We have this tendency to say that social-emotional learning is one thing, and academic learning is another thing,” said Pranikoff. “But we cannot separate our social-emotional selves from our academic selves. It’s just not possible, even if people report that it is. It’s not part of being a human. They go hand in hand.”

As microcosms of society, schools experience their own versions of national debates over issues such as religion, LGBTQ rights, and immigration, creating third-rail moments for teachers, the panelists said.

“There are things that you can say that are going to trigger a parent,” Weissbourd said. “Without support from your administration, these conversations become very difficult.”

But those conversations are important, said Weissbourd, who directs the Ed School program Making Caring Common, which provides resources for families and educators to help children develop empathy and other emotional capacities.

“It’s important to be able to mend fractures and for people to get along,” said Weissbourd. “But we want to have these conversations because we really believe in principles of human rights, justice, inclusion, and fairness. Part of the work, too, is how do you have conversations in ways that advance those principles?”

Educators should rise to their daily challenges by communicating with parents and building support from school administrators, Green said.

“I’d say to parents, ‘I think you want me to help your child be a good human, right?’ and if you have questions about me helping your child to be a good human in the context of the other little humans, I’m open to that, but that’s what I’m committed to doing,” said Green. “We are educating good humans here.”

  • ✇Harvard Gazette
  • Too much sitting hurts the heartTerry Murphy
    Health Too much sitting hurts the heart Even with exercise, sedentary behavior can increase risk of heart failure by up to 60%, according to study MGB Communications November 18, 2024 4 min read A new study shows that being sedentary increases the risk of the most common types of heart disease, even among those who get enough exercise. Investigators at Mass General Brigham found sedentary behav
     

Too much sitting hurts the heart

November 18th 2024 at 10:25 pm
Health

Too much sitting hurts the heart

Even with exercise, sedentary behavior can increase risk of heart failure by up to 60%, according to study

MGB Communications

4 min read
Businessman sitting at desk and working with clock in background

A new study shows that being sedentary increases the risk of the most common types of heart disease, even among those who get enough exercise.

Investigators at Mass General Brigham found sedentary behavior was associated with higher risks of all four types of heart disease, with a marked 40-60 percent greater risk of heart failure and cardiovascular death when sedentary behavior exceeded 10.6 hours a day. (Sedentary behavior is defined as waking activity with low energy expenditure while sitting, reclining, or lying down and does not include hours spent sleeping at night.)

Researchers also emphasized that meeting guideline levels of moderate-to-vigorous physical activity may be insufficient on its own to reduce cardiovascular risk if one is also sitting too much.

Their results are published in the Journal of the American College of Cardiology.

“Many of us spend the majority of our waking day sitting, and while there’s a lot of research supporting the importance of physical activity, we knew relatively little about the potential consequences of sitting too much beyond a vague awareness that it might be harmful,” said lead author Ezimamaka Ajufo, a cardiology fellow at Brigham and Women’s Hospital.

“Sedentary risk remained even in people who were physically active, which is important because many of us sit a lot and think that if we can get out at the end of the day and do some exercise we can counterbalance it,” Ajufo says. “However, we found it to be more complex than that.”

Ajufo’s team, which included researchers from across MGB, analyzed one week of activity-tracker data from 89,530 individuals from the U.K. Biobank prospective cohort.

They looked at associations between daily time spent sitting and the future risk of four common cardiovascular diseases: atrial fibrillation, heart attacks, heart failure, and death from cardiovascular causes. The team used a machine learning algorithm to classify sedentary behavior.

Many of the negative effects of sedentary behavior persisted even among those individuals who achieved the guideline-recommended more than 150 minutes of moderate-to-vigorous physical activity per week.

For example, although the study found that the risk of atrial fibrillation and heart attacks could be mostly eliminated by engaging in physical activity, the excess risk of heart failure and cardiovascular  death could only be partially offset by physical activity.

“Our data supports the idea that it is always better to sit less and move more to reduce heart disease risk, and that avoiding excessive sitting is especially important for lowering risk of heart failure and cardiovascular death,” said co-senior author Shaan Khurshid,  an electrophysiologist and faculty member in the Telemachus And Irene Demoulas Family Foundation Center for Cardiac Arrythmias at Massachusetts General Hospital.

The research team hopes these findings will help inform future guidelines and public health efforts. They would like future prospective studies to test the efficacy of public health interventions that help people reduce the number of hours they spend being sedentary and see how that affects cardiovascular health.

Next, they plan to extend this research to investigate the impacts of sedentary behavior on a range of other diseases and for longer spans of time.

“Exercise is critical, but avoiding excessive sitting appears separately important,” said co-senior author Patrick Ellinor,  a cardiologist and co-director of the Corrigan Minehan Heart Center at Massachusetts General Hospital. “Our hope is that this work can empower patients and providers by offering another way to leverage movement behaviors to improve cardiovascular health.”

Authorship: Additional Mass General Brigham authors include Timothy W. Churchill, J. Sawalla Guseh, and Krishna G. Aragam. Additional authors include Shinwan Kany and Joel T. Rämö.

Disclosures: Krishna G. Aragam receives sponsored research support from Sarepta Therapeutics and Bayer AG; he also reports a research collaboration with the Novartis Institutes for Biomedical Research. Patrick T. Ellinor receives sponsored research support from Bayer AG, IBM Research, Bristol Myers Squibb, Pfizer and Novo Nordisk; he has also served on advisory boards and/or consulted for Bayer AG.

Researchers were supported by the John S. LaDue Memorial Fellowship in Cardiovascular Medicine or Vascular Biology grant, the Walter Benjamin Fellowship from the Deutsche Forschungsgemeinschaft (521832260), a research fellowship from the Sigrid Jusélius Foundation, the National Institutes of Health (K23HL159262-01A1, 1K08HL153937, RO1HL092577, R01HL157635, and K23HL169839-01), the American Heart Association (19AMFDP34990046, 862032, 18SFRN34230127, 961045, and 2023CDA1050571), the President and Fellows of Harvard College (5KL2TR002542-04), and the European Union (MAESTRIA 965286).

  • ✇MIT News
  • How can electrons split into fractions of themselves?Jennifer Chu | MIT News
    MIT physicists have taken a key step toward solving the puzzle of what leads electrons to split into fractions of themselves. Their solution sheds light on the conditions that give rise to exotic electronic states in graphene and other two-dimensional systems.The new work is an effort to make sense of a discovery that was reported earlier this year by a different group of physicists at MIT, led by Assistant Professor Long Ju. Ju’s team found that electrons appear to exhibit “fractional charge” i
     

How can electrons split into fractions of themselves?

November 18th 2024 at 10:00 pm

MIT physicists have taken a key step toward solving the puzzle of what leads electrons to split into fractions of themselves. Their solution sheds light on the conditions that give rise to exotic electronic states in graphene and other two-dimensional systems.

The new work is an effort to make sense of a discovery that was reported earlier this year by a different group of physicists at MIT, led by Assistant Professor Long Ju. Ju’s team found that electrons appear to exhibit “fractional charge” in pentalayer graphene — a configuration of five graphene layers that are stacked atop a similarly structured sheet of boron nitride.

Ju discovered that when he sent an electric current through the pentalayer structure, the electrons seemed to pass through as fractions of their total charge, even in the absence of a magnetic field. Scientists had already shown that electrons can split into fractions under a very strong magnetic field, in what is known as the fractional quantum Hall effect. Ju’s work was the first to find that this effect was possible in graphene without a magnetic field — which until recently was not expected to exhibit such an effect.

The phenemonon was coined the “fractional quantum anomalous Hall effect,” and theorists have been keen to find an explanation for how fractional charge can emerge from pentalayer graphene.

The new study, led by MIT professor of physics Senthil Todadri, provides a crucial piece of the answer. Through calculations of quantum mechanical interactions, he and his colleagues show that the electrons form a sort of crystal structure, the properties of which are ideal for fractions of electrons to emerge.

“This is a completely new mechanism, meaning in the decades-long history, people have never had a system go toward these kinds of fractional electron phenomena,” Todadri says. “It’s really exciting because it makes possible all kinds of new experiments that previously one could only dream about.”

The team’s study appeared last week in the journal Physical Review Letters. Two other research teams — one from Johns Hopkins University, and the other from Harvard University, the University of California at Berkeley, and Lawrence Berkeley National Laboratory  — have each published similar results in the same issue. The MIT team includes Zhihuan Dong PhD ’24 and former postdoc Adarsh Patri.

“Fractional phenomena”

In 2018, MIT professor of physics Pablo Jarillo-Herrero and his colleagues were the first to observe that new electronic behavior could emerge from stacking and twisting two sheets of graphene. Each layer of graphene is as thin as a single atom and structured in a chicken-wire lattice of hexagonal carbon atoms. By stacking two sheets at a very specific angle to each other, he found that the resulting interference, or moiré pattern, induced unexpected phenomena such as both superconducting and insulating properties in the same material. This “magic-angle graphene,” as it was soon coined, ignited a new field known as twistronics, the study of electronic behavior in twisted, two-dimensional materials.

“Shortly after his experiments, we realized these moiré systems would be ideal platforms in general to find the kinds of conditions that enable these fractional electron phases to emerge,” says Todadri, who collaborated with Jarillo-Herrero on a study that same year to show that, in theory, such twisted systems could exhibit fractional charge without a magnetic field. “We were advocating these as the best systems to look for these kinds of fractional phenomena,” he says.

Then, in September of 2023, Todadri hopped on a Zoom call with Ju, who was familiar with Todari’s theoretical work and had kept in touch with him through Ju’s own experimental work.

“He called me on a Saturday and showed me the data in which he saw these [electron] fractions in pentalayer graphene,” Todadri recalls. “And that was a big surprise because it didn’t play out the way we thought.”

In his 2018 paper, Todadri predicted that fractional charge should emerge from a precursor phase characterized by a particular twisting of the electron wavefunction. Broadly speaking, he theorized that an electron’s quantum properties should have a certain twisting, or degree to which it can be manipulated without changing its inherent structure. This winding, he predicted, should increase with the number of graphene layers added to a given moiré structure.

“For pentalayer graphene, we thought the wavefunction would wind around five times, and that would be a precursor for electron fractions,” Todadri says. “But he did his experiments and discovered that it does wind around, but only once. That then raised this big question: How should we think about whatever we are seeing?”

Extraordinary crystal

In the team’s new study, Todadri went back to work out how electron fractions could emerge from pentalayer graphene if not through the path he initially predicted. The physicists looked through their original hypothesis and realized they may have missed a key ingredient.

“The standard strategy in the field when figuring out what’s happening in any electronic system is to treat electrons as independent actors, and from that, figure out their topology, or winding,” Todadri explains. “But from Long’s experiments, we knew this approximation must be incorrect.”

While in most materials, electrons have plenty of space to repel each other and zing about as independent agents, the particles are much more confined in two-dimensional structures such as pentalayer graphene. In such tight quarters, the team realized that electrons should also be forced to interact, behaving according to their quantum correlations in addition to their natural repulsion. When the physicists added interelectron interactions to their theory, they found it correctly predicted the winding that Ju observed for pentalayer graphene.

Once they had a theoretical prediction that matched with observations, the team could work from this prediction to identify a mechanism by which pentalayer graphene gave rise to fractional charge.

They found that the moiré arrangement of pentalayer graphene, in which each lattice-like layer of carbon atoms is arranged atop the other and on top of the boron-nitride, induces a weak electrical potential. When electrons pass through this potential, they form a sort of crystal, or a periodic formation, that confines the electrons and forces them to interact through their quantum correlations. This electron tug-of-war creates a sort of cloud of possible physical states for each electron, which interacts with every other electron cloud in the crystal, in a wavefunction, or a pattern of quantum correlations, that gives the winding that should set the stage for electrons to split into fractions of themselves.

“This crystal has a whole set of unusual properties that are different from ordinary crystals, and leads to many fascinating questions for future research,” Todadri says. “For the short term, this mechanism provides the theoretical foundation for understanding the observations of fractions of electrons in pentalayer graphene and for predicting other systems with similar physics.”

This work was supported, in part, by the National Science Foundation and the Simons Foundation. 

© Credit: iStock

A cloudy crystal of electrons could explain the puzzling fractional charge recently discovered in pentalayer graphene.

ETH Zurich team takes home a quarter million in biodiversity prize

November 18th 2024 at 4:30 pm
The XPRIZE Rainforest competition acknowledged ETH Zurich-led team for its development and deployment of novel, autonomous technologies that enable near real-time insights about biodiversity.
  • ✇Harvard Gazette
  • 8 Harvard students named Rhodes ScholarsAnne Manning
    Getty Images Campus & Community 8 Harvard students named Rhodes Scholars 5 in U.S. class, most for any institution, joined by 3 international recipients FAS Communications November 17, 2024 4 min read Five Harvard College students are among the 32 U.S. Rhodes Scholars for 2025, the most awarded to any institution this year. Three international students in the College also received Rhodes Schola
     

8 Harvard students named Rhodes Scholars

November 18th 2024 at 2:13 am
Oxford campus.

Getty Images

Campus & Community

8 Harvard students named Rhodes Scholars

5 in U.S. class, most for any institution, joined by 3 international recipients

FAS Communications

4 min read

Five Harvard College students are among the 32 U.S. Rhodes Scholars for 2025, the most awarded to any institution this year. Three international students in the College also received Rhodes Scholarships, bringing Harvard’s total to eight.

The students will attend Oxford University next year to pursue graduate studies in fields ranging from political theory to neuroscience.

Harvard’s 2025 Rhodes Scholars:

Matthew Anzarouth of Quebec, Canada, was awarded a Rhodes Scholarship for Canada. A former competitive debater, Anzarouth won the World Schools Debating Championship with Team Canada in 2020 and 2021, and competed for the Harvard College Debating Union in his first year at the University. During his time at Harvard, where he concentrated in social studies, he served as senior world editor at the Harvard Political Review, co-founded and co-hosted a podcast exploring political and philosophical issues, and coached debate for high school students. Combining his interests in political theory and Canadian politics, Anzarouth is writing his senior thesis on Canadian federalism and multiculturalism. He plans to study political theory at Oxford.

Lena R. Ashooh of Shelburne, Vermont, designed a major in animal studies, with research in philosophy, psychology, biology, political science, and other disciplines. She has worked with land law examiners as an intern at the U.S. Bureau of Land Management and has lobbied legislators as an environmental justice intern at the Center on Race, Poverty, and the Environment, a California nonprofit. Ashooh conducted field research on macaque monkeys in Puerto Rico, plays classical harp, and has created a stop-motion animation film about the ethics of eating animals. She plans to study political theory at Oxford.

Shahmir Aziz of Lahore, Pakistan, was named one of two Rhodes Scholars for Pakistan last month. He has conducted research in drug delivery and bio-nanotechnology. Outside the classroom, he is passionate about diplomacy and global governance, serving as a leader of the Harvard International Relations Council and Harvard’s Model UN Team. Aziz plans to continue researching bio-nanotechnology at Oxford while also studying diplomacy with a focus on global health to better understand how to cultivate cross-border ideas in biotech.

Thomas Barone of Little Falls, New Jersey, is a social studies concentrator focused on intellectual history, political rhetoric, and policy. He has interned at the national politics desk of ABC News and serves as editorial chair of The Harvard Crimson, where he won first place for editorial writing in collegiate journalism in the Society of Professional Journalists’ Mark of Excellence Awards. Barone intends to study history at Oxford and plans to pursue a career in journalism.

Sofia L. Corona of Delray Beach, Florida, is studying applied mathematics and economics. She designed her course of study to develop a multidisciplinary perspective on issues in transportation policy, including infrastructure development, clean energy governance, and community decision-making. She worked on federal transportation oversight cases as a legal intern at the U.S. Department of Transportation; researched community participation and renewable energy implementation at the Allen Lab for Democracy Renovation in Harvard Kennedy School’s Ash Center for Democratic Governance and Innovation; and analyzed alternative vehicle upgrades for car models at BMW. She has climbed Aconcagua, Denali, and Mount Kilimanjaro. At Oxford, Corona plans to pursue economics and focus on development, sustainability, and enterprise.

Aneesh Muppidi of Schenectady, New York, is a concentrator in computer science and neuroscience. He has conducted research at the Computational Robotics Lab and the Computational Cognitive Neuroscience Lab, both at Harvard, and MIT’s Fiete Lab, and has been involved in AI policy discussions for New York State and the federal government. Muppidi served as president of the Harvard Computational Neuroscience Undergraduate Society, co-president of the Hindu Students Association, and president of the Harvard Spikeball Club. At Oxford, he will study advanced computer science and public policy.

Ayush Noori of Bellevue, Washington, is studying computer science and neuroscience. His research uses artificial intelligence to comb large-scale biomedical data for diagnosis and treatment options, and he has developed an AI model that can be deployed to predict treatment outcomes in bipolar disorder, Parkinson’s disease, and neuropathic conditions. He has co-authored more than 20 peer-reviewed papers and was awarded the Barry Goldwater Scholarship for natural sciences. Noori is co-founder and co-president of the Harvard Undergraduate OpenBio Laboratory. At Oxford, he hopes to complete degrees in clinical neurosciences and in physiology, anatomy, and genetics.

Laura Wegner of Walsrode, Germany, was one of two recipients of German Rhodes Scholarships. She studies economics and computer science and founded Mii, a digital healthcare passport that empowers patients to manage and access their health records anywhere in the world. At Oxford, Wegner plans to pursue graduate work focused on digital health care technology.

Read more about this year’s Rhodes Scholars at the Rhodes Trust.

  • ✇Harvard Gazette
  • Summers says Trump’s plans could damage economyChristina Pazzanese
    Lawrence Summers (right) talks with journalist John Ellis at Harvard Kennedy School.Photo by Martha Stewart Nation & World Summers says Trump’s plans could damage economy Professor and former Treasury secretary discusses why Democrats lost election, need for more patriotism Christina Pazzanese Harvard Staff Writer November 15, 2024 5 min read Democrats lost the 2024 election because t
     

Summers says Trump’s plans could damage economy

November 16th 2024 at 1:41 am
Journalist John Ellis and Lawrence Summers.

Lawrence Summers (right) talks with journalist John Ellis at Harvard Kennedy School.

Photo by Martha Stewart

Nation & World

Summers says Trump’s plans could damage economy

Professor and former Treasury secretary discusses why Democrats lost election, need for more patriotism

Christina Pazzanese

Harvard Staff Writer

5 min read

Democrats lost the 2024 election because they paid too much attention to positive macroeconomic trendlines and not enough to Americans’  economic reality, according to economist Larry Summers.

“In too many ways, Democrats have lost sight of the common man and woman in favor of the attitudes and philosophies of the faculty common room,” said Summers during a talk Thursday night on why the Democrats lost the 2024 election and the risks President-elect Donald Trump’s policy plans pose for the U.S. economy.

Many voters moved toward the Republican Party and Trump, who hammered Democrats over inflation, because they felt the GOP understood what they were going through better than Democrats, who strayed from their traditional focus on issues like kitchen-table economics, said Summers, who was Treasury secretary during the Clinton administration and is currently the Charles W. Eliot University Professor and the Frank and Denie Weil Director of the Mossavar-Rahmani Center for Business and Government at the Harvard Kennedy School.

The Federal Reserve also contributed to voters’ anger over inflation, he suggested.

In 2021, when $2.5 trillion in stimulus funding was flooding the economy, the Fed was still anticipating interest rates would stay at 0 percent through summer 2024 and buying back long-term Treasury debt by issuing “what was, in effect, floating-rate short-term debt.” This led to significant losses to the government that some estimate — in market value terms — at $500 billion to $1 trillion, before the Fed finally course-corrected, said Summers, who also served as director of National Economic Council during the Obama administration.

“I think that if there had not been hyper-expansionary policy in 2021, it would have been easier for Democrats to escape blame for whatever inflation took place,” he said.

Summers worries the Fed could err once again during the new administration given current economic conditions, and he warned Trump’s economic policy plans, such as raising or adding new tariffs, could worsen inflation.

“If President Trump does what he said he would do during his campaign, the inflation shock administered to the economy is substantially larger than anything that happened at the beginning of the last administration,” Summers said.

“He’s vowed huge deficit increases through continuation of his tax cuts and new tax cuts; he has trashed the idea of the independence of the central bank; he said that we should want to have a less highly valued currency, which means less valuable money [and] higher prices, and that’s just on the demand side,” he said.

More importantly, “He’s talked about a big tariff on every good that we import, which means higher import prices [and] also means higher prices for everything that competes with imports,” Summers said.

Summers criticized Trump’s promise to implement 60 percent tariffs on all Chinese goods, saying it will not only force American consumers to pay much higher prices, but will further strain U.S.-China relations. The U.S. ought to precisely “calibrate” its trade policies to the nation’s overall strategic objectives, he said.

“At a time when the Chinese economy is struggling, when there are very difficult economic problems, the worst thing we could do would be to make it completely easy for the Chinese government to scapegoat us for their own economic failings. And so, we need to be very careful that we are focused on our own security [and] … not pursue policies that can be interpreted as reflecting a generalized desire to suppress the Chinese economy,” he said, adding “That’s going to require subtle choices about policy and it’s going to require not bluster, but very careful communication.”

In addition, tightening U.S. borders is “clearly something we have to do,” he noted. “But if you’re talking about sending millions of people out of the country who are here now, that’s a prescription for large-scale labor shortages, and we’ve seen in the past what that does to inflation.”

Vice President Kamala Harris made a pitch to voters who “love our country,” a sentiment Summers said he’d like to see the Democratic Party and institutions like Harvard champion.

“I’d frankly like to see it as a value embraced more in our University, where it’s not something we talk about or celebrate or think about,” he said. “There’s plenty that we have done wrong in our history. But there’s something odd about the degree to which the history that is received in our educational system is as negative about our country as it is.”

The University needs to “find a way” to encourage patriotism as a positive principle on campus because the U.S. today faces “real threats” and because it is “an alternative to each subgroup of Americans embracing a particular identity, which leads to a great deal of divisiveness.”

  • ✇ETH News
  • “We need more time to reflect”Noe Lüthi, Corporate Communications
    Rector Günther Dissertori explained on the 169th anniversary of ETH Zurich the fundamental objective he was pursuing with a reform package in teaching. President of ETH Zurich Joël Mesot and Federal Councillor Albert Rösti also spoke to the many guests from politics, business and science. The Head of the Federal Department of the Environment, Transport, Energy and Communications and former ETH graduate gave this year’s ceremonial address.
     

“We need more time to reflect”

November 16th 2024 at 6:30 pm
Rector Günther Dissertori explained on the 169th anniversary of ETH Zurich the fundamental objective he was pursuing with a reform package in teaching. President of ETH Zurich Joël Mesot and Federal Councillor Albert Rösti also spoke to the many guests from politics, business and science. The Head of the Federal Department of the Environment, Transport, Energy and Communications and former ETH graduate gave this year’s ceremonial address.
  • ✇MIT News
  • A launchpad for entrepreneurship in aerospaceMarisa Demers | Department of Aeronautics and Astronautics
    At age 22, aerospace engineer Eric Shaw worked on some of the world’s most powerful airplanes, yet learning to fly even the smallest one was out of reach. Just out of college, he could not afford civilian flight school and spent the next two years saving $12,000 to earn his private pilot’s license. Shaw knew there had to be a better, less expensive way to train pilots.  Now a graduate student at the MIT Sloan School of Management’s Leaders for Global Operations (LGO) program, Shaw joined the MIT
     

A launchpad for entrepreneurship in aerospace

At age 22, aerospace engineer Eric Shaw worked on some of the world’s most powerful airplanes, yet learning to fly even the smallest one was out of reach. Just out of college, he could not afford civilian flight school and spent the next two years saving $12,000 to earn his private pilot’s license. Shaw knew there had to be a better, less expensive way to train pilots.  

Now a graduate student at the MIT Sloan School of Management’s Leaders for Global Operations (LGO) program, Shaw joined the MIT Department of Aeronautics and Astronautics’ (AeroAstro) Certificate in Aerospace Innovation program to turn a years-long rumination into a viable solution. Along with fellow graduate students Gretel Gonzalez and Shaan Jagani, Shaw proposed training aspiring pilots on electric and hybrid planes. This approach reduces flight school expenses by up to 34 percent while shrinking the industry’s carbon footprint.

The trio shared their plan to create the Aeroelectric Flight Academy at the certificate program’s signature Pitchfest event last spring. Equipped with a pitch deck and a business plan, the team impressed the judges, who awarded them the competition’s top prize of $10,000.

What began as a curiosity to test an idea has reshaped Shaw’s view of his industry.

“Aerospace and entrepreneurship initially seemed antithetical to me,” Shaw says. “It’s a hard sector to break into because the capital expenses are huge and a few big dogs have a lot of influence. Earning this certificate and talking face-to-face with folks who have overcome this seemingly impossible gap has filled me with confidence.”

Disruption by design

AeroAstro introduced the Certificate in Aerospace Innovation in 2021 after engaging in a strategic planning process to take full advantage of the research and ideas coming out of the department. The initiative is spearheaded by AeroAstro professors Olivier L. de Weck SM ʼ99, PhD ʼ01 and Zoltán S. Spakovszky SM ʼ99, PhD ʼ00, in partnership with the Martin Trust Center for MIT Entrepreneurship. Its creation recognizes the aerospace industry is at an inflection point. Major advancements in drone, satellite, and other technologies, coupled with an infusion of nongovernmental funding, have made it easier than ever to bring aerospace innovations to the marketplace.

“The landscape has radically shifted,” says Spakovszky, the Institute’s T. Wilson (1953) Professor in Aeronautics. “MIT students are responding to this change because startups are often the quickest path to impact.”

The certificate program has three requirements: coursework in both aerospace engineering and entrepreneurship, a speaker series primarily featuring MIT alumni and faculty, and hands-on entrepreneurship experience. In the latter, participants can enroll in the Trust Center’s StartMIT program and then compete in Pitchfest, which is modeled after the MIT $100K Entrepreneurship Competition. They can also join a summer incubator, such as the Trust Center’s MIT delta v or the Venture Exploration Program, run by the MIT Office of Innovation and the National Science Foundation’s Innovation Corps.

“At the end of the program, students will be able to look at a technical proposal and fairly quickly run some numbers and figure out if this innovation has market viability or if it’s completely utopian,” says de Weck, the Apollo Program Professor of Astronautics and associate department head of AeroAstro.

Since its inception, 46 people from the MIT community have participated and 13 have fulfilled the requirements of the two-year program to earn the certificate. The program’s fourth cohort is underway this fall with its largest enrollment yet, with 21 postdocs, graduate students, and undergraduate seniors across seven courses and programs at MIT.

A unicorn industry

When Eddie Obropta SM ʼ13, SM ʼ15 attended MIT, aerospace entrepreneurship meant working for SpaceX or Blue Origin. Yet he knew more was possible. He gave himself a crash course in entrepreneurship by competing in the MIT $100K Entrepreneurship Competition four times. Each year, his ideas became more refined and battle-tested by potential customers.

In his final entry in the competition, Obropta, along with MIT doctoral student Nikhil Vadhavkar and Forrest Meyen SM ’13 PhD ’17, proposed using drones to maximize crop yields. Their business, Raptor Maps, won. Today, Obropta serves as the co-founder and chief technology officer of Raptor Maps, which builds software to automate the operations and maintenance of solar farms using drones, robots, and artificial intelligence

While Obropta received support from AeroAstro and MIT's existing entrepreneurial ecosystem, the tech leader was excited when de Weck and Spakovszky shared their plans to launch the Certificate in Aerospace Innovation. Obropta currently serves on the program’s advisory board, has been a presenter at the speaker series, and has served as a mentor and judge for Pitchfest.

“While there are a lot of excellent entrepreneurship programs across the Institute, the aerospace industry is its own unique beast,” Obropta says. “Today’s aspiring founders are visionaries looking to build a spacefaring civilization, but they need specialized support in navigating complex multidisciplinary missions and heavy government involvement.”

Entrepreneurs are everywhere, not just at startups

While the certificate program will likely produce success stories like Raptor Maps, that is not the ultimate goal, say de Weck and Spakovszky. Thinking and acting like an entrepreneur — such as understanding market potential, dealing with failure, and building a deep professional network — are characteristics that benefit everyone, no matter their occupation. 

Paul Cheek, executive director of the Trust Center who also teaches a course in the certificate program, agrees.

“At its core, entrepreneurship is a mindset and a skill set; it’s about moving the needle forward for maximum impact,” Cheek says. “A lot of organizations, including large corporations, nonprofits, and the government, can benefit from that type of thinking.”

That form of entrepreneurship resonates with the Aeroelectric Flight Academy team. Although they are meeting with potential investors and looking to scale their business, all three plan to pursue their first passions: Jagani hopes to be an astronaut, Shaw would like to be an executive at one of the “big dog” aerospace companies, and Gonzalez wants to work for the Mexican Space Agency.

Gonzalez, who is on track to earn her certificate in 2025, says she is especially grateful for the people she met through the program.

“I didn’t know an aerospace entrepreneurship community even existed when I began the program,” Gonzalez says. “It’s here and it’s filled with very dedicated and generous people who have shared insights with me that I don’t think I would have learned anywhere else.”

At the Aerospace Innovation Pitchfest event last spring, the Aeroelectric Flight Academy presented a pitch deck and business plan that impressed the judges, earning them the competition's top prize of $10,000.
  • ✇Harvard Gazette
  • What’s ahead for U.S. foreign policy in ‘Trump 2.0’?Christina Pazzanese
    Nation & World What’s ahead for U.S. foreign policy in ‘Trump 2.0’? Peter Baker and Susan Glasser. Photo by Grace DuVal Christina Pazzanese Harvard Staff Writer November 15, 2024 4 min read Peter Baker and Susan Glasser predict push to end Ukraine war on Russia’s terms, instability for NATO President-elect Donald Trump is moving swiftly to announce Cabinet and other appointments for
     

What’s ahead for U.S. foreign policy in ‘Trump 2.0’?

November 15th 2024 at 11:48 pm
Nation & World

What’s ahead for U.S. foreign policy in ‘Trump 2.0’?

Peter Baker and Susan Glasser.

Peter Baker and Susan Glasser.

Photo by Grace DuVal

Christina Pazzanese

Harvard Staff Writer

4 min read

Peter Baker and Susan Glasser predict push to end Ukraine war on Russia’s terms, instability for NATO

President-elect Donald Trump is moving swiftly to announce Cabinet and other appointments for a second term in office, which many observers expect to pick up where he left off in January 2021 on major policy issues like immigration, trade, and foreign relations.

What will be different, say veteran Washington journalists Susan Glasser ’90, and Peter Baker, is the speed at which Trump will move to advance his agenda, with a likely boost from a Republican majority in Congress.

“Trump 2.0 is Trump on steroids,” Baker, senior White House correspondent at The New York Times, told moderator Yevgenia Albats, Ph.D. ’04, a Russian journalist and political scientist. The discussion on Tuesday with Baker and Glasser, a staff writer for The New Yorker, examined what U.S. policy with Russia, China, and the European Union may look like during a second Trump administration.

The pair, who are married, served in Moscow as co-bureau chiefs for The Washington Post from 2001 to 2004, and have written several books together, including “Kremlin Rising: Vladimir Putin’s Russia and the End of Revolution” in 2005 and “The Divider: Trump in the White House 2017-2021” in 2022.

Unlike in 2016, when he ran as a celebrity businessman who wanted to shake up Washington, Trump will return to the White House in January having run on “an explicit campaign of revenge and retribution,” according to Glasser, and intending to take care of what he sees as “unfinished business,” namely to “fundamentally reorient” U.S. foreign policy to his own more isolationist view of the country’s role in the world.

Trump has more experience now in how to use the levers of presidential power. And his loyalist picks for secretaries of state and defense and national security adviser — Sen. Marco Rubio, Army veteran and Fox TV host Pete Hegseth, M.P.P. ’13, and Rep. Mike Waltz — lack deep experience in foreign policy and will likely do little to restrain Trump’s plans, unlike their counterparts in Trump’s first term, they said.

“If you look [at] who’s in the room making decisions right now, there is no dissent,” Baker noted.

The fate of Ukraine is likely to be among the first matters Trump takes up.

The incoming president, who has reportedly engaged in back-channel talks with Putin, made a campaign promise to end the Ukraine war quickly. He is almost certain to cut off U.S. aid to Ukraine and try to broker a deal that will favor Russia, the pair told Albats, editor in chief of The New Times, an independent Russian language news outlet, and a visiting scholar at the Davis Center for Russian and Eurasian Studies at Harvard.

NATO’s fate in a second Trump term is unclear. As the president-elect demonstrated in his first term, “He has no interest and no commitment whatsoever to defend, frankly, anybody, but especially the Eastern European countries,” said Baker.

Even without a formal withdrawal by the U.S., as Trump repeatedly threatened during his first term, NATO is already weaker than it was before Nov. 5, he said.

“If you’re an adversary of NATO, Article 5 [which calls for the nations to defend one another if attacked] is meaningless, because if it’s a conditional thing, depending on the mood of the president of the United States as opposed to a solid commitment, it’s a dead letter,” said Baker.

“He has, just by getting elected, undercut NATO in a way that it has not been undercut” since its beginnings after World War II amid concerns over the rise of the Soviet Union as a nuclear power, he said.

  • ✇Harvard Gazette
  • The very model of a modern major initiativeTerry Murphy
    Arts & Culture The very model of a modern major initiative On the nights they attend A.R.T. performances, Lavine Learning Lab students welcome audiences to the Loeb Drama Center.Photo by Lauren Miller November 15, 2024 5 min read A.R.T. and Lavine Learning Lab aim to create a space for intergenerational dialogue, deepen student engagement with theater Supporting student engagement in live theater as
     

The very model of a modern major initiative

November 15th 2024 at 11:03 pm
Arts & Culture

The very model of a modern major initiative

Lavine Learning Lab students welcome audiences at the Loeb Drama Center on the nights they attend A.R.T. performances.

On the nights they attend A.R.T. performances, Lavine Learning Lab students welcome audiences to the Loeb Drama Center.

Photo by Lauren Miller

5 min read

A.R.T. and Lavine Learning Lab aim to create a space for intergenerational dialogue, deepen student engagement with theater

Supporting student engagement in live theater as it fosters lasting relationships between the two is the idea behind the American Repertory Theater’s Lavine Learning Lab. The new student initiative will, among other exercises, bring participating public high school students to an evening performance of every show in the company’s season.

Rooted in A.R.T.’s core values of inquiry and collaboration, the Lavine Learning Lab uses A.R.T. productions as the foundation for student workshops that bridge the arts, humanities, and social and emotional learning, fostering lasting relationships between the theater and its young audience.

“The theater is where we develop our muscles for inquiry, empathy, and debate,” said Artistic Director Diane Paulus ’88. “The Lavine Learning Lab will be a gymnasium where high school students will come to exercise their humanity so they can become the most impactful citizens and participants in our society.”  

“The lab’s students will diversify A.R.T.’s audience in multiple dimensions, turning our theater into a space for intergenerational dialogue among people with different lived experiences and perspectives.”

Dayron J. Miles, A.R.T. associate artistic director

For each production, students participate in an introductory in-school workshop centered around the production’s “Essential Questions”; a pre-show workshop at A.R.T., held alongside a second Learning Lab school, exploring one of the production’s themes or elements, followed by dinner and a performance; and a post-show, in-school student-led workshop for students to unpack their own perspectives and those of others.  

In addition, two educators from each participating school join a Professional Learning Community in which A.R.T. facilitates ongoing collaborative learning and provides professional development.   

An important aspect of the program is Learning Lab students will attend evening performances of every show in A.R.T.’s season — instead of morning matinees traditionally designated for school groups. Students will sit in groups of two to four, alongside the general evening audience. 

“Romeo and Juliet” actor Alex Ross engages with students. Credit A Priori Photography.

Students at a pre-show workshop with “Romeo and Juliet” actor Alex Ross.

Credit: A Priori Photography

“When we attend a performance, we aren’t impacted only by what we see onstage, but also by our fellow audience members,” said A.R.T. Associate Artistic Director Dayron J. Miles. “The lab’s students will diversify A.R.T.’s audience in multiple dimensions, turning our theater into a space for intergenerational dialogue among people with different lived experiences and perspectives. Empathy is a necessary tool for responsible democratic participation, and that’s what we can cultivate with this model.”   

Evening attendance also builds familiarity with theatergoing and sense of belonging at the theater to cultivate a culture of lifelong theatergoing. To increase accessibility by removing common barriers, A.R.T. provides transportation between the schools and the theater and a pre-show dinner onsite.  

 The Lavine Learning Lab is supported by a $5 million gift from the Crimson Lion / Lavine Family Foundation, which was founded by Bain Capital Chair Jonathan Lavine, M.B.A. ’92,  and Jeannie Lavine ’88, M.B.A. ’92, to support nonprofit organizations focused on leveling the playing field for individuals and families.   

“We’ve been struck by A.R.T.’s commitment to expanding access to theater,” said Jeannie and Jonathan Lavine in a statement. “We are delighted to play a part in engaging Boston’s students and teachers in the essential questions sparked by A.R.T.’s world-class programming and in supporting A.R.T., whose work inspires people all throughout our city and this country.”  

The Learning Lab exemplifies the type of community-centered, accessible programming A.R.T. will offer from its new home, the David E. and Stacey L. Goel Center for Creativity & Performance. Currently under construction at 175 N. Harvard St. in the Allston neighborhood of Boston, the center is expected to be completed in the fall of 2026.  

A.R.T. facilitated a pilot with six public high schools during the 2023-2024 school year to develop the current model.  

“I feel like a lot of my analytical skills have been reinforced and retaught in the Learning Lab, but I’ve also taken the vulnerability that I feel when I’m in the lab and applied it to other parts of my life,” said Malden High School student and pilot and Learning Lab participant Addison McWayne. “This experience has provided me with opportunities to speak up for myself and to share my opinion, which has made me a stronger and more confident person.”   

 “The lab is one of the ways that A.R.T. shares the resources of Harvard University with our community, but the A.R.T. community gains so much, too,” said Kelvin Dinkins Jr., executive director of the A.R.T. “The students bring their anticipation and excitement, which translates into a galvanizing energy on the sidewalk, in our lobbies, and in the theater itself that enhances the experience for everyone. Thanks to this incredible support from the Crimson Lion / Lavine Family Foundation, A.R.T. is positioned to bring our mission into public high schools across Boston for years to come.”    

  “When the Lavine Learning Lab works in Boston, we hope it will be a model for other cities, because A.R.T. has led the way in so many areas, and A.R.T. can help lead the way in providing this kind of access and inspiration to students all over the country,” said the Lavines.   

  

  • ✇MIT News
  • Ensuring a durable transitionLeda Zimmerman | MIT Energy Initiative
    To fend off the worst impacts of climate change, “we have to decarbonize, and do it even faster,” said William H. Green, director of the MIT Energy Initiative (MITEI) and Hoyt C. Hottel Professor, MIT Department of Chemical Engineering, at MITEI’s Annual Research Conference.“But how the heck do we actually achieve this goal when the United States is in the middle of a divisive election campaign, and globally, we’re facing all kinds of geopolitical conflicts, trade protectionism, weather disaster
     

Ensuring a durable transition

November 15th 2024 at 11:40 pm

To fend off the worst impacts of climate change, “we have to decarbonize, and do it even faster,” said William H. Green, director of the MIT Energy Initiative (MITEI) and Hoyt C. Hottel Professor, MIT Department of Chemical Engineering, at MITEI’s Annual Research Conference.

“But how the heck do we actually achieve this goal when the United States is in the middle of a divisive election campaign, and globally, we’re facing all kinds of geopolitical conflicts, trade protectionism, weather disasters, increasing demand from developing countries building a middle class, and data centers in countries like the U.S.?”

Researchers, government officials, and business leaders convened in Cambridge, Massachusetts, Sept. 25-26 to wrestle with this vexing question at the conference that was themed, “A durable energy transition: How to stay on track in the face of increasing demand and unpredictable obstacles.”

“In this room we have a lot of power,” said Green, “if we work together, convey to all of society what we see as real pathways and policies to solve problems, and take collective action.”

The critical role of consensus-building in driving the energy transition arose repeatedly in conference sessions, whether the topic involved developing and adopting new technologies, constructing and siting infrastructure, drafting and passing vital energy policies, or attracting and retaining a skilled workforce.

Resolving conflicts

There is “blowback and a social cost” in transitioning away from fossil fuels, said Stephen Ansolabehere, the Frank G. Thompson Professor of Government at Harvard University, in a panel on the social barriers to decarbonization. “Companies need to engage differently and recognize the rights of communities,” he said.

Nora DeDontney, director of development at Vineyard Offshore, described her company’s two years of outreach and negotiations to bring large cables from ocean-based wind turbines onshore.

“Our motto is, 'community first,'” she said. Her company works to mitigate any impacts towns might feel because of offshore wind infrastructure construction with projects, such as sewer upgrades; provides workforce training to Tribal Nations; and lays out wind turbines in a manner that provides safe and reliable areas for local fisheries.

Elsa A. Olivetti, professor in the Department of Materials Science and Engineering at MIT and the lead of the Decarbonization Mission of MIT’s new Climate Project, discussed the urgent need for rapid scale-up of mineral extraction. “Estimates indicate that to electrify the vehicle fleet by 2050, about six new large copper mines need to come on line each year,” she said. To meet the demand for metals in the United States means pushing into Indigenous lands and environmentally sensitive habitats. “The timeline of permitting is not aligned with the temporal acceleration needed,” she said.

Larry Susskind, the Ford Professor of Urban and Environmental Planning in the MIT Department of Urban Studies and Planning, is trying to resolve such tensions with universities playing the role of mediators. He is creating renewable energy clinics where students train to participate in emerging disputes over siting. “Talk to people before decisions are made, conduct joint fact finding, so that facilities reduce harms and share the benefits,” he said.

Clean energy boom and pressure

A relatively recent and unforeseen increase in demand for energy comes from data centers, which are being built by large technology companies for new offerings, such as artificial intelligence.

“General energy demand was flat for 20 years — and now, boom,” said Sean James, Microsoft’s senior director of data center research. “It caught utilities flatfooted.” With the expansion of AI, the rush to provision data centers with upwards of 35 gigawatts of new (and mainly renewable) power in the near future, intensifies pressure on big companies to balance the concerns of stakeholders across multiple domains. Google is pursuing 24/7 carbon-free energy by 2030, said Devon Swezey, the company’s senior manager for global energy and climate.

“We’re pursuing this by purchasing more and different types of clean energy locally, and accelerating technological innovation such as next-generation geothermal projects,” he said. Pedro Gómez Lopez, strategy and development director, Ferrovial Digital, which designs and constructs data centers, incorporates renewable energy into their projects, which contributes to decarbonization goals and benefits to locales where they are sited. “We can create a new supply of power, taking the heat generated by a data center to residences or industries in neighborhoods through District Heating initiatives,” he said.

The Inflation Reduction Act and other legislation has ramped up employment opportunities in clean energy nationwide, touching every region, including those most tied to fossil fuels. “At the start of 2024 there were about 3.5 million clean energy jobs, with 'red' states showing the fastest growth in clean energy jobs,” said David S. Miller, managing partner at Clean Energy Ventures. “The majority (58 percent) of new jobs in energy are now in clean energy — that transition has happened. And one-in-16 new jobs nationwide were in clean energy, with clean energy jobs growing more than three times faster than job growth economy-wide”

In this rapid expansion, the U.S. Department of Energy (DoE) is prioritizing economically marginalized places, according to Zoe Lipman, lead for good jobs and labor standards in the Office of Energy Jobs at the DoE. “The community benefit process is integrated into our funding,” she said. “We are creating the foundation of a virtuous circle,” encouraging benefits to flow to disadvantaged and energy communities, spurring workforce training partnerships, and promoting well-paid union jobs. “These policies incentivize proactive community and labor engagement, and deliver community benefits, both of which are key to building support for technological change.”

Hydrogen opportunity and challenge

While engagement with stakeholders helps clear the path for implementation of technology and the spread of infrastructure, there remain enormous policy, scientific, and engineering challenges to solve, said multiple conference participants. In a “fireside chat,” Prasanna V. Joshi, vice president of low-carbon-solutions technology at ExxonMobil, and Ernest J. Moniz, professor of physics and special advisor to the president at MIT, discussed efforts to replace natural gas and coal with zero-carbon hydrogen in order to reduce greenhouse gas emissions in such major industries as steel and fertilizer manufacturing.

“We have gone into an era of industrial policy,” said Moniz, citing a new DoE program offering incentives to generate demand for hydrogen — more costly than conventional fossil fuels — in end-use applications. “We are going to have to transition from our current approach, which I would call carrots-and-twigs, to ultimately, carrots-and-sticks,” Moniz warned, in order to create “a self-sustaining, major, scalable, affordable hydrogen economy.”

To achieve net zero emissions by 2050, ExxonMobil intends to use carbon capture and sequestration in natural gas-based hydrogen and ammonia production. Ammonia can also serve as a zero-carbon fuel. Industry is exploring burning ammonia directly in coal-fired power plants to extend the hydrogen value chain. But there are challenges. “How do you burn 100 percent ammonia?”, asked Joshi. “That's one of the key technology breakthroughs that's needed.” Joshi believes that collaboration with MIT’s “ecosystem of breakthrough innovation” will be essential to breaking logjams around the hydrogen and ammonia-based industries.

MIT ingenuity essential

The energy transition is placing very different demands on different regions around the world. Take India, where today per capita power consumption is one of the lowest. But Indians “are an aspirational people … and with increasing urbanization and industrial activity, the growth in power demand is expected to triple by 2050,” said Praveer Sinha, CEO and managing director of the Tata Power Co. Ltd., in his keynote speech. For that nation, which currently relies on coal, the move to clean energy means bringing another 300 gigawatts of zero-carbon capacity online in the next five years. Sinha sees this power coming from wind, solar, and hydro, supplemented by nuclear energy.

“India plans to triple nuclear power generation capacity by 2032, and is focusing on advancing small modular reactors,” said Sinha. “The country also needs the rapid deployment of storage solutions to firm up the intermittent power.” The goal is to provide reliable electricity 24/7 to a population living both in large cities and in geographically remote villages, with the help of long-range transmission lines and local microgrids. “India’s energy transition will require innovative and affordable technology solutions, and there is no better place to go than MIT, where you have the best brains, startups, and technology,” he said.

These assets were on full display at the conference. Among them a cluster of young businesses, including:

  • the MIT spinout Form Energy, which has developed a 100-hour iron battery as a backstop to renewable energy sources in case of multi-day interruptions;
  • startup Noya that aims for direct air capture of atmospheric COusing carbon-based materials;
  • the firm Active Surfaces, with a lightweight material for putting solar photovoltaics in previously inaccessible places;
  • Copernic Catalysts, with new chemistry for making ammonia and sustainable aviation fuel far more inexpensively than current processes; and
  • Sesame Sustainability, a software platform spun out of MITEI that gives industries a full financial analysis of the costs and benefits of decarbonization.

The pipeline of research talent extended into the undergraduate ranks, with a conference “slam” competition showcasing students’ summer research projects in areas from carbon capture using enzymes to 3D design for the coils used in fusion energy confinement.

“MIT students like me are looking to be the next generation of energy leaders, looking for careers where we can apply our engineering skills to tackle exciting climate problems and make a tangible impact,” said Trent Lee, a junior in mechanical engineering researching improvements in lithium-ion energy storage. “We are stoked by the energy transition, because it’s not just the future, but our chance to build it.”

© Photo: Jake Belcher

At the MIT Energy Initiative's 2024 Annual Research Conference, panelists examined the social barriers to decarbonization and the importance of community involvement in decision-making.
  • ✇University of Cambridge
  • Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmaniasc604
    A team of researchers from the UK and Australia analysed charcoal and pollen contained in ancient mud to determine how Aboriginal Tasmanians shaped their surroundings. This is the earliest record of humans using fire to shape the Tasmanian environment. Early human migrations from Africa to the southern part of the globe were well underway during the early part of the last ice age – humans reached northern Australia by around 65,000 years ago. When the first Palawa/Pakana (Tasmanian Indigenous)
     

Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmania

By: sc604
November 15th 2024 at 10:30 pm
Emerald Swamp, Tasmania

A team of researchers from the UK and Australia analysed charcoal and pollen contained in ancient mud to determine how Aboriginal Tasmanians shaped their surroundings. This is the earliest record of humans using fire to shape the Tasmanian environment.

Early human migrations from Africa to the southern part of the globe were well underway during the early part of the last ice age – humans reached northern Australia by around 65,000 years ago. When the first Palawa/Pakana (Tasmanian Indigenous) communities eventually reached Tasmania (known to the Palawa people as Lutruwita), it was the furthest south humans had ever settled.

These early Aboriginal communities used fire to penetrate and modify dense, wet forest for their own use – as indicated by a sudden increase in charcoal accumulated in ancient mud 41,600 years ago.

The researchers say their results, reported in the journal Science Advances, could not only help us understand how humans have been shaping the Earth’s environment for tens of thousands of years, but also help understand the long-term Aboriginal-landscape connection, which is vital for landscape management in Australia today.

Tasmania currently lies about 240 kilometres off the southeast Australian coast, separated from the Australian mainland by the Bass Strait. However, during the last ice age, Australia and Tasmania were connected by a huge land bridge, allowing people to reach Tasmania on foot. The land bridge remained until about 8,000 years ago, after the end of the last ice age, when rising sea levels eventually cut Tasmania off from the Australian mainland.

“Australia is home to the world’s oldest Indigenous culture, which has endured for over 50,000 years,” said Dr Matthew Adeleye from Cambridge’s Department of Geography, the study’s lead author. “Earlier studies have shown that Aboriginal communities on the Australian mainland used fire to shape their habitats, but we haven’t had similarly detailed environmental records for Tasmania.”

The researchers studied ancient mud taken from islands in the Bass Strait, which is part of Tasmania today, but would have been part of the land bridge connecting Australia and Tasmania during the last ice age. Due to low sea levels at the time, Palawa/Pakana communities were able to migrate from the Australian mainland.

Analysis of the ancient mud showed a sudden increase in charcoal around 41,600 years ago, followed by a major change in vegetation about 40,000 years ago, as indicated by different types of pollen in the mud.

“This suggests these early inhabitants were clearing forests by burning them, in order to create open spaces for subsistence and perhaps cultural activities,” said Adeleye. “Fire is an important tool, and it would have been used to promote the type of vegetation or landscape that was important to them.”

The researchers say that humans likely learned to use fire to clear and manage forests during their migration across the glacial landscape of Sahul – a palaeocontinent that encompassed modern-day Australia, Tasmania, New Guinea and eastern Indonesia – as part of the extensive migration out of Africa.

“As natural habitats adapted to these controlled burnings, we see the expansion of fire-adapted species such as Eucalyptus, primarily on the wetter, eastern side of the Bass Strait islands,” said Adeleye.

Burning practices are still practiced today by Aboriginal communities in Australia, including for landscape management and cultural activities. However, using this type of burning, known as cultural burning, for managing severe wildfires in Australia remains contentious. The researchers say understanding this ancient land management practice could help define and restore pre-colonial landscapes.

“These early Tasmanian communities were the island’s first land managers,” said Adeleye. “If we’re going to protect Tasmanian and Australian landscapes for future generations, it’s important that we listen to and learn from Indigenous communities who are calling for a greater role in helping to manage Australian landscapes into the future.”

The research was supported in part by the Australian Research Council.

Reference:
Matthew A. Adeleye et al. ‘Landscape burning facilitated Aboriginal migration into Lutruwita/Tasmania 41,600 years ago.’ Science Advances (2024). DOI: 10.1126/sciadv.adp6579

Some of the first human beings to arrive in Tasmania, over 41,000 years ago, used fire to shape and manage the landscape, about 2,000 years earlier than previously thought.

Emerald Swamp, Tasmania

Creative Commons License.
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes
  • ✇University of Cambridge
  • Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmaniasc604
    A team of researchers from the UK and Australia analysed charcoal and pollen contained in ancient mud to determine how Aboriginal Tasmanians shaped their surroundings. This is the earliest record of humans using fire to shape the Tasmanian environment. Early human migrations from Africa to the southern part of the globe were well underway during the early part of the last ice age – humans reached northern Australia by around 65,000 years ago. When the first Palawa/Pakana (Tasmanian Indigenous)
     

Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmania

By: sc604
November 15th 2024 at 10:30 pm
Emerald Swamp, Tasmania

A team of researchers from the UK and Australia analysed charcoal and pollen contained in ancient mud to determine how Aboriginal Tasmanians shaped their surroundings. This is the earliest record of humans using fire to shape the Tasmanian environment.

Early human migrations from Africa to the southern part of the globe were well underway during the early part of the last ice age – humans reached northern Australia by around 65,000 years ago. When the first Palawa/Pakana (Tasmanian Indigenous) communities eventually reached Tasmania (known to the Palawa people as Lutruwita), it was the furthest south humans had ever settled.

These early Aboriginal communities used fire to penetrate and modify dense, wet forest for their own use – as indicated by a sudden increase in charcoal accumulated in ancient mud 41,600 years ago.

The researchers say their results, reported in the journal Science Advances, could not only help us understand how humans have been shaping the Earth’s environment for tens of thousands of years, but also help understand the long-term Aboriginal-landscape connection, which is vital for landscape management in Australia today.

Tasmania currently lies about 240 kilometres off the southeast Australian coast, separated from the Australian mainland by the Bass Strait. However, during the last ice age, Australia and Tasmania were connected by a huge land bridge, allowing people to reach Tasmania on foot. The land bridge remained until about 8,000 years ago, after the end of the last ice age, when rising sea levels eventually cut Tasmania off from the Australian mainland.

“Australia is home to the world’s oldest Indigenous culture, which has endured for over 50,000 years,” said Dr Matthew Adeleye from Cambridge’s Department of Geography, the study’s lead author. “Earlier studies have shown that Aboriginal communities on the Australian mainland used fire to shape their habitats, but we haven’t had similarly detailed environmental records for Tasmania.”

The researchers studied ancient mud taken from islands in the Bass Strait, which is part of Tasmania today, but would have been part of the land bridge connecting Australia and Tasmania during the last ice age. Due to low sea levels at the time, Palawa/Pakana communities were able to migrate from the Australian mainland.

Analysis of the ancient mud showed a sudden increase in charcoal around 41,600 years ago, followed by a major change in vegetation about 40,000 years ago, as indicated by different types of pollen in the mud.

“This suggests these early inhabitants were clearing forests by burning them, in order to create open spaces for subsistence and perhaps cultural activities,” said Adeleye. “Fire is an important tool, and it would have been used to promote the type of vegetation or landscape that was important to them.”

The researchers say that humans likely learned to use fire to clear and manage forests during their migration across the glacial landscape of Sahul – a palaeocontinent that encompassed modern-day Australia, Tasmania, New Guinea and eastern Indonesia – as part of the extensive migration out of Africa.

“As natural habitats adapted to these controlled burnings, we see the expansion of fire-adapted species such as Eucalyptus, primarily on the wetter, eastern side of the Bass Strait islands,” said Adeleye.

Burning practices are still practiced today by Aboriginal communities in Australia, including for landscape management and cultural activities. However, using this type of burning, known as cultural burning, for managing severe wildfires in Australia remains contentious. The researchers say understanding this ancient land management practice could help define and restore pre-colonial landscapes.

“These early Tasmanian communities were the island’s first land managers,” said Adeleye. “If we’re going to protect Tasmanian and Australian landscapes for future generations, it’s important that we listen to and learn from Indigenous communities who are calling for a greater role in helping to manage Australian landscapes into the future.”

The research was supported in part by the Australian Research Council.

Reference:
Matthew A Adeleye et al. ‘Landscape burning facilitated Aboriginal migration into Lutruwita/Tasmania 41,600 years ago.’ Science Advances (2024). DOI: 10.1126/sciadv.adp6579

Some of the first human beings to arrive in Tasmania, over 41,000 years ago, used fire to shape and manage the landscape, about 2,000 years earlier than previously thought.

Emerald Swamp, Tasmania

Creative Commons License.
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

New long-term collaboration with Suzano begins with a £10 million donation to support conservation and sustainability education and research

By: plc32
November 15th 2024 at 7:35 pm
Image of a forest

An initial £10 million donation will be used to support education and research into areas including the conservation of biodiversity, enhancing business sustainability, and the restoration of natural habitats in Brazil and beyond. The agreement will establish the Suzano Scholars Fund, a perpetual endowment at Jesus College to fund Brazilian nationals studying for a postgraduate degree at the University of Cambridge connected to the environment, ecology and conservation, educating the next generation of sustainability experts and leaders. Funding will also be provided to academics based at the Conservation Research Institute to undertake research projects exploring the interaction between human and natural systems in areas such as biodiversity, climate change, water resource management, and ecosystem restoration. Read more about this new initiative here

Suzano, one the world’s largest producers of bio-based raw materials, based in São Paulo, Brazil, establishes a long-term initiative with Jesus College and the University of Cambridge. 

This visionary initiative will help to build strong links between the University of Cambridge and Brazil
Professor Bhaskar Vira
Green forests stretch out to the horizon

Creative Commons License.
The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes
  • ✇University of Cambridge
  • Presidents' Challenge marks start of 2025 Boat Race seasonhcf38
    This year’s Challenge, held at the iconic Somerset House in London, saw the Oxford and Cambridge University Boat Clubs come together in celebration of one of British sport’s most enduring rivalries. The event traditionally sees the Presidents representing the losing teams of the previous year’s races formally challenge those from the winning teams, marking the renewal of an intense competition which stretches back nearly 200 years. Those in attendance gathered with anticipation to witness Oxfor
     

Presidents' Challenge marks start of 2025 Boat Race season

By: hcf38
November 15th 2024 at 3:33 pm
Oxford Presidents Tom Mackintosh and Annie Anezakis challenge Cambridge Presidents Luca Ferraro and Lucy Havard

This year’s Challenge, held at the iconic Somerset House in London, saw the Oxford and Cambridge University Boat Clubs come together in celebration of one of British sport’s most enduring rivalries. The event traditionally sees the Presidents representing the losing teams of the previous year’s races formally challenge those from the winning teams, marking the renewal of an intense competition which stretches back nearly 200 years.

Those in attendance gathered with anticipation to witness Oxford Presidents Tom Mackintosh and Annie Anezakis challenge Cambridge Presidents Luca Ferraro and Lucy Havard. The pairs faced off before shaking hands on stage in front of the coveted men’s and women’s trophies.

The Umpires were confirmed as Sarah Winckless MBE and Sir Matthew Pinsent, for the Men’s and Women’s races respectively. Winckless becomes the first woman to umpire the Men’s Race on The Championship Course.

The Boat Race will take place on Sunday 13 April, with The 79th Women’s Boat Race to be followed shortly after by The 170th Men’s Boat Race. Two hundred thousand spectators are expected to line the banks of the River Thames to watch the event - which is free to attend and broadcast live on the BBC - while millions more are expected to watch globally.

The Boat Race is made up of six races and in 2024, Cambridge won five. The make-up of the squads will be more diverse than ever in 2025, with 157 student rowers spanning 18 different nationalities from countries such as Nigeria, Sweden, Australia, New Zealand, Switzerland, Germany, Italy, France, Sri Lanka and China. Oxford’s Luisa Fernandez Chirino, should she be selected to face Cambridge, would be the first Mexican woman to compete at The Boat Race.

There will also be six Olympians within the squads. For Cambridge, this includes two-time Olympian Claire Collins, alongside reserve athlete for the 2024 British Olympic team, James Robson. For Oxford, this includes Paris men’s eight bronze medallist Nick Rusher, Paris women’s eight bronze medallist Heidi Long, Tokyo men’s eight gold medallist Tom Mackintosh, as well as Paris Olympian Nicholas Kohl. Meanwhile, Harry Brightmore, Paris gold medallist in the men’s eight, has joined Oxford as an assistant coach.

Asked by host, Olympic champion and four-time Boat Race winner Constantine Louloudis MBE, if this year's race would be "rinse and repeat" for Cambridge, Women's President, Lucy Havard, who is pursuing a PhD in Early Modern History at Gonville & Caius College, said: "Absolutely not - it's never the same, every year it's new people and Boat Race wins don't come easily. Everyone is gunning for it, everyone is putting so much time and effort in."

Luca Ferraro, who is taking an MPhil in History of Art and Architecture at Peterhouse, was asked about how it felt to take on the responsibility of Men's President. "I would be lying if I didn't say it didn't add a certain extra layer... racing an opponent you don't really get to meet at full strength until next year," he said. "You have the odd moment of thinking are we doing the right things, are we going fast enough and no-one feels that quite as keenly as the President, but we are surrounded by such a great team and it is so rewarding to have that extra level of responsibility."

First raced by crews from Oxford and Cambridge University in 1829, The Boat Race is now one of the world’s oldest and most famous amateur sporting events, offering an unrivalled educational experience to the student athletes who take part. The famous Championship Course stretches over 4.25 miles of tidal Thames in West London between Putney and Mortlake.

 

The countdown to the 2025 Boat Race is officially underway, with the annual Presidents’ Challenge ushering in another season of competition between the universities of Oxford and Cambridge.

Oxford Presidents Tom Mackintosh and Annie Anezakis challenge Cambridge Presidents Luca Ferraro and Lucy Havard

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J-PAL North America announces new evaluation incubator collaborators from state and local governments

November 15th 2024 at 5:30 pm

J-PAL North America recently selected government partners for the 2024-25 Leveraging Evaluation and Evidence for Equitable Recovery (LEVER) Evaluation Incubator cohort. Selected collaborators will receive funding and technical assistance to develop or launch a randomized evaluation for one of their programs. These collaborations represent jurisdictions across the United States and demonstrate the growing enthusiasm for evidence-based policymaking.

Launched in 2023, LEVER is a joint venture between J-PAL North America and Results for America. Through the Evaluation Incubator, trainings, and other program offerings, LEVER seeks to address the barriers many state and local governments face around finding and generating evidence to inform program design. LEVER offers government leaders the opportunity to learn best practices for policy evaluations and how to integrate evidence into decision-making. Since the program’s inception, more than 80 government jurisdictions have participated in LEVER offerings.

J-PAL North America’s Evaluation Incubator helps collaborators turn policy-relevant research questions into well-designed randomized evaluations, generating rigorous evidence to inform pressing programmatic and policy decisions. The program also aims to build a culture of evidence use and give government partners the tools to continue generating and utilizing evidence in their day-to-day operations.

In addition to funding and technical assistance, the selected state and local government collaborators will be connected with researchers from J-PAL’s network to help advance their evaluation ideas. Evaluation support will also be centered on community-engaged research practices, which emphasize collaborating with and learning from the groups most affected by the program being evaluated.

Evaluation Incubator selected projects

Pierce County Human Services (PCHS) in the state of Washington will evaluate two programs as part of the Evaluation Incubator. The first will examine how extending stays in a fentanyl detox program affects the successful completion of inpatient treatment and hospital utilization for individuals. “PCHS is interested in evaluating longer fentanyl detox stays to inform our funding decisions, streamline our resource utilization, and encourage additional financial commitments to address the unmet needs of individuals dealing with opioid use disorder,” says Trish Crocker, grant coordinator.

The second PCHS program will evaluate the impact of providing medication and outreach services via a mobile distribution unit to individuals with opioid use disorders on program take-up and substance usage. Margo Burnison, a behavioral health manager with PCHS, says that the team is “thrilled to be partnering with J-PAL North America to dive deep into the data to inform our elected leaders on the best way to utilize available resources.”

The City of Los Angeles Youth Development Department (YDD) seeks to evaluate a research-informed program: Student Engagement, Exploration, and Development in STEM (SEEDS). This intergenerational STEM mentorship program supports underrepresented middle school and college students in STEM by providing culturally responsive mentorship. The program seeks to foster these students’ STEM identity and degree attainment in higher education. YDD has been working with researchers at the University of Southern California to measure the SEEDS program’s impact, but is interested in developing a randomized evaluation to generate further evidence. Darnell Cole, professor and co-director of the Research Center for Education, Identity and Social Justice, shares his excitement about the collaboration with J-PAL: “We welcome the opportunity to measure the impact of the SEEDS program on our students’ educational experience. Rigorously testing the SEEDS program will help us improve support for STEM students, ultimately enhancing their persistence and success.”

The Fort Wayne Police Department’s Hope and Recovery Team in Indiana will evaluate the impact of two programs that connect social workers with people who have experienced an overdose, or who have a mental health illness, to treatment and resources. “We believe we are on the right track in the work we are doing with the crisis intervention social worker and the recovery coach, but having an outside evaluation of both programs would be extremely helpful in understanding whether and what aspects of these programs are most effective,” says Police Captain Kevin Hunter.

The County of San Diego’s Office of Evaluation, Performance and Analytics, and Planning & Development Services will engage with J-PAL staff to explore evaluation opportunities for two programs that are a part of the county’s Climate Action Plan. The Equity-Driven Tree Planting Program seeks to increase tree canopy coverage, and the Climate Smart Land Stewardship Program will encourage climate-smart agricultural practices. Ricardo Basurto-Davila, chief evaluation officer, says that “the county is dedicated to evidence-based policymaking and taking decisive action against climate change. The work with J-PAL will support us in combining these commitments to maximize the effectiveness in decreasing emissions through these programs.”

J-PAL North America looks forward to working with the selected collaborators in the coming months to learn more about these promising programs, clarify our partner’s evidence goals, and design randomized evaluations to measure their impact.

© Photo: Shutterstock

Fort Wayne, Indiana, is one of J-PAL North America’s LEVER Evaluation Incubator collaborators. With support from J-PAL staff, Fort Wayne is designing evaluations of two programs that connect social workers with people who have experienced an overdose or have a mental health illness to treatment and resources.

J-PAL North America announces new evaluation incubator collaborators from state and local governments

November 15th 2024 at 5:30 pm

J-PAL North America recently selected government partners for the 2024-25 Leveraging Evaluation and Evidence for Equitable Recovery (LEVER) Evaluation Incubator cohort. Selected collaborators will receive funding and technical assistance to develop or launch a randomized evaluation for one of their programs. These collaborations represent jurisdictions across the United States and demonstrate the growing enthusiasm for evidence-based policymaking.

Launched in 2023, LEVER is a joint venture between J-PAL North America and Results for America. Through the Evaluation Incubator, trainings, and other program offerings, LEVER seeks to address the barriers many state and local governments face around finding and generating evidence to inform program design. LEVER offers government leaders the opportunity to learn best practices for policy evaluations and how to integrate evidence into decision-making. Since the program’s inception, more than 80 government jurisdictions have participated in LEVER offerings.

J-PAL North America’s Evaluation Incubator helps collaborators turn policy-relevant research questions into well-designed randomized evaluations, generating rigorous evidence to inform pressing programmatic and policy decisions. The program also aims to build a culture of evidence use and give government partners the tools to continue generating and utilizing evidence in their day-to-day operations.

In addition to funding and technical assistance, the selected state and local government collaborators will be connected with researchers from J-PAL’s network to help advance their evaluation ideas. Evaluation support will also be centered on community-engaged research practices, which emphasize collaborating with and learning from the groups most affected by the program being evaluated.

Evaluation Incubator selected projects

Pierce County Human Services (PCHS) in the state of Washington will evaluate two programs as part of the Evaluation Incubator. The first will examine how extending stays in a fentanyl detox program affects the successful completion of inpatient treatment and hospital utilization for individuals. “PCHS is interested in evaluating longer fentanyl detox stays to inform our funding decisions, streamline our resource utilization, and encourage additional financial commitments to address the unmet needs of individuals dealing with opioid use disorder,” says Trish Crocker, grant coordinator.

The second PCHS program will evaluate the impact of providing medication and outreach services via a mobile distribution unit to individuals with opioid use disorders on program take-up and substance usage. Margo Burnison, a behavioral health manager with PCHS, says that the team is “thrilled to be partnering with J-PAL North America to dive deep into the data to inform our elected leaders on the best way to utilize available resources.”

The City of Los Angeles Youth Development Department (YDD) seeks to evaluate a research-informed program: Student Engagement, Exploration, and Development in STEM (SEEDS). This intergenerational STEM mentorship program supports underrepresented middle school and college students in STEM by providing culturally responsive mentorship. The program seeks to foster these students’ STEM identity and degree attainment in higher education. YDD has been working with researchers at the University of Southern California to measure the SEEDS program’s impact, but is interested in developing a randomized evaluation to generate further evidence. Darnell Cole, professor and co-director of the Research Center for Education, Identity and Social Justice, shares his excitement about the collaboration with J-PAL: “We welcome the opportunity to measure the impact of the SEEDS program on our students’ educational experience. Rigorously testing the SEEDS program will help us improve support for STEM students, ultimately enhancing their persistence and success.”

The Fort Wayne Police Department’s Hope and Recovery Team in Indiana will evaluate the impact of two programs that connect social workers with people who have experienced an overdose, or who have a mental health illness, to treatment and resources. “We believe we are on the right track in the work we are doing with the crisis intervention social worker and the recovery coach, but having an outside evaluation of both programs would be extremely helpful in understanding whether and what aspects of these programs are most effective,” says Police Captain Kevin Hunter.

The County of San Diego’s Office of Evaluation, Performance and Analytics, and Planning & Development Services will engage with J-PAL staff to explore evaluation opportunities for two programs that are a part of the county’s Climate Action Plan. The Equity-Driven Tree Planting Program seeks to increase tree canopy coverage, and the Climate Smart Land Stewardship Program will encourage climate-smart agricultural practices. Ricardo Basurto-Davila, chief evaluation officer, says that “the county is dedicated to evidence-based policymaking and taking decisive action against climate change. The work with J-PAL will support us in combining these commitments to maximize the effectiveness in decreasing emissions through these programs.”

J-PAL North America looks forward to working with the selected collaborators in the coming months to learn more about these promising programs, clarify our partner’s evidence goals, and design randomized evaluations to measure their impact.

© Photo: Shutterstock

Fort Wayne, Indiana, is one of J-PAL North America’s LEVER Evaluation Incubator collaborators. With support from J-PAL staff, Fort Wayne is designing evaluations of two programs that connect social workers with people who have experienced an overdose or have a mental health illness to treatment and resources.
  • ✇MIT News
  • Linzixuan (Rhoda) Zhang wins 2024 Collegiate Inventors CompetitionNina Tamburello | Koch Institute
    Linzixuan (Rhoda) Zhang, a doctoral candidate in the MIT Department of Chemical Engineering, recently won the 2024 Collegiate Inventors Competition, medaling in both the Graduate and People’s Choice categories for developing materials to stabilize nutrients in food with the goal of improving global health.  The annual competition, organized by the National Inventors Hall of Fame and United States Patent and Trademark Office (USPTO), celebrates college and university student inventors. The finali
     

Linzixuan (Rhoda) Zhang wins 2024 Collegiate Inventors Competition

November 15th 2024 at 1:00 am

Linzixuan (Rhoda) Zhang, a doctoral candidate in the MIT Department of Chemical Engineering, recently won the 2024 Collegiate Inventors Competition, medaling in both the Graduate and People’s Choice categories for developing materials to stabilize nutrients in food with the goal of improving global health.  

The annual competition, organized by the National Inventors Hall of Fame and United States Patent and Trademark Office (USPTO), celebrates college and university student inventors. The finalists present their inventions to a panel of final-round judges composed of National Inventors Hall of Fame inductees and USPTO officials. 

No stranger to having her work in the limelight, Zhang is a three-time winner of the Koch Institute Image Awards in 2022, 2023, and 2024, as well as a 2022 fellow at the MIT Abdul Latif Jameel Water and Food Systems Lab.  

"Rhoda is an exceptionally dedicated and creative student. Her well-deserved award recognizes the potential of her research on nutrient stabilization, which could have a significant impact on society," says Ana Jaklenec, one of Zhang’s advisors and a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. Zhang is also advised by David H. Koch (1962) Institute Professor Robert Langer. 

Frameworks for global health

In a world where nearly 2 billion people suffer from micronutrient deficiencies, particularly iron, the urgency for effective solutions has never been greater. Iron deficiency is especially harmful for vulnerable populations such as children and pregnant women, since it can lead to weakened immune systems and developmental delays. 

The World Health Organization has highlighted food fortification as a cost-effective strategy, yet many current methods fall short. Iron and other nutrients can break down during processing or cooking, and synthetic additives often come with high costs and environmental drawbacks. 

Zhang, along with her teammate, Xin Yang, a postdoc associate at Koch Institute, set out to innovate new technologies for nutrient fortification that are effective, accessible, and sustainable, leading to the invention nutritional metal-organic frameworks (NuMOFs) and the subsequent launch of MOFe Coffee, the world’s first iron-fortified coffee. NuMOFs not only protect essential nutrients such as iron while in food for long periods of time, but also make them more easily absorbed and used once consumed.

The inspiration for the coffee came from the success of iodized salt, which significantly reduced iodine deficiency worldwide. Because coffee and tea are associated with low iron absorption, iron fortification would directly address the challenge.

However, replicating the success of iodized salt for iron fortification has been extremely challenging due to the micronutrient’s high reactivity and the instability of iron(II) salts. As researchers with backgrounds in material science, chemistry, and food technology, Zhang and Yang leveraged their expertise to develop a solution that could overcome these technical barriers. 

The fortified coffee serves as a practical example of how NuMOFs can help people increase their iron intake by engaging in a habit that’s already part of their daily routine, with significant potential benefits for women, who are disproportionately affected by iron deficiency. The team plans to expand the technology to incorporate additional nutrients to address a wider array of nutritional deficiencies and improve health equity globally.

Fast-track to addressing global health improvements

Looking ahead, Zhang and Yang in the Jaklenec Group are focused on both product commercialization and ongoing research, refining MOFe Coffee to enhance nutrient stability and ensuring the product remains palatable while maximizing iron absorption.

Winning the CIC competition means that Zhang, Yang, and the team can fast-track their patent application with the USPTO. The team hopes that their fast-tracked patent will allow them to attract more potential investors and partners, which is crucial for scaling their efforts. A quicker patent process also means that the team can bring the technology to market faster, helping improve global nutrition and health for those who need it most. 

“Our goal is to make a real difference in addressing micronutrient deficiencies around the world,” says Zhang.  

© Photo courtesy of the Jaklenec Group.

Left to right: Koch Institute Principal Investigator Ana Jaklenec, David H. Koch (1962) Institute Professor Robert Langer, doctoral candidate Linzixuan (Rhoda) Zhang, and postdoc Xin Yang.
  • ✇Harvard Gazette
  • Is cheese bad for you?Anna Lamb
    Health Is cheese bad for you? Nutritionist explains why you’re probably eating way too much November 14, 2024 3 min read Part of the Wondering series A series of random questions answered by Harvard experts. The average American consumes 41.8 pounds of cheese per year. We asked Harvard Chan School nutritionist Walter C. Willett about the health i
     

Is cheese bad for you?

By: Anna Lamb
November 14th 2024 at 11:40 pm
Cheese.
Health

Is cheese bad for you?

Nutritionist explains why you’re probably eating way too much

3 min read

Part of the Wondering series

A series of random questions answered by Harvard experts.

The average American consumes 41.8 pounds of cheese per year. We asked Harvard Chan School nutritionist Walter C. Willett about the health impact.

Whether cheese is good or bad for health depends on the comparison. It is somewhere in the middle of the spectrum from great (nuts and soy foods) to processed red meat. Like other dairy foods, cheese does have nutritional value, including a high calcium content. However, our calcium recommendations are seriously overstated because they are based on studies of several weeks, which is far too short.

Current National Institutes of Health recommendations suggest Americans older than 18 get 1,000 mg of calcium daily. However, as little as 600 mg is probably enough for most people.

Of course, the amount of cheese makes an important difference, and it has become common to put a huge amount in sandwiches and salads. About one serving of dairy foods a day is probably a good target; some evidence suggests that yogurt has some health advantages, and cheese could be part of that mix. But if you are thinking of a cheese sandwich, consider peanut butter on whole grain bread as an alternative, or adding nuts to your salad instead of cheese.

Like other dairy foods, cheese does have nutritional value, including a high calcium content. However, our calcium recommendations are seriously overstated.

Americans consume about 1.5 servings of dairy foods per day, and the majority of this is now in the form of cheese. This is a major shift over the last several decades; the total amount of dairy foods consumed has not changed greatly, but until recently this was mainly milk. The USDA has been strongly supporting consumption of cheese (despite their own guidelines encouraging reduction in saturated fat), which has probably contributed to this trend.

Some of the increases in cheese consumption are probably due to more people reducing red meat for various reasons including health, animal welfare, and climate change, but the strong promotion of cheese by the USDA has very likely been an important factor. Starting with the Dairy Production Stabilization Act of 1983, a small tax on sales of dairy has gone to the USDA to promote sales of dairy foods, creating a massive conflict of interest within the organization. 

In the past, the vast majority of cheese consumed by Americans was cheddar, but we now consume a wider variety. There is no good evidence that one type or another is different for health. 

The differences in nutrient content of cheeses are primarily due to the amount of water. Cottage cheese and other fresh cheeses with high water content have higher percentages of lactose — a carbohydrate that decreases with aging. As cheese ages and becomes hard like parmesan or manchego, the lactose is fermented and lost.

However, volume matters. We usually eat more cottage cheese than an aged cheese, so the amount of calories, calcium, and saturated fat can end up not being very different.  

In addition to the direct effects of cheese on health, it is important to consider the implications for climate change because dairy production has a large impact on greenhouse gas emissions and land use. In an analysis conducted as part of the EAT-Lancet Commission on healthy and sustainable food systems, we found that if global production of dairy foods increased to 2 servings per day, limiting severe climate change would be difficult.  

As told to Anna Lamb/Harvard Staff Writer

Also in this series:

  • ✇MIT News
  • Dancing with currents and waves in the MaldivesLisa Capone | Office of the Vice Provost for International Activities
    Any child who’s spent a morning building sandcastles only to watch the afternoon tide ruin them in minutes knows the ocean always wins.Yet, coastal protection strategies have historically focused on battling the sea — attempting to hold back tides and fighting waves and currents by armoring coastlines with jetties and seawalls and taking sand from the ocean floor to “renourish” beaches. These approaches are temporary fixes, but eventually the sea retakes dredged sand, intense surf breaches seawa
     

Dancing with currents and waves in the Maldives

Any child who’s spent a morning building sandcastles only to watch the afternoon tide ruin them in minutes knows the ocean always wins.

Yet, coastal protection strategies have historically focused on battling the sea — attempting to hold back tides and fighting waves and currents by armoring coastlines with jetties and seawalls and taking sand from the ocean floor to “renourish” beaches. These approaches are temporary fixes, but eventually the sea retakes dredged sand, intense surf breaches seawalls, and jetties may just push erosion to a neighboring beach. The ocean wins.

With climate change accelerating sea level rise and coastal erosion, the need for better solutions is urgent. Noting that eight of the world’s 10 largest cities are near a coast, a recent National Oceanic and Atmospheric Administration (NOAA) report pointed to 2023’s record-high global sea level and warned that high tide flooding is now 300 to 900 percent more frequent than it was 50 years ago, threatening homes, businesses, roads and bridges, and a range of public infrastructure, from water supplies to power plants.    

Island nations face these threats more acutely than other countries and there’s a critical need for better solutions. MIT’s Self-Assembly Lab is refining an innovative one that demonstrates the value of letting nature take its course — with some human coaxing.

The Maldives, an Indian Ocean archipelago of nearly 1,200 islands, has traditionally relied on land reclamation via dredging to replenish its eroding coastlines. Working with the Maldivian climate technology company Invena Private Limited, the Self-Assembly Lab is pursuing technological solutions to coastal erosion that mimic nature by harnessing ocean currents to accumulate sand. The Growing Islands project creates and deploys underwater structures that take advantage of wave energy to promote accumulation of sand in strategic locations — helping to expand islands and rebuild coastlines in sustainable ways that can eventually be scaled to coastal areas around the world. 

“There’s room for a new perspective on climate adaptation, one that builds with nature and leverages data for equitable decision-making,” says Invena co-founder and CEO Sarah Dole.

MIT’s pioneering work was the topic of multiple presentations during the United Nations General Assembly and Climate week in New York City in late September. During the week, Self-Assembly Lab co-founder and director Skylar Tibbits and Maldives Minister of Climate Change, Environment and Energy Thoriq Ibrahim also presented findings of the Growing Islands project at MIT Solve’s Global Challenge Finals in New York.

“There’s this interesting story that’s emerging around the dynamics of islands,” says Tibbits, whose U.N.-sponsored panel (“Adaptation Through Innovation: How the Private Sector Could Lead the Way”) was co-hosted by the Government of Maldives and the U.S. Agency for International Development, a Growing Islands project funder. 

In a recent interview, Tibbits said islands “are almost lifelike in their characteristics. They can adapt and grow and change and fluctuate.” Despite some predictions that the Maldives might be inundated by sea level rise and ravaged by erosion, “maybe these islands are actually more resilient than we thought. And maybe there’s a lot more we can learn from these natural formations of sand … maybe they are a better model for how we adapt in the future for sea level rise and erosion and climate change than our man-made cities.”

Building on a series of lab experiments begun in 2017, the MIT Self-Assembly Lab and Invena have been testing the efficacy of submersible structures to expand islands and rebuild coasts in the Maldivian capital of Male since 2019. Since then, researchers have honed the experiments based on initial results that demonstrate the promise of using submersible bladders and other structures to utilize natural currents to encourage strategic accumulation of sand.

The work is “boundary-pushing,” says Alex Moen, chief explorer engagement officer at the National Geographic Society, an early funder of the project.

“Skylar and his team’s innovative technology reflect the type of forward-thinking, solutions-oriented approaches necessary to address the growing threat of sea level rise and erosion to island nations and coastal regions,” Moen said.

Most recently, in August 2024, the team submerged a 60-by-60-meter structure in a lagoon near Male. The structure is six times the size of its predecessor installed in 2019, Tibbits says, adding that while the 2019 island-building experiment was a success, ocean currents in the Maldives change seasonally and it only allowed for accretion of sand in one season.

“The idea of this was to make it omnidirectional. We wanted to make it work year-round. In any direction, any season, we should be accumulating sand in the same area,” Tibbits says. “This is our largest experiment so far, and I think it has the best chance to accumulate the most amount of sand, so we’re super excited about that.”

The next experiment will focus not on building islands, but on overcoming beach erosion. This project, planned for installation later this fall, is envisioned to not only enlarge a beach but also provide recreational benefits for local residents and enhanced habitat for marine life such as fish and corals.

“This will be the first large-scale installment that’s intentionally designed for marine habitats,” Tibbits says.

Another key aspect of the Growing Islands project takes place in Tibbits’ lab at MIT, where researchers are improving the ability to predict and track changes in low-lying islands through satellite imagery analysis — a technique that promises to facilitate what is now a labor-intensive process involving land and sea surveys by drones and researchers on foot and at sea.

“In the future, we could be monitoring and predicting coastlines around the world — every island, every coastline around the world,” Tibbits says. “Are these islands getting smaller, getting bigger? How fast are they losing ground? No one really knows unless we do it by physically surveying right now and that’s not scalable. We do think we have a solution for that coming.”

Also hopefully coming soon is financial support for a Mobile Ocean Innovation Lab, a “floating hub” that would provide small island developing states with advanced technologies to foster coastal and climate resilience, conservation, and renewable energy. Eventually, Tibbits says, it would enable the team to travel “any place around the world and partner with local communities, local innovators, artists, and scientists to help co-develop and deploy some of these technologies in a better way.”

Expanding the reach of climate change solutions that collaborate with, rather than oppose, natural forces depends on getting more people, organizations, and governments on board. 

“There are two challenges,” Tibbits says. “One of them is the legacy and history of what humans have done in the past that constrains what we think we can do in the future. For centuries, we’ve been building hard infrastructure at our coastlines, so we have a lot of knowledge about that. We have companies and practices and expertise, and we have a built-up confidence, or ego, around what’s possible. We need to change that.

“The second problem,” he continues, “is the money-speed-convenience problem — or the known-versus-unknown problem. The hard infrastructure, whether that’s groins or seawalls or just dredging … these practices in some ways have a clear cost and timeline, and we are used to operating in that mindset. And nature doesn’t work that way. Things grow, change, and adapt on their on their own timeline.”

Teaming up with waves and currents to preserve islands and coastlines requires a mindset shift that’s difficult, but ultimately worthwhile, Tibbits contends.

“We need to dance with nature. We’re never going to win if we’re trying to resist it,” he says. “But the best-case scenario is that we can take all the positive attributes in the environment and take all the creative, positive things we can do as humans and work together to create something that’s more than the sum of its parts.”

© Photo courtesy of the MIT Self-Assembly Lab.

Underwater structures created by MIT’s Self-Assembly Lab and Invena, an organization based out of the Maldives.
  • ✇MIT News
  • School of Engineering faculty receive awards in summer 2024Jordan Silva | School of Engineering
    Faculty and researchers receive many external awards throughout the year. The MIT School of Engineering periodically highlights the honors, prizes, and medals won by community members working in academic departments, labs, and centers. Summer 2024 honorees include the following:Polina Anikeeva, the Matoula S. Salapatas Professor of Materials Science and Engineering, professor of brain and cognitive sciences, and head of the Department of Materials Science and Engineering, was recognized as a fin
     

School of Engineering faculty receive awards in summer 2024

November 14th 2024 at 10:20 pm

Faculty and researchers receive many external awards throughout the year. The MIT School of Engineering periodically highlights the honors, prizes, and medals won by community members working in academic departments, labs, and centers. Summer 2024 honorees include the following:

Polina Anikeeva, the Matoula S. Salapatas Professor of Materials Science and Engineering, professor of brain and cognitive sciences, and head of the Department of Materials Science and Engineering, was recognized as a finalist for the Blavatnik National Awards in the category of physical sciences and engineering. The Blavatnik National Awards for Young Scientists is the largest unrestricted scientific prize offered to America’s most promising, faculty-level scientific researchers under the age of 42.

Gabriele Farina, the X-Window Consortium Career Development Professor and assistant professor in the Department of Electrical Engineering and Computer Science (EECS), received an honorable mention for the 2023 Doctoral Dissertation Award. The award is presented annually to the author(s) of the best doctoral dissertation(s) in computer science and engineering.

James Fujimoto, the Elihu Thomson Professor in Electrical Engineering, won the 2024 Honda Prize for his research group’s development of optical coherence tomography. The Honda Prize is an international award that acknowledges the efforts of an individual or a group to contribute new ideas that may lead the next generation in the field of ecotechnology.

Jeehwan Kim, an associate professor in MIT’s departments of Mechanical Engineering and Materials Science and Engineering, won the engineering and technology category for the 2024 Falling Walls Global Call for his innovations in semiconductor technology. The Falling Walls Global Call is an international competition that seeks the most recent and innovative science breakthroughs, bringing together science enthusiasts from diverse backgrounds.

Samuel Madden, the College of Computing Distinguished Professor of Computing and faculty head of computer science in the Department of EECS, received the Edgar F Codd Innovations Award. The award is given for innovative and highly significant contributions of enduring value to the development, understanding, or use of database systems and databases.

Jelena Notaros, an assistant professor in the Department of EECS, received the 2024 Optica CLEO Highlighted Talk Award as co-principal investigator. The Optica CLEO Awards Program celebrates the field's technical, research, education, business, leadership, and service accomplishments.

Carlos Portela, the Robert N. Noyce Career Development Professor in the Department of Mechanical Engineering, received the Army Early Career Program Award. The award is among the most prestigious honors granted by the U.S. Army Research Office to outstanding early-career scientists.

Yogesh Surendranath, the Donner Professor of Science in the departments of Chemical Engineering and Chemistry, was recognized as a finalist for the Blavatnik National Awards in the category of chemical sciences. The Blavatnik National Awards for Young Scientists is the largest unrestricted scientific prize offered to the United States' most promising, faculty-level scientific researchers under the age of 42.

Ashia Wilson, an assistant professor in the Department of EECS, received the Best Paper Award at the 2024 ACM Conference on Fairness, Accountability, and Transparency (ACM FAccT). ACM FAccT is an interdisciplinary conference dedicated to bringing together a diverse community of scholars from computer science, law, social sciences, and humanities to investigate and tackle issues in this emerging area.

© Photo: Mary Beth Gallagher

Members of the MIT engineering faculty received a number of awards in recognition of their scholarship, service, and overall excellence last summer.
  • ✇Harvard Gazette
  • Many in Native communities applaud U.S. apology over boarding schoolsTerry Murphy
    Nation & World Many in Native communities applaud U.S. apology over boarding schools President Biden speaking at the Gila River Indian Community reservation in Laveen, Arizona, on Oct. 25.Manuel Balce Ceneta/AP Nikki Rojas Harvard Staff Writer November 14, 2024 5 min read Deloria, Gone say action over decadeslong initiative to forcibly assimilate children overdue, necessary Philip D
     

Many in Native communities applaud U.S. apology over boarding schools

November 14th 2024 at 7:49 pm
Nation & World

Many in Native communities applaud U.S. apology over boarding schools

President Biden speaking.

President Biden speaking at the Gila River Indian Community reservation in Laveen, Arizona, on Oct. 25.

Manuel Balce Ceneta/AP

Nikki Rojas

Harvard Staff Writer

5 min read

Deloria, Gone say action over decadeslong initiative to forcibly assimilate children overdue, necessary

Philip Deloria and Joseph P. Gone had family members who were taken from their homes and placed in government- or church-run boarding schools as part of a decadeslong federal initiative aimed at forcibly assimilating thousands of Native children.

Late last month, President Biden made a historic apology to Native Americans on behalf of the U.S. government. “I know no apology can or will make up for what was lost during the darkness of the federal boarding school policy,” Biden said during a visit to the Gila River Indian Community in Arizona. “But today, we’re finally moving forward into the light.”

The gesture was applauded by many in the community, and for good reason, said Deloria, the Leverett Saltonstall Professor of History.

“Apologies have not exactly been forthcoming from the federal and state governments and the churches, and the various entities that have enacted some of these programs on any people over the years. Any time that there’s recognition of those histories, I think it’s really important,” he said. “For many Native people, the moments where the rituals of formal American diplomacy are actually visible is also recognition of Native nationhood and of Native continuities and futurities.”

“A lot of people will be grateful for this apology, irrespective of the motivators for it, and are grateful that he appointed Secretary [Debra] Haaland, because it wouldn’t have happened without her,” added Gone, anthropology professor and faculty director of the Harvard University Native American Program. Gone credited Haaland, the first Native American to serve as U.S. secretary of the interior, for making the “boarding school wound” a priority during Biden’s administration.

Boarding schools, which often kept children away from their families for long periods of time, forced American Indian, Alaska Native, and Native Hawaiian students to speak English and prohibited them from speaking their own languages. These children were also banned from learning or practicing their own religions.

“The parts that are worth emphasizing are just the sheer brutality of many of these schools,” Deloria said. The children were subjected to physical and emotional abuse and sometimes served as free labor. Many died after contracting illnesses at the schools, he pointed out.

The federal initiative continued well into the 20th century. A July investigative report by Haaland’s department revealed that 19,000 Native children were forced into these boarding schools, with nearly 1,000 dying while there.

At the age of 5, Gone’s great-grandfather Many-Plumes was taken to a federally run industrial school in Fort Belknap Agency in Montana, where his name was changed to Frederick Peter Gone. There, the young boy was kept away from family and abused, he said.

 “It colored his life and the life of our descendants ever since in part because of these experiences,” Gone noted.

Similar boarding or industrial schools were also run by Christian, Mormon, and Catholic churches. Deloria’s grandfather and great-aunts went to church boarding schools that were just “a little better” than other federal or religious-run institutions.

“There’s an entire theory of historical trauma, which is largely based around the kinds of ways in which boarding-school trauma suffered by these children is passed down to subsequent generations,” he said.

In 1928, the “Meriam Report: The Problem of Indian Administration” highlighted the ineffectiveness of the boarding-school policy. Following reforms, some of the federally run schools transformed into places where Native students could interact with members of different tribes, Gone said.

“In the ’60s and ’70s, going to these schools sometimes could be more interesting than being in your tiny, little rural school on the reservation where you already know everybody,” Gone said. “One of the unintended consequences is you had a lot of intermarriage among Indian people who met at boarding schools.”

Despite reforms, the impact of boarding schools is felt to this day. In addition to calling on the federal government to apologize, Haaland’s report recommended creating a national memorial commemorating of Native children who died in the schools, and an investment in Native communities and their languages.

The Biden administration signed legislation that invested more than $45 billion in Native communities through the American Rescue Plan, the Bipartisan Infrastructure Law, and the Inflation Reduction Act.

Deloria and Gone suggested some of the funds should be invested in healthcare, particularly in a way in which tribal nations can retain their sovereignty and autonomy. “There’s no domain of Indian life that wouldn’t benefit from additional resources,” Gone said.

Biden’s apology came just days before the recent presidential election, but the two professors said the timing was unimportant to them. “It may be that this is like a capstone for Biden, and it may be a cynical gesture in relation to the election, but it may also be the beginning of something new that goes forward,” Deloria said.

Global experts converge at Cornell to drive solutions in climate finance

By: jes575
November 14th 2024 at 7:41 pm
Over 1,200 people from 49 countries convened at the inaugural “Global Climate Finance and Risks,” virtual conference co-hosted by Cornell Atkinson, the Cornell S.C. Johnson College of Business and the U.S. Treasury’s Office of Financial Research. This year’s U.N. COP29 in Baku will emphasize climate finance solutions. 
  • ✇MIT News
  • Stopping the bombLeda Zimmerman | Department of Political Science
    “The question behind my doctoral research is simple,” says Kunal Singh, an MIT political science graduate student in his final year of studies. “When one country learns that another country is trying to make a nuclear weapon, what options does it have to stop the other country from achieving that goal?” While the query may be straightforward, answers are anything but, especially at a moment when some nations appear increasingly tempted by the nuclear option.From the Middle East to India and Paki
     

Stopping the bomb

“The question behind my doctoral research is simple,” says Kunal Singh, an MIT political science graduate student in his final year of studies. “When one country learns that another country is trying to make a nuclear weapon, what options does it have to stop the other country from achieving that goal?” While the query may be straightforward, answers are anything but, especially at a moment when some nations appear increasingly tempted by the nuclear option.

From the Middle East to India and Pakistan, and from the Korean peninsula to Taiwan, Singh has been developing a typology of counterproliferation strategies based on historical cases and to some degree on emergent events. His aim is to clarify what states can do “to stop the bomb before it is made.” Singh’s interviews with top security officials and military personnel involved in designing and executing these strategies have illuminated tense episodes in the past 75 years or so when states have jockeyed to enter the elite atomic club. His insights might upend some of the binary thinking that dominates the field of nuclear security.

“Ultimately, I’d like my work to help decision-makers predict counterproliferation strategy, and draw lessons from it on how to shield their own citizens and economies from the impact of these strategies,” he says.

Types of nonproliferation tactics

On Oct. 7, 2023, Singh awoke to air raid sirens in Jerusalem, where he was conducting interviews, and discovered Israel was under attack. He was airlifted to safety back to the United States, having borne witness to the start of a regional war that “now has become relevant to my research,” he says.

Before his hasty departure, Singh was investigating two singular episodes where military force was deployed to advance nonproliferation goals: Israel’s airstrikes against nuclear reactors in 1981 in Iraq, and in 2007 in Syria. To date, these have been the only major attacks on nuclear facilities outside of an active war.

“I spoke with Prime Minister Ehud Olmert, who ordered the strike in Syria, and with the commander of the Israeli Air Force who planned the Iraq airstrike, as well as with other members of the security bureaucracy,” says Singh. “Israel feels a large degree of threat because it is a very small country surrounded by hostile powers, so it takes a military route to stop another state from acquiring nuclear weapons,” says Singh. But, he notes, “most of the states which are not in this predicament generally resort to diplomatic methods first, and threaten violence only as a last resort.”

Singh defines the military response by Israel as “kinetic reversion,” one of five types of counterproliferation strategies he has identified. Another is “military coercion,” where a state threatens the use of military force or uses moderate force to demonstrate its commitment to preventing the pursuit of the bomb. States can also use diplomatic and economic leverage over the proliferant to persuade it to drop its nuclear program, what Singh calls “diplomatic inhibition.” 

One form this strategy takes is when one country agrees to give up its program in return for the other doing the same. Another form involves “placing sanctions on a country and excluding them from the world economy, until the country rolls back its program — a strategy the U.S. has employed against Iran, North Korea, Libya, and Pakistan,” says Singh.

India was rumored to have embraced military tactics. “I had always read about the claim that India was ready to attack the Pakistani uranium enrichment plant in Kahuta, and that planes were called off at the last minute,” Singh says. “But in interview after interview I found this was not the case, and I discovered that many written accounts of this episode had been completely blown up.”

In another strategy, “pooled prevention,” nations can band together to apply economic, diplomatic, and military pressure on a potential proliferator.

Singh notes that diplomatic inhibition, pooled prevention, and military coercion have succeeded, historically. “In 2003, Libya gave up its nuclear weapons program completely after the U.S. and U.K. placed sanctions on it, and many states do not even start a nuclear weapons program because they anticipate an attack or a sanction.”

The final strategy Singh defines is “accommodation,” where one or more states decide not to take action against nuclear weapon development. The United States arrived at this strategy when China began its nuclear program — after first considering and rejecting military attacks.

Singh hopes that his five kinds of strategies challenge a “binary trap” that most academics in the field fall into. “They think of counterproliferation either as military attack or no military attack, economic sanctions or no sanctions, and so they miss out on the spectrum of behaviors, and how fluid they can be.”

From journalism to security studies

Singh grew up in Varanasi, a Hindu holy city in the state of Uttar Pradesh. Frequent terrorist attacks throughout India, and some inside his city’s temples, made a deep impression on him during his childhood, he says. A math and science talent, he attended the Indian Institute of Technology, majoring in metallurgical and materials engineering. After a brief stint with a management consulting firm, after college, he landed a job at a think tank, the Center for Policy Research in New Delhi.

“When I moved to New Delhi, I suddenly saw a world which I didn’t know existed,” Singh recalls. “I began meeting people for an evening round of discussions and began reading voraciously: books, editorial and opinion pages in newspapers, and looking for a greater sense of purpose and meaning in my work.”

His widening interests led to a job as staff writer, first at Mint, a business newspaper, and then to the Hindustan Times, working on both papers’ editorial pages. “This was where most of my intellectual development happened,” says Singh. “I made social connections, and many of them grew more towards the academics in the security field.”

Writing about a nuclear security question one day, Singh reached out to an expert in the United States: Vipin Narang, the Frank Stanton Professor of Nuclear Security and Political Science at MIT. Over time, Narang helped Singh realize that the kind of questions Singh hoped to answer “lay more in the academic than in the journalistic domain,” recounts Singh.

In 2019, he headed to MIT and began a doctoral program focused on security studies and international relations. In his dissertation, “Nipping the Atom in the Bud: Strategies of Counterproliferation and How States Choose Among Them,” Singh hopes to move beyond a classic, academic debate: that nuclear weapons are either very destabilizing, or very stabilizing.

“Some argue that there is stability in the world because two states armed with nuclear weapons will avoid nuclear war, because they understand nobody will win a nuclear war,” explains Singh. “If this view is true, then we shouldn’t be alarmed by the proliferation of these weapons.” But “the counterargument is that there will always be an off chance someone will use these weapons, and so states should “try to use all their military and economic might to prevent another state from gaining nuclear weapons.”

As it turns out, neither extreme view governs in the real world. “The main takeaway from my research is that states are obviously concerned when some other country tries to make nuclear weapons, but they are not so concerned that in order to prevent a future destabilizing event, they are ready to destabilize the world as of now.”

In the final throes of writing his thesis and preparing for life as an academic, Singh remains alert to the parlous state of affairs in the Middle East and elsewhere. “I keep following events, knowing that something may prove relevant to my research,” he says.

Given the tense times and the often dark implications of his subject matter, Singh has found an optimal mode of blowing off steam: a daily badminton match. He and his wife also “binge watch either a spy thrill or a murder mystery every Saturday,” he says.

In a world both increasingly interconnected and increasingly threatened by regional conflicts, Singh believes, “there is still much to be discovered about how the world thinks about nuclear weapons, including what the impacts of nuclear weapons use might be,” he says. “I’d like to help shine a light on those new things, and broaden our understanding of nuclear weapons and the politics of nuclear security.”

© Photo courtesy of Kunal Singh.

Kunal Singh hopes that the five nuclear strategies he's identified challenge a “binary trap” that most academics in nuclear security fall into. “They think of counterproliferation either as military attack or no military attack, economic sanctions or no sanctions, and so they miss out on the spectrum of behaviors, and how fluid they can be.”
  • ✇NUS - National University of Singapore Newsroom
  • NUS graduates are 9th most sought-after employees by companies worldwide
    NUS graduates are regarded as the ninth most employable in the world, according to the Global Employability University Ranking and Survey (GEURS) 2025.Produced by French consultancy Emerging and published by the Times Higher Education, the annual study gathers global employer insights to rank the top 250 universities that are the best at developing career- and workplace-ready graduates.  NUS has been consistently ranked in the top 10 since 2020. This year, it ranked second-highest in Asia behind
     

NUS graduates are 9th most sought-after employees by companies worldwide

November 14th 2024 at 12:45 pm

NUS graduates are regarded as the ninth most employable in the world, according to the Global Employability University Ranking and Survey (GEURS) 2025.

Produced by French consultancy Emerging and published by the Times Higher Education, the annual study gathers global employer insights to rank the top 250 universities that are the best at developing career- and workplace-ready graduates.  

NUS has been consistently ranked in the top 10 since 2020. This year, it ranked second-highest in Asia behind eighth-placed The University of Tokyo. The first, second and third spots in the overall ranking went to the Massachusetts Institute of Technology, California Institute of Technology and Stanford University respectively.

Professor Aaron Thean, NUS Deputy President (Academic Affairs) and Provost said, “The NUS educational experience nurtures in our students a keen sense of curiosity, critical thinking, data-driven analytical skills, and global sensibilities. Strongly grounded in academics with market and global exposure, they are highly sought after across industries in Singapore and internationally, confident and ready to create impact and change. With technological disruptions now the norm, NUS is actively integrating skills and knowledge of fast-developing domains like AI and data analytics into our curriculum so that our students are future-ready.

“Our consistently high rankings in the Global Employability University Ranking and Survey are a testament to the quality of our interdisciplinary education and the outstanding capabilities of our graduates, who continue to thrive and lead in the competitive global workforce,” he added.

According to Emerging’s Co-founder and Managing Director Ms Sandrine Belloc, the three main drivers that positioned NUS in the top 10 were graduate skills, digital mindset and academic performance. With employability becoming a key benchmark for universities, NUS’ ranking reflects its commitment to preparing students for the future, she added. “By offering a combination of essential skills, a powerful network, and real-world job opportunities, they ensure students are ready to thrive in the workforce and excel in the years ahead."

Conducted between June to September 2024, the 2025 survey was expanded to include 13,240 international employers from 33 countries across five continents who recruited 1.3 million young graduates for non-technical, business, IT and engineering roles in 2024 to 2025.

Universities are assessed across 35 criteria, from which the following seven key employability drivers were identified: academic excellence, specialisation, graduate skills, digital mindset, focus on work expertise, social impact and leadership, and internationality

Nurturing diverse skills to prepare students for the future workplace

NUS has placed a strong emphasis on nurturing workplace-ready graduates. Earlier this year, the University launched the NUSOne initiative to foster a holistic and well-rounded university experience that integrates formal learning with student life and other out-of-classroom experiences to encourage greater self-directed personal growth and development.

Key features of the initiative include the Transition to Higher Education Programme, which offers courses to equip first-year students with academic and non-academic skills related to the science of learning and the use of generative AI tools; dedicating Wednesday afternoons for students to participate in non-academic activities, as well as the addition of a new sports-themed hostel named Valour House that seeks to build an active and inclusive community bonded through shared athletic experiences.

The University has also been intensifying efforts on equipping our students with career competencies to excel in the workplace. The NUS Centre for Future-ready Graduates supports students with a four-year career-readiness roadmap to encourage early career planning while broadening their exposure to industry.

They offer an impressive suite of resources and initiatives such as opportunities for overseas internships and study trips to fast-growing economies in Southeast Asia, India and China; career-readiness programmes including programmes like Career Booster and Career Advancement which advance students’ job search, interview, and workplace skills; access to a University-wide jobs and internships portal, mentorship programmes, dedicated career advisors, in addition to regular career fairs and recruitment talks.

Behavioural analysis in mice: more precise results despite fewer animals

November 14th 2024 at 9:30 am
Researchers at ETH Zurich are utilising artificial intelligence to analyse the behaviour of laboratory mice more efficiently and reduce the number of animals in experiments.
  • ✇Harvard Gazette
  • Buttigieg urges focus on local, state projects that can win wide supportTerry Murphy
    Setti Warren (left) and Pete Buttigieg.Niles Singer/Harvard Staff Photographer Nation & World Buttigieg urges focus on local, state projects that can win wide support Transportation secretary discusses aviation, roadway challenges during his time in office, administration’s frustrations, issues awaiting new president Clea Simon Harvard Correspondent November 13, 2024 4 min read The de
     

Buttigieg urges focus on local, state projects that can win wide support

November 14th 2024 at 12:47 am
Setti Warren (left) and Pete Buttigieg.

Setti Warren (left) and Pete Buttigieg.

Niles Singer/Harvard Staff Photographer

Nation & World

Buttigieg urges focus on local, state projects that can win wide support

Transportation secretary discusses aviation, roadway challenges during his time in office, administration’s frustrations, issues awaiting new president

Clea Simon

Harvard Correspondent

4 min read

The deeply divided U.S. is like “two people locked in a wrestling match on the edge of a cliff,” said Secretary of Transportation Pete Buttigieg at a campus event Monday evening.

“The implicit working theory of our administration has been if we could just deliver on the basics,” such as safe roads and bridges and clean drinking water, “solving some of those basic problems would move our wrestling match a few feet from the edge of the cliff,” he said. “But as everyone has noticed, we don’t seem to be that far from the edge of the cliff.”

He noted that part of the problem for the Biden White House was time. “I would argue that we’ve made enormous progress, basically full employment,” he said. “But so many of the economic benefits that we’ve been working on are things that take years.”

Buttigieg ’04 returned to campus for a Harvard Kennedy School discussion before a capacity crowd with Setti Warren, Institute of Politics director, on his own work at the Department of Transportation, some of the issues awaiting incoming President Donald Trump, and the need for Democrats to focus on advancing priorities through projects on the local and state level that can win wide support.

The transportation secretary said that as he was speaking in his official capacity he would largely avoid talking partisan politics. And he spent much of this time detailing his time in office.

Problems with commercial aviation, he said, loomed large, with issues ranging from a lack of transparency about fees and passenger reimbursements to safety concerns, such as when a section of the fuselage of an Alaska Airlines plane blew out during a flight in January.

In response, Buttigieg said, his department took a holistic response, from a package of consumer protections to a “dashboard” that tracks consumer complaints and airline compliance.

“First we used transparency to supply change, and now we have the letter of the [recently passed aviation] law” while also stepping up enforcement, he said, citing such regulations as new ones that make refunds automatic when flights are canceled (without alternatives being offered) or unduly delayed (three hours for a domestic flight, six hours for an international flight).

“We’re doing these things not against the airlines, but because we need them to deliver better service,” he said.

Ongoing issues include equal access for those with disabilities, he said, noting how some of those passengers say they dehydrate themselves because they know they will not be able to access airplane restrooms. Road safety, as well, remains a concern.

“We lose more than 100 people a day on our roadways,” he said. Comparing this statistic to the safety of air travel, with all its shortcomings, he concluded: “We should be able to do better with forms of transportation on the surface.”

Such basic concerns were the goals of the Biden administration, he said. Acknowledging issues with inflation even as the economy enjoyed robust employment, he explained that focusing on infrastructure improvements was viewed as a possible way to ease the country’s divisiveness.

Looking back on the past four years, the secretary noted the long-term nature of the majority of the Biden administration’s projects and how those have set up the Trump administration for its next moves.

Trying “not to sound bitter,” he pointed out that the incoming administration “will inherit a lot of groundwork that has been laid, jobs that were always expected to come online in 2026 and ’27.” This could provide the basis for a boom, he said.

“The building trades have a pipeline of work that they haven’t seen since before I was born,” said the 42-year-old, who also cited “interest rates ticking down.”

However, he added, the new administration may also create its own challenges. For example, he said, “if something disrupts our supply chains, such as mass deportations,” Americans may once again have to worry about the economy.

Looking ahead, Buttigieg saw common ground in “local voices.” “We’re doing 63,000 local projects,” he said, citing projects that came to the administration “because a state or a city or a tribe … wanted to get something done.”

He stressed the potential for Democrats to muster bipartisan support for such projects. “Principled conservatism has some regard for the local — if anything more regard than the left,” said the former mayor of South Bend, Indiana. “I am hopeful that that principle will survive.

“In moments like this our salvation will come from the local and the state level. A lot of the answers are going to come from mayors, from communities, from states.”

  • ✇Harvard Gazette
  • 12 centuries of Ukrainian literature in 12 weeks? Eileen O'Grady
    Bohdan Tokarskyi. Stephanie Mitchell/Harvard Staff Photographer Arts & Culture 12 centuries of Ukrainian literature in 12 weeks?  Bohdan Tokarskyi, new assistant professor, says he’s up to the challenge Eileen O’Grady Harvard Staff Writer November 13, 2024 4 min read At times this fall, Bohdan Tokarskyi has felt split between two contrasting worlds. On one side is Cambridge, where
     

12 centuries of Ukrainian literature in 12 weeks? 

November 13th 2024 at 11:09 pm
Bohdan Tokarskyi

Bohdan Tokarskyi.

Stephanie Mitchell/Harvard Staff Photographer

Arts & Culture

12 centuries of Ukrainian literature in 12 weeks? 

Bohdan Tokarskyi, new assistant professor, says he’s up to the challenge

Eileen O’Grady

Harvard Staff Writer

4 min read

At times this fall, Bohdan Tokarskyi has felt split between two contrasting worlds.

On one side is Cambridge, where he works as a new assistant professor of Slavic languages and literatures. On the other are the sirens, bomb shelters, blackouts, and flattened universities that flash across his phone each morning when reading about Russia’s war with Ukraine.

“I feel great responsibility to be teaching Ukrainian literature and culture at a historic moment like this, when Ukraine is at the forefront of the clash between democracies and dictatorships,” said Tokarskyi. “It is really humbling for me what impressive work the educators and students in Ukraine continue to do against all odds and in spite of the horror of the war. This is a gigantic reminder that education is a privilege.”

“I feel great responsibility to be teaching Ukrainian literature and culture at a historic moment like this, when Ukraine is at the forefront of the clash between democracies and dictatorships.”

Tokarskyi started his new role in July. This semester he is teaching “Poetics of Resistance: An Introduction to Ukrainian Literature,” an ambitious “crash course,” by his own telling, covering 12 centuries in 12 weeks.

“I want to provide a bird’s-eye view of Ukraine’s centuries-long literature and culture,” said Tokarskyi, who was a fellow at Harvard’s Ukrainian Research Institute in the spring. “Because Ukraine’s lands have been subjected to different imperial powers over the many centuries, there has been a lot of oppression of the Ukrainian language and culture. In my course, I show to my students how time and again in Ukrainian literature we find themes like solidarity, human rights, the pursuit of justice, feminism and, of course, resilience.”

Literature has played a central role in shaping Ukraine’s history, Tokarskyi said, and still does. During the 2013-2014 Euromaidan demonstrations, graffiti portraits, and quotes from Lesya Ukrainka, Taras Shevchenko, and other writers were used as inspiration to protesters. This past January, poet Maksym Kryvtsov read works by the 20th-century poet Vasyl Stus in videos posted to social media. The very next day, Kryvtsov was killed on the frontlines

“This reminds us that even nowadays Ukrainian writers are fighting and being killed defending their country and their culture,” Tokarskyi said. “But it also shows what great importance this cultural tradition has in Ukraine. It connects cultural thought across history, even when the producers of this culture were oppressed and executed.” 

Tokarskyi is currently writing the first-ever English-language book on Stus, a dissident poet who spent more than a decade in Soviet prisons. He is also collaborating with poet and translator Nina Murray on an English-language volume of Stus’ selected works. 

“Picture a poet of the stature of T.S. Eliot or Rainer Maria Rilke, working deep in the mines of a Gulag labor camp with an 80-kilogram-heavy rock bolt, managing nonetheless to produce some of the most exquisite post-war poetry in Europe,” Tokarskyi said. “You would expect that someone with a biography like that would create a work that is overtly political. But in his case, his response to the extreme conditions in which he found himself was instead producing this highly introspective poetry.”

“One of the extraordinary things about Stus’ poetic style is the sheer number of neologisms — new words he coined to be able to capture these between states of our own identity, of these not-yet-crystallized selves.”

The book is a passion project for Tokarskyi, who said Stus’ work helped inspire him to switch fields and pursue literature after completing an international law degree at the Taras Shevchenko National University of Kyiv in 2014.

“To me, Stus is a paragon of moral imperative and the pursuit of authenticity that is not only fighting against something but also asking oneself ceaselessly, ‘How can I become my true self?’ — and doing that by creating an absolutely innovative poetic language,” he said. “One of the extraordinary things about Stus’ poetic style is the sheer number of neologisms — new words he coined to be able to capture these between states of our own identity, of these not-yet-crystallized selves.”

Next semester Tokarskyi will teach the graduate-level seminar “Modernisms: Ukrainian, Soviet, European.” Also on the agenda is a first-year seminar titled “Making the Self: Poetics of Authenticity,” which will examine how writers and philosophers seek to answer the question “What does it mean to be authentic?” which Tokarskyi says is all the more urgent in the era of social media and artificial intelligence. 

Tokarskyi is excited about introducing graduate students to a “treasure trove” of potential Ph.D. projects. “My door is always open for students, and I cannot wait to help them explore and discover Ukrainian literature.”

  • ✇Harvard Gazette
  • ‘Harnessing evolution’Anne Manning
    Science & Tech ‘Harnessing evolution’ Anne J. Manning Harvard Staff Writer November 13, 2024 3 min read New tool allows researchers to study gene mutation directly within living human cells Gene mutations have consequences both good and bad — from resistance to conditions like diabetes to susceptibility to certain cancers. In order to study these mutations, scientists need to int
     

‘Harnessing evolution’

November 13th 2024 at 9:06 pm
Science & Tech

‘Harnessing evolution’

Blue DNA structure

Anne J. Manning

Harvard Staff Writer

3 min read

New tool allows researchers to study gene mutation directly within living human cells

Gene mutations have consequences both good and bad — from resistance to conditions like diabetes to susceptibility to certain cancers.

In order to study these mutations, scientists need to introduce them directly into human cells. But changing genetic instructions inside cells is complex. The human genome comprises 3 billion base pairs of DNA divided across tens of thousands of genes.

To that end, Harvard researchers have created a tool that allows them to rapidly create mutations only in particular genes of interest without disturbing the rest of the genome. Described in Science, their tool, called Helicase-Assisted Continuous Editing (HACE), can be deployed to predetermined regions of the genome in intact, living cells.

“The development of tools like this marks a significant leap forward in our ability to harness evolution directly within human cells,” said first author Xi Dawn Chen, a Griffin Graduate School of Arts and Sciences student studying synthetic biology in the Department of Stem Cell and Regenerative Biology. “By allowing targeted mutagenesis in specific parts of the genome, this tool opens the door to creating enzymes and treatments that were previously out of reach.”

“HACE combines CRISPR’s precision with the ability to edit long stretches of DNA, making it a powerful tool for targeted evolution.”

 Fei Chen.
Fei Chen

Unlike current methods for mutagenesis, which involve inserting extra copies of genes or broadly mutating many different genes at once, HACE offers the advantage of being directed to locations — like going to a specific address, rather than a neighborhood. The team’s novel bioengineering involves combining a helicase, which is an enzyme that naturally “unzips” DNA, with a gene-editing enzyme. They then use the gene-editing technology CRISPR-Cas9 to guide the protein pair to the gene they want to mutate. As the helicase unzips the DNA, it introduces mutations into only that gene sequence.

“HACE combines CRISPR’s precision with the ability to edit long stretches of DNA, making it a powerful tool for targeted evolution,” explained senior author Fei Chen, assistant professor in the Department of Stem Cell and Regenerative Biology and member at the Broad Institute.

To demonstrate the tool’s power in the lab, the scientists used it to identify drug resistance mutations in a gene called MEK1, which cancer treatments often target but frequently fail because the diseased cells mutate resistance mechanisms. Using HACE, the team sequenced only those mutated genes and pinpointed several unique changes associated with resistance to cancer drugs like trametinib and selumetinib, offering insights into how mutations affect drug performance.

They also examined how mutations in SF3B1, a gene involved in a biomolecular process called RNA splicing, affects RNA assembly. Mutations in this gene are common in blood cancers, but it’s been unclear which mutations cause the splicing defects; with HACE, the team could easily identify those changes.

And in partnership with Bradley Bernstein’s lab at Harvard Medical School and Dana-Farber Cancer Institute, the researchers also used the tool to better understand how changes in a regulatory DNA region affect the production of a protein in immune cells recognized as a potential target for cancer immunotherapies.

Bernstein said tools like HACE could someday allow massive edits of gene regulatory sequences that could then be coupled with deep learning computation for deciphering. “One can imagine many new therapeutic opportunities that involve precise edits or tuning of these regulatory sequences to ‘fix’ gene activity and ameliorate disease,” Bernstein said.

This research was supported by multiple sources including the National Institutes of Health, the Broad Institute, and the Harvard Stem Cell Institute.

  • ✇Harvard Gazette
  • How mammals got their strideTerry Murphy
    Science & Tech How mammals got their stride Fossil of the early sail-backed synapsid Dimetrodon from 290 million years ago was investigated during the study.Credit: Peter Bishop/Museum of Comparative Zoology, © President and Fellows of Harvard College Wendy Heywood Harvard Correspondent November 13, 2024 5 min read Revealing twists, turns of evolution from sprawling to upright posture
     

How mammals got their stride

November 13th 2024 at 9:05 pm
Science & Tech

How mammals got their stride

Fossil of the early sail-backed synapsid Dimetrodon from 290 million years ago, investigated during the study.

Fossil of the early sail-backed synapsid Dimetrodon from 290 million years ago was investigated during the study.

Credit: Peter Bishop/Museum of Comparative Zoology, © President and Fellows of Harvard College

Wendy Heywood

Harvard Correspondent

5 min read

Revealing twists, turns of evolution from sprawling to upright posture

Mammals, including humans, stand out with their distinctively upright posture, a trait that fueled their evolutionary success. Yet the earliest known ancestors of modern mammals more closely resembled reptiles, with limbs stuck out to their sides in a sprawled posture.

The shift from a sprawled stance like that of lizards to the upright posture of modern mammals, as in humans, dogs, and horses, marked a pivotal moment in evolution. Despite more than a century of study, the exact how, why, and when behind this leap has remained elusive.

A new study published in Science Advances provides fresh insights into this mystery, revealing the shift from a sprawled to upright posture in mammals was anything but straightforward. Using methods that blend fossil data with advanced biomechanical modeling, the researchers found that this transition was surprisingly complex and nonlinear, and occurred much later than previously believed.

Lead author and postdoctoral fellow Peter Bishop, and senior author Professor Stephanie Pierce, both in the Department of Organismic and Evolutionary Biology, began by examining the biomechanics of five modern species that represent the full spectrum of limb postures, including a tegu lizard (sprawled), an alligator (semi-upright), and a greyhound (upright).

“By first studying these modern species, we greatly improved our understanding of how an animal’s anatomy relates to the way it stands and moves,” said Bishop. “We could then put it into an evolutionary context of how posture and gait actually changed.”

Evolutionary interrelationships of the modern (black) and extinct (gray) species investigated.

Evolutionary interrelationships of the modern (black) and extinct (gray) species investigated. The study revealed a complex history of posture evolution in synapsids, and that a fully “upright” posture typical of modern placentals and marsupials was late to evolve.

Credit: Peter Bishop

The researchers extended their analysis to eight exemplar fossil species from four continents spanning 300 million years of evolution. The species ranged from the 1-ounce proto-mammal Megazostrodon to the Ophiacodon, which weighed hundreds of pounds, and also included animals like the sail-backed Dimetrodon and the saber-toothed predator Lycaenops. Using principles from physics and engineering, Bishop and Pierce built digital biomechanical models of how the muscles and bones attached to each other. These models allowed them to generate simulations that determined how much force the hindlimbs could apply on the ground.

“The amount of force that a limb can apply to the ground is a critical determinant of locomotor performance in animals,” said Bishop. “If you cannot produce sufficient force in a given direction when it’s needed, you won’t be able to run as fast, turn as quickly, or worse still, you could well fall over.”

The computer simulations produced a 3D “feasible force space” that captures a limb’s overall functional performance. “Computing feasible force spaces implicitly accounts for all the interactions that can occur between muscles, joints, and bones throughout a limb,” said Pierce. “This gives us a clearer view of the bigger picture, a more holistic view of limb function and locomotion and how it evolved over hundreds of millions of years.”

While the concept of a feasible force space has been around since the 1990s, this study is the first to apply it to the fossil record to understand how extinct animals once moved. The authors packaged the simulations into new “fossil-friendly” computational tools that can aid other paleontologists in exploring their own questions, as well as help engineers design better bio-inspired robots that can navigate complex or unstable terrain.

The study revealed several important “signals” of locomotion, including that the overall force-generating ability in the modern species was maximal around the postures that each species used in their daily behavior. Bishop and Pierce say this made them confident that the results obtained for the extinct species genuinely reflected how they stood and moved when alive.

After analyzing the extinct species, the researchers discovered that locomotor performance peaked and dipped over millions of years, rather than progressing in a simple, linear fashion from sprawling to upright. Some extinct species also appeared to be more flexible — able to shift back and forth between more sprawled or more upright postures, like modern alligators and crocodiles do. Others showed a strong reversal toward more sprawled postures before mammals evolved. Paired with the study’s other results, this indicated that the traits associated with upright posture in today’s mammals evolved much later than previously thought, most likely close to the common ancestor of therian mammals.

These findings also help reconcile several unresolved problems in the fossil record. For example, it explains the persistence of asymmetric hands, feet, and limb joints in many mammal ancestors, traits typically associated with sprawling postures among modern animals. It can also help explain why fossils of early mammal ancestors are frequently found in a squashed, spread-eagle pose — a pose more likely to be achieved with sprawled limbs, while modern placental and marsupial fossils are typically found lying on their sides.

“It is very gratifying as a scientist, when one set of results can help illuminate other observations, moving us closer to a more comprehensive understanding,” Bishop said.

  • ✇Harvard Gazette
  • ‘Art and Identity’ in a changing GermanySamantha Perfas
    “Die leere Mitte” (“The Empty Centre”) is presented in its own gallery with a custom large-format display designed by Hito Steyerl.Photo © President and Fellows of Harvard College; courtesy of the Harvard Art Museums Arts & Culture ‘Art and Identity’ in a changing Germany Filmmaker’s documentaries bring complex history to Busch-Reisinger Samantha Laine Perfas Harvard Staff Writer November 13, 2024 4 min
     

‘Art and Identity’ in a changing Germany

November 13th 2024 at 6:09 pm
A small audience is watching “Die leere Mitte” (“The Empty Centre”), which is presented in its own gallery.

“Die leere Mitte” (“The Empty Centre”) is presented in its own gallery with a custom large-format display designed by Hito Steyerl.

Photo © President and Fellows of Harvard College; courtesy of the Harvard Art Museums

Arts & Culture

‘Art and Identity’ in a changing Germany

Filmmaker’s documentaries bring complex history to Busch-Reisinger

Samantha Laine Perfas

Harvard Staff Writer

4 min read

Berlin-based filmmaker Hito Steyerl was 23 when she witnessed the fall of the Berlin Wall in the late 1980s and early ’90s. Some of her earliest films document this fraught period of Germany’s history, capturing the rise in xenophobic, racist, and anti-Semitic violence that followed unification. But that was more than 30 years ago, making the specifics a bit difficult to remember, she joked during an event held at the Harvard Art Museums on Oct. 29.

“It almost feels as if … a different person made these films,” she told those gathered. “It’s strange for me to try to talk about it; don’t ask me any details,” she added with a laugh.

Three films by Steyerl — “Deutschland und das Ich” (“Germany and Identity”), “Die leere Mitte” (“The Empty Centre”), and “Normalität 1-X” (“Normality 1-X”) — were recently acquired by the Busch-Reisinger Museum, the sole museum to own the works. These films are featured prominently in a current exhibition titled “Made in Germany? Art and Identity in a Global Nation.”

Nevin Aladağ’s “Best Friends Dortmund #4,” 2012, color photo with three girls standing together.

Nevin Aladağ’s “Best Friends Dortmund #4,” 2012.

Harvard Art Museums/Busch-Reisinger Museum, Antonia Paepcke DuBrul Fund, 2023.461. © Nevin Aladağ. Photo © President and Fellows of Harvard College; courtesy of the Harvard Art Museums

Henrike Naumann’s “Ostalgie” (2019), is 
 a room-sized installation

Henrike Naumann’s “Ostalgie” (2019), a room-sized installation addressing the immediate post-Wall period in Germany’s “new” federal states.

Courtesy of Henrike Naumann. Photo © President and Fellows of Harvard College; courtesy of the Harvard Art Museums

“As an exhibition, [it] features artists from different backgrounds and generations and [has work] that complicates notions of German identity, especially the idea of ethnic and cultural homogeneity,” said Lynette Roth, the Daimler Curator of the Busch-Reisinger. “We’ve seen that in recent months incredible conversations and questions around the question of national identity, both here in the United States and abroad.”

Steyerl was invited to speak as part of the annual Busch-Reisinger Museum Lecture series, which started in 2005 and is supported by the German Friends of the Busch-Reisinger Museum. She shared her experience filming her early documentaries, and explained the connection between some of her modern work and Germany’s evolution as a country, historically and technologically.

Steyerl said that one of the films, “The Empty Center” (1998), took eight years to complete. At the time, she was working with Wim Wenders, a filmmaker she met while studying in Tokyo. He was shooting a film called “Until the End of the World” and was “too busy” to capture the fall of the Berlin Wall himself, so he gave Steyerl a camera and told her to go document what she saw. Over the course of eight years, she filmed the wall coming down in an area she called “no man’s land” — what used to be a minefield between the East and the West between the two walls — and its subsequent transition and real estate development. In many ways, she hoped to highlight the transition from going to one border system (a literal wall) to another (the borders of privatization and capitalism).

“That’s basically the organizing principle of that film,” she said. “The superimpositions [are] showing something which had remained the same … but everything else had changed a lot.”

Throughout her lecture, Steyerl showed clips of her older documentaries. She also shared portions of her more contemporary work, such as her 2015 film “Factory of the Sun,” which uses different forms of imagery — video games, drone surveillance, dance — to explore financial power, control, and the spread of information in our increasingly technology-driven world.

After the event, attendees were invited to explore the “Made in Germany?” exhibit, which includes three of Steyerl’s films. Other works on display include Katharina Sieverding’s monumental pigment-on-metal print “Deutschland wird deutscher XLI/92” (“Germany Becomes More German XLI/92”) from 1992; Ulrich Wüst’s hand-crafted leporello (accordion book) “Hausbuch” (“House Book”) (1989–2010); and a loan of East Germany-born Henrike Naumann’s “Ostalgie” (2019), a room-sized installation addressing the immediate post-Wall period in Germany’s “new” federal states. Additionally, a special “Made in Germany?” playlist featuring music from the 1980s to today is available on Spotify, as well as a print catalog accompanying the exhibit.

The exhibition is on view through Jan. 5, 2025, in the Special Exhibitions Gallery and adjacent University Research Gallery on Level 3 of the Harvard Art Museums.

  • ✇University of Cambridge
  • Time alone heightens ‘threat alert’ in teenagers – even when connecting onlinefpjl2
    People in their late teens experience an increased sensitivity to threats after just a few hours left in a room on their own – an effect that endures even if they are interacting online with friends and family. This is according to latest findings from a cognitive neuroscience experiment conducted at the University of Cambridge, which saw 40 young people aged 16-19 undergo testing before and after several hours alone – both with and without their smartphones. Many countries have declared an ep
     

Time alone heightens ‘threat alert’ in teenagers – even when connecting online

By: fpjl2
November 13th 2024 at 12:33 pm

People in their late teens experience an increased sensitivity to threats after just a few hours left in a room on their own – an effect that endures even if they are interacting online with friends and family.

This is according to latest findings from a cognitive neuroscience experiment conducted at the University of Cambridge, which saw 40 young people aged 16-19 undergo testing before and after several hours alone – both with and without their smartphones.

Many countries have declared an epidemic of loneliness*. The researchers set out to “induce” loneliness in teenagers and study the effects through a series of tests, from a Pavlovian task to electrodes that measure sweat. 

Scientists found that periods of isolation, including those in which participants could use their phones, led to an increased threat response – the sensing of and reacting to potential dangers. This alertness can cause people to feel anxious and uneasy.

The authors of the study say that isolation and loneliness might lead to excessive “threat vigilance”, even when plugged in online, which could negatively impact adolescent mental health over time.

They say it could contribute to the persistent and exaggerated fear responses typical of anxiety disorders on the rise among young people around the world.

While previous studies show isolation leads to anxious behaviour and threat responses in rodents, this is believed to be the first study to demonstrate these effects through experiments involving humans.

The findings are published today in the journal Royal Society Open Science.

“We detected signs of heightened threat vigilance after a few hours of isolation, even when the adolescents had been connected through smartphones and social media,” said Emily Towner, study lead author from Cambridge’s Department of Psychology.

“This alertness to perceived threats might be the same mechanism that leads to the excessive worry and inability to feel safe which characterises anxiety,” said Towner, a Gates Cambridge Scholar.   

“It makes evolutionary sense that being alone increases our vigilance to potential threats. These threat response mechanisms undergo a lot of changes in adolescence, a stage of life marked by increasing independence and social sensitivity.”

"Our experiment suggests that periods of isolation in adolescents might increase their vulnerability to the development of anxiety, even when they are connected virtually.”

Researchers recruited young people from the local area in Cambridge, UK, conducting extensive screening to create a pool of 18 boys and 22 girls who had good social connections and no history of mental health issues.

Participants were given initial tests and questionnaires to establish a “baseline”. These included the Pavlovian threat test, in which they were shown a series of shapes on a screen, one of which was paired with a harsh noise played through headphones, so the shape became associated with a feeling of apprehension.

Electrodes attached to fingers monitored “electrodermal activity” – a physiological marker of stress – throughout this test.**

Each participant returned for two separate stints of around four hours isolated in a room in Cambridge University’s Psychology Department, after which the tests were completed again. There was around a month, on average, between sessions.

All participants underwent two isolation sessions. One was spent with a few puzzles to pass the time, but no connection to the outside world. For the other, participants were allowed smartphones and given wi-fi codes, as well as music and novels. The only major rule in both sessions was they had to stay awake.***

“We set out to replicate behaviour in humans that previous animal studies had found after isolation,” said Towner. “We wanted to know about the experience of loneliness, and you can’t ask animals how lonely they feel.”

Self-reported loneliness increased from baseline after both sessions. It was lower on average after isolation with social media, compared to full isolation.****

However, participants found the threat cue – the shape paired with a jarring sound – more anxiety-inducing and unpleasant after both isolation sessions, with electrodes also measuring elevated stress activity.

On average across the study, threat responses were 70% higher after the isolation sessions compared to the baseline, regardless of whether participants had been interacting digitally.

“Although virtual social interactions helped our participants feel less lonely compared to total isolation, their heightened threat response remained,” said Towner.

Previous studies have found a link between chronic loneliness and alertness to threats. The latest findings support the idea that social isolation may directly contribute to heightened fear responses, say researchers.  

Dr Livia Tomova, co-senior author and lecturer in Psychology at Cardiff University, who conducted the work while at Cambridge, added: “Loneliness among adolescents around the world has nearly doubled in recent years. The need for social interaction is especially intense during adolescence, but it is not clear whether online socialising can fulfil this need.

“This study has shown that digital interactions might not mitigate some of the deep-rooted effects that isolation appears to have on teenagers.”

Scientists say the findings might shed light on the link between loneliness and mental health conditions such as anxiety disorders, which are on the rise in young people.

Notes

*For example, in 2023 the U.S. Surgeon General declared an epidemic of loneliness and isolation.

**Electrodes placed on the fingers record small deflections in sweat and subsequent changes in electrical conductivity of the skin (electrodermal activity). Electrodermal activity is used to detect stress levels and increases with emotional or physical arousal.

***The baseline tests were always taken first. The order of the two isolation sessions was randomly allocated. For sessions with digital interactions allowed, most participants used social media (35 out of 40), with texting being the most common form of interaction (37 out of 40). Other popular platforms included Snapchat, Instagram, and WhatsApp. Participants mainly connected virtually with friends (38), followed by family (19), romantic partners (13), and acquaintances (4).

**** Average self-reported loneliness more than doubled after the isolation session with social media compared to baseline and nearly tripled after the complete isolation session compared to baseline.

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  • ✇MIT News
  • MIT engineers make converting CO2 into useful products more practicalDavid L. Chandler | MIT News
    As the world struggles to reduce greenhouse gas emissions, researchers are seeking practical, economical ways to capture carbon dioxide and convert it into useful products, such as transportation fuels, chemical feedstocks, or even building materials. But so far, such attempts have struggled to reach economic viability.New research by engineers at MIT could lead to rapid improvements in a variety of electrochemical systems that are under development to convert carbon dioxide into a valuable comm
     

MIT engineers make converting CO2 into useful products more practical

November 13th 2024 at 1:30 pm

As the world struggles to reduce greenhouse gas emissions, researchers are seeking practical, economical ways to capture carbon dioxide and convert it into useful products, such as transportation fuels, chemical feedstocks, or even building materials. But so far, such attempts have struggled to reach economic viability.

New research by engineers at MIT could lead to rapid improvements in a variety of electrochemical systems that are under development to convert carbon dioxide into a valuable commodity. The team developed a new design for the electrodes used in these systems, which increases the efficiency of the conversion process.

The findings are reported today in the journal Nature Communications, in a paper by MIT doctoral student Simon Rufer, professor of mechanical engineering Kripa Varanasi, and three others.

“The CO2 problem is a big challenge for our times, and we are using all kinds of levers to solve and address this problem,” Varanasi says. It will be essential to find practical ways of removing the gas, he says, either from sources such as power plant emissions, or straight out of the air or the oceans. But then, once the CO2 has been removed, it has to go somewhere.

A wide variety of systems have been developed for converting that captured gas into a useful chemical product, Varanasi says. “It’s not that we can’t do it — we can do it. But the question is how can we make this efficient? How can we make this cost-effective?”

In the new study, the team focused on the electrochemical conversion of CO2 to ethylene, a widely used chemical that can be made into a variety of plastics as well as fuels, and which today is made from petroleum. But the approach they developed could also be applied to producing other high-value chemical products as well, including methane, methanol, carbon monoxide, and others, the researchers say.

Currently, ethylene sells for about $1,000 per ton, so the goal is to be able to meet or beat that price. The electrochemical process that converts CO2 into ethylene involves a water-based solution and a catalyst material, which come into contact along with an electric current in a device called a gas diffusion electrode.

There are two competing characteristics of the gas diffusion electrode materials that affect their performance: They must be good electrical conductors so that the current that drives the process doesn’t get wasted through resistance heating, but they must also be “hydrophobic,” or water repelling, so the water-based electrolyte solution doesn’t leak through and interfere with the reactions taking place at the electrode surface.

Unfortunately, it’s a tradeoff. Improving the conductivity reduces the hydrophobicity, and vice versa. Varanasi and his team set out to see if they could find a way around that conflict, and after many months of work, they did just that.

The solution, devised by Rufer and Varanasi, is elegant in its simplicity. They used a plastic material, PTFE (essentially Teflon), that has been known to have good hydrophobic properties. However, PTFE’s lack of conductivity means that electrons must travel through a very thin catalyst layer, leading to significant voltage drop with distance. To overcome this limitation, the researchers wove a series of conductive copper wires through the very thin sheet of the PTFE.

“This work really addressed this challenge, as we can now get both conductivity and hydrophobicity,” Varanasi says.

Research on potential carbon conversion systems tends to be done on very small, lab-scale samples, typically less than 1-inch (2.5-centimeter) squares. To demonstrate the potential for scaling up, Varanasi’s team produced a sheet 10 times larger in area and demonstrated its effective performance.

To get to that point, they had to do some basic tests that had apparently never been done before, running tests under identical conditions but using electrodes of different sizes to analyze the relationship between conductivity and electrode size. They found that conductivity dropped off dramatically with size, which would mean much more energy, and thus cost, would be needed to drive the reaction.

“That’s exactly what we would expect, but it was something that nobody had really dedicatedly investigated before,” Rufer says. In addition, the larger sizes produced more unwanted chemical byproducts besides the intended ethylene.

Real-world industrial applications would require electrodes that are perhaps 100 times larger than the lab versions, so adding the conductive wires will be necessary for making such systems practical, the researchers say. They also developed a model which captures the spatial variability in voltage and product distribution on electrodes due to ohmic losses. The model along with the experimental data they collected enabled them to calculate the optimal spacing for conductive wires to counteract the drop off in conductivity.

In effect, by weaving the wire through the material, the material is divided into smaller subsections determined by the spacing of the wires. “We split it into a bunch of little subsegments, each of which is effectively a smaller electrode,” Rufer says. “And as we’ve seen, small electrodes can work really well.”

Because the copper wire is so much more conductive than the PTFE material, it acts as a kind of superhighway for electrons passing through, bridging the areas where they are confined to the substrate and face greater resistance.

To demonstrate that their system is robust, the researchers ran a test electrode for 75 hours continuously, with little change in performance. Overall, Rufer says, their system “is the first PTFE-based electrode which has gone beyond the lab scale on the order of 5 centimeters or smaller. It’s the first work that has progressed into a much larger scale and has done so without sacrificing efficiency.”

The weaving process for incorporating the wire can be easily integrated into existing manufacturing processes, even in a large-scale roll-to-roll process, he adds.

“Our approach is very powerful because it doesn’t have anything to do with the actual catalyst being used,” Rufer says. “You can sew this micrometric copper wire into any gas diffusion electrode you want, independent of catalyst morphology or chemistry. So, this approach can be used to scale anybody’s electrode.”

“Given that we will need to process gigatons of CO2 annually to combat the CO2 challenge, we really need to think about solutions that can scale,” Varanasi says. “Starting with this mindset enables us to identify critical bottlenecks and develop innovative approaches that can make a meaningful impact in solving the problem. Our hierarchically conductive electrode is a result of such thinking.”

The research team included MIT graduate students Michael Nitzsche and Sanjay Garimella,  as well as Jack Lake PhD ’23. The work was supported by Shell, through the MIT Energy Initiative.

This work was carried out, in part, through the use of MIT.nano facilities.

© Image: Courtesy of the researchers, edited by MIT News

A conceptual schematic of the new woven electrode design. Researchers wove a series of conductive copper wires (the brown-orange pipe) through a very thin membrane to reach the catalyst.
  • ✇ETH News
  • Everyday routines as the key to logging inDeborah Kyburz
    Smart homes are intended to make life easier, but logging into individual devices is often still an onerous task. Researchers from ETH Zurich have investigated how everyday routines could be used for secure and user-friendly authentication – with no need for cumbersome passwords.
     
  • ✇Harvard Gazette
  • Former Saudi intelligence chief urges greater international role in Gaza warAl Powell
    His Royal Highness Prince Turki Al Faisal (left) and Professor Tarek Masoud.Photo by Benn Craig Nation & World Former Saudi intelligence chief urges greater international role in Gaza war Al Faisal calls for Israel to reduce civilian casualties, lays out plan for U.N.-brokered two-state solution Alvin Powell Harvard Staff Writer November 12, 2024 5 min read Editor’s note: This story h
     

Former Saudi intelligence chief urges greater international role in Gaza war

By: Al Powell
November 13th 2024 at 12:43 am
Professor Tarek Masoud and His Royal Highness Prince Turki Al Faisal.

His Royal Highness Prince Turki Al Faisal (left) and Professor Tarek Masoud.

Photo by Benn Craig

Nation & World

Former Saudi intelligence chief urges greater international role in Gaza war

Al Faisal calls for Israel to reduce civilian casualties, lays out plan for U.N.-brokered two-state solution

Alvin Powell

Harvard Staff Writer

5 min read

Editor’s note: This story has been updated to correct the death toll in Gaza. The territory’s health ministry reports that more than 40,000 Palestinians have been killed in the conflict, but it does not distinguish between civilian and combatant deaths. Israel says it has killed more than 17,000 militants.

A former Saudi Arabian intelligence chief called international inaction in Gaza “criminal” and called on Israel’s sophisticated military to employ more targeted methods to reduce civilian deaths in its conflict with Hamas.

“What we need there is for both sides — not just the Israelis but also the Arabs — to say enough is enough and to turn to wiser heads and more capable leadership around the world to bring an end to the cycle of tit for tat and death for death and destruction for destruction,” said His Royal Highness Prince Turki Al Faisal, who served for 24 years as head of the Saudi Arabian Intelligence Presidency before stepping down in 2001.

Al Faisal, current chair of the King Faisal Center for Research and Islamic Studies in Riyadh, also proposed a U.N.-brokered process for a two-state solution during the Middle East Initiative’s “Middle East Dialogues” last Thursday at the Harvard Kennedy School. Hosted by Tarek Masoud, the initiative’s faculty chair, the series brings prominent actors from across the Middle East to discuss the war in Gaza and broader regional issues.

“This is something we began at Harvard last year to bring to this University genuine, candid, open conversations with people who hold wildly varied but widely shared views on the conflict between Israel and Palestine, the causes of that conflict and how it might be brought to an end,” said Masoud, who is also the Ford Foundation Professor of Democracy and Governance, as he introduced the event, the first of this school year.

Al Faisal, a member of the Saudi royal family and former ambassador to the U.S. and U.K., said that Hamas — whose Oct. 7, 2023, attack on Israel sparked the war — is a terrorist group, but argued that if Hamas mingles with civilians and digs tunnels under hospitals and mosques, Israeli soldiers should fight in the tunnels, not bomb indiscriminately.

Al Faisal called for establishment of a Palestinian state with its capital in Jerusalem to resolve the conflict as part of the creation of a two-state solution, with talks guided by the United Nations and participation of global powers.

“Part of the U.N. setup would be an article to come out in the United Nations Security Council resolution barring anybody on the side of the Palestinians and Israelis who does not accept a two-state solution from being in negotiations for a two-state solution,” Al Faisal said, adding that that would include even major players like Hamas and Hezbollah. “A mechanism should be put in place to get only those committed to the principle of peace between Arabs and Israelis to be party to the negotiations.”

Masoud described Al Faisal as “one of the broadest minds in our region, if not our planet” and as “not just a witness to history, but a shaper of it.”

Despite repeated calls for peace, the war has killed thousands of civilians and displaced hundreds of thousands. It has expanded in recent months into southern Lebanon after Iran-backed Hezbollah repeatedly fired rockets into Israel. Concerns about the war widening further have risen as Israel and Iran exchanged rocket fire.

In response to Masoud’s questions, Al Faisal said the ongoing fighting is planting seeds of anguish and anger among today’s children in Gaza. Those seeds will fuel the continuation of the long-running cycle of violence that has plagued the region.

“My view is even one death on both sides is not worth the destruction that is taking place,” Al Faisal said. “There is a verse in the Quran which says, ‘The killing of an innocent person is like killing all mankind.’ That is the attitude I think a state with the recognition that Israel has in the world should take into consideration.”  

Al Faisal also addressed Saudi Arabia’s approach to relations with Israel, saying normalization by other nations like Egypt and Jordan has had no impact on the fighting, so Saudi Arabia shouldn’t pursue it until the fighting has concluded, and a Palestinian state is assured.

Asked why Saudi Arabia hasn’t responded as it did to U.S. support for Israel in the 1973 Arab-Israeli War, when it imposed a painful oil embargo, Al Faisal said that times have changed. Such an approach today would be ineffective, he said, largely because the U.S. has become a major oil-producing nation.  

Prior speakers in the Dialogues series included Jared Kushner, former senior adviser to former President Donald Trump; Matt Duss, executive director of the Center for International Policy and former foreign policy adviser to Vermont Sen. Bernie Sanders; Salam Fayyad, former prime minister of the Palestinian Authority; and Einat Wilf, a political scientist and former member of the Knesset.

Al Faisal also addressed broader issues outside the conflict and praised the recent loosening of cultural rules in the kingdom and its more welcoming approach to outsiders. He also said there are opportunities for the U.S. and Saudi Arabia to cooperate more. Saudi Arabia is a significant provider of international aid, he said, and together the two could make a difference on international poverty.

“We are an evolving country, like all countries are,” Al Faisal said. “It’s not going to be a matter of a top-down decree on what to do, but rather an integration of the sense of what people want and what leadership can provide them.”

More from Middle East Dialogues

  • ✇MIT News
  • Graph-based AI model maps the future of innovationStephanie Martinovich | Department of Civil and Environmental Engineering
    Imagine using artificial intelligence to compare two seemingly unrelated creations — biological tissue and Beethoven’s “Symphony No. 9.” At first glance, a living system and a musical masterpiece might appear to have no connection. However, a novel AI method developed by Markus J. Buehler, the McAfee Professor of Engineering and professor of civil and environmental engineering and mechanical engineering at MIT, bridges this gap, uncovering shared patterns of complexity and order.“By blending gen
     

Graph-based AI model maps the future of innovation

Imagine using artificial intelligence to compare two seemingly unrelated creations — biological tissue and Beethoven’s “Symphony No. 9.” At first glance, a living system and a musical masterpiece might appear to have no connection. However, a novel AI method developed by Markus J. Buehler, the McAfee Professor of Engineering and professor of civil and environmental engineering and mechanical engineering at MIT, bridges this gap, uncovering shared patterns of complexity and order.

“By blending generative AI with graph-based computational tools, this approach reveals entirely new ideas, concepts, and designs that were previously unimaginable. We can accelerate scientific discovery by teaching generative AI to make novel predictions about never-before-seen ideas, concepts, and designs,” says Buehler.

The open-access research, recently published in Machine Learning: Science and Technology, demonstrates an advanced AI method that integrates generative knowledge extraction, graph-based representation, and multimodal intelligent graph reasoning.

The work uses graphs developed using methods inspired by category theory as a central mechanism to teach the model to understand symbolic relationships in science. Category theory, a branch of mathematics that deals with abstract structures and relationships between them, provides a framework for understanding and unifying diverse systems through a focus on objects and their interactions, rather than their specific content. In category theory, systems are viewed in terms of objects (which could be anything, from numbers to more abstract entities like structures or processes) and morphisms (arrows or functions that define the relationships between these objects). By using this approach, Buehler was able to teach the AI model to systematically reason over complex scientific concepts and behaviors. The symbolic relationships introduced through morphisms make it clear that the AI isn't simply drawing analogies, but is engaging in deeper reasoning that maps abstract structures across different domains.

Buehler used this new method to analyze a collection of 1,000 scientific papers about biological materials and turned them into a knowledge map in the form of a graph. The graph revealed how different pieces of information are connected and was able to find groups of related ideas and key points that link many concepts together.

“What’s really interesting is that the graph follows a scale-free nature, is highly connected, and can be used effectively for graph reasoning,” says Buehler. “In other words, we teach AI systems to think about graph-based data to help them build better world representations models and to enhance the ability to think and explore new ideas to enable discovery.”

Researchers can use this framework to answer complex questions, find gaps in current knowledge, suggest new designs for materials, and predict how materials might behave, and link concepts that had never been connected before.

The AI model found unexpected similarities between biological materials and “Symphony No. 9,” suggesting that both follow patterns of complexity. “Similar to how cells in biological materials interact in complex but organized ways to perform a function, Beethoven's 9th symphony arranges musical notes and themes to create a complex but coherent musical experience,” says Buehler.

In another experiment, the graph-based AI model recommended creating a new biological material inspired by the abstract patterns found in Wassily Kandinsky’s painting, “Composition VII.” The AI suggested a new mycelium-based composite material. “The result of this material combines an innovative set of concepts that include a balance of chaos and order, adjustable property, porosity, mechanical strength, and complex patterned chemical functionality,” Buehler notes. By drawing inspiration from an abstract painting, the AI created a material that balances being strong and functional, while also being adaptable and capable of performing different roles. The application could lead to the development of innovative sustainable building materials, biodegradable alternatives to plastics, wearable technology, and even biomedical devices.

With this advanced AI model, scientists can draw insights from music, art, and technology to analyze data from these fields to identify hidden patterns that could spark a world of innovative possibilities for material design, research, and even music or visual art.

“Graph-based generative AI achieves a far higher degree of novelty, explorative of capacity and technical detail than conventional approaches, and establishes a widely useful framework for innovation by revealing hidden connections,” says Buehler. “This study not only contributes to the field of bio-inspired materials and mechanics, but also sets the stage for a future where interdisciplinary research powered by AI and knowledge graphs may become a tool of scientific and philosophical inquiry as we look to other future work.” 

“Markus Buehler’s analysis of papers on bioinspired materials transformed gigabytes of information into knowledge graphs representing the connectivity of various topics and disciplines,” says Nicholas Kotov, the Irving Langmuir Distinguished Professor of Chemical Sciences and Engineering at the University of Michigan, who was not involved with this work. “These graphs can be used as information maps that enable us to identify central topics, novel relationships, and potential research directions by exploring complex linkages across subsections of the bioinspired and biomimetic materials. These and other graphs like that are likely to be an essential research tool for current and future scientists.”

© Image: Wassily Kandinsky (left), Markus Buehler, with the assistance of his new artificial intelligence system (center and right)

A graph-based AI model (center) recommended creating a new mycelium-based biological material (right), using inspiration from the abstract patterns found in Wassily Kandinsky’s painting, “Composition VII” (left).
  • ✇MIT News
  • Graph-based AI model maps the future of innovationStephanie Martinovich | Department of Civil and Environmental Engineering
    Imagine using artificial intelligence to compare two seemingly unrelated creations — biological tissue and Beethoven’s “Symphony No. 9.” At first glance, a living system and a musical masterpiece might appear to have no connection. However, a novel AI method developed by Markus J. Buehler, the McAfee Professor of Engineering and professor of civil and environmental engineering and mechanical engineering at MIT, bridges this gap, uncovering shared patterns of complexity and order.“By blending gen
     

Graph-based AI model maps the future of innovation

Imagine using artificial intelligence to compare two seemingly unrelated creations — biological tissue and Beethoven’s “Symphony No. 9.” At first glance, a living system and a musical masterpiece might appear to have no connection. However, a novel AI method developed by Markus J. Buehler, the McAfee Professor of Engineering and professor of civil and environmental engineering and mechanical engineering at MIT, bridges this gap, uncovering shared patterns of complexity and order.

“By blending generative AI with graph-based computational tools, this approach reveals entirely new ideas, concepts, and designs that were previously unimaginable. We can accelerate scientific discovery by teaching generative AI to make novel predictions about never-before-seen ideas, concepts, and designs,” says Buehler.

The open-access research, recently published in Machine Learning: Science and Technology, demonstrates an advanced AI method that integrates generative knowledge extraction, graph-based representation, and multimodal intelligent graph reasoning.

The work uses graphs developed using methods inspired by category theory as a central mechanism to teach the model to understand symbolic relationships in science. Category theory, a branch of mathematics that deals with abstract structures and relationships between them, provides a framework for understanding and unifying diverse systems through a focus on objects and their interactions, rather than their specific content. In category theory, systems are viewed in terms of objects (which could be anything, from numbers to more abstract entities like structures or processes) and morphisms (arrows or functions that define the relationships between these objects). By using this approach, Buehler was able to teach the AI model to systematically reason over complex scientific concepts and behaviors. The symbolic relationships introduced through morphisms make it clear that the AI isn't simply drawing analogies, but is engaging in deeper reasoning that maps abstract structures across different domains.

Buehler used this new method to analyze a collection of 1,000 scientific papers about biological materials and turned them into a knowledge map in the form of a graph. The graph revealed how different pieces of information are connected and was able to find groups of related ideas and key points that link many concepts together.

“What’s really interesting is that the graph follows a scale-free nature, is highly connected, and can be used effectively for graph reasoning,” says Buehler. “In other words, we teach AI systems to think about graph-based data to help them build better world representations models and to enhance the ability to think and explore new ideas to enable discovery.”

Researchers can use this framework to answer complex questions, find gaps in current knowledge, suggest new designs for materials, and predict how materials might behave, and link concepts that had never been connected before.

The AI model found unexpected similarities between biological materials and “Symphony No. 9,” suggesting that both follow patterns of complexity. “Similar to how cells in biological materials interact in complex but organized ways to perform a function, Beethoven's 9th symphony arranges musical notes and themes to create a complex but coherent musical experience,” says Buehler.

In another experiment, the graph-based AI model recommended creating a new biological material inspired by the abstract patterns found in Wassily Kandinsky’s painting, “Composition VII.” The AI suggested a new mycelium-based composite material. “The result of this material combines an innovative set of concepts that include a balance of chaos and order, adjustable property, porosity, mechanical strength, and complex patterned chemical functionality,” Buehler notes. By drawing inspiration from an abstract painting, the AI created a material that balances being strong and functional, while also being adaptable and capable of performing different roles. The application could lead to the development of innovative sustainable building materials, biodegradable alternatives to plastics, wearable technology, and even biomedical devices.

With this advanced AI model, scientists can draw insights from music, art, and technology to analyze data from these fields to identify hidden patterns that could spark a world of innovative possibilities for material design, research, and even music or visual art.

“Graph-based generative AI achieves a far higher degree of novelty, explorative of capacity and technical detail than conventional approaches, and establishes a widely useful framework for innovation by revealing hidden connections,” says Buehler. “This study not only contributes to the field of bio-inspired materials and mechanics, but also sets the stage for a future where interdisciplinary research powered by AI and knowledge graphs may become a tool of scientific and philosophical inquiry as we look to other future work.” 

“Markus Buehler’s analysis of papers on bioinspired materials transformed gigabytes of information into knowledge graphs representing the connectivity of various topics and disciplines,” says Nicholas Kotov, the Irving Langmuir Distinguished Professor of Chemical Sciences and Engineering at the University of Michigan, who was not involved with this work. “These graphs can be used as information maps that enable us to identify central topics, novel relationships, and potential research directions by exploring complex linkages across subsections of the bioinspired and biomimetic materials. These and other graphs like that are likely to be an essential research tool for current and future scientists.”

© Image: Wassily Kandinsky (left), Markus Buehler, with the assistance of his new artificial intelligence system (center and right)

A graph-based AI model (center) recommended creating a new mycelium-based biological material (right), using inspiration from the abstract patterns found in Wassily Kandinsky’s painting, “Composition VII” (left).
  • ✇Harvard Gazette
  • Study pinpoints optimal timing for RSV vaccine during pregnancyTerry Murphy
    Health Study pinpoints optimal timing for RSV vaccine during pregnancy Five weeks before giving birth best transfers maternal antibodies to the fetus, say researchers MGB Communications November 12, 2024 4 min read To better protect newborns from respiratory syncytial virus (RSV), the leading cause of hospitalization in U.S. infants, pregnant women should receive a vaccine five weeks before delive
     

Study pinpoints optimal timing for RSV vaccine during pregnancy

November 12th 2024 at 11:11 pm
Health

Study pinpoints optimal timing for RSV vaccine during pregnancy

Five weeks before giving birth best transfers maternal antibodies to the fetus, say researchers

MGB Communications

4 min read
Pregnant woman getting a RSV vaccine.

To better protect newborns from respiratory syncytial virus (RSV), the leading cause of hospitalization in U.S. infants, pregnant women should receive a vaccine five weeks before delivery, according to new research led by investigators at Mass General Brigham.

RSV typically causes mild, cold-like symptoms in most adults but can be deadly for infants. While current guidelines recommend a vaccine during weeks 32–36 of pregnancy, new findings suggest that vaccination closer to 32 weeks could provide the best protection. Results of the study are published in the American Journal of Obstetrics & Gynecology.

To assess whether maternal vaccine timing is an important consideration for RSV vaccination, the investigators measured RSV antibodies in the umbilical cord at the time of delivery among 124 women who received the RSV vaccine during weeks 32–36 of pregnancy and in the blood of 29 2-month-old infants of these mothers.

All study participants were receiving care at MGH or Mount Sinai Health System in New York City. Levels of RSV antibodies can predict protection against RSV infection in infants too young to yet receive their own vaccines.

The investigators found that maternal RSV vaccination at least five weeks before delivery led to the most efficient transfer of maternal antibodies across the placenta to the newborn, compared with maternal vaccination at two to three or three to four weeks prior to delivery.

In an additional analysis, RSV antibody levels in maternal and cord blood after RSV vaccination were compared with RSV antibody levels in 20 unvaccinated mothers. Maternal RSV vaccination resulted in significantly higher and longer-lasting maternal and cord RSV antibody levels.

“Our findings suggest that being vaccinated earlier within the approved timeframe allows for the most efficient placental transfer of antibody to the newborn,” said senior author Andrea Edlow, a maternal-fetal medicine specialist in the Department of Obstetrics and Gynecology at Massachusetts General Hospital. “They also may have implications for when the RSV monoclonal antibody, Nirsevimab, should be administered to newborns. Similar research should be conducted for other vaccines administered during pregnancy.

“This work provides much-needed data to guide physicians in counseling patients about RSV vaccine timing during pregnancy,” Edlow added.

The investigators noted that additional studies are needed to determine the minimum amount of antibody transfer and/or infant blood antibody levels to adequately protect infants against RSV. It will also be important to understand the potential additive protection for infants provided by breastmilk from RSV-vaccinated mothers. This study was designed to measure antibody transfer, but larger studies of infants 2 to 6 months of age will be needed to determine the extent to which this leads to enhanced protection.

Disclosures: Outside of this work, Edlow serves as a consultant for Mirvie, Inc. and is a consultant for and has received research funding from Merck Pharmaceuticals. Additional disclosures can be found in the paper.

Authorship: In addition to Edlow, Mass General Brigham authors include Olyvia J. Jasset, Paola Andrea Lopez Zapana, Lydia Shook, Emily Gilbert, Zhaojing Ariel Liu, Rachel V. Yinger, Caroline Bald, Caroline G. Bradford, Alexa H. Silfen, and Lael M. Yonker.

This work was funded by National Institute of Allergy and Infectious Disease (1U19AI167899, R01AI171980), the National Institute of Child Health and Human Development (5K12HD103096 to L.L.S; NIH/NHLBI: R01HL173059 to L.Y.; MGH ECOR: MGH Research Scholar Award to A.G.E., Claflin Award to L.L.S.; Binational Science Foundation Award number 2019075 to L.K.) None of the funders had any role in the design of the study; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.

  • ✇MIT News
  • When muscles work out, they help neurons to grow, a new study showsJennifer Chu | MIT News
    There’s no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines. In the presence of these muscle-generated signals, neurons grew four times farther compared to neurons that were not exposed
     

When muscles work out, they help neurons to grow, a new study shows

November 12th 2024 at 11:35 am

There’s no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.

Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines. In the presence of these muscle-generated signals, neurons grew four times farther compared to neurons that were not exposed to myokines. These cellular-level experiments suggest that exercise can have a significant biochemical effect on nerve growth.

Surprisingly, the researchers also found that neurons respond not only to the biochemical signals of exercise but also to its physical impacts. The team observed that when neurons are repeatedly pulled back and forth, similarly to how muscles contract and expand during exercise, the neurons grow just as much as when they are exposed to a muscle’s myokines.

While previous studies have indicated a potential biochemical link between muscle activity and nerve growth, this study is the first to show that physical effects can be just as important, the researchers say. The results, which are published today in the journal Advanced Healthcare Materials, shed light on the connection between muscles and nerves during exercise, and could inform exercise-related therapies for repairing damaged and deteriorating nerves.

“Now that we know this muscle-nerve crosstalk exists, it can be useful for treating things like nerve injury, where communication between nerve and muscle is cut off,” says Ritu Raman, the Eugene Bell Career Development Assistant Professor of Mechanical Engineering at MIT. “Maybe if we stimulate the muscle, we could encourage the nerve to heal, and restore mobility to those who have lost it due to traumatic injury or neurodegenerative diseases.”

Raman is the senior author of the new study, which includes Angel Bu, Ferdows Afghah, Nicolas Castro, Maheera Bawa, Sonika Kohli, Karina Shah, and Brandon Rios of MIT’s Department of Mechanical Engineering, and Vincent Butty of MIT’s Koch Institute for Integrative Cancer Research.

Muscle talk

In 2023, Raman and her colleagues reported that they could restore mobility in mice that had experienced a traumatic muscle injury, by first implanting muscle tissue at the site of injury, then exercising the new tissue by stimulating it repeatedly with light. Over time, they found that the exercised graft helped mice to regain their motor function, reaching activity levels comparable to those of healthy mice.

When the researchers analyzed the graft itself, it appeared that regular exercise stimulated the grafted muscle to produce certain biochemical signals that are known to promote nerve and blood vessel growth.

“That was interesting because we always think that nerves control muscle, but we don’t think of muscles talking back to nerves,” Raman says. “So, we started to think stimulating muscle was encouraging nerve growth. And people replied that maybe that’s the case, but there’s hundreds of other cell types in an animal, and it’s really hard to prove that the nerve is growing more because of the muscle, rather than the immune system or something else playing a role.”

In their new study, the team set out to determine whether exercising muscles has any direct effect on how nerves grow, by focusing solely on muscle and nerve tissue. The researchers grew mouse muscle cells into long fibers that then fused to form a small sheet of mature muscle tissue about the size of a quarter.

The team genetically modified the muscle to contract in response to light. With this modification, the team could flash a light repeatedly, causing the muscle to squeeze in response, in a way that mimicked the act of exercise. Raman previously developed a novel gel mat on which to grow and exercise muscle tissue. The gel’s properties are such that it can support muscle tissue and prevent it from peeling away as the researchers stimulated the muscle to exercise.

The team then collected samples of the surrounding solution in which the muscle tissue was exercised, thinking that the solution should hold myokines, including growth factors, RNA, and a mix of other proteins.

“I would think of myokines as a biochemical soup of things that muscles secrete, some of which could be good for nerves and others that might have nothing to do with nerves,” Raman says. “Muscles are pretty much always secreting myokines, but when you exercise them, they make more.”

“Exercise as medicine”

The team transferred the myokine solution to a separate dish containing motor neurons — nerves found in the spinal cord that control muscles involved in voluntary movement. The researchers grew the neurons from stem cells derived from mice. As with the muscle tissue, the neurons were grown on a similar gel mat. After the neurons were exposed to the myokine mixture, the team observed that they quickly began to grow, four times faster than neurons that did not receive the biochemical solution.

“They grow much farther and faster, and the effect is pretty immediate,” Raman notes.

For a closer look at how neurons changed in response to the exercise-induced myokines, the team ran a genetic analysis, extracting RNA from the neurons to see whether the myokines induced any change in the expression of certain neuronal genes.

“We saw that many of the genes up-regulated in the exercise-stimulated neurons was not only related to neuron growth, but also neuron maturation, how well they talk to muscles and other nerves, and how mature the axons are,” Raman says. “Exercise seems to impact not just neuron growth but also how mature and well-functioning they are.”

The results suggest that biochemical effects of exercise can promote neuron growth. Then the group wondered: Could exercise’s purely physical impacts have a similar benefit?

“Neurons are physically attached to muscles, so they are also stretching and moving with the muscle,” Raman says. “We also wanted to see, even in the absence of biochemical cues from muscle, could we stretch the neurons back and forth, mimicking the mechanical forces (of exercise), and could that have an impact on growth as well?”

To answer this, the researchers grew a different set of motor neurons on a gel mat that they embedded with tiny magnets. They then used an external magnet to jiggle the mat — and the neurons — back and forth. In this way, they “exercised” the neurons, for 30 minutes a day. To their surprise, they found that this mechanical exercise stimulated the neurons to grow just as much as the myokine-induced neurons, growing significantly farther than neurons that received no form of exercise.

“That’s a good sign because it tells us both biochemical and physical effects of exercise are equally important,” Raman says.

Now that the group has shown that exercising muscle can promote nerve growth at the cellular level, they plan to study how targeted muscle stimulation can be used to grow and heal damaged nerves, and restore mobility for people who are living with a neurodegenerative disease such as ALS.

“This is just our first step toward understanding and controlling exercise as medicine,” Raman says. 

© Credit: Angel Bu

MIT scientists find that motor neuron growth increased significantly over 5 days in response to biochemical (left) and mechanical (right) signals related to exercise. The green ball represents cluster of neurons that grow outward in long tails, or axons.
  • ✇NUS - National University of Singapore Newsroom
  • Touching the lives of those young and old, through community service
    Whether it is providing academic support to vulnerable youth or befriending seniors living alone, heartwarming stories of NUS students working to uplift local and regional communities abound each year. Embodying the University’s spirit of service to country and society, members of the NUS Community Service Club (NUS CSC) have been key drivers of volunteerism among our student population over the past 22 years.  Through NUS CSC programmes, more than 1,300 NUS students clocked close to 15,500 volu
     

Touching the lives of those young and old, through community service

Whether it is providing academic support to vulnerable youth or befriending seniors living alone, heartwarming stories of NUS students working to uplift local and regional communities abound each year. Embodying the University’s spirit of service to country and society, members of the NUS Community Service Club (NUS CSC) have been key drivers of volunteerism among our student population over the past 22 years.  

Through NUS CSC programmes, more than 1,300 NUS students clocked close to 15,500 volunteer hours in the last academic year. Three of the club’s members share what inspired their passion for service, the various ways they are making a difference in the community and how their efforts have enriched the lives of many – including their own.

Dewi Murni Bte Musa: Leading change through community service

Dewi Murni Bte Musa, a Year 4 student at the NUS Faculty of Science, began volunteering at the age of 16. But it was a seemingly ordinary day chaperoning primary school students for a national education show in 2018, held in conjunction with Singapore’s National Day Parade, that ignited her passion for community service.

At the end of the show, a primary schooler, beaming with excitement, thanked her for the day he had and told her that he aspired to be like her in the future. “It was a touching moment that made me realise the power of making someone’s day,” said Dewi, recalling that pivotal moment.

Since then, Dewi has dedicated herself to various community projects, both within and beyond Singapore. Now, in her fourth year at NUS CSC, Dewi has been elected the Club’s president, and set her sights on making an even bigger impact.

Reflecting on her time at NUS CSC, Dewi shared that her involvement in various programmes and projects played a significant role in her personal development. For example, as former Assistant Project Director, Dewi led a team of nearly 160 volunteers in Project C.A.N. XXI to prepare specially curated care packs containing food and essential items for low-income households in Choa Chu Kang and Tampines. The massive undertaking sharpened her organisational skills and taught her the importance of adaptability in team dynamics.

Yet, it was her moments of connection with community members at one NUS CSC Day that stood out most vividly to her. The annual event brings together NUS CSC’s four main sectors – children and youth, persons with intellectual disabilities, the elderly and those with life-limiting illnesses and healthcare. As a game master for the day, Dewi met a secondary school student from one of their partner organisations who told her that it felt like a dream to come to NUS. Her words struck a chord with Dewi who was reminded of her own childhood, when a university education seemed like an unattainable dream. “I’m the first in my extended family to attend university, so growing up, I didn’t really have anyone to talk to about getting a higher education,” she said. “But I was so happy that through CSC Day, we were able to give this young girl that opportunity,” she added.

Empowerment for youth and children is a cause that resonates with Dewi deeply, and she aspires to one day, build a passion project working with schools in rural areas, particularly in Indonesia, where she is fluent in the language and familiar with the culture.

As the incoming president of NUS CSC, Dewi envisions a club that not only mobilises volunteers but also fosters leadership and personal growth for its members. “We want to ensure that our volunteers are adequately prepared before they engage with community members and cultivate an environment where they can thrive as volunteer leaders,” she said. “I also want to see our club evolve to meet the changing needs of both our volunteers and the community.”

For those considering joining NUS CSC, Dewi encourages them to embrace the experience with an open mind and a willingness to learn. “It’s all about stepping out of your comfort zone and discovering the impact you can make,” she says, inviting new volunteers to share in the transformative power of community service.

Lim Si En: Painting lives, one home at a time

Like Dewi, Lim Si En, a Year 3 student at the NUS Faculty of Arts and Social Sciences (FASS), began his volunteering journey in junior college, tutoring primary school students and volunteering his time at national events like the National Day Parade. His passion for service led him to join NUS CSC in his first year at NUS. “Volunteering called out to me more than other CCAs,” he recalled, highlighting the breadth and accessibility of projects that resonate with his desire to help others.

In his second year, Si En took on the role of Project Director for NUS CSC’s annual Paint-A-Home initiative, pouring his heart into every detail of the six-month-long project, from recruiting committee members to collaborating with partner organisations. “Seeing our labour pay off was incredibly fulfilling,” he says, reflecting on the tangible improvements made in the homes they painted.

For Si En, the initiative was more than just applying a fresh coat of paint; it was about building relationships with community members to understand their needs and preferences, ensuring that his team’s work truly reflected the desires of those they served.

“The initial visit helped break the ice and build rapport,” he explained. This rapport was crucial, as many of the community members they assisted were elderly or from low-income families, facing various challenges. As Si En and most of his team members had no prior experience with painting, they contacted an organisation for painting lessons. The team also held a practice run, painting the multipurpose hall at the PERTAPIS Centre for Women and Girls, which kindly offered them use of the space for a trial session.

“Once we finished painting, the visible improvement felt great. We knew we made a difference,” he shared, acknowledging that their work wasn’t perfect but was heartfelt and impactful.

Si En’s commitment to the community extends beyond NUS CSC. As a Volunteer Welfare Officer with the Ministry of Social and Family Development since 2023, he conducts check-ins with families at risk of child neglect. “It’s an eye-opening experience,” he admits. “Even as I help others, I learn so much about the challenges they face.”

Hope Sng Xin Le: A heart for service

Taking over the reins from Si En at Clementi Youth Sparks this semester is Hope Sng Xin Le, a Year 2 NUS FASS student who embodies the spirit of service and compassion. Specialising in Social Work and Political Science, Hope’s journey into the realm of social service is deeply rooted in her own experiences and the values instilled in her by her family.

Growing up, Hope faced some challenges in her childhood. “My grandparents helped me through that tough time,” she recalled, citing this early experience as the spark that ignited her passion for social work. 

Another source of inspiration was a documentary that highlighted how exposure to domestic violence can ripple through generations. “It’s important to break the cycle of violence,” she remarked.

Hope’s academic pursuits complement her passion. Studying Political Science gives her insight into governmental structures and resource allocation, while her Social Work studies provide a ground-level perspective on societal issues. “Social work is where my calling is,” she says, expressing a desire to join Child or Adult Protective Services upon graduation to safeguard vulnerable individuals and families.

Hope’s commitment to volunteering blossomed at NUS, where she joined NUS CSC in her first year. At Ethelontêr, the NUS CSC’s orientation camp for incoming NUS students, she was introduced to various volunteer opportunities, including Havenue, a programme supporting individuals with life-limiting illnesses. “Havenue is my happy place,” she states with warmth, volunteering there two to three times a month.

Her work at Havenue holds a profound significance for her. Engaging with the elderly patients has reshaped her perspective on life and death. One particularly poignant memory is of Uncle Chew, a vibrant 90-year-old she befriended during his last days. His passing, along with that of another patient, reminded her of life’s fragility and the importance of cherishing every moment. “These experiences have shown me how precious life is,” she reflects, prompting her to be more expressive of her love and appreciation for those around her.

In Academic Year 2023/2024, Hope served the highest number of volunteer hours among all NUS CSC volunteers, staggering her time between seven projects throughout the year. Pulling off the 2024 edition of Ethelontêr as Assistant Project Director is something she is particularly proud of and she expressed her deep appreciation for her fellow organising committee members for being a strong support system during the five-month project where things were ‘fast and furious’.

“Prior to university, I thought of volunteering as something that was part of the school requirements. But over the past year, I realised my deeper calling to serve the community. It has strengthened my desire to pursue social work as a major and has been a source of joy and meaning in my life,” said Hope.

NUS launches BLOCK71 Nagoya to accelerate the growth of Southeast Asian start-ups in Japan

NUS Enterprise, the entrepreneurial arm of NUS, has expanded its global presence with the launch of BLOCK71 Nagoya. Officially inaugurated on 10 October 2024 by Mr Heng Swee Keat, Deputy Prime Minister of Singapore, BLOCK71 Nagoya is the first BLOCK71 location in Japan, strengthening a global BLOCK71 network that spans Southeast Asia, the United States, and China. The new office aims to create a technology-focused ecosystem connecting Japan and Southeast Asia, providing Southeast Asian start-ups with the support needed to navigate Japan’s cultural and business nuances, and helping Japanese start-ups scale and grow across Southeast Asia.

This milestone strengthens NUS’ long-standing partnership with the Aichi government and the city of Nagoya. The collaboration between NUS and Aichi dates back to 2018, with joint efforts focusing on driving cross-border innovation and entrepreneurship. Key initiatives include the NUS Summer Programme in Entrepreneurship, Asia’s largest university start-up showcase InnovFest, and the NUS Enterprise Market Immersion Programme in Japan which was launched last year. The opening of BLOCK71 Nagoya is the latest chapter in this collaboration and reflects a shared commitment to nurturing vibrant start-up ecosystems in both countries.

Following its official inauguration, BLOCK71 Nagoya opened its doors to start-ups on 1 November 2024, providing a dedicated space for entrepreneurs to collaborate, innovate, and access essential resources. The operational opening of the centre was graced by His Excellency Hideaki Omura, the Governor of Aichi Prefecture, who was joined by NUS President Professor Tan Eng Chye; Associate Professor Benjamin Tee, Vice President (Ecosystem Building), NUS Enterprise; Professor Naoshi Sugiyama, President of Nagoya University; and Mr Hirotaka Sahashi, President and CEO of STATION Ai Corporation.

Unlike other BLOCK71 global offices that focus on incubation, BLOCK71 in Japan prioritises market launch activities due to the country’s mature start-up landscape. BLOCK71 Nagoya and other future Japanese offices will support start-ups in developing Proof of Concept (PoC), securing funding, establishing partnerships, and integrating into the BLOCK71 global network. Beyond providing physical workspaces within partners’ co-working facilities, BLOCK71 in Japan will deploy dedicated staff across key cities to identify growth opportunities and help start-ups capitalise on Japan’s multifaceted market environment.

“Japan’s business environment is renowned for its rich traditions, strong emphasis on relationships, and high standards. Through BLOCK71 in Japan, we aim to empower Southeast Asian entrepreneurs to navigate this unique market, while simultaneously supporting Japanese start-ups in exploring opportunities in Southeast Asia. Located within STATION Ai, the largest start-up support centre in Japan, BLOCK71 Nagoya is well-positioned to cultivate a global ecosystem that fosters cross-border innovation. Our focus is on providing comprehensive business support, facilitating meaningful partnerships, and developing strategic roadmaps for growth that will benefit all involved,” said Prof Tan.

Prof Chen Tsuhan, NUS Deputy President (Innovation and Enterprise), highlighted the valuable resources available at BLOCK71 Nagoya. “By leveraging BLOCK71’s extensive global network and over a decade of experience in catalysing start-up communities, start-ups in Nagoya will have access to crucial resources such as technology, talent, markets and funding opportunities between Singapore and Japan. This new hub will not only support local start-ups but also attract international talent to Aichi, contributing to a vibrant, globally connected start-up environment. Additionally, BLOCK71 Nagoya will support start-ups in refining their go-to-market and fundraising strategies, which are essential for successful international expansion.”

Collaboration with ENEOS to enhance innovation

In addition to the launch of BLOCK71 Nagoya, NUS has formed a strategic partnership with ENEOS Holdings, Inc. (ENEOS), one of Japan’s largest energy companies, on 31 October 2024. This collaboration aims to enhance venture-building activities for NUS start-ups by exposing them to real-world industry challenges. Together, NUS Enterprise and ENEOS will work together to identify promising Southeast Asian start-ups and innovative solutions that can tackle critical industry issues relating to mobility, decarbonisation, the circular economy, and artificial intelligence. 

"Collaborating with NUS Enterprise provides ENEOS with a unique opportunity to harness the dynamic energy of Southeast Asia's start-up ecosystem,” said Mr Miyata Tomohide, Representative Director, CEO of ENEOS. “By engaging with innovative start-ups, we can gain fresh insights and co-create solutions that address the pressing challenges in our industry. This partnership will not only enhance our ability to adapt to market changes but also position us at the forefront of sustainable energy advancements. We are eager to work alongside these visionary entrepreneurs to drive meaningful progress in the energy sector.” 

Assimilating to the Japanese social fabric via the Market Immersion Programme

Recognising Japan’s culturally distinct business environment, BLOCK71 launched the Japan Immersion Programme last year to provide tailored support for Southeast Asian start-ups to better understand the Japanese market. The programme is structured in two phases: a pre-programme held in Singapore and an immersion phase in Japan.

From mid-August to the end of September 2024, the second cohort of five Singaporean start-ups participated in a series of lectures and mentorship sessions during the pre-programme. These activities equipped them with essential skills for developing their go-to-market (GTM) strategies and effective fundraising techniques to support their market expansion in Japan.

The immersion phase, during which the five start-ups engaged directly with potential Japanese partners, took place from 28 October to 1 November 2024 in Japan. Leveraging BLOCK71’s expansive network, the start-ups were invited to a site visit in Aichi Prefecture, participated in individual business meetings with Japanese stakeholders, and attended Messe Nagoya 2024, one of Japan’s largest cross-industry trade fairs. The Immersion Programme concluded with a pitching event organised by the Aichi government, which coincided with the operational opening of BLOCK71 Nagoya. This event provided a platform for the start-ups to showcase their refined pitching skills, demonstrating their potential to attract investment.

“We have secured collaboration interests with manufacturers in Nagoya, thanks to the support and opportunities provided by BLOCK71 Nagoya, JETRO, and ForStartups. The factory visits were immensely productive, giving us first-hand insights into the pain points of our prospective clients. We look forward to strengthening our partnerships with our Japanese colleagues and continuing to benefit from the comprehensive support of the NUS Enterprise ecosystem,” said Mr Ricky Vian Kartolo, CEO of Indas Technologies.

“Through the Japan Immersion Programme, we had the opportunity to speak with potential partners and gain insights into the business environment in Japan. The programme was valuable as it included factory visits, one-on-one corporate meetings, and an exhibition, allowing us to connect with a variety of partners throughout the week,” said Low Jin Huat, CEO of RoPlus.

 

By NUS Enterprise

  • ✇University of Pennsylvania
  • Top five election takeaways
    Stephanie Perry, exit polling manager for NBC News and executive director of the Penn Program on Opinion Research and Election Studies, shares insights into what drove voters in Tuesday’s election.
     

Top five election takeaways

November 12th 2024 at 2:00 am

Stephanie Perry, exit polling manager for NBC News and executive director of the Penn Program on Opinion Research and Election Studies, shares insights into what drove voters in Tuesday’s election.

  • ✇University of Cambridge
  • Gender inequality ingrained in global climate negotiations, say researcherscjb250
    In an article published today in Lancet Planetary Health, a team of researchers – including several from the University of Cambridge – argue that much more needs to be done to mitigate the impacts of climate change on women, girls and gender-diverse individuals. Focusing specifically on the intersection between climate change, gender, and human health, the researchers call on countries to work harder to ensure there is gender equity within their delegations to climate conferences and to ensure
     

Gender inequality ingrained in global climate negotiations, say researchers

By: cjb250
November 11th 2024 at 12:22 pm
Surviving the flood at Ahoada in Rivers state Nigeria

In an article published today in Lancet Planetary Health, a team of researchers – including several from the University of Cambridge – argue that much more needs to be done to mitigate the impacts of climate change on women, girls and gender-diverse individuals.

Focusing specifically on the intersection between climate change, gender, and human health, the researchers call on countries to work harder to ensure there is gender equity within their delegations to climate conferences and to ensure climate strategies identify gender-specific risks and vulnerabilities and address their root causes.

As the world prepares for COP29, concerns about gender representation and equality have reignited following the initial appointment of 28 men and no women to the COP29 organising committee in January 2024.

The effects of climate change – from heavy rains, rising temperatures, storms and floods through to sea level rises and droughts – exacerbate systemic inequalities and disproportionately affect marginalised populations, particularly those living in low-income areas.

While the specific situation may be different depending on where people live or their social background (like their class, race, ability, sexuality, age, or location), women, girls, and gender minorities are often at greater risk from the impacts of climate change. For example, in many countries, women are less likely to own land and resources to protect them in post-disaster situations, and have less control over income and less access to information, resulting in increased vulnerability to acute and long-term climate change impacts.

They are also particularly at risk from climate-related threats to their health, say the researchers. For example, studies have linked high temperatures to adverse birth outcomes such as spontaneous preterm births, pre-eclampsia and birth defects. Extreme events, which are expected to become more likely and intense due to climate change, also take a severe toll on women's social, physical, and mental well-being. Numerous studies highlight that gender-based violence is reported to increase during or after extreme events, often due to factors related to economic instability, food insecurity, disrupted infrastructure and mental stress.

Dr Kim Robin van Daalen, a former Gates Cambridge Scholar at the University of Cambridge, and researcher at the Barcelona Supercomputing Center (BSC), said: “Given how disproportionately climate change affects women, girls and gender minorities – a situation that is only likely to get worse – we need to ensure that their voices are heard and meaningfully included in discussions of how we respond to this urgent climate crisis. This is not currently happening at anywhere near the level it needs to.”

The team summarised the inclusion of gender, health and their intersection in key decisions and initiatives under the United Nations Framework Convention on Climate Change (UNFCCC), and analysed gender representation among representatives of Party and Observer State delegations at COPs between 1995-2023. Progress has been slow, they say.

They highlight how previous scholars have consistently noted that emphasis remains mainly on achieving a gender ‘number-based balance’ in climate governance, over exploring gender-specific risks and vulnerabilities and addressing their root causes. They also discuss how there remains limited recognition of the role climate change has in worsening gendered impacts on health, including gender-based violence and the lack of safeguarding reproductive health in the face of climate change.

Although the situation is slowly improving, at COP28, almost three-quarters (73%) of Party delegations were still majority men, and only just over one in six (16%) showed gender parity (that is, 45-55% women). In fact, gender parity has only been achieved in the ‘Western European and Other’ UN grouping (which also includes North America, Australia and New Zealand). Based on current trends, several countries - particularly those in the Asia-Pacific and Africa regions - are expected to take at least a decade from COP28 before reaching gender parity in their delegations.

Dr Ramit Debnath, former Gates Cambridge Scholar and now an Assistant Professor at Cambridge, said: “The urgency of climate action, as well as the slow understanding of climate, gender, and health connections, is cause for concern. Institutions like the UNFCCC must recognize these disparities, design appropriate methods to improve gender parity in climate governance, and keep these representation gaps from growing into societal and health injustices.”

Beyond ensuring that their voices are heard, more equitable inclusion of women has consistently been suggested to transform policymaking across political and social systems, including the generation of policies that better represent women’s interests. Previous recent analyses of 49 European countries revealed that greater women’s political representation correlates with reduced inequalities in self-reported health, lower geographical inequalities in infant mortality and fewer disability-adjusted life-years lost across genders.

Similar positive findings have been reported related to environmental policies, with women’s representation in national parliaments being associated with increased ratification of environmental treaties and more stringent climate change policies. For example, women legislators in the European parliament and US House of Representatives have been found to be more inclined to support environmental legislation than men.

Dr Ronita Bardhan, Associate Professor at the University of Cambridge, said: "Achieving equitable gender representation in climate action is not just about fairness - it's a strategic necessity with significant co-benefits. We can shape climate policies and infrastructure that address a broader spectrum of societal needs, leading to more inclusive solutions enhancing public health, social equity, and environmental resilience."

While the researchers’ analyses focused on achieving gender balance, studies on women’s involvement in climate governance suggest that increased representation does not by itself always lead to meaningful policy changes. Even when formally included, women’s active participation in male-dominated institutions is often constrained by existing social and cultural norms, implicit biases and structural barriers.

Dr van Daalen added: “If we’re to meaningfully incorporate gender into climate policy and practice, we need to understand the risks and vulnerabilities that are gender-specific and look at how we can address them and their root causes at all phases of programme and policy development.

“But we also need to resist reducing women to a single, homogenous group, which risks deepening existing inequalities and overlooks opportunities to address the needs of all individuals. It is crucial to recognise the diversity of women and their embodiment of multiple, intersecting identities that shape their climate experiences as well as their mitigation and adaptation needs.”

The team also highlights that gender-diverse people face unique health and climate-related risks due to their increased vulnerability, stigma, and discrimination. For example, during and after extreme events, transgender people in the United States report being threatened or prohibited access to shelters. Similarly, in the Philippines, Indonesia, and Samoa, gender-diverse individuals often face discrimination, mockery, and exclusion from evacuation centres or access to food. Yet, say the researchers, there are major gaps in knowledge about the health implications of climate change for such groups.

Find out how Cambridge's pioneering research in climate and nature is regenerating nature, rewiring energy, rethinking transport and redefining economics - forging a future for our planet.

Reference
Van Daalen, KR et al. Bridging the gender, climate, and health gap: the road to COP29. Lancet Planetary Health; 11 Nov 2024; DOI: 10.1016/S2542-5196(24)00270-5

Climate governance is dominated by men, yet the health impacts of the climate crisis often affect women, girls, and gender-diverse people disproportionately, argue researchers ahead of the upcoming 29th United Nations Climate Summit (COP29) in Azerbaijan.

Given how disproportionately climate change affects women, girls and gender minorities, we need to ensure that their voices are heard and meaningfully included in discussions of how we respond to this urgent climate crisis
Kim van Daalen
Surviving the flood at Ahoada in Rivers state Nigeria

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Between crystals, cats and quantum

November 11th 2024 at 9:30 am
ETH Professor Yiwen Chu is investigating how to apply quantum states to ever larger objects. This should help to gain new insights into physics and develop more efficient technologies. She has now been awarded the ETH Zurich Latsis Prize for her outstanding research.
  • ✇Harvard Gazette
  • Did Trump election signal start of new political era?Christina Pazzanese
    President-elect Donald Trump waves at an election night watch party at the Palm Beach Convention Center.Evan Vucci/AP Photo Nation & World Did Trump election signal start of new political era? Christina Pazzanese Harvard Staff Writer November 8, 2024 5 min read Analysts weigh issues, strategies, media decisions at work in contest, suggest class may become dominant factor President-el
     

Did Trump election signal start of new political era?

November 9th 2024 at 2:16 am
Republican presidential nominee former President Donald Trump waves as he walks with former first lady Melania Trump at an election night watch party.

President-elect Donald Trump waves at an election night watch party at the Palm Beach Convention Center.

Evan Vucci/AP Photo

Nation & World

Did Trump election signal start of new political era?

Christina Pazzanese

Harvard Staff Writer

5 min read

Analysts weigh issues, strategies, media decisions at work in contest, suggest class may become dominant factor

President-elect Donald Trump’s election victory over Vice President Kamala Harris was made possible partly by a significantly expanded coalition of multi-ethnic, working-class voters, signaling a potentially seismic shift in the American political landscape, according to a political analyst.

“I believe that we are in a new political era in which class will be the dominant factor in political divisions,” said William Galston, a columnist for The Wall Street Journal and senior fellow at the Brookings Institution, during a panel discussion Thursday hosted by the Center for American Political Studies.

Analysts at the election post-mortem, moderated by Harvey Mansfield, William R. Kenan Jr. Professor of Government, Emeritus, noted Trump made gains with voters in every age group, across racial and ethnic demographics, particularly Hispanic and Black men, and even improved over 2020 with women.

Class and gender were more determinative than race and ethnicity this year, Galston noted, with class, as defined by educational level rather than income, being the most important. The split between people with higher and lower levels of education is a development the country “will be wrestling with for the next generation with consequences that I can’t begin to predict,” he said.

Moderator Harvey Mansfield (from left) and panelists Bill Kristol, William Galston, and Ross Douthat
Moderator Harvey Mansfield (from left) and panelists Bill Kristol, William Galston, and Ross Douthat.

The group noted the Trump campaign correctly predicted wide-ranging voter discontent over the economy and immigration would override any misgivings about their candidate’s personality or behavior. And Trump’s recent pledge to veto a national abortion ban appeared to allay concerns with many voters over an issue Democrats had expected would drive turnout their way.

They also noted the campaign’s media strategy proved very effective. TV ads attacking Harris as being too liberal did some damage. And the unconventional decision to put less emphasis on mainstream news outlets in favor of more friendly, less overtly political settings, like “The Joe Rogan Podcast,” along with aggressive use of social media influencers, crypto and gambling events, and internet memes, helped the campaign reach likely supporters, the panelists said.

The Harris campaign had much to overcome, tied as it was to the coattails of a deeply unpopular administration that was blamed for the nation’s high inflation and problems with border security and immigration, the analysts said.

President Biden ran on restoring normalcy to the pandemic-battered U.S. economy and using his considerable foreign policy chops to cool global hotspots and repair international relations damaged by Trump, said Ross Douthat ’02, opinion columnist at The New York Times, who anticipated that Trump would prevail.

Instead, he said, voters faced much higher prices on essentials like gas and food and witnessed a botched U.S. withdrawal from Afghanistan and two wars erupt in Ukraine and in the Middle East.

Trump “said a lot of wild and deplorable things over the course of the 2024 election but having lived through the first Trump administration in which there was a huge disconnect between Trumpian rhetoric and the actual realities of governance, I don’t think it was that surprising that the voting public [told themselves] if we went through this for four years and things were OK, and Donald Trump did not become a fascist dictator, we can go through it for four more years’” because he offers better prospects than the alternative, Douthat said.  

In addition, Biden’s seeming retreat from his 2020 pledge to be a one-term “transitional president,” waiting until July to step aside, gave Harris no time to introduce herself to voters and to lay out and sharpen the substance and presentation of her agenda in just three months put her at a great disadvantage from the outset, said Galston.

Without a primary, Harris also had no real chance to establish an identity independent of Biden, making it easier to tie her to everything voters disliked about his administration. And arguments that Harris and Democrats thought would be key, such as reproductive rights and Trump’s role in the Jan. 6 attack, proved less powerful than hoped.

“There is a mountain of political science evidence to the effect that for people who feel hard-pressed economically or insecure physically, democracy is a luxury good,” said Galston.

Then there was the appeal of Trump himself. The president-elect has had 50 years as a celebrity, skillful marketer, and TV performer, so it’s not surprising that he excels at creating effective political images and viral content, like pretending to serve McDonald’s french fries, that cut through today’s fragmented media landscape and deliver his intended messages, said Bill Kristol ’73, Ph.D. ’79, a longtime conservative intellectual and founder of the now-defunct Weekly Standard, who became a critic of the Republican Party under Trump.

He said Trump returns to office with a more supportive Republican majority in the Senate and possibly the House, expanded presidential protections conferred by the Supreme Court, and a plan to purge the federal government of those who would try to block his initiatives. And so, he appears much more powerful than he was in 2016.

Referencing Karl Marx’s famous quip about history repeating itself the first time as tragedy, the second time as farce, Kristol said about a second Trump term: “What makes me most worried about the next four years is that it could end up being ‘first time farce, second time tragedy.’”

  • ✇Harvard Gazette
  • Cutting through the fog of long COVIDTerry Murphy
    Health Cutting through the fog of long COVID MGB Communications November 8, 2024 5 min read Researchers say new AI tool sharpens diagnostic process, may help identify more people needing care While earlier diagnostic studies have suggested that 7 percent of the population suffers from long COVID, a new AI tool developed by  Mass General Brigham revealed a much higher 22.8 percent, according to th
     

Cutting through the fog of long COVID

November 8th 2024 at 10:14 pm
Health

Cutting through the fog of long COVID

AI and medical records illustration.

MGB Communications

5 min read

Researchers say new AI tool sharpens diagnostic process, may help identify more people needing care

While earlier diagnostic studies have suggested that 7 percent of the population suffers from long COVID, a new AI tool developed by  Mass General Brigham revealed a much higher 22.8 percent, according to the study. 

The AI-based tool can sift through electronic health records to help clinicians identify cases of long COVID. The often-mysterious condition can encompass a litany of enduring symptoms, including fatigue, chronic cough, and brain fog after infection from SARS-CoV-2. 

The algorithm used was developed by drawing de-identified patient data from the clinical records of nearly 300,000 patients across 14 hospitals and 20 community health centers in the Mass General Brigham system. The results, published in the journal Med, could identify more people who should be receiving care for this potentially debilitating condition.

“Our AI tool could turn a foggy diagnostic process into something sharp and focused, giving clinicians the power to make sense of a challenging condition,” said senior author Hossein Estiri, head of AI Research at the Center for AI and Biomedical Informatics of the Learning Healthcare System (CAIBILS) at MGB and an associate professor of medicine at Harvard Medical School. “With this work, we may finally be able to see long COVID for what it truly is — and more importantly, how to treat it.”

“With this work, we may finally be able to see long COVID for what it truly is — and more importantly, how to treat it.”

Hossein Estiri

For the purposes of their study, Estiri and colleagues defined long COVID as a diagnosis of exclusion that is also infection-associated. That means the diagnosis could not be explained in the patient’s unique medical record but was associated with a COVID infection. In addition, the diagnosis needed to have persisted for two months or longer in a 12-month follow up window. 

The novel method developed by Estiri and colleagues, called “precision phenotyping,” sifts through individual records to identify symptoms and conditions linked to COVID-19 to track symptoms over time in order to differentiate them from other illnesses. For example, the algorithm can detect if shortness of breath results from pre-existing conditions like heart failure or asthma rather than long COVID. Only when every other possibility was exhausted would the tool flag the patient as having long COVID. 

“Physicians are often faced with having to wade through a tangled web of symptoms and medical histories, unsure of which threads to pull, while balancing busy caseloads. Having a tool powered by AI that can methodically do it for them could be a game-changer,” said Alaleh Azhir, co-lead author and an internal medicine resident at Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system.

The new tool’s patient-centered diagnoses may also help alleviate biases built into current diagnostics for long COVID, said researchers, who noted diagnoses with the official ICD-10 diagnostic code for long COVID trend toward those with easier access to healthcare.

The researchers said their tool is about 3 percent more accurate than the data ICD-10 codes capture, while being less biased. Specifically, their study demonstrated that the individuals they identified as having long COVID mirror the broader demographic makeup of Massachusetts, unlike long COVID algorithms that rely on a single diagnostic code or individual clinical encounters, skewing results toward certain populations such as those with more access to care.

“This broader scope ensures that marginalized communities, often sidelined in clinical studies, are no longer invisible,” said Estiri.

Limitations of the study and AI tool include that health record data the algorithm uses to account for long COVID symptoms may be less complete than the data physicians capture in post-visit clinical notes. Another limitation was the algorithm did not capture possible worsening of a prior condition that may have been a long COVID symptom. For example, if a patient had COPD that worsened before they developed COVID-19, the algorithm might have removed the episodes even if they were long COVID indicators. Declines in COVID-19 testing in recent years also makes it difficult to identify when a patient may have first gotten COVID-19.

The study was limited to patients in Massachusetts.

Future studies may explore the algorithm in cohorts of patients with specific conditions, like COPD or diabetes. The researchers also plan to release this algorithm publicly on open access so physicians and healthcare systems globally can use it in their patient populations. 

In addition to opening the door to better clinical care, this work may lay the foundation for future research into the genetic and biochemical factors behind long COVID’s various subtypes. “Questions about the true burden of long COVID — questions that have thus far remained elusive — now seem more within reach,” said Estiri.

Support was given by the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID) R01AI165535, National Heart, Lung, and Blood Institute (NHLBI) OT2HL161847, and National Center for Advancing Translational Sciences (NCATS) UL1 TR003167, UL1 TR001881, and U24TR004111. J. Hügel’s work was partially funded by a fellowship within the IFI program of the German Academic Exchange Service (DAAD) and by the Federal Ministry of Education and Research (BMBF) as well by the German Research Foundation (426671079).

  • ✇Harvard Gazette
  • So, here’s the thing about women comedians that isn’t funnyEileen O'Grady
    Bess Kalb (left) and Iliza Shlesinger.Niles Singer/Harvard Staff Photographer Arts & Culture So, here’s the thing about women comedians that isn’t funny Veteran stand-up headliner Iliza Shlesinger details self-censorship, social media, and double standards in Mahindra talk Eileen O’Grady Harvard Staff Writer November 8, 2024 4 min read Comedian Iliza Shlesinger doesn’t jot down her jo
     

So, here’s the thing about women comedians that isn’t funny

November 8th 2024 at 9:10 pm
Bess Kalb (left) and Iliza Shlesinger.

Bess Kalb (left) and Iliza Shlesinger.

Niles Singer/Harvard Staff Photographer

Arts & Culture

So, here’s the thing about women comedians that isn’t funny

Veteran stand-up headliner Iliza Shlesinger details self-censorship, social media, and double standards in Mahindra talk

Eileen O’Grady

Harvard Staff Writer

4 min read

Comedian Iliza Shlesinger doesn’t jot down her jokes — she stores them in her head until showtime. Even her setlists are just single-word prompts, like “giraffe” (for her baby giraffe impression) or “armpit” (she has joked that no man has ever dumped a woman over armpit stubble).

But that doesn’t mean her routine is mostly impromptu, or “unfiltered,” a label Shlesinger told a Paine Hall audience last Wednesday is overused for female comedians. In reality, she said, most audiences don’t realize how much stand-up material is edited and refined before it’s delivered.

“When you do stand-up, it’s a polished piece of art,” said Shlesinger, a national headliner who has starred in six of her own stand-up comedy specials on Netflix (considered a top-notch venue for comedians) and has toured internationally to sold-out theaters. “Every laugh that is elicited is purposefully placed. I know where the tension is. It’s a symphony.”

“As women we are constantly having to justify everything and make sure that you know that ‘I don’t mean to offend.’”

Iliza Shlesinger

At the Hauser Forum for the Arts talk hosted by the Mahindra Humanities Center, Shlesinger spoke with comedy writer Bess Kalb about self-censoring, comedy in the age of social media, and double standards for female comedians.

Shlesinger said that when it comes to the balancing act between not offending and not allowing public opinion to ruin a good joke, female comedians are always judged more harshly for their choices. She believes this could discourage them from wanting to make art.

“As women we are constantly having to justify everything and make sure that you know that ‘I don’t mean to offend,’” Shlesinger said. “We love to pick apart people and women. We do it deliciously. We love the schadenfreude of ‘I know that all she said was she loves fluffy clouds, but she didn’t say she loved rain clouds also, which means you hate the rain, which means you love climate change.’”

Kalb, an Emmy-nominated comedy writer who has written for “Jimmy Kimmel Live!” and The New Yorker, said she’s witnessed this double standard firsthand while writing for an all-female comedy special.

“It was at the same network where there were men who had their own specials, and the notes that we got about what all these women could and couldn’t say were astounding,” Kalb said.

Part of the reason behind the nitpicking, Shlesinger believes, is that social media algorithms have normalized content tailored to individual tastes.

“We all have our own personalized channels on Netflix, and we all have our own personalized comedians because we have so much to pick from on social media,” Schlesinger said. “That’s just not the way the human brain works. How could I tailor something that 100 percent speaks to you?”

Female comedians are often disproportionately expected to pull out anecdotes about trauma onstage to be relatable, said Shlesinger, who added that she speaks about her own experience with miscarriage during stand-ups. Kalb dubbed these moments “trauma gems.” Still, Shlesinger said, vulnerability onstage is important for engaging an audience.

“I always think if I’m feeling this, particularly when it comes to the experiences of being a woman, everybody else is feeling this,” Shlesinger said.

Though she knows her jokes won’t land with everyone, Shlesinger said she works to find the common denominator for her audience in whatever venue she’s in.

“At the end of the day, we are all people, and we do all go through the same things,” Shlesinger said. “When you can tap into that, which I always strive to do, that’s how you’re able to play Kuala Lumpur and also Ireland and also Tokyo. You’re reaching a very human thing.”

  • ✇Harvard Gazette
  • Making art as process of reclamationEileen O'Grady
    Arts & Culture Making art as process of reclamation Davóne Tines and Jennifer Koh.Photos by Jodi Hilton Eileen O’Grady Harvard Staff Writer November 8, 2024 5 min read Singer Davóne Tines ’09 and violinist Jennifer Koh discuss ‘Everything Rises,’ their work about race, complex ties to white world of classical music Jennifer Koh stood onstage in Paine Concert Hall and lifted her bow t
     

Making art as process of reclamation

November 8th 2024 at 9:03 pm
Arts & Culture

Making art as process of reclamation

Opera singer Davóne Tines, and violinist Jennifer Koh.

Davóne Tines and Jennifer Koh.

Photos by Jodi Hilton

Eileen O’Grady

Harvard Staff Writer

5 min read

Singer Davóne Tines ’09 and violinist Jennifer Koh discuss ‘Everything Rises,’ their work about race, complex ties to white world of classical music

Jennifer Koh stood onstage in Paine Concert Hall and lifted her bow to her violin, drawing out the first haunting notes of a Bach sonata. 

The back door of the hall then opened, and Davóne Tines ’09 entered singing a Handel aria, his rich bass-baritone interrupting Koh’s performance as he walked down the aisle. They traded notes in call-and-response until Tines joined Koh onstage, and the two performed a duet from Holst’s Songs for Voice and Violin, Op. 35.

The performance was the artists’ re-enactment of the real-life moment Tines and Koh met and began collaborating on “Everything Rises,” a staged performance that premiered at the University of California, Santa Barbara, in 2022. Tines and Koh told the audience at a recent evening talk hosted by the Department of Music how they created their show, which traces their family histories of racialized trauma and their own experiences navigating racism in the majority-white, tradition-bound world of classical music.

“Oftentimes things that are traditional or a part of the core of what institutions uphold go unexcavated, which is really detrimental,” Tines said, pausing to note the names of white European composers like Haydn, Schubert, and Wagner written on the walls in Paine Hall. “We say, ‘Oh, this Beethoven symphony is nonpareil, the best thing that you could be listening to’ so the institution doesn’t go to the lengths of actually self-reflecting to tell the audience why.”

“Oftentimes things that are traditional or a part of the core of what institutions uphold go unexcavated, which is really detrimental.”

Davóne Tines

Tines, who concentrated in sociology, was a member of the Harvard-Radcliffe Orchestra and sang his first opera, Stravinsky’s “Rake’s Progress,” his senior year with the Dunster House Opera Society. Currently he combines opera with gospel and spirituals, and often uses art to highlight and confront societal issues.

The award-winning Tines recalled meeting the violin virtuoso Koh backstage at the Paris Opera several years ago, and when they spotted each other, the only two people of color in the room, each felt an immediate connection. 

“We banded together and went to dinner, and continued to get to know each other,” Tines said. “As we compared and contrasted our life experiences, we found that we had a lot of similarities in our journeys as artists of color within classical music.” 

Soon after, they began working on “Everything Rises” and slowly assembled a team of collaborators, including composer Ken Ueno, Ph.D. ’05. They approached the show through a lens of lineage, telling the stories of Koh’s mother, a refugee from North Korea during the Korean War, and Tines’ grandmother, who holds vivid memories of anti-Black discrimination and violence in the U.S. Recorded interviews with the two women are included in the show.

“[Famed cellist] Yo-Yo Ma often says that it takes three generations to make an artist: the first generation to pull the family out of poverty, the second generation to become educated, and then the third generation then has the freedom and foundation to have creative pursuits,” Tines said. 

The lyrics of one song by Ueno, “Story of the Moth,” comes directly from frustrations Tines expressed about feeling objectified as a performer.

“Those words, which might seem affronting or surprising — ‘dear white people,’ ‘money, access and fame’ ‘I yearn for your validation’ — these were all things I’ve actually felt,” Tines said.

Tines and Koh adapted a setting of the 1930s anti-racism protest song “Strange Fruit” — which they also performed in their show — into a film for Carnegie Hall’s “Voices of Hope” series. That project came together shortly after the 2021 Atlanta spa shootings. In it, their music accompanies a gallery of racist political cartoons and CCTV footage of anti-Asian violence.

Jennifer Koh.
Jennifer Koh.

Koh said she’s noticed a clear difference in audience enthusiasm when she performs, say, a work by Tchaikovsky as opposed to a socially and politically charged piece like “Embers,” which was inspired by her years of anger and frustration over anti-Asian hate in the U.S.

“As performers, of course [we hope] you guys will clap at the end,” Koh said. “But to a certain degree, art is not about entertainment. It’s about confrontation of oneself. It’s not only an excavation of our own experience, but something, I think, for the audience to experience as well.”

One of their biggest challenges was finding the perfect way to end their show. At first, Tines said, he had suggested ending with the triumphantly hopeful “Ode to Joy” — both the Beethoven and the gospel hymn version — to suggest a move toward unity. 

But Koh disagreed, saying that type of resolution would be letting the audience “off the hook.” 

Tines turned to her. “Another thing you said was, ‘Davóne, you don’t have to give that to them. That can be for you,’” herecalled. “’You can find resolution and hope for yourself, but the audience will continue to contend with what was presented.’”

Ultimately, they went with an original composition by Ueno titled “Better Angels” (a reference to Lincoln’s first inaugural address), which they perform directly to each other, a choice Tines felt struck the appropriate chord.

“You want people to go to places that are doubtful,” Tines said. “You hope that those things sit with them, but you don’t want to let them off the hook. You don’t want them to eviscerate what actually has been built in the performance.”

  • ✇MIT News
  • Faces of MIT: Gene KeselmanKaty Dandurand | MIT Human Resources
    Gene Keselman wears a lot of hats. He is a lecturer at the MIT Sloan School of Management, the executive director of Mission Innovation Experimental (MIx), and managing director of MIT’s venture studio, Proto Ventures. Colonel in the Air Force Reserves at the Pentagon, board director, and startup leader are only a few of the titles and leadership positions Keselman has held. Now in his seventh year at MIT, his work as an innovator will impact the Institute for years to come. Keselman and his fam
     

Faces of MIT: Gene Keselman

November 8th 2024 at 9:30 pm

Gene Keselman wears a lot of hats. He is a lecturer at the MIT Sloan School of Management, the executive director of Mission Innovation Experimental (MIx), and managing director of MIT’s venture studio, Proto Ventures. Colonel in the Air Force Reserves at the Pentagon, board director, and startup leader are only a few of the titles and leadership positions Keselman has held. Now in his seventh year at MIT, his work as an innovator will impact the Institute for years to come. 

Keselman and his family are refugees from the Soviet Union. To say that the United States opened its arms and took care of his family is something Keselman calls “an understatement.” Growing up, he felt both gratitude and the need to give back to the country that took in his family. Because of this, Keselman joined the U.S. Air Force after college. Originally, he thought he would spend a few years in the Air Force, earn money to attend graduate school, and leave. Instead, he found a sense of belonging in the military lifestyle.

Early on, Keselman was a nuclear operations officer for four years, watching over nuclear weapons in Wyoming; while it was not a glamorous job, it was a strategically important one. He then joined the intelligence community in Washington, working on special programs for space. Next, he became an acquisition and innovation generalist inside the Air Force, working his way up to the rank of colonel, working on an innovation team at the Pentagon. Meanwhile, Keselman started exploring what his nonmilitary entrepreneurial life could look like. He left active duty after 12 years, entered the reserves, and began his relationship with MIT as an MBA student at the MIT Sloan School of Management.

At MIT Sloan, Keselman met Fiona Murray, associate dean of innovation and inclusion, who took an interest in Keselman’s experience. When the position of executive director of the Innovation Initiative (a program launched by then-President L. Rafael Reif) became available, Murray and MIT.nano Director Vladimir Bulovic hired Keselman and became his managers and main collaborators. While he was unsure that he would be a natural inside academia, Keselman credits Murray and Bulovic with seeing that his skill set from working with the Department of Defense (DoD) and in the military could translate and be useful in academia.

As a military officer, Keselman focused on process, innovation, leadership, and team building — tools he found useful in his new position. Over the next five years at MIT — a place, he admits, that was already at the forefront of innovation — he ran and created programs that augment how the Institute’s cutting-edge research is shared with the world. When the Innovation Initiative became the Office of Innovation, Keselman handed off executive duties to his deputy. Today, he oversees two programs. The first, MIx, focuses on national security innovation, defense technology, and dual-use (creating a commercial product and a capability for the government or defense). The other, Proto Ventures, is centered around venture building and translation of research.

With MIx and Proto Ventures established, it was time to build a teaching component for students interested in working for a startup that the government might want to partner with and learn from. Keselman becoming a lecturer at Sloan seemed like a clear next step. What started as a hackathon for MIT Air Force, Army, and Navy ROTC students to introduce the special operations community to those who were planning to become military officers turned into a class open to all undergrad and graduate students. Keselman co-teaches innovation engineering for global security systems, a design/build class in collaboration with U.S. Special Operations Command, where students learn to build innovative solutions in response to global security problems. Students who do not plan to work for the government enroll because of their desire to work on the most interesting — and difficult — problems in the world. Enrollment in these courses sometimes changes the career trajectory of students who decide they would like to work on national security-related problems in the future. While teaching was not an initial part of his plan, the opportunity to teach has become one of his joys. 

Soundbytes

Q: What project brings you the most pride?

Keselman: Proto Ventures is probably what I will look back on that will have made the most impact on MIT. I’m proud that I've continued to sustain it. Building a venture studio inside MIT is unique and is not replicated anywhere.

I’m also really proud of our work with North Atlantic Treaty Organization (NATO) Defence Innovation Accelerator for the North Atlantic (DIANA). DIANA is NATO’s effort to start its own accelerator program for startups to encourage them to work on solving national security questions in their country, based on the model at MIT. We built the curriculum, and I’ve taught it to DIANA startups in places including Italy, Poland, Denmark, and Estonia. The fact that NATO recognized that we need to promote access to startups and that there is a need to create an accelerator network is amazing. When it started, MIT was probably one of the only places teaching dual-use in the country. The fact that I got to take this curriculum and build it to scale in 32 countries and hundreds of startups is really rewarding. 

Q: In recognition of their service to our country, MIT actively seeks to recruit and employ veterans throughout its workforce. As a reservist, how does MIT support the time you take away from the Institute to fulfill your duties?

Keselman: MIT has a long history with the military, especially back in WWII times. With that comes a deep history of supporting the military. When I came to MIT I found a welcoming community that enables me to run centers, teach, and have students work on problems brought to us by the government. The magical thing about MIT is an openness to collaboration.

[At MIT,] Being an officer in the reserves is seen as a benefit, not a distraction. No one says, “He's gone again for his military duties at the Pentagon. He's not doing his work.” Instead, my work is viewed as an advantage for the Institute. MIT is a special place for the veteran and military community.

Q: A Veteran and Military Employee Resource Group (ERG) was recently launched at MIT. What do you hope will come from the ERG?

Keselman: The ERG once again underscores the uniqueness of MIT. Recruiter Nicolette Clifford from Human Resources and I had the idea for the group, but I thought, “Would anyone want this?” The reception from MIT Human Resources was positive and reinforcing. To put veterans and military into a supported group and make them feel like they have a home is amazing. I was blown away by it. We don’t usually get this kind of treatment. People thank us for our service, but then move on. It sends a message that MIT is a very friendly place for veterans. It also shows that MIT supports the people that defend our national security and support our way of life. 

© Photo courtesy of Gene Keselman.

Gene Keselman
  • ✇MIT News
  • Tackling the energy revolution, one sector at a timeCK Taylor | Climate and Sustainability Consortium
    As a major contributor to global carbon dioxide (CO2) emissions, the transportation sector has immense potential to advance decarbonization. However, a zero-emissions global supply chain requires re-imagining reliance on a heavy-duty trucking industry that emits 810,000 tons of CO2, or 6 percent of the United States’ greenhouse gas emissions, and consumes 29 billion gallons of diesel annually in the U.S. alone.A new study by MIT researchers, presented at the recent American Society of Mechanical
     

Tackling the energy revolution, one sector at a time

As a major contributor to global carbon dioxide (CO2) emissions, the transportation sector has immense potential to advance decarbonization. However, a zero-emissions global supply chain requires re-imagining reliance on a heavy-duty trucking industry that emits 810,000 tons of CO2, or 6 percent of the United States’ greenhouse gas emissions, and consumes 29 billion gallons of diesel annually in the U.S. alone.

A new study by MIT researchers, presented at the recent American Society of Mechanical Engineers 2024 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, quantifies the impact of a zero-emission truck’s design range on its energy storage requirements and operational revenue. The multivariable model outlined in the paper allows fleet owners and operators to better understand the design choices that impact the economic feasibility of battery-electric and hydrogen fuel cell heavy-duty trucks for commercial application, equipping stakeholders to make informed fleet transition decisions.

“The whole issue [of decarbonizing trucking] is like a very big, messy pie. One of the things we can do, from an academic standpoint, is quantify some of those pieces of pie with modeling, based on information and experience we’ve learned from industry stakeholders,” says ZhiYi Liang, PhD student on the renewable hydrogen team at the MIT K. Lisa Yang Global Engineering and Research Center (GEAR) and lead author of the study. Co-authored by Bryony DuPont, visiting scholar at GEAR, and Amos Winter, the Germeshausen Professor in the MIT Department of Mechanical Engineering, the paper elucidates operational and socioeconomic factors that need to be considered in efforts to decarbonize heavy-duty vehicles (HDVs).

Operational and infrastructure challenges

The team’s model shows that a technical challenge lies in the amount of energy that needs to be stored on the truck to meet the range and towing performance needs of commercial trucking applications. Due to the high energy density and low cost of diesel, existing diesel drivetrains remain more competitive than alternative lithium battery-electric vehicle (Li-BEV) and hydrogen fuel-cell-electric vehicle (H2 FCEV) drivetrains. Although Li-BEV drivetrains have the highest energy efficiency of all three, they are limited to short-to-medium range routes (under 500 miles) with low freight capacity, due to the weight and volume of the onboard energy storage needed. In addition, the authors note that existing electric grid infrastructure will need significant upgrades to support large-scale deployment of Li-BEV HDVs.

While the hydrogen-powered drivetrain has a significant weight advantage that enables higher cargo capacity and routes over 750 miles, the current state of hydrogen fuel networks limits economic viability, especially once operational cost and projected revenue are taken into account. Deployment will most likely require government intervention in the form of incentives and subsidies to reduce the price of hydrogen by more than half, as well as continued investment by corporations to ensure a stable supply. Also, as H2-FCEVs are still a relatively new technology, the ongoing design of conformal onboard hydrogen storage systems — one of which is the subject of Liang’s PhD — is crucial to successful adoption into the HDV market.

The current efficiency of diesel systems is a result of technological developments and manufacturing processes established over many decades, a precedent that suggests similar strides can be made with alternative drivetrains. However, interactions with fleet owners, automotive manufacturers, and refueling network providers reveal another major hurdle in the way that each “slice of the pie” is interrelated — issues must be addressed simultaneously because of how they affect each other, from renewable fuel infrastructure to technological readiness and capital cost of new fleets, among other considerations. And first steps into an uncertain future, where no one sector is fully in control of potential outcomes, is inherently risky. 

“Besides infrastructure limitations, we only have prototypes [of alternative HDVs] for fleet operator use, so the cost of procuring them is high, which means there isn’t demand for automakers to build manufacturing lines up to a scale that would make them economical to produce,” says Liang, describing just one step of a vicious cycle that is difficult to disrupt, especially for industry stakeholders trying to be competitive in a free market. 

Quantifying a path to feasibility

“Folks in the industry know that some kind of energy transition needs to happen, but they may not necessarily know for certain what the most viable path forward is,” says Liang. Although there is no singular avenue to zero emissions, the new model provides a way to further quantify and assess at least one slice of pie to aid decision-making.

Other MIT-led efforts aimed at helping industry stakeholders navigate decarbonization include an interactive mapping tool developed by Danika MacDonell, Impact Fellow at the MIT Climate and Sustainability Consortium (MCSC); alongside Florian Allroggen, executive director of MITs Zero Impact Aviation Alliance; and undergraduate researchers Micah Borrero, Helena De Figueiredo Valente, and Brooke Bao. The MCSC’s Geospatial Decision Support Tool supports strategic decision-making for fleet operators by allowing them to visualize regional freight flow densities, costs, emissions, planned and available infrastructure, and relevant regulations and incentives by region.

While current limitations reveal the need for joint problem-solving across sectors, the authors believe that stakeholders are motivated and ready to tackle climate problems together. Once-competing businesses already appear to be embracing a culture shift toward collaboration, with the recent agreement between General Motors and Hyundai to explore “future collaboration across key strategic areas,” including clean energy. 

Liang believes that transitioning the transportation sector to zero emissions is just one part of an “energy revolution” that will require all sectors to work together, because “everything is connected. In order for the whole thing to make sense, we need to consider ourselves part of that pie, and the entire system needs to change,” says Liang. “You can’t make a revolution succeed by yourself.” 

The authors acknowledge the MIT Climate and Sustainability Consortium for connecting them with industry members in the HDV ecosystem; and the MIT K. Lisa Yang Global Engineering and Research Center and MIT Morningside Academy for Design for financial support.

© Photo: Bob Adams/Flickr

A new study by MIT researchers quantifies the impact of a zero-emission truck’s design range on its energy storage requirements and operational revenue.
  • ✇University of Cambridge
  • Cambridge win golds at legendary rowing eventhcf38
    Cambridge University Boat Club (CUBC) student and alumni crews took part in the race, which is held on the Charles River over a 3-mile course comprising several bends that require skilled coxing. Cambridge walked away with gold in the Men’s Championship Eights, Women’s Master’s Double, Men’s Alumni Fours, and Men’s Senior Master’s Fours against top international crews, with an impressive set of results across the board. Read the full story on the CUBC website. Cambridge have claimed four golds
     

Cambridge win golds at legendary rowing event

By: hcf38
October 22nd 2024 at 7:12 pm
The Cambridge Men’s ‘A’ boat en route to victory

Cambridge University Boat Club (CUBC) student and alumni crews took part in the race, which is held on the Charles River over a 3-mile course comprising several bends that require skilled coxing. Cambridge walked away with gold in the Men’s Championship Eights, Women’s Master’s Double, Men’s Alumni Fours, and Men’s Senior Master’s Fours against top international crews, with an impressive set of results across the board.

Read the full story on the CUBC website.

Cambridge have claimed four golds at one of the biggest events in the global rowing calendar, the Head of the Charles Regatta in Boston, Massachusetts, USA.

The Cambridge Men’s ‘A’ boat en route to victory

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Yes

Homeless shelters that feel like home can help keep people off the streets in Singapore

By Dr Harry Tan, Research Fellow from the Policy Lab at the Institute of Policy Studies, Lee Kuan Yew School of Public Policy at NUS; Ms Vanessa Lim, Social Worker and Research Analyst at New Hope Community Services; Ms Belle Phang, a Year 6 Student at ACS (Independent); and Mr Brian Monteiro, Manager from the Shelters and Programs at Catholic Welfare Services

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