The research team, led by the University of Cambridge, adapted an algorithm originally designed for humans and found it could automatically detect and grade heart murmurs in dogs, based on audio recordings from digital stethoscopes. In tests, the algorithm detected heart murmurs with a sensitivity of 90%, a similar accuracy to expert cardiologists.

Heart murmurs are a key indicator of mitral valve disease, the most common heart condition in adult dogs. Roughly one in 30 dogs seen by a veterinarian has a heart murmur, although the prevalence is higher in small breed dogs and older dogs.

Since mitral valve disease and other heart conditions are so common in dogs, early detection is crucial as timely medication can extend their lives. The technology developed by the Cambridge team could offer an affordable and effective screening tool for primary care veterinarians, and improve quality of life for dogs. The results are reported in the Journal of Veterinary Internal Medicine.

“Heart disease in humans is a huge health issue, but in dogs it’s an even bigger problem,” said first author Dr Andrew McDonald from Cambridge’s Department of Engineering. “Most smaller dog breeds will have heart disease when they get older, but obviously dogs can’t communicate in the same way that humans can, so it’s up to primary care vets to detect heart disease early enough so it can be treated.”

Professor Anurag Agarwal, who led the research, is a specialist in acoustics and bioengineering. “As far as we’re aware, there are no existing databases of heart sounds in dogs, which is why we started out with a database of heart sounds in humans,” he said. “Mammalian hearts are fairly similar, and when things go wrong, they tend to go wrong in similar ways.”

The researchers started with a database of heart sounds from about 1000 human patients and developed a machine learning algorithm to replicate whether a heart murmur had been detected by a cardiologist. They then adapted the algorithm so it could be used with heart sounds from dogs.

The researchers gathered data from almost 800 dogs who were undergoing routine heart examination at four veterinary specialist centres in the UK. All dogs received a full physical examination and heart scan (echocardiogram) by a cardiologist to grade any heart murmurs and identify cardiac disease, and heart sounds were recorded using an electronic stethoscope. By an order of magnitude, this is the largest dataset of dog heart sounds ever created.

“Mitral valve disease mainly affects smaller dogs, but to test and improve our algorithm, we wanted to get data from dogs of all shapes, sizes and ages,” said co-author Professor Jose Novo Matos from Cambridge’s Department of Veterinary Medicine, a specialist in small animal cardiology. “The more data we have to train it, the more useful our algorithm will be, both for vets and for dog owners.”

The researchers fine-tuned the algorithm so it could both detect and grade heart murmurs based on the audio recordings, and differentiate between murmurs associated with mild disease and those reflecting advanced heart disease that required further treatment.  

“Grading a heart murmur and determining whether the heart disease needs treatment requires a lot of experience, referral to a veterinary cardiologist, and expensive specialised heart scans,” said Novo Matos. “We want to empower general practitioners to detect heart disease and assess its severity to help owners make the best decisions for their dogs.”

Analysis of the algorithm’s performance found it agreed with the cardiologist’s assessment in over half of cases, and in 90% of cases, it was within a single grade of the cardiologist’s assessment. The researchers say this is a promising result, as it is common for there to be significant variability in how different vets grade heart murmurs.

“The grade of heart murmur is a useful differentiator for determining next steps and treatments, and we’ve automated that process,” said McDonald. “For vets and nurses without as much stethoscope skill, and even those who are incredibly skilled with a stethoscope, we believe this algorithm could be a highly valuable tool.”

In humans with valve disease, the only treatment is surgery, but for dogs, effective medication is available. “Knowing when to medicate is so important, in order to give dogs the best quality of life possible for as long as possible,” said Agarwal. “We want to empower vets to help make those decisions.”

“So many people talk about AI as a threat to jobs, but for me, I see it as a tool that will make me a better cardiologist,” said Novo Matos. “We can’t perform heart scans on every dog in this country  – we just don’t have enough time or specialists to screen every dog with a murmur. But tools like these could help vets and owners, so we can quickly identify those dogs who are most in need of treatment.”

The research was supported in part by the Kennel Club Charitable Trust, the Medical Research Council, and Emmanuel College Cambridge.

Reference:
Andrew McDonald et al. ‘A machine learning algorithm to grade canine heart murmurs and stage preclinical myxomatous mitral valve disease.’ Journal of Veterinary Internal Medicine (2024). DOI: 10.1111/jvim.17224

Researchers have developed a machine learning algorithm to accurately detect heart murmurs in dogs, one of the main indicators of cardiac disease, which affects a large proportion of some smaller breeds such as King Charles Spaniels.

Huxley, a healthy volunteer Havanese, undergoes a physical examination at the Queen's Veterinary School Hospital, Cambridge.

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

The research team, led by the University of Cambridge, adapted an algorithm originally designed for humans and found it could automatically detect and grade heart murmurs in dogs, based on audio recordings from digital stethoscopes. In tests, the algorithm detected heart murmurs with a sensitivity of 90%, a similar accuracy to expert cardiologists.

Heart murmurs are a key indicator of mitral valve disease, the most common heart condition in adult dogs. Roughly one in 30 dogs seen by a veterinarian has a heart murmur, although the prevalence is higher in small breed dogs and older dogs.

Since mitral valve disease and other heart conditions are so common in dogs, early detection is crucial as timely medication can extend their lives. The technology developed by the Cambridge team could offer an affordable and effective screening tool for primary care veterinarians, and improve quality of life for dogs. The results are reported in the Journal of Veterinary Internal Medicine.

“Heart disease in humans is a huge health issue, but in dogs it’s an even bigger problem,” said first author Dr Andrew McDonald from Cambridge’s Department of Engineering. “Most smaller dog breeds will have heart disease when they get older, but obviously dogs can’t communicate in the same way that humans can, so it’s up to primary care vets to detect heart disease early enough so it can be treated.”

Professor Anurag Agarwal, who led the research, is a specialist in acoustics and bioengineering. “As far as we’re aware, there are no existing databases of heart sounds in dogs, which is why we started out with a database of heart sounds in humans,” he said. “Mammalian hearts are fairly similar, and when things go wrong, they tend to go wrong in similar ways.”

The researchers started with a database of heart sounds from about 1000 human patients and developed a machine learning algorithm to replicate whether a heart murmur had been detected by a cardiologist. They then adapted the algorithm so it could be used with heart sounds from dogs.

The researchers gathered data from almost 800 dogs who were undergoing routine heart examination at four veterinary specialist centres in the UK. All dogs received a full physical examination and heart scan (echocardiogram) by a cardiologist to grade any heart murmurs and identify cardiac disease, and heart sounds were recorded using an electronic stethoscope. By an order of magnitude, this is the largest dataset of dog heart sounds ever created.

“Mitral valve disease mainly affects smaller dogs, but to test and improve our algorithm, we wanted to get data from dogs of all shapes, sizes and ages,” said co-author Professor Jose Novo Matos from Cambridge’s Department of Veterinary Medicine, a specialist in small animal cardiology. “The more data we have to train it, the more useful our algorithm will be, both for vets and for dog owners.”

The researchers fine-tuned the algorithm so it could both detect and grade heart murmurs based on the audio recordings, and differentiate between murmurs associated with mild disease and those reflecting advanced heart disease that required further treatment.  

“Grading a heart murmur and determining whether the heart disease needs treatment requires a lot of experience, referral to a veterinary cardiologist, and expensive specialised heart scans,” said Novo Matos. “We want to empower general practitioners to detect heart disease and assess its severity to help owners make the best decisions for their dogs.”

Analysis of the algorithm’s performance found it agreed with the cardiologist’s assessment in over half of cases, and in 90% of cases, it was within a single grade of the cardiologist’s assessment. The researchers say this is a promising result, as it is common for there to be significant variability in how different vets grade heart murmurs.

“The grade of heart murmur is a useful differentiator for determining next steps and treatments, and we’ve automated that process,” said McDonald. “For vets and nurses without as much stethoscope skill, and even those who are incredibly skilled with a stethoscope, we believe this algorithm could be a highly valuable tool.”

In humans with valve disease, the only treatment is surgery, but for dogs, effective medication is available. “Knowing when to medicate is so important, in order to give dogs the best quality of life possible for as long as possible,” said Agarwal. “We want to empower vets to help make those decisions.”

“So many people talk about AI as a threat to jobs, but for me, I see it as a tool that will make me a better cardiologist,” said Novo Matos. “We can’t perform heart scans on every dog in this country  – we just don’t have enough time or specialists to screen every dog with a murmur. But tools like these could help vets and owners, so we can quickly identify those dogs who are most in need of treatment.”

The research was supported in part by the Kennel Club Charitable Trust, the Medical Research Council, and Emmanuel College Cambridge.

Reference:
Andrew McDonald et al. ‘A machine learning algorithm to grade canine heart murmurs and stage preclinical myxomatous mitral valve disease.’ Journal of Veterinary Internal Medicine (2024). DOI: 10.1111/jvim.17224

Researchers have developed a machine learning algorithm to accurately detect heart murmurs in dogs, one of the main indicators of cardiac disease, which affects a large proportion of some smaller breeds such as King Charles Spaniels.

Huxley, a healthy volunteer Havanese, undergoes a physical examination at the Queen's Veterinary School Hospital, Cambridge.

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

The treatment – known as repetitive transcranial magnetic stimulation (TMS) – involves placing an electromagnetic coil against the scalp to relay a high-frequency magnetic field to the brain.

Around one in 20 adults is estimated to suffer from depression. Although treatments exist, such as anti-depressant medication and cognitive behavioural therapy (‘talking therapy’), they are ineffective for just under one in three patients.

One of the key characteristics of depression is under-activity of some regions (such as the dorsolateral prefrontal cortex) and over-activity of others (such as the orbitofrontal cortex (OFC)).

Repetitive transcranial magnetic stimulation applied to the left side of the dorsolateral prefrontal cortex (an area at the upper front area of the brain) is approved for treatment of depression in the UK by NICE and in the US by the FDA. It has previously been shown to lead to considerable improvements among patients after a course of 20 sessions, but because the sessions usually take place over 20-30 days, the treatment is not ideal for everyone, particularly in acute cases or where a person is suicidal.

In research published in Psychological Medicine, scientists from Cambridge, UK, and Guiyang, China, tested how effective an accelerated form of TMS is. In this approach, the treatment is given over 20 sessions, but with four sessions per day over a period of five consecutive days.

The researchers also tested a ‘dual’ approach, whereby a magnetic field was additionally applied to the right-hand side of the OFC (which sits below the dorsolateral prefrontal cortex).

Seventy-five patients were recruited to the trial from the Second People’s Hospital of Guizhou Province in China. The severity of their depression was measured on a scale known as the Hamilton Rating Scale of Depression.

Participants were split randomly into three groups: a ‘dual’ group receiving TMS applied first to the right- and then to the left-hand sides of the brain; a ‘single’ group receiving sham TMS to the right-side followed by active TMS applied to the left-side; and a control group receiving a sham treatment to both sides. Each session lasted in total 22 minutes.

There was a significant improvement in scores assessed immediately after the final treatment in the dual treatment group compared to the other two groups. When the researchers looked for clinically-relevant responses – that is, where an individual’s score fell by at least 50% – they found that almost half (48%) of the patients in the dual treatment group saw such a reduction, compared to just under one in five (18%) in the single treatment group and fewer than one in 20 (4%) in the control group.

Four weeks later, around six in 10 participants in both the dual and single treatment groups (61% and 59% respectively) showed clinically relevant responses, compared to just over one in five (22%) in the control group.

Professor Valerie Voon from the Department of Psychiatry at the University of Cambridge, who led the UK side of the study, said: “Our accelerated approach means we can do all of the sessions in just five days, rapidly reducing an individual’s symptoms of depression. This means it could be particularly useful in severe cases of depression, including when someone is experiencing suicidal thoughts. It may also help people be discharged from hospital more rapidly or even avoid admission in the first place.

“The treatment works faster because, by targeting two areas of the brain implicated in depression, we’re effectively correcting imbalances in two import processes, getting brain regions ‘talking’ to each other correctly.”

The treatment was most effective in those patients who at the start of the trial showed greater connectivity between the OFC and the thalamus (an area in the middle of the brain responsible for, among other things, regulation of consciousness, sleep, and alertness). The OFC is important for helping us make decisions, particularly in choosing rewards and avoiding punishment. Its over-activity in depression, particularly in relation to its role in anti-reward or punishment, might help explain why people with depression show a bias towards negative expectations and ruminations.

Dr Yanping Shu from the Guizhou Mental Health Centre, Guiyang, China, said: “This new treatment has demonstrated a more pronounced – and faster – improvement in response rates for patients with major depressive disorder. It represents a significant step forward in improving outcomes, enabling rapid discharge from hospitals for individuals with treatment-resistant depression, and we are hopeful it will lead to new possibilities in mental health care.”

Dr Hailun Cui from Fudan University, a PhD student in Professor Voon’s lab at the time of the study, added: “The management of treatment-resistant depression remains one of the most challenging areas in mental health care. These patients often fail to respond to standard treatments, including medication and psychotherapy, leaving them in a prolonged state of severe distress, functional impairment, and increased risk of suicide.

“This new TMS approach offers a beacon of hope in this difficult landscape. Patients frequently reported experiencing ‘lighter and brighter’ feelings as early as the second day of treatment. The rapid improvements, coupled with a higher response rate that could benefit a broader depressed population, mark a significant breakthrough in the field.”

Just under a half (48%) of participants in the dual treatment group reported local pain where the dual treatment was applied, compared to just under one in 10 (9%) of participants in the single treatment group. However, despite this, there were no dropouts.

For some individuals, this treatment may be sufficient, but for others ‘maintenance therapy’ may be necessary, with an additional day session if their symptoms appear to be worsening over time. It may also be possible to re-administer standard therapy as patients can then become more able to engage in psychotherapy. Other options include using transcranial direct current stimulation, a non-invasive form of stimulation using weak electrical impulses that can be delivered at home.

The researchers are now exploring exactly which part of the orbitofrontal cortex is most effective to target and for which types of depression.

The research was supported by in the UK by the Medical Research Council and by the National Institute for Health and Care Research Cambridge Biomedical Research Centre.*

Reference
Cui, H, Ding, H & Hu, L et al. A novel dual-site OFC-dlPFC accelerated repetitive transcranial magnetic stimulation for depression: a pilot randomized controlled study. Psychological Medicine; 23 Oct 2024; DOI: 10.1017/S0033291724002289

*A full list of funders is available in the journal paper.

A type of therapy that involves applying a magnetic field to both sides of the brain has been shown to be effective at rapidly treating depression in patients for whom standard treatments have been ineffective.

Our accelerated approach means we can do all of the sessions in just five days, rapidly reducing an individual’s symptoms of depression

Valerie Voon

Digital image of a brain

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Election to the Academy is considered one of the highest honours in the fields of health and medicine and recognises individuals who have demonstrated outstanding professional achievement and commitment to service.

“It is a great honour to have been elected to the National Academy of Medicine,”  said Professor Rowitch.

Professor Rowitch obtained his PhD from the University of Cambridge. His research in the field of developmental neurobiology has focused on glial cells that comprise the ‘white matter’ of the human brain. It has furthered understanding human neonatal brain development as well as white matter injury in premature infants, multiple sclerosis and leukodystrophy. Amongst numerous awards, he was elected a Fellow of the Academy of Medical Sciences in 2018 and Fellow of the Royal Society in 2021.

Professor Rowitch’s current interest focuses on functional genomic technologies to better diagnose and treat rare neurogenetic disorders in children. He is academic lead for the new Cambridge Children’s Hospital, developing integrated paediatric physical-mental healthcare and research within the NHS and University of Cambridge.

NAM President Victor J. Dzau said: “This class of new members represents the most exceptional researchers and leaders in health and medicine, who have made significant breakthroughs, led the response to major public health challenges, and advanced health equity.

“Their expertise will be necessary to supporting NAM’s work to address the pressing health and scientific challenges we face today. It is my privilege to welcome these esteemed individuals to the National Academy of Medicine.”

Professor Rowitch is one of 90 regular members and 10 international members announced during the Academy’s annual meeting. New members are elected by current members through a process that recognises individuals who have made major contributions to the advancement of the medical sciences, health care, and public health. 

Professor David Rowitch, Head of the Department of Paediatrics at the University of Cambridge, has been elected to the prestigious National Academy of Medicine in the USA.

Professor David Rowitch

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Latest research has revealed a ‘positive association’ between the number of properties listed as Airbnb rentals and police-reported robberies and violent crimes in thousands of London neighbourhoods between 2015 and 2018.

In fact, the study led by the University of Cambridge suggests that a 10% increase in active Airbnb rentals in the city would correspond to an additional 1,000 robberies per year across London.*

Urban sociologists say the rapid pace at which crime rises in conjunction with new rentals suggests that the link is related more to opportunities for crime, rather than loss of cohesion within communities – although both are likely contributing factors.  

“We tested for the most plausible alternative explanations, from changes in police patrols to tourist hotspots and even football matches,” said Dr Charles Lanfear from Cambridge’s Institute of Criminology, co-author of the study published today in the journal Criminology.

“Nothing changed the core finding that Airbnb rentals are related to higher crime rates in London neighbourhoods.”

“While Airbnb offers benefits to tourists and hosts in terms of ease and financial reward, there may be social consequences to turning large swathes of city neighbourhoods into hotels with little regulation,” Lanfear said.

Founded in 2008, Airbnb is a giant of the digital economy, with more than 5 million property hosts now active on the platform in some 100,000 cities worldwide.

However, concerns that Airbnb is contributing to unaffordable housing costs has led to a backlash among residents of cities such as Barcelona, and calls for greater regulation.

London is one of the most popular Airbnb markets in the world. An estimated 4.5 million guests stayed in a London Airbnb during the period covered by the study.

Lanfear and his University of Pennsylvania co-author Professor David Kirk used masses of data from AirDNA: a site that scrapes Airbnb to provide figures, trends and approximate geolocations for the short-term letting market.

They mapped AirDNA data from 13 calendar quarters (January 2015 to March 2018) onto ‘Lower Layer Super Output Areas’, or LSOAs.

These are designated areas of a few streets containing around two thousand residents, used primarily for UK census purposes. There are 4,835 LSOAs in London, and all were included in the study.

Crime statistics from the UK Home Office and Greater London Authority for 6 categories – robbery, burglary, theft, anti-social behaviour, any violence, and bodily harm – were then mapped onto LSOAs populated with AirDNA data. 

The researchers analysed all forms of Airbnb lets, but found the link between active Airbnbs and crime is primarily down to entire properties for rent, rather than spare or shared rooms.

The association between active Airbnb rentals and crime was most significant for robbery and burglary, followed by theft and any violence. No link was found for anti-social behaviour and bodily harm.

On average across London, an additional Airbnb property was associated with a 2% increase in the robbery rate within an LSOA. This association was 1% for thefts, 0.9% for burglaries, and 0.5% for violence.

“While the potential criminogenic effect for each Airbnb rental is small, the accumulative effect of dozens in a neighbourhood, or tens of thousands across the city, is potentially huge,” Lanfear said.

He points out that London had an average of 53,000 active lettings in each calendar-quarter of the study period, and an average of 11 lettings per LSOA.

At its most extreme, one neighbourhood in Soho, an area famed for nightlife, had a high of 318 dedicated Airbnbs – some 30% of all households in the LSOA.  

The data models suggest that a 3.2% increase in all types of Airbnb rentals per LSOA would correspond to a 1% increase in robberies city-wide: 325 additional robberies based on the figure of 32,500 recorded robberies in London in 2018.

Lanfear and Kirk extensively stress-tested the association between Airbnb listings and London crime rates.

This included factoring in ‘criminogenic variables’ such as property prices, police stops, the regularity of police patrols, and even English Premier League football games (by both incorporating attendance into data modelling, and removing all LSOAs within a kilometre of major games).

The duo re-ran their data models excluding all the 259 LSOAs in central London’s Zone One, to see if the association was limited to high tourism areas with lots of Airbnb listings. The data models even incorporated the seasonal ‘ebb and flow’ of London tourism. Nothing changed the overall trends. 

Prior to crunching the numbers, the researchers speculated that any link might be down to Airbnbs affecting ‘collective efficacy’: the social cohesion within a community, combined with a willingness to intervene for the public good.

The study measured levels of collective efficacy across the city using data from both the Metropolitan Police and the Mayor of London’s Office, who conduct surveys on public perceptions of criminal activity and the likely responses of their community.    

Collective efficacy across London is not only consistently high, but did not explain the association between Airbnbs and crime in the data models.

Moreover, when Airbnb listings rise, the effect on crime is more immediate than one caused by a slow erosion of collective efficacy. “Crime seems to go up as soon as Airbnbs appear, and stays elevated for as long as they are active,” said Lanfear.

The researchers conclude it is likely driven by criminal opportunity. “A single Airbnb rental can create different types of criminal opportunity,” said Lanfear.

“An Airbnb rental can provide an easy potential victim such as a tourist unfamiliar with the area, or a property that is regularly vacant and so easier to burgle. A very temporary occupant may be more likely to cause criminal damage.”

“Offenders may learn to return to areas with more Airbnbs to find unguarded targets,” said Lanfear. “More dedicated Airbnb properties may mean fewer long-term residents with a personal stake in the area who are willing to report potential criminal activity.”

Airbnb has taken steps to prevent crime, including some background checks as well as requirements for extended bookings on occasions popular for one-night parties, such as New Year’s Eve. “The fact that we still find an increase in crime despite Airbnb’s efforts to curtail it reveals the severity of the predicament,” said Kirk.

Added Lanfear: “Short-term letting sites such as Airbnb create incentives for landlords that lead to property speculation, and we can see the effect on urban housing markets. We can now see that the expansion of Airbnb may contribute to city crime rates.”

“It is not the company or even the property owners who experience the criminogenic side effects of Airbnb, it is the local residents building their lives in the neighbourhood.”   

Notes:

*Above 2018 levels, which is when the study data ends. 

Rising numbers of houses and flats listed as short-term lets on Airbnb are associated with higher rates of crimes such as burglaries and street robberies right across London, according to the most detailed study of its kind.

There may be social consequences to turning large swathes of city neighbourhoods into hotels with little regulation

Charles Lanfear

London townhouses in Greenwich

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Writing in the journal Science Robotics, the research team, led by the University of Cambridge, outline how ‘palaeo-inspired robotics’ could provide a valuable experimental approach to studying how the pectoral and pelvic fins of ancient fish evolved to support weight on land.

“Since fossil evidence is limited, we have an incomplete picture of how ancient life made the transition to land,” said lead author Dr Michael Ishida from Cambridge’s Department of Engineering. “Palaeontologists examine ancient fossils for clues about the structure of hip and pelvic joints, but there are limits to what we can learn from fossils alone. That’s where robots can come in, helping us fill gaps in the research, particularly when studying major shifts in how vertebrates moved.”

Ishida is a member of Cambridge’s Bio-Inspired Robotics Laboratory, led by Professor Fumiya Iida. The team is developing energy-efficient robots for a variety of applications, which take their inspiration from the efficient ways that animals and humans move.

With funding from the Human Frontier Science Program, the team is developing palaeo-inspired robots, in part by taking their inspiration from modern-day ‘walking fish’ such as mudskippers, and from fossils of extinct fish. “In the lab, we can’t make a living fish walk differently, and we certainly can’t get a fossil to move, so we’re using robots to simulate their anatomy and behaviour,” said Ishida.

The team is creating robotic analogues of ancient fish skeletons, complete with mechanical joints that mimic muscles and ligaments. Once complete, the team will perform experiments on these robots to determine how these ancient creatures might have moved.

“We want to know things like how much energy different walking patterns would have required, or which movements were most efficient,” said Ishida. “This data can help confirm or challenge existing theories about how these early animals evolved.”

One of the biggest challenges in this field is the lack of comprehensive fossil records. Many of the ancient species from this period in Earth’s history are known only from partial skeletons, making it difficult to reconstruct their full range of movement.

“In some cases, we’re just guessing how certain bones connected or functioned,” said Ishida. “That’s why robots are so useful—they help us confirm these guesses and provide new evidence to support or rebut them.”

While robots are commonly used to study movement in living animals, very few research groups are using them to study extinct species. “There are only a few groups doing this kind of work,” said Ishida. “But we think it’s a natural fit – robots can provide insights into ancient animals that we simply can’t get from fossils or modern species alone.”

The team hopes that their work will encourage other researchers to explore the potential of robotics to study the biomechanics of long-extinct animals. “We’re trying to close the loop between fossil evidence and real-world mechanics,” said Ishida. “Computer models are obviously incredibly important in this area of research, but since robots are interacting with the real world, they can help us test theories about how these creatures moved, and maybe even why they moved the way they did.”

The team is currently in the early stages of building their palaeo-robots, but they hope to have some results within the next year. The researchers say they hope their robot models will not only deepen understanding of evolutionary biology, but could also open up new avenues of collaboration between engineers and researchers in other fields.

The research was supported by the Human Frontier Science Program. Fumiya Iida is a Fellow of Corpus Christi College, Cambridge. Michael Ishida a Postdoctoral Research Associate at Gonville and Caius College, Cambridge.

Reference:
Michael Ishida et al. ‘Paleo-inspired robotics as an experimental approach to the history of life.’ Science Robotics (2024). DOI: 10.1126/scirobotics.adn1125

The transition from water to land is one of the most significant events in the history of life on Earth. Now, a team of roboticists, palaeontologists and biologists is using robots to study how the ancestors of modern land animals transitioned from swimming to walking, about 390 million years ago.

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

Yes

Latest research has revealed a “positive association” between the number of properties listed as Airbnb rentals and police-reported robberies and violent crimes in thousands of London neighbourhoods between 2015 and 2018.

In fact, the study led by the University of Cambridge suggests that a 10% increase in active Airbnb rentals in the city would correspond to an additional 1,000 robberies per year across London.*

Urban sociologists say the rapid pace at which crime rises in conjunction with new rentals suggests that the link is related more to opportunities for crime, rather than loss of cohesion within communities – although both are likely contributing factors.  

“We tested for the most plausible alternative explanations, from changes in police patrols to tourist hotspots and even football matches,” said Dr Charles Lanfear from Cambridge’s Institute of Criminology, co-author of the study published today in the journal Criminology.

“Nothing changed the core finding that Airbnb rentals are related to higher crime rates in London neighbourhoods.”

“While Airbnb offers benefits to tourists and hosts in terms of ease and financial reward, there may be social consequences to turning large swathes of city neighbourhoods into hotels with little regulation,” Lanfear said.

Founded in 2008, Airbnb is a giant of the digital economy, with more than five million property hosts now active on the platform in some 100,000 cities worldwide.

However, concerns that Airbnb is contributing to unaffordable housing costs has led to a backlash among residents of cities such as Barcelona, and calls for greater regulation.

London is one of the most popular Airbnb markets in the world. An estimated 4.5 million guests stayed in a London Airbnb during the period covered by the study.

Lanfear and his University of Pennsylvania co-author Prof David Kirk used masses of data from AirDNA: a site that scrapes Airbnb to provide figures, trends and approximate geolocations for the short-term letting market.

They mapped AirDNA data from 13 calendar quarters (January 2015 to March 2018) onto “Lower Layer Super Output Areas”, or LSOAs.

These are designated areas of a few streets containing around two thousand residents, used primarily for UK census purposes. There are 4,835 LSOAs in London, and all were included in the study.

Crime statistics from the UK Home Office and Greater London Authority for six categories – robbery, burglary, theft, anti-social behaviour, any violence, and bodily harm – were then mapped onto LSOAs populated with AirDNA data. 

The researchers analysed all forms of Airbnb lets, but found the link between active Airbnbs and crime is primarily down to entire properties for rent, rather than spare or shared rooms.

The association between active Airbnb rentals and crime was most significant for robbery and burglary, followed by theft and any violence. No link was found for anti-social behaviour and bodily harm.

On average across London, an additional Airbnb property was associated with a 2% increase in the robbery rate within an LSOA. This association was 1% for thefts, 0.9% for burglaries, and 0.5% for violence.

“While the potential criminogenic effect for each Airbnb rental is small, the accumulative effect of dozens in a neighbourhood, or tens of thousands across the city, is potentially huge,” Lanfear said.

He points out that London had an average of 53,000 active lettings in each calendar-quarter of the study period, and an average of 11 lettings per LSOA.

At its most extreme, one neighbourhood in Soho, an area famed for nightlife, had a high of 318 dedicated Airbnbs – some 30% of all households in the LSOA.  

The data models suggest that a 3.2% increase in all types of Airbnb rentals per LSOA would correspond to a 1% increase in robberies city-wide: 325 additional robberies based on the figure of 32,500 recorded robberies in London in 2018.

Lanfear and Kirk extensively stress-tested the association between Airbnb listings and London crime rates.

This included factoring in “criminogenic variables” such as property prices, police stops, the regularity of police patrols, and even English Premier League football games (by both incorporating attendance into data modelling, and removing all LSOAs within a kilometre of major games).

The duo re-ran their data models excluding all the 259 LSOAs in central London’s Zone One, to see if the association was limited to high tourism areas with lots of Airbnb listings. The data models even incorporated the seasonal “ebb and flow” of London tourism. Nothing changed the overall trends. 

Prior to crunching the numbers, the researchers speculated that any link might be down to Airbnbs affecting “collective efficacy”: the social cohesion within a community, combined with a willingness to intervene for the public good.

The study measured levels of ‘collective efficacy’ across the city using data from both the Metropolitan Police and the Mayor of London’s Office, who conduct surveys on public perceptions of criminal activity and the likely responses of their community.    

Collective efficacy across London is not only consistently high, but did not explain the association between Airbnbs and crime in the data models.

Moreover, when Airbnb listings rise, the effect on crime is more immediate than one caused by a slow erosion of collective efficacy. “Crime seems to go up as soon as Airbnbs appear, and stays elevated for as long as they are active,” said Lanfear.

The researchers conclude it is likely driven by criminal opportunity. “A single Airbnb rental can create different types of criminal opportunity,” said Lanfear.

“An Airbnb rental can provide an easy potential victim such as a tourist unfamiliar with the area, or a property that is regularly vacant and so easier to burgle. A very temporary occupant may be more likely to cause criminal damage.”

“Offenders may learn to return to areas with more Airbnbs to find unguarded targets,” said Lanfear. “More dedicated Airbnb properties may mean fewer long-term residents with a personal stake in the area who are willing to report potential criminal activity.”

Airbnb has taken steps to prevent crime, including some background checks as well as requirements for extended bookings on occasions popular for one-night parties, such as New Year’s Eve. “The fact that we still find an increase in crime despite Airbnb’s efforts to curtail it reveals the severity of the predicament,” said Kirk.

Added Lanfear: “Short-term letting sites such as Airbnb create incentives for landlords that lead to property speculation, and we can see the effect on urban housing markets. We can now see that the expansion of Airbnb may contribute to city crime rates.”

“It is not the company or even the property owners who experience the criminogenic side effects of Airbnb, it is the local residents building their lives in the neighbourhood.”   

Notes:

*Above 2018 levels, which is when the study data ends. 

Rising numbers of houses and flats listed as short-term lets on Airbnb are associated with higher rates of crimes such as burglaries and street robberies right across London, according to the most detailed study of its kind.

There may be social consequences to turning large swathes of city neighbourhoods into hotels with little regulation

Charles Lanfear

London townhouses in Greenwich

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Yes

Writing in the journal Science Robotics, the research team, led by the University of Cambridge, outline how ‘palaeo-inspired robotics’ could provide a valuable experimental approach to studying how the pectoral and pelvic fins of ancient fish evolved to support weight on land.

“Since fossil evidence is limited, we have an incomplete picture of how ancient life made the transition to land,” said lead author Dr Michael Ishida from Cambridge’s Department of Engineering. “Palaeontologists examine ancient fossils for clues about the structure of hip and pelvic joints, but there are limits to what we can learn from fossils alone. That’s where robots can come in, helping us fill gaps in the research, particularly when studying major shifts in how vertebrates moved.”

Ishida is a member of Cambridge’s Bio-Inspired Robotics Laboratory, led by Professor Fumiya Iida. The team is developing energy-efficient robots for a variety of applications, which take their inspiration from the efficient ways that animals and humans move.

With funding from the Human Frontier Science Program, the team is developing palaeo-inspired robots, in part by taking their inspiration from modern-day ‘walking fish’ such as mudskippers, and from fossils of extinct fish. “In the lab, we can’t make a living fish walk differently, and we certainly can’t get a fossil to move, so we’re using robots to simulate their anatomy and behaviour,” said Ishida.

The team is creating robotic analogues of ancient fish skeletons, complete with mechanical joints that mimic muscles and ligaments. Once complete, the team will perform experiments on these robots to determine how these ancient creatures might have moved.

“We want to know things like how much energy different walking patterns would have required, or which movements were most efficient,” said Ishida. “This data can help confirm or challenge existing theories about how these early animals evolved.”

One of the biggest challenges in this field is the lack of comprehensive fossil records. Many of the ancient species from this period in Earth’s history are known only from partial skeletons, making it difficult to reconstruct their full range of movement.

“In some cases, we’re just guessing how certain bones connected or functioned,” said Ishida. “That’s why robots are so useful—they help us confirm these guesses and provide new evidence to support or rebut them.”

While robots are commonly used to study movement in living animals, very few research groups are using them to study extinct species. “There are only a few groups doing this kind of work,” said Ishida. “But we think it’s a natural fit – robots can provide insights into ancient animals that we simply can’t get from fossils or modern species alone.”

The team hopes that their work will encourage other researchers to explore the potential of robotics to study the biomechanics of long-extinct animals. “We’re trying to close the loop between fossil evidence and real-world mechanics,” said Ishida. “Computer models are obviously incredibly important in this area of research, but since robots are interacting with the real world, they can help us test theories about how these creatures moved, and maybe even why they moved the way they did.”

The team is currently in the early stages of building their palaeo-robots, but they hope to have some results within the next year. The researchers say they hope their robot models will not only deepen understanding of evolutionary biology, but could also open up new avenues of collaboration between engineers and researchers in other fields.

The research was supported by the Human Frontier Science Program. Fumiya Iida is a Fellow of Corpus Christi College, Cambridge. Michael Ishida a Postdoctoral Research Associate at Gonville and Caius College, Cambridge.

Reference:
Michael Ishida et al. ‘Paleo-inspired robotics as an experimental approach to the history of life.’ Science Robotics (2024). DOI: 10.1126/scirobotics.adn1125

The transition from water to land is one of the most significant events in the history of life on Earth. Now, a team of roboticists, palaeontologists and biologists is using robots to study how the ancestors of modern land animals transitioned from swimming to walking, about 390 million years ago.

Illustration of palaeo-robots

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Yes

• The Cambridge-GSK Translational Immunology Collaboration (CG-TIC) combines University and GSK expertise in the science of the immune system, AI and clinical development with access to patients and their data provided by Cambridge University Hospitals.
• GSK is investing more than £50 million in CG-TIC, further strengthening Cambridge’s position as Europe’s leading life sciences cluster.

GSK plc is making this investment to establish the Cambridge-GSK Translational Immunology Collaboration (CG-TIC), a five-year collaboration with the University of Cambridge and Cambridge University Hospitals. The collaboration is focused on understanding the onset of a disease, its progression, how patients respond to therapies and on developing biomarkers for rapid diagnosis. Ultimately, the goal is to trial more effective, personalised medicines.

The collaboration will focus on kidney and respiratory diseases, both of which affect large numbers of people worldwide. Kidney disease is estimated to affect 850 million people (roughly 10% of the world’s population) (International Society of Nephrology) and chronic respiratory diseases around 545 million (The Lancet).

Many types of kidney disease remain poorly understood and treatments, where they exist, tend to have limited efficacy. Chronic kidney disease is particularly unpleasant and debilitating for patients, often leading to end-stage disease. Treatments such as transplant and dialysis involve complex medical regimes and frequent hospital visits, making effective prevention and treatment the aim.

To make progress in treating these challenging disease areas, CG-TIC will apply an array of new techniques, including the use of cutting-edge single cell technologies to characterise how genes are expressed in individual cells. AI and machine learning have a critical role to play in transforming how data is combined and interrogated.

Using these techniques, the ambition is to be able to initiate new studies and early phase trials of new therapies for a number of hard-to-treat diseases which affect the kidneys. The same techniques will be applied to respiratory diseases and findings will be shared across the disease areas potentially to help identify and share better treatments across these different targets.

Peter Kyle, Secretary of State for Science, Innovation and Technology, welcomed the collaboration: "The UK's life sciences industry is thriving, driving innovation and improving lives. This collaboration between GSK and the University of Cambridge demonstrates our country's leading research and development capabilities.

“By focusing on cutting-edge research and harnessing the power of AI, this has the potential to advance the treatment of immune-related diseases, which could benefit patients both here in the UK and internationally. It's a clear example of how collaboration between industry, academia, and healthcare can deliver tangible results and strengthen the UK's position in healthcare innovation."

Tony Wood, Chief Scientific Officer, GSK, added: “Collaboration is at the heart of scientific progress and is fundamental to how we do R&D at GSK. We’re excited to build on our existing work with the University of Cambridge to further this world-leading scientific and technological capability in the UK. By bringing together Cambridge’s expertise and our own internal capabilities, including understanding of the immune system and the use of AI to accelerate drug development, we have an opportunity to help patients struggling with complex disease.”

The aim of CG-TIC is to improve outcomes for patients and Cambridge provides a unique environment in which to involve them, with Cambridge University Hospitals playing a pivotal role in the collaboration and Royal Papworth Hospital NHS Foundation Trust, the UK’s leading heart and lung hospital, a likely future partner.

Home to the hospitals and to much of the collaboration’s research activity, the Cambridge Biomedical Campus provides a unique environment where academia, industry and healthcare can come together and where human translational research is supported by the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre.

Professor Deborah Prentice, Vice-Chancellor of the University of Cambridge, said: “The University sits at the heart of Europe’s leading life sciences cluster, where excellent research and the NHS’s clinical resources combine with the talent generated by the many innovative bioscience companies that call Cambridge home. Through this very important collaboration with GSK, Cambridge will be able to drive economic growth for the UK while improving the health of people in this country and around the world.”

Roland Sinker, CEO of Cambridge University Hospitals NHS Foundation Trust, also welcomed the collaboration, saying: “We are very excited to be part of this important partnership, which is another example of Cambridge experts working together to develop transformational new therapies, and use existing ones more precisely, to improve outcomes for patients with chronic and debilitating conditions.”

The Cambridge-GSK Translational Immunology Collaboration will be co-led by Nicolas Wisniacki, VP, Clinical Research Head, GSK (above left) and David Thomas, Professor of Renal Medicine, University of Cambridge and principal investigator at the Cambridge Institute for Therapeutic Immunology and Infectious Diseases.

The ambition of the partnership is to treat immune-related diseases more precisely with existing therapies and to rapidly develop new ones.

The UK's life sciences industry is thriving, driving innovation and improving lives. This collaboration between GSK and the University of Cambridge demonstrates our country's leading research and development capabilities.

Peter Kyle, Secretary of State for Science, Innovation and Technology

David Thomas, Professor of Renal Medicine, University of Cambridge and Dr Nicolas Wisniacki, VP, Clinical Research Head, GSK

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Yes

It is Nobel prize-giving season and last week alumni of Cambridge University were awarded four of them for their brilliant work. In a leading article last week, The Times pointed out that if it were a country, Cambridge’s total of 125 would place it third for Nobel laureates behind only the UK and the US. This is a tribute to outstanding work which changes lives.

As an American who took over the role of vice-chancellor a little over a year ago, I am struck by how often the value of world-class research universities — to our economy, and to society and our daily lives — is underestimated here in Britain. Two of the top five in the world are British and in higher education terms this country punches well above its weight. This week we will announce a huge new investment in transformative research focused on a common foe: cancer. It will bring global benefits.

Our world-class, research-intensive universities are national assets. They can be genuine drivers of economic growth. Cambridge research contributes a staggering £30 billion to the UK economy each year. By contrast, no single US university plays such a national role.

And yet some UK research universities are in a precarious financial state. They are vital to their local and regional communities, as well as to Britain as a whole. They need more than just recognition if they are to drive future sustainable growth: they need investment, yes, but also support to innovate so they can continue to break new research frontiers and to serve their communities.

In Cambridge, we plan to launch an innovation hub that attracts and hosts the best researchers from around the world, plus entrepreneurs, funders and philanthropists. Under one roof, ideas will be driven forward, before they are spun out. The US and France have successfully pointed the way in these hothouses for innovation, in Boston and Paris. The UK must catch up — and fast.

With the budget looming, even — or perhaps especially — in tough times, the government must see our research universities as key allies and partners in its mission to drive economic growth. They are one of the main advantages this country enjoys in the global race for economic success.

At the start of a new academic year, thousands of students and researchers have arrived in Cambridge and at other British universities. We should invest in our world-class institutions and their contributions to tackling society’s greatest challenges so that in the decades to come we will have more Nobel laureates to celebrate.

This article first appeared in The Times on 14 October 2024.

 

Professor Deborah Prentice, Vice-Chancellor of the University of Cambridge, writes in The Times about how universities can drive UK growth - but they need more than just recognition.

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Yes

The significant funding commitment will enable world-class discovery science, unlocking new insights into how cancers develop, grow and spread, as well as examining how the immune system can be harnessed to combat the disease.  

Research at the CRUK Cambridge Institute focuses on understanding every stage of the cancer life cycle – how tumours grow and spread and how this is impacted by the characteristics of each individual patient.  By studying how tumours develop, adapt, and interact with their surroundings, scientists aim to uncover crucial insights into their behaviour. 

Vice-Chancellor of the University of Cambridge, Professor Deborah Prentice, said: “From understanding and detecting cancer at its very earliest stages, to developing kinder treatments to building Cambridge Cancer Research Hospital, a transformative new cancer research hospital for the region, Cambridge is changing the story of cancer. For many years now, Cancer Research UK has played a vital role in enabling this world-leading work. Today’s announcement will ensure our researchers continue to find new ways to transform the lives of patients locally, nationally and internationally.”

Today’s £173 million announcement further boosts CRUK’s unwavering commitment towards its mission to beat cancer. The charity is investing in exciting new research programmes, forging new partnerships and is on track to invest more than £1.5bn on research over the five-year period 2021/22 to 2025/26.   

Director of the CRUK Cambridge Institute, Professor Greg Hannon, said: “In a golden era for life sciences, this funding bolsters Cambridge as a major global hub for cancer research on an increasingly competitive worldwide stage and will greatly aid the recruitment of top-tier international talent.   

“Research from the Institute has already made a positive impact for patients and their families, from the development of innovative technologies, diagnostic tests, and advanced imaging methods to the roll out of personalised medicine programmes for those with brain, breast, pancreatic, and ovarian cancers. We believe that only by embracing the complexity of cancer and how the disease interacts with the normal cells of patients can we move the needle on the hardest to treat cancers.” 

The Institute is dedicated to improving cancer patients’ lives through discovery science and clinical translational research and has over 300 scientists working on groundbreaking discoveries taking research from laboratory bench to bedside.  

Established in 2007, it was the first major new cancer research centre in the UK for over 50 years. In 2013, it became a department of the University of Cambridge School of Clinical Medicine, strengthening links with researchers across the University and at Addenbrooke's Hospital,  and further enhancing its position as a world leader with research transitioning into clinical trials, and ultimately new and better cancer treatments. 

Professor Hannon added: "The Institute serves as a foundation for the entire Cambridge cancer research community through access to cutting-edge equipment and technical expertise. Only through understanding all aspects of the disease can we prevent, detect and treat cancer so that everybody can lead longer, better lives, free from fear of cancer.

“With this new funding, the Institute aims to accelerate its impact for patients, with new schemes to integrate clinicians into every aspect of our research and to embrace new technologies, including the promise of machine learning and artificial intelligence to enhance our discovery portfolio.”  

The award, which will support the Institute over the next seven years, follows a comprehensive review of the facility led by an independent panel of international cancer experts who recognised research innovation.  

CRUK Chief Executive, Michelle Mitchell, said: “We are delighted to confirm this incredible investment which is a reflection of  the world-leading research community at the CRUK Cambridge Institute. The funding will underpin long-term cutting-edge discovery research, as well as supporting researchers to find new ways to improve cancer prevention and treatment, while creating innovative solutions to diagnose the disease earlier. 

“This kind of funding would not be possible without the generosity of Cancer Research UK supporters and philanthropists."

Work undertaken at the Institute includes: 

• Understanding cancer: By gaining a deeper understanding of how tumours grow, adapt, and interact with their surroundings, scientists hope to uncover why some cells become cancerous and learn how each tumour's lifecycle can affect a patient’s response to treatment and prognosis.  Professor Greg Hannon's team developed a diagnostic tool using virtual reality to explore every cell and aspect of breast tumours in unprecedented detail.
• Unravelling tumour interactions: Researchers are investigating a tumours’ ‘microenvironment' – which includes the surrounding cells, blood vessels, and immune cells and how they interact. This is helping scientists to predict how well immunotherapy treatments will work.
• Cancer detection: Scientists are finding new ways to detect cancer earlier, predict the best course of treatments and tailor therapies to individual needs, to improve survival.  Using tumour DNA, scientists can monitor the effectiveness of treatments and catch signs of cancer returning.  Cambridge scientists are also working on a simple at-home test for future patients to regularly monitor their progress. 
• Personalised medicine: Looking at the unique genetic mutations of a person’s tumour, including how it behaves and responds to treatment, allows treatments to be developed and matched to the specific genetic change.  For example, Professor James Brenton's team discovered a specific mutation in the most common form of ovarian cancer which is now used across the NHS as a cancer marker to measure treatment response for the disease. 

Thanks to research, cancer death rates have fallen by 10% percent in the UK over the past decade. But in the East of England, around 37,400 people are still diagnosed, and around 15,700 lose their lives to the disease every year - underlining the vital need for new and better treatments. 

Major studies seeking more accurate treatments for the deadliest cancers like ovarian and oesophageal cancer will also be supported at the Institute.  Research undertaken by Professor Florian Markowetz and his team includes predicting cancer weaknesses to treatment, and spotting cancers as early as possible using AI technology. 

There are 17 research groups based at the Institute – based on the largest biomedical campus in Europe - studying a range of cancer and technologies to support improved cancer treatments. 

Find out how Cambridge is changing the story of cancer

Adapted from a press release from Cancer Research UK

Cancer Research UK (CRUK) has today announced a £173 million investment in its institute at the University of Cambridge - the largest single grant ever awarded by the charity outside of London.  

Today’s announcement will ensure our researchers continue to find new ways to transform the lives of patients locally, nationally and internationally

Deborah Prentice, Vice-Chancellor

Cancer Research UK Cambridge Institute

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Yes

From Tuesday 15 October the University of Cambridge’s Museum of Zoology is offering visitors a unique experience: the chance to chat with the animals on display – whether skeletal, taxidermy, or extinct.

In a collaboration with the company Nature Perspectives, the Museum’s Assistant Director Jack Ashby has chosen a range of animal specimens to bring back to life using generative Artificial Intelligence.

Visitors can pose their questions to thirteen specimens - including dodo and whale skeletons, a taxidermied red panda, and a preserved cockroach - by scanning QR codes that open a chat-box on their mobile phone. In two-way conversations, which can be voice- or text-based, the specimens will answer as if they are still alive.

This is believed to be the first time a museum has used generative Artificial Intelligence to enable visitors to chat with objects on display in this way.

By analysing data from the conversations, the team hopes that the month-long experiment will help them learn more about how AI can help the public to better engage with nature, and about the potential for AI in museums. It will also provide the museum with new insights into what visitors really want to know about the specimens on display.

Nature Perspectives uses AI to enable cultural institutions like the Museum of Zoology to engage the public through these unique conversational experiences. The company aims to reverse a growing apathy towards biodiversity loss by enabling new ways to engage with the natural world.

“This is an amazing opportunity for people to test out an emerging technology in our inspiring Museum setting, and we also hope to learn something about how our visitors see the animals on display,” said Jack Ashby, Assistant Director of the University of Cambridge’s Museum of Zoology.

He added: “Our whole purpose is to get people engaged with the natural world. So we're curious to see whether this will work, and whether chatting to the animals will change people’s attitudes towards them - will the cockroach be better liked, for example, as a result of having its voice heard?”

“By using AI to simulate non-human perspectives, our technology offers a novel way for audiences to connect with the natural world,” said Gal Zanir, co-founder of the company Nature Perspectives, which developed the AI technology for the experience.

He added: “One of the most magical aspects of the simulations is that they’re age-adaptive. For the first time, visitors of all ages will be able to ask the specimens anything they like.”

The technology brings together all available information on each animal involved – including details particular to the individual specimens such as where they came from and how they were prepared for display in the museum. This is all repackaged from a first-person perspective, so that visitors can experience realistic, meaningful conversations.

The animals will adjust their tone and language to suit the age of the person they’re talking to. And they’re multi-lingual - speaking over 20 languages including Spanish and Japanese so that visitors can chat in their native languages.

The team has chosen a range of specimens that include skeletons, taxidermy, models, and whole preserved animals. The specimens are: dodo skeleton, narwhal skeleton, brain coral, red admiral butterfly, fin whale skeleton, American cockroach, huia taxidermy (a recently extinct bird from New Zealand), red panda taxidermy, freeze-dried platypus, giant sloth fossil skeleton, giant deer skull and antlers, mallard taxidermy, and Ichthyostega model (an extinct ancestor of all animals with four legs).

Nature Perspectives was created by a team of graduates from the University of Cambridge’s Masters in Conservation Leadership programme, who noticed that people seem to feel more connected to machines when they can talk to them. This inspired the team to apply the same principle to nature - giving nature a voice to promote its agency and foster deeper, more personal connections between people and the natural world.

“Artificial Intelligence is opening up exciting new opportunities to connect people with non-human life, but the impacts need to be carefully studied. I’m delighted to be involved in exploring how the Nature Perspectives pilot affects the way people feel about and understand the species they ‘meet’ in the Museum of Zoology,” said Professor Chris Sandbrook, Director of the University of Cambridge’s Masters in Conservation Leadership programme.

“Enabling museums to engage visitors with the simulated perspectives of exhibits is only the first step for Nature Perspectives. We aim to apply this transformative approach widely, from public engagement and education to scientific research, to representing nature in legal processes, policy-making and beyond," said Zanir.

The Nature Perspectives AI experiment runs for one month, from 15th October to 15th of November 2024. For visiting times see www.museum.zoo.cam.ac.uk/visit-us 

Specimens in a Cambridge museum will be brought to life through the power of Artificial Intelligence, by a team aiming to strengthen our connection with the natural world and reverse apathy towards biodiversity loss.

This is an amazing opportunity for people to test out an emerging technology in our inspiring Museum setting.

Jack Ashby

Jack Ashby talking to the Museum's fin whale

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Yes

Volatiles are elements or compounds that change into vapour at relatively low temperatures. They include the six most common elements found in living organisms, as well as water. The zinc found in meteorites has a unique composition, which can be used to identify the sources of Earth’s volatiles.

The researchers, from the University of Cambridge and Imperial College London, have previously found that Earth’s zinc came from different parts of our Solar System: about half came from beyond Jupiter and half originated closer to Earth.

“One of the most fundamental questions on the origin of life is where the materials we need for life to evolve came from,” said Dr Rayssa Martins from Cambridge’s Department of Earth Sciences. “If we can understand how these materials came to be on Earth, it might give us clues to how life originated here, and how it might emerge elsewhere.”

Planetesimals are the main building blocks of rocky planets, such as Earth. These small bodies are formed through a process called accretion, where particles around a young star start to stick together, and form progressively larger bodies.

But not all planetesimals are made equal. The earliest planetesimals that formed in the Solar System were exposed to high levels of radioactivity, which caused them to melt and lose their volatiles. But some planetesimals formed after these sources of radioactivity were mostly extinct, which helped them survive the melting process and preserved more of their volatiles.

In a study published in the journal Science Advances, Martins and her colleagues looked at the different forms of zinc that arrived on Earth from these planetesimals. The researchers measured the zinc from a large sample of meteorites originating from different planetesimals and used this data to model how Earth got its zinc, by tracing the entire period of the Earth’s accretion, which took tens of millions of years.

Their results show that while these ‘melted’ planetesimals contributed about 70% of Earth’s overall mass, they only provided around 10% of its zinc.

According to the model, the rest of Earth’s zinc came from materials that didn’t melt and lose their volatile elements. Their findings suggest that unmelted, or ‘primitive’ materials were an essential source of volatiles for Earth.

“We know that the distance between a planet and its star is a determining factor in establishing the necessary conditions for that planet to sustain liquid water on its surface,” said Martins, the study’s lead author. “But our results show there’s no guarantee that planets incorporate the right materials to have enough water and other volatiles in the first place – regardless of their physical state.”

The ability to trace elements through millions or even billions of years of evolution could be a vital tool in the search for life elsewhere, such as on Mars, or on planets outside our Solar System.

“Similar conditions and processes are also likely in other young planetary systems,” said Martins. “The roles these different materials play in supplying volatiles is something we should keep in mind when looking for habitable planets elsewhere.”

The research was supported in part by Imperial College London, the European Research Council, and UK Research and Innovation (UKRI).

 

Reference:
Rayssa Martins et al. ‘Primitive asteroids as a major source of terrestrial volatiles.’ Science Advances (2024). DOI: 10.1126/sciadv.ado4121

Researchers have used the chemical fingerprints of zinc contained in meteorites to determine the origin of volatile elements on Earth. The results suggest that without ‘unmelted’ asteroids, there may not have been enough of these compounds on Earth for life to emerge.

An iron meteorite from the core of a melted planetesimal (left) and a chondrite meteorite, derived from a ‘primitive’, unmelted planetesimal (right).

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Yes

.

The Cambridge Conservation Initiative and the University of Cambridge Institute for Sustainability Leadership (CISL) co-hosted a panel discussion featuring key industry leaders in the run-up to the 16th Conference of the Parties to the Convention on Biological Diversity (CBD COP16). Please read more about the panel here

Panel members from CCI and CISL discuss the upcoming COP16

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Yes

This galaxy is one hundred times smaller than the Milky Way, but is surprisingly mature for so early in the universe. Like a large city, this galaxy has a dense collection of stars at its core but becomes less dense in the galactic ‘suburbs’. And like a large city, this galaxy is starting to sprawl, with star formation accelerating in the outskirts.

This is the earliest-ever detection of inside-out galactic growth. Until Webb, it had not been possible to study galaxy growth so early in the universe’s history. Although the images obtained with Webb represent a snapshot in time, the researchers, led by the University of Cambridge, say that studying similar galaxies could help us understand how they transform from clouds of gas into the complex structures we observe today. The results are reported in the journal Nature Astronomy.

“The question of how galaxies evolve over cosmic time is an important one in astrophysics,” said co-lead author Dr Sandro Tacchella from Cambridge’s Cavendish Laboratory. “We’ve had lots of excellent data for the last ten million years and for galaxies in our corner of the universe, but now with Webb, we can get observational data from billions of years back in time, probing the first billion years of cosmic history, which opens up all kinds of new questions.”

The galaxies we observe today grow via two main mechanisms: either they pull in, or accrete, gas to form new stars, or they grow by merging with smaller galaxies. Whether different mechanisms were at work in the early universe is an open question which astronomers are hoping to address with Webb.

“You expect galaxies to start small as gas clouds collapse under their own gravity, forming very dense cores of stars and possibly black holes,” said Tacchella. “As the galaxy grows and star formation increases, it’s sort of like a spinning figure skater: as the skater pulls in their arms, they gather momentum, and they spin faster and faster. Galaxies are somewhat similar, with gas accreting later from larger and larger distances spinning the galaxy up, which is why they often form spiral or disc shapes.”

This galaxy, observed as part of the JADES (JWST Advanced Extragalactic Survey) collaboration, is actively forming stars in the early universe. It has a highly dense core, which despite its relatively young age, is of a similar density to present-day massive elliptical galaxies, which have 1000 times more stars. Most of the star formation is happening further away from the core, with a star-forming ‘clump’ even further out.

The star formation activity is strongly rising toward the outskirts, as the star formation spreads out and the galaxy grows. This type of growth had been predicted with theoretical models, but with Webb, it is now possible to observe it.

“One of the many reasons that Webb is so transformational to us as astronomers is that we’re now able to observe what had previously been predicted through modelling,” said co-author William Baker, a PhD student at the Cavendish. “It’s like being able to check your homework.”

Using Webb, the researchers extracted information from the light emitted by the galaxy at different wavelengths, which they then used to estimate the number of younger stars versus older stars, which is converted into an estimate of the stellar mass and star formation rate.

Because the galaxy is so compact, the individual images of the galaxy were ‘forward modelled’ to take into account instrumental effects. Using stellar population modelling that includes prescriptions for gas emission and dust absorption, the researchers found older stars in the core, while the surrounding disc component is undergoing very active star formation. This galaxy doubles its stellar mass in the outskirts roughly every 10 million years, which is very rapid: the Milky Way galaxy doubles its mass only every 10 billion years.

The density of the galactic core, as well as the high star formation rate, suggest that this young galaxy is rich with the gas it needs to form new stars, which may reflect different conditions in the early universe.

“Of course, this is only one galaxy, so we need to know what other galaxies at the time were doing,” said Tacchella. “Were all galaxies like this one? We’re now analysing similar data from other galaxies. By looking at different galaxies across cosmic time, we may be able to reconstruct the growth cycle and demonstrate how galaxies grow to their eventual size today.”

 

Reference:
William M. Baker, Sandro Tacchella, et al. ‘A core in a star-forming disc as evidence of inside-out growth in the early Universe.’ Nature Astronomy (2024). DOI: 10.1038/s41550-024-02384-8

Astronomers have used the NASA/ESA James Webb Space Telescope (JWST) to observe the ‘inside-out’ growth of a galaxy in the early universe, only 700 million years after the Big Bang.

Galaxy NGC 1549, seen today and possibly 13 billion years ago

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Yes

The collaboration, which includes researchers from the University of Cambridge, aims to accelerate progress on new neuro-technologies, including miniaturised brain implants designed to treat depression, dementia, chronic pain, epilepsy and injuries to the nervous system.

Neurological and mental health disorders will affect four in every five people in their lifetimes, and present a greater overall health burden than cancer and cardiovascular disease combined. For example, 28 million people in the UK are living with chronic pain and 1.3 million people with traumatic brain injury.

Neuro-technology – where technology is used to control the nervous system - has the potential to deliver new treatments for these disorders, in much the same way that heart pacemakers, cochlear implants and spinal implants have transformed medicine in recent decades.

The technology can be in the form of electronic brain implants that reset abnormal brain activity or help deliver targeted drugs more effectively, brain-computer interfaces that control prosthetic limbs, or technologies that train the patient’s own cells to fight disease. ARIA’s Scalable Neural Interfaces opportunity space is exploring ways to make the technology more precise, less invasive, and applicable to a broader range of diseases.

Currently, an implant can only interact with large groups of neurons, the cells that transmit information around the brain. Building devices that interact with single neurons will mean a more accurate treatment. Neuro-technologies also have the potential to treat autoimmune disorders, including rheumatoid arthritis, Crohn’s disease and type-1 diabetes.

The science of building technology small enough, precise enough and cheap enough to make a global impact requires an environment where the best minds from across the UK can collaborate, dream up radical, risky ideas and test them without fear of failure.

Professor George Malliaras from the University of Cambridge’s Department of Engineering is one of the project leaders. “Miniaturised devices have the potential to change the lives of millions of people currently suffering from neurological conditions and diseases where drugs have no effect,” he said. “But we are working at the very edge of what is possible in medicine, and it is hard to find the support and funding to try radical, new things. That is why the partnership with ARIA is so exhilarating, because it is giving brilliant people the tools to turn their original ideas into commercially viable devices that are cheap enough to have a global impact.”

Cambridge’s partnership with ARIA will create a home for original thinkers who are struggling to find the funding, space and mentoring needed to stress-test their radical ideas. The three-year partnership is made up of two programmes:

The Fellowship Programme (up to 18 fellowships)

Blue Sky Fellows – a UK-wide offer - we will search the UK for people from any background, with a radical idea in this field and the plan and personal skills to develop it. The best people will be offered a fellowship with the funding to test their ideas in Cambridge rapidly. These Blue Sky Fellows will receive mentorship from our best medical, scientific and business experts and potentially be offered accommodation at a Cambridge college. We will be looking for a specific type of person to be a Blue Sky Fellow. They must be the kind of character who thinks at the very edge of the possible, who doesn’t fear failure, and whose ideas have the potential to change billions of lives, yet would struggle to find funding from existing sources. Not people who think outside the box, more people who don’t see a box at all.

Activator Fellows - a UK-wide offer - those who have already proved that their idea can work, yet need support to turn it into a business, will be invited to become Activator Fellows. They will be offered training in entrepreneurial skills including grant writing, IP management and clinical validation, so their innovation can be ready for investment.

The Ecosystem Programme

The Ecosystem Programme is about creating a vibrant, UK-wide neurotechnology community where leaders from business, science, engineering, academia and the NHS can meet, spark ideas and form collaborations. This will involve quarterly events in Cambridge, road trip events across the UK and access to the thriving online Cambridge network, Connect: Health Tech.

“This unique partnership is all about turning radical ideas into practical, low-cost solutions that change lives,” said Kristin-Anne Rutter, Executive Director of Cambridge University Health Partners. “Cambridge is fielding its best team to make this work and using its networks to bring in the best people from all over the UK. From brilliant scientists to world-leading institutes, hospitals and business experts, everyone in this collaboration is committed to the ARIA partnership because, by working together, we all see an unprecedented opportunity to make a real difference in the world.”

“Physical and mental illnesses and diseases that affect the brain such as dementia are some of the biggest challenges we face both as individuals and as a society,” said Dr Ben Underwood, Associate Professor of Psychiatry at the University of Cambridge and Honorary Consultant Psychiatrist at Cambridgeshire and Peterborough NHS Foundation Trust. “This funding will bring together different experts doing things at the very limits of science and developing new technology to improve healthcare. We hope this new partnership with the NHS will lead to better care and treatment for people experiencing health conditions.”

Cambridge partners in the project include the Departments of Engineering and Psychiatry, Cambridge Neuroscience, the Milner Therapeutics Institute, the Maxwell Centre, Cambridge University Health Partners (CUHP), Cambridge Network, the Babraham Research Campus, Cambridgeshire and Peterborough NHS Foundation Trust, and Vellos. 

A team from across the Cambridge life sciences, technology and business worlds has announced a multi-million-pound, three-year collaboration with the Advanced Research and Invention Agency (ARIA), the UK government’s new research funding agency.

Illustration of human brain

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Yes

In 2020, Hassabis and Jumper of Google DeepMind presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified.

Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic.

The duo received the Nobel along with Professor David Baker of the University of Washington, who succeeded in using amino acids to design a new protein in 2003.

Sir Demis Hassabis read Computer Science as an undergraduate at Queens' College, Cambridge, matriculating in 1994. He went on to complete a PhD in cognitive neuroscience at University College London and create the videogame company Elixir Studios.

Hassabis co-founded DeepMind in 2010, a company that devel­oped masterful AI models for popular boardgames. The company was sold to Google in 2014 and, two years later, DeepMind came to global attention when the company achieved what many then believed to be the holy grail of AI: beating the champion player of one of the world’s oldest board­games, Go.

In 2014, Hassabis was elected as a Fellow Benefactor and, later, as an Honorary Fellow of Queens' College. In 2024, he was knighted by the King for services to artificial intelligence.

In 2018, the University announced the establishment of a DeepMind Chair of Machine Learning, thanks to a benefaction from Hassabis’s company, and appointed Professor Neil Lawrence to the position the following year.

“I have many happy memories from my time as an undergraduate at Cambridge, so it’s now a real honour for DeepMind to be able to contribute back to the Department of Computer Science and Technology and support others through their studies,” said Hassabis in 2018.   

“It is wonderful to see Demis’s work recognised at the highest level — his contributions have been really transformative across many domains. I’m looking forward to seeing what he does next!” said Professor Alastair Beresford, Head of the Department of Computer Science and Technology and Robin Walker Fellow in Computer Science at Queens' College.

In a statement released by Google DeepMind following the announcement by the Nobel committee, Hassabis said: "I’ve dedicated my career to advancing AI because of its unparalleled potential to improve the lives of billions of people... I hope we'll look back on AlphaFold as the first proof point of AI's incredible potential to accelerate scientific discovery."

Dr John Jumper completed an MPhil in theoretical condensed matter physics at Cambridge's famous Cavendish Laboratory in 2008, during which time he was a member of St Edmund’s College, before going on to receive his PhD in Chemistry from the University of Chicago.

"Computational biology has long held tremendous promise for creating practical insights that could be put to use in real-world experiments," said Jumper, Director of Google DeepMind, in a statement released by the company. "AlphaFold delivered on this promise. Ahead of us are a universe of new insights and scientific discoveries made possible by the use of AI as a scientific tool." 

“The whole of the St Edmund’s community joins me in congratulating our former Masters student Dr John Jumper on this illustrious achievement – the most inspiring example imaginable to our new generation of students as they go through their matriculation this week,” said St Edmund’s College Master, Professor Chris Young.

Professor Deborah Prentice, Vice-Chancellor of the University of Cambridge: “I’d like to congratulate Demis Hassabis and John Jumper, who, alongside Geoffrey Hinton yesterday, are all alumni of our University. Together, their pioneering work in the development and application of machine learning is transforming our understanding of the world around us. They join an illustrious line-up of Cambridge people to have received Nobel Prizes – now totalling 125 individuals – for which we can be very proud.”

Article updated on 10 October 2024 to reflect that the number of Cambridge people to have received Nobel Prizes now totals 125.

Two University alumni, Sir Demis Hassabis and Dr John Jumper, have been jointly awarded this year’s Nobel Prize in Chemistry for developing an AI model to solve a 50-year-old problem: predicting the complex structures of proteins.

I have many happy memories from my time as an undergraduate at Cambridge

Sir Demis Hassabis

Left: Demis Hassabis; Right: John Jumper

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Yes

Hinton (King’s 1967) and Hopfield were awarded the prize ‘for foundational discoveries and inventions that enable machine learning with artificial neural networks.’ Hinton, who is known as the ‘Godfather of AI’ is Emeritus Professor of Computer Science at the University of Toronto. 

This year’s two Nobel Laureates in Physics have used tools from physics to develop methods that are the foundation of today’s powerful machine learning. John Hopfield, a Guggenheim Fellow at the University of Cambridge in 1968-1969, created an associative memory that can store and reconstruct images and other types of patterns in data. Geoffrey Hinton invented a method that can autonomously find properties in data, and perform tasks such as identifying specific elements in pictures.

When we talk about artificial intelligence, we often mean machine learning using artificial neural networks. This technology was originally inspired by the structure of the brain. In an artificial neural network, the brain’s neurons are represented by nodes that have different values. These nodes influence each other through con­nections that can be likened to synapses and which can be made stronger or weaker. The network is trained, for example by developing stronger connections between nodes with simultaneously high values. This year’s laureates have conducted important work with artificial neural networks from the 1980s onward.

Geoffrey Hinton used a network invented by John Hopfield as the foundation for a new network: the Boltzmann machine. This can learn to recognise characteristic elements in a given type of data. Hinton used tools from statistical physics, the science of systems built from many similar components. The machine is trained by feeding it examples that are very likely to arise when the machine is run. The Boltzmann machine can be used to classify images or create new examples of the type of pattern on which it was trained. Hinton has built upon this work, helping initiate the current explosive development of machine learning.

Vice-Chancellor Professor Deborah Prentice said:

“Many congratulations to Professor Hinton on receiving the Nobel Prize. Our alumni are a vital part of the Cambridge community, and many of them, like Professor Hinton, have made discoveries and advances that have genuinely changed our world. On behalf of the University of Cambridge, I congratulate him on this enormous accomplishment.”

“The laureates’ work has already been of the greatest benefit. In physics we use artificial neural networks in a vast range of areas, such as developing new materials with specific properties,” says Ellen Moons, Chair of the Nobel Committee for Physics. Hinton and Hopfield are the 122nd and 123rd Members of the University of Cambridge to be awarded the Nobel Prize. 

From 1980 to 1982, Hinton was a Scientific Officer at the MRC Applied Psychology Unit (as the MRC Cognition and Brain Sciences Unit was then known), before taking up a position at Carnegie Mellon University in Pittsburgh.

In May 2023, Hinton gave a public lecture at the University's Centre for the Study of Existential Risk entitled 'Two Paths to Intelligence', in which he argued that "large scale digital computation is probably far better at acquiring knowledge than biological computation and may soon be much more intelligent than us". 

Geoffrey Hinton, an alumnus of the University of Cambridge, was awarded the 2024 Nobel Prize in Physics, jointly with John Hopfield of Princeton University.

Right: Geoffrey Hinton (circled) at his Matriculation at King's College. Right: Illustration of Geoffrey Hinton

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Yes

Using ultra-high-resolution scanners that can see the living brain in fine detail, researchers from the Universities of Cambridge and Oxford were able to observe the damaging effects Covid-19 can have on the brain.

The study team scanned the brains of 30 people who had been admitted to hospital with severe Covid-19 early in the pandemic, before vaccines were available. The researchers found that Covid-19 infection damages the region of the brainstem associated with breathlessness, fatigue and anxiety.

The powerful MRI scanners used for the study, known as 7-Tesla or 7T scanners, can measure inflammation in the brain. Their results, published in the journal Brain, will help scientists and clinicians understand the long-term effects of Covid-19 on the brain and the rest of the body. Although the study was started before the long-term effects of Covid were recognised, it will help to better understand this condition.

The brainstem, which connects the brain to the spinal cord, is the control centre for many basic life functions and reflexes. Clusters of nerve cells in the brainstem, known as nuclei, regulate and process essential bodily functions such as breathing, heart rate, pain and blood pressure.

“Things happening in and around the brainstem are vital for quality of life, but it had been impossible to scan the inflammation of the brainstem nuclei in living people, because of their tiny size and difficult position.” said first author Dr Catarina Rua, from the Department of Clinical Neurosciences. “Usually, scientists only get a good look at the brainstem during post-mortem examinations.”

“The brainstem is the critical junction box between our conscious selves and what is happening in our bodies,” said Professor James Rowe, also from the Department of Clinical Neurosciences, who co-led the research. “The ability to see and understand how the brainstem changes in response to Covid-19 will help explain and treat the long-term effects more effectively.”

In the early days of the Covid-19 pandemic, before effective vaccines were available, post-mortem studies of patients who had died from severe Covid-19 infections showed changes in their brainstems, including inflammation. Many of these changes were thought to result from a post-infection immune response, rather than direct virus invasion of the brain.  

“People who were very sick early in the pandemic showed long-lasting brain changes, likely caused by an immune response to the virus. But measuring that immune response is difficult in living people,” said Rowe. “Normal hospital-type MRI scanners can’t see inside the brain with the kind of chemical and physical detail we need.”

“But with 7T scanners, we can now measure these details. The active immune cells interfere with the ultra-high magnetic field, so that we’re able to detect how they are behaving,” said Rua. “Cambridge was special because we were able to scan even the sickest and infectious patients, early in the pandemic.”

Many of the patients admitted to hospital early in the pandemic reported fatigue, breathlessness and chest pain as troubling long-lasting symptoms. The researchers hypothesised these symptoms were in part the result of damage to key brainstem nuclei, damage which persists long after Covid-19 infection has passed.

The researchers saw that multiple regions of the brainstem, in particular the medulla oblongata, pons and midbrain, showed abnormalities consistent with a neuroinflammatory response. The abnormalities appeared several weeks after hospital admission, and in regions of the brain responsible for controlling breathing.

“The fact that we see abnormalities in the parts of the brain associated with breathing strongly suggests that long-lasting symptoms are an effect of inflammation in the brainstem following Covid-19 infection,” said Rua. “These effects are over and above the effects of age and gender, and are more pronounced in those who had had severe Covid-19.”

In addition to the physical effects of Covid-19, the 7T scanners provided evidence of some of the psychiatric effects of the disease. The brainstem monitors breathlessness, as well as fatigue and anxiety. “Mental health is intimately connected to brain health, and patients with the most marked immune response also showed higher levels of depression and anxiety,” said Rowe. “Changes in the brainstem caused by Covid-19 infection could also lead to poor mental health outcomes, because of the tight connection between physical and mental health.”

The researchers say the results could aid in the understanding of other conditions associated with inflammation of the brainstem, like MS and dementia. The 7T scanners could also be used to monitor the effectiveness of different treatments for brain diseases.

“This was an incredible collaboration, right at the peak of the pandemic, when testing was very difficult, and I was amazed how well the 7T scanners worked,” said Rua. “I was really impressed with how, in the heat of the moment, the collaboration between lots of different researchers came together so effectively.”

The research was supported in part by the NIHR Cambridge Biomedical Research Centre, the NIHR Oxford Biomedical Research Centre, and the University of Oxford COVID Medical Sciences Division Rapid Response Fund.

 

Reference:
Catarina Rua et al. ‘7-Tesla quantitative susceptibility mapping in COVID-19: brainstem effects and outcome associations.’ Brain (2024). DOI: 10.1093/brain/awae215

Damage to the brainstem – the brain’s ‘control centre’ – is behind long-lasting physical and psychiatric effects of severe Covid-19 infection, a study suggests.

3D projections of QSM maps on the rendered brainstem

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Yes

Cambridge aspires to create a positive research culture where all staff working in research, whether in academic, technical or support roles, feel welcomed, supported and able to give of their best. The Research Culture Celebration event aims to recognise and celebrate the good practice that is already happening, and to inspire further efforts across the University.

The original idea for the nominations and event (where those honoured are put forward by their colleagues) was part of the Action Research on Research Culture (ARRC) project’s study on researcher development. The ARRC project is one of several initiatives to nurture and promote positive research culture at Cambridge. 

See the full list of nominees

The event coincides with the launch of a wider programme of work being led by the University's Research Culture Team. Four priority areas have been identified. These are: 

- Precarity: how do we address the issues created by fixed-term contracts in early research careers? 

- Access & Participation: who gets to do research? Can everyone fully participate as is expected of them? 

- Challenging interpersonal and group dynamics: how do we support researchers who are struggling with difficult research dynamics? How do we support leaders to change? 

- Time & space: how do we ensure people have the time and space to embody and enact good research culture? 

This year the Research Steering Committee, which oversees the work, is expecting to allocate between £600,000 and £700,000 to facilitate research culture activities around the University. It will also contact individual departments to better understand the concerns they have around research culture. If you would like to be involved, please contact the research culture team. 

For more about the event, including a gallery of images, see the Staff Hub (Cambridge users only; University login required).

Colleagues from across the University were recognised for their contributions to research culture at the inaugural Research Culture Celebration event on 30 September.

Three researchers at the University of Cambridge in conversation at an event celebrating colleagues for their positive contribution to research culture

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Yes

A Memorandum of Understanding – first signed between the institutions in 2009 to formally recognise their decades-long partnership – was renewed during a ceremony at the Belgian Embassy in London.

The relationship was first established in 1965 by the Belgian public interest organisation Fondation Wiener-Anspach (FWA), and since then students, researchers and academics have travelled across the Channel in both directions as part of academic exchanges.

The FWA promotes the development of scientific exchanges between the ULB and the universities of Oxford and Cambridge by awarding fellowships and grants, and by supporting research collaborations in all fields. It also organises conferences and encourages contacts between academics by funding short-term visits.

The ceremony was attended by Professor Deborah Prentice, Vice-Chancellor of Cambridge University; Professor Irene Tracey, Vice-Chancellor of Oxford University; Professor Anne Weyembergh, Vice-Rector for External Relations and Cooperation (ULB); Professor Didier Viviers, President of Fondation Wiener-Anspach, and Bruno van der Pluijm, Belgian Ambassador to the UK.

Speaking at the ceremony, Professor Prentice, said: “The partnership has allowed students and scholars in Brussels, in Cambridge and Oxford to find a firm footing in the world of academia and beyond. In the years ahead, I am confident that it will continue to enable new accomplishments and scientific breakthroughs, as well as the creation of innovative businesses and the nurturing of careers in public service on both sides of the Channel.”

The Vice-Chancellors of Cambridge and Oxford universities reaffirmed a triple partnership with Université Libre de Bruxelles (ULB) that has supported world-class research through cross-border collaborations for more than half a century.

"The partnership will continue to enable new accomplishments and scientific breakthroughs, as well as the creation of innovative businesses and the nurturing of careers in public service on both sides of the Channel."

Professor Deborah Prentice, Vice-Chancellor

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Yes

This landmark achievement has been conducted by the FlyWire Consortium, a large international collaboration including researchers from the University of Cambridge, the MRC Laboratory of Molecular Biology in Cambridge, Princeton University, and the University of Vermont. It is published today in two papers in the journal Nature.

The diagram of all 139,255 neurons in the adult fly brain is the first of an entire brain for an animal that can walk and see. Previous efforts have completed the whole brain diagrams for much smaller brains, for example a fruit fly larva which has 3,016 neurons, and a nematode worm which has 302 neurons.

The researchers say the whole fly brain map is a key first step to completing larger brains. Since the fruit fly is a common tool in research, its brain map can be used to advance our understanding of how neural circuits work.

Dr Gregory Jefferis, from the University of Cambridge and the MRC Laboratory of Molecular Biology, one of the co-leaders of the research, said: “If we want to understand how the brain works, we need a mechanistic understanding of how all the neurons fit together and let you think. For most brains we have no idea how these networks function. 

“Flies can do all kinds of complicated things like walk, fly, navigate, and the males sing to the females. Brain wiring diagrams are a first step towards understanding everything we’re interested in – how we control our movement, answer the telephone, or recognise a friend.”

Dr Mala Murthy from Princeton University, one of the co-leaders of the research, said: “We have made the entire database open and freely available to all researchers. We hope this will be transformative for neuroscientists trying to better understand how a healthy brain works. In the future we hope that it will be possible to compare what happens when things go wrong in our brains, for example in mental health conditions.” 

Dr Marta Costa from the University of Cambridge, who was also involved in the research, said “This brain map, the biggest so far, has only been possible thanks to technical advances that didn’t seem possible ten years ago. It is a true testament to the way that innovation can drive research forward. The next steps will be to generate even bigger maps, such as a mouse brain, and ultimately, a human one.”

The scientists found that there were substantial similarities between the wiring in this map and previous smaller-scale efforts to map out parts of the fly brain. This led the researchers to conclude that there are many similarities in wiring between individual brains – that each brain isn’t a unique structure.

When comparing their brain diagram to previous diagrams of small areas of the brain, the researchers also found that about 0.5% of neurons have developmental variations that could cause connections between neurons to be mis-wired. The researchers say it will be important to understand, through future research, if these changes are linked to individuality or brain disorders. 

Making the map

3D rendering of all ~140k neurons in the fruit fly brain. Credit: Data source FlyWire.ai; Rendering by Philipp Schlegel (University of Cambridge/MRC LMB).

A whole fly brain is less than one millimetre wide. The researchers started with one female brain cut into seven thousand slices, each only 40 nanometres thick, that were previously scanned using high resolution electron microscopy in the laboratory of project co-leader Davi Bock at Janelia Research Campus in the US.

Analysing over 100 terabytes of image data (equivalent to the storage in 100 typical laptops) to extract the shapes of about 140,000 neurons and 50 million connections between them is too big a challenge for humans to complete manually. The researchers built on AI developed at Princeton University to identify and map neurons and their connections to each other.

However, the AI still makes many errors in datasets of this size. The Princeton University researchers established the FlyWire Consortium – made up of teams in more than 76 laboratories and 287 researchers around the world, as well as volunteers from the general public – which spent an estimated 33 person-years painstakingly proofreading all the data.

Dr Sebastian Seung, from Princeton University, who was one of the co-leaders of the research, said: “Mapping the whole brain has been made possible by advances in AI computing - it would have not been possible to reconstruct the entire wiring diagram manually. This is a display of how AI can move neuroscience forward. The fly brain is a milestone on our way to reconstructing a wiring diagram of a whole mouse brain.”

The researchers also annotated many details on the wiring diagram, such as classifying more than 8,000 cell types across the brain. This allows researchers to select particular systems within the brain for further study, such as the neurons involved in sight or movement. 

Dr Philipp Schlegel, the first author of one of the studies, from the MRC Laboratory of Molecular Biology, said: “This dataset is a bit like Google Maps but for brains: the raw wiring diagram between neurons is like knowing which structures on satellite images of the Earth correspond to streets and buildings. Annotating neurons is like adding the names for streets and towns, business opening times, phone numbers and reviews to the map – you need both for it to be really useful.”

Simulating brain function

This is also the first whole brain wiring map – often called a connectome – to predict the function of all the connections between neurons. 

Neurons use electrical signals to send messages. Each neuron can have hundreds of branches that connect it to other neurons. The points where these branches meet and transmit signals between neurons are called synapses. There are two main ways that neurons communicate across synapses: excitatory (which promotes the continuation of the electrical signal in the receiving neuron), or inhibitory (which reduces the likelihood that the next neuron will transmit signals).

Researchers from the team used AI image scanning technology to predict whether each synapse was inhibitory or excitatory.

Dr Gregory Jefferis added: “To begin to simulate the brain digitally, we need to know not only the structure of the brain, but also how the neurons function to turn each other on and off.”

“Using our data, which has been shared online as we worked, other scientists have already started trying to simulate how the fly brain responds to the outside world. This is an important start, but we will need to collect many different kinds of data to produce reliable simulations of how a brain functions.”

Associate Professor Davi Bock, one of the co-leaders of the research from the University of Vermont, said: “The hyper-detail of electron microscopy data creates its own challenges, especially at scale. This team wrote sophisticated software algorithms to identify patterns of cell structure and connectivity within all that detail. 

“We now can make precise synaptic level maps and use these to better understand cell types and circuit structure at whole-brain scale. This will inevitably lead to a deeper understanding of how nervous systems process, store and recall information. I think this approach points the way forward for the analysis of future whole-brain connectomes, in the fly as well as in other species."

This research was conducted using a female fly brain. Since there are differences in neuronal structure between male and female fly brains, the researchers also plan to characterise a male brain in the future. 

The principal funders were the National Institutes of Health BRAIN Initiative, Wellcome, Medical Research Council, Princeton University and National Science Foundation.

References

Schlegel, P. et al: Whole-brain annotation and multi-connectome cell typing of Drosophila. Nature, Oct 2024. DOI: 10.1038/s41586-024-07686-5

Dorkenwald, S. et al: Neuronal wiring diagram of an adult brain. Nature, Oct 2024. DOI: 10.1038/s41586-024-07558-y

 

The first wiring diagram of every neuron in an adult brain and the 50 million connections between them has been produced for a fruit fly.

Brain wiring diagrams are a first step towards understanding everything we’re interested in – how we control our movement, answer the telephone, or recognise a friend.

Gregory Jefferis

3D rendering of all 140,000 neurons in the adult fruit fly brain.

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Yes

Events in Cambridge for Black History Month

Cambridge's Race Equality Lecture

Jesus College, Thursday 31 October

It may seem odd, but we start at the end of the month because this year’s Race Equality Lecture will take place on Thursday 31 October. The lecture is titled “Racism without racists – how racism works in the USA and the western world.” It will be delivered by Eduardo Bonilla-Silva, Professor of Sociology at Duke University and former President of the American Sociological Association. It will take place in the Frankopan Hall at Jesus College and will be available to view online.

Book your place at the Race Equality Lecture

Olaudah Equiano Annual Lecture on Race Justice

Anglia Ruskin University, Wednesday 9 October

Lord Simon Woolley, Principal of Homerton College and co-founder of Operation Black Vote, will deliver the Olaudah Equiano Annual Lecture on Race Justice at Anglia Ruskin University on Wednesday 9 October. The event will take place at the Cambridge campus and starts at 6pm. Lord Woolley is a tireless campaigner for equality, not just for Black communities but all under-represented or marginalised groups. During the event he will discuss the fight for racial equality drawing on his own personal experiences.

Book tickets for the Olaudah Equiano Annual Lecture on Race Justice

Moving beyond stereotypes surrounding Black women

King's College, Thursday 10 October

On the evening of Thursday 10 October, celebrated authors Kelechi Okafor and Afua Hirsch will discuss the challenges and opportunities they have faced when calling out social injustices in their work, with a focus on how their own identities have shaped their activism. They will share insights on the creative processes involved in their writing and how it has impacted on conversations about race, womanhood and justice. 

Reserve a place for the discussion at King's

Collaborative art workshops

Robinson College, Wednesday 16 and Saturday 19 October

For those interested in modern art Robinson College is hosting two collaborative art workshops. The first, on Wednesday 16 October, will be hosted by London artist, Shem, on the theme ‘Black present now’. And then, on Saturday 19 October, the College will host Joshua Obichere, a Cambridge alumnus.

Register your interest in the art workshops

Panel discussion: Black excellence, health and wellness

St Edmund's College, Wednesday 16 October

Also on the afternoon of Wednesday 16 October, St Edmund’s College will be hosting a panel discussion on the themes of Black excellence, health and wellness. Speakers include economist and entrepreneur Ebenezer Ademisoye, clinical scientist, Dr Rafia Al-Lamki and Mastercard Scholar, Godspower Major.

Reserve your ticket for the panel discussion at St Edmund's College

Fireside chat at the Business School

Cambridge Judge Business School, Thursday 17 October

Lord Woolley will participate in a ‘fireside chat’ at the Business School on the afternoon of Thursday 17 October. The event will be chaired by Kamiar Mohaddes and will also include Tabitha Mwangi, Programme Director of the Mastercard Foundation, and Orobosa Isokpan from the Cambridge Africa Business Network. There will be networking opportunities as well but registration is essential.  

Register for the fireside chat at Judge Business School

An exhibition and events at St Catharine's College

St Catharine's College, throughout October

During the entire month of October, St Catharine’s College is hosting an exhibition showcasing the achievements of two prominent Black alumni. The pioneering doctor and civil rights activist Dr Cecil Clarke matriculated in 1914 in the first months of the First World War. Wendell Mottley was an Olympic athlete and economist who served as Trinidad and Tobago’s Finance Minister between 1991 and 1995. The exhibition commemorating them is being held in the Shakeshaft Library.

See the full programme of Black History Month events at St Catharine's College

The Blacktionary Show

Wolfson College, Saturday 19 October

On Saturday 19 October Wolfson College hosts the ‘Blacktionary Show’. Authors Dr Maggie Semple and Jane Oremosu will be discussing their new work ‘My Little Book: A Blacktionary - The pocket guide to the language of race’. The book aims to help break down barriers when it comes to engaging in conversations on race. The event will be introduced by Dr Kenny Monrose, from the University’s Department of Sociology.

Register for the Blacktionary Show

Panel discussion: how organisations promote equality and diversity in the face of a cultural backlash

Homerton College, Tuesday 22 October

On Tuesday 22 October Lord Woolley will again be participating in a discussion being held at Homerton College looking at how companies and other organisations promote equality and diversity in the face of a cultural backlash. Other prominent speakers include the successful businesswomen, Olu Orugboh and Yemi Jackson.

Register for a panel discussion with Lord Woolley

The Trevelyan Lecture: 'Black Genius: Science, Race and the Extraordinary Portrait of Francis Williams'

Bateman Auditorium, Gonville and Caius College 5 pm Friday 25 October (Faculty of History)

Francis Williams was a Jamaican polymath who was born into slavery but ended his life as a gentleman and a scholar. His portrait, dating from the 1740s, shows him surrounded by books and scientific instruments. Was he Cambridge's first Black student? And who commissioned the portrait, and why? Princeton historian, Fara Dabhoiwala, will tackle these questions when he presents new research on the painting and its intriguing sitter. 

Black History Month Academic Seminar

Hughes Hall, Monday 28 October

An opportunity to hear from the College's Black staff and PhD students and celebrate their achievements but also to hear about the challenges facing Black students at Cambridge. One of the main subjects for discussion will be the low numbers of Black academics in the UK. 

More details about the seminar here

The Really Popular Book Club: Mr Loverman by Bernardine Evaristo

Online, Tuesday 29 October

On Tuesday 29 October the University Library’s Really Popular Book Club will be discussing Bernardine Evaristo’s ‘Mr Loverman’. The book follows an Antiguan born immigrant living in Hackney, London, who leads a double life. The discussion will be hosted by Yvonne Battle Felton, Academic Director of Creative Writing at Cambridge’s Institute of Continuing Education. This is an online event.

Sign up for the Really Popular Book Club

Black Advisory Hub events

St John's College, Wednesday 30 October

During the afternoon of Wednesday 30 October, the Black Advisory Hub is hosting a social and afternoon tea for Black students at St John’s College. It's one of many events the Hub is hosting. These include induction sessions for both undergraduates and postgraduates and the prizegiving ceremony for the Bridgetower essay competition.

Visit the Black Advisory Hub to register

Cambridge Students' Union events

St John's College, Thursday 3 October

The Cambridge Students' Union is also hosting several events to mark Black History Month. This opens with a screening of the documentary 'Educationally Subnormal: a British scandal' on Thursday 3 October.

Visit the Cambridge SU to see what's on

Black History Month in Cambridge brings an opportunity to take part in topical discussions, appreciate art and hear from a range of engaging speakers. 

Montage of faces

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Yes

Celebrating Cambridge’s most recent achievements – and looking ahead to the opportunities and challenges of the future – she emphasised both the University’s “extraordinary significance” in the UK, and the importance of its global outlook.

Professor Prentice used the speech, in Senate House, to announce the Collegiate University’s milestone success in reaching its £500m student support fundraising target, set in 2018.

This vital philanthropic support was transformative, said Professor Prentice, and had already enabled a number of Cambridge widening participation programmes and initiatives – including the Cambridge Foundation Year and scholarships for specific under-represented groups – to ensure the University continues to welcome students with the potential to thrive here, regardless of background. Student health and wellbeing services at Cambridge had also been transformed with generous gifts to the student support fundraising initiative, she said.

The Vice-Chancellor told Senate House: “I have met the students in many of these programmes, so for me, the student support initiative has names, faces, and life stories attached. It’s a thrilling achievement.”

Describing the University as a “national asset”, Professor Prentice went on to highlight Cambridge’s contribution to the rest of the UK, and its economy – estimated at approximately £30 billion a year.

The Vice-Chancellor said Cambridge’s reputation for expertise and world-class research meant it was uniquely placed to become the “go-to location for the world’s leading innovators”, and pointed to the University’s ambitious plans for Cambridge West and for an innovation hub to bring together researchers, entrepreneurs, spin-outs, and funders under one roof to “help solve the world’s biggest challenges”.

Her address also highlighted other significant milestones and initiatives, including the completion of the Ray Dolby Centre, the groundbreaking of the new Whittle Lab, the expansion of the Bennett Institute for Public Policy, and the advanced planning stages of two new hospitals on the Cambridge Biomedical Campus – the Cambridge Cancer Research Hospital and the Cambridge Children’s Hospital.

Professor Prentice finished the address by paying tribute to the University’s current Chancellor, Lord Sainsbury of Turville, who announced last year that he will step down. She expressed the University’s gratitude for “his unwavering service and his commitment to Cambridge.”

Read the full address

Professor Deborah Prentice marked the start of the academic year by delivering the Vice-Chancellor’s annual address to the University.

I have met the students in many of these programmes, so for me, the student support initiative has names, faces, and life stories attached. It’s a thrilling achievement.

Vice-Chancellor, Professor Deborah Prentice

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Yes

The Global Innovation Index (GII) 2024 – which captures the innovation ecosystem performance of 133 economies and tracks the global innovation trends – has ranked Cambridge as the world’s leading science and technological (S&T) cluster by intensity, in relation to its size, for the third consecutive year. San Jose, San Franciso (USA) was named second, unchanged from the 2023 Index, with Eindhoven, (Kingdom of the Netherlands) third.

S&T clusters are established by analysing patent-filing activity and scientific article publication relative to population, and documenting the geographical areas around the world with the highest density of inventors and scientific authors.

According to the Index, the Cambridge cluster filed 6,379 Patent Cooperation Treaty (PCT) patent applications and published 35,000 scientific articles, both per 1 million inhabitants, over the past 5 years.

The University of Cambridge sits at the heart of this cluster, powering world-leading research, driving a vibrant innovation ecosystem, and cultivating a thriving environment for collaboration, services and investment. The University contributes nearly £30 billion to the UK economy annually, including over £23 billion from commercialisation and innovation activities.

According to the Global Innovation Index 2024: “S&T clusters – which can be entire regions or cities – serve as the backbone of a robust national innovation ecosystem. Situated in areas such as San Francisco’s Silicon Valley, Cambridge, Munich and Paris in Europe, or Bengaluru, Seoul, Shenzhen and Tokyo in Asia, these S&T clusters are home to renowned universities, brilliant scientists, R&D-intensive companies, and prolific inventors. It is the collaboration among these entities that results in the groundbreaking scientific advancements.”

Earlier this year, a report by Dealroom revealed that the Cambridge tech ecosystem has a combined value of $191 billion, representing 18% of the entire UK’s tech ecosystem and reinforcing Cambridge’s reputation as Europe’s deep tech leader.

Dr Diarmuid O’Brien, Pro-Vice-Chancellor for Innovation, University of Cambridge, commented:

“It’s great to see this continued recognition of Cambridge as the world’s most intensive science and technological cluster. With its exceptional research and science, people and partners, companies and commitment, Cambridge drives innovation that fuels local, national, and global growth, tackling global challenges and delivering life-changing impact.”

Release first published by Cambridge Enterprise

Cambridge has once again been named as the most intensive science and technological cluster in the world, according to a new report ranking innovation around the globe.

 

 

It’s great to see this continued recognition of Cambridge as the world’s most intensive science and technological cluster. With its exceptional research and science, people and partners, companies and commitment, Cambridge drives innovation that fuels local, national, and global growth, tackling global challenges and delivering life-changing impact.

Diarmuid O’Brien

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Yes

Sir David said of visiting CCI that he felt “an undercurrent of joy” whenever he came to the conservation campus, which is housed in the building bearing his own name.

The campus was opened in 2016 and is the first of its kind, with over 500 conservation professionals and researchers, from 10 different organisations and the University of Cambridge, all collaborating to stop the biodiversity crisis and build more hopeful futures for people and nature.

Read the full story: 'An Undercurrent of Joy'

Sir David Attenborough spoke of how he feels during visits to the Cambridge Conservation Initiative (CCI) when he stopped by the CCI conservation campus at the University of Cambridge this week.

Photo of Sir David Attenborough on a visit to Cambridge Conservation Research Initiative

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Yes

Representatives of the Semiconductors Point of Contact Group from the G7 group of nations met in Cambridge on 26 September. The meeting was held at ARM, which designs over 95% of the processors in the world. Representatives from the University of Cambridge, as well as representatives from local semiconductor companies, participated in the events.

Semiconductors underpin nearly every electrical, optical and quantum device, from mobile phones and medical equipment to electric vehicles. They are of global strategic significance due to the integral role they play in net zero, artificial intelligence and quantum technology.

The G7 Semiconductor Points of Contact group is dedicated to facilitating information exchange and sharing best practices among G7 members. The PoC Group plans to exchange information on issues impacting the semiconductor industry, including pre-competitive industrial research and development priorities, sustainable manufacturing, the effect of non-market policies and practices, and crisis coordination channels.

Cambridge was chosen for the meeting in part because of its strong innovation ecosystem, which has produced more ‘unicorns’ – privately held startup companies valued at over US$1 billion – than anywhere else in the UK.

A 2023 report found that the University of Cambridge contributes nearly £30 billion to the UK economy annually and supports more than 86,000 jobs across the UK, including 52,000 in the East of England.

For every £1 the University spends, it creates £11.70 of economic impact, and for every £1 million of publicly-funded research income it receives, it generates £12.65 million in economic impact across the UK.

The National Quantum Strategy (2023) and the National Semiconductor Strategy (2023) highlight the UK’s national strengths in quantum and photonic technologies and compound semiconductors. These sectors foster growth and create high-skilled jobs, and position the UK as a hub of global innovation. 

Dr Diarmuid O’Brien, Pro-Vice-Chancellor for Innovation at the University of Cambridge, said: “Semiconductors are a vital technology for the UK’s economic growth, and Cambridge is a leader in semiconductor research and development. Working with our partners in academia, industry and government, we can develop next-generation semiconductor technologies and companies, and train the next generation of semiconductor scientists and engineers.” 

Professor Andrea Ferrari, Director of the Cambridge Graphene Centre, hosted, on behalf of the University, a formal dinner in Pembroke College for the attendees of the G7 Semiconductors group. He stated that: “Cambridge played a key foundational role in the development of electronics. The electron was discovered here in 1897, by JJ Thomson. In 1961, electron beam lithography, a key method for integrated circuit fabrication, was invented in Cambridge. These early achievements were followed by many advances in circuit design, innovative advanced materials, photonic and quantum communications. It is thus fitting that the G7 Semiconductors representatives met at the heart of where all started.”

Science Minister Lord Vallance said: "Semiconductors are an unseen but vital component in so many of the technologies we rely on in our lives and backing UK innovators offers a real opportunity to growth these firms into industry leaders, strengthening our £10 billion sector and ensuring it drives economic growth. Hosting the G7 semiconductors Points of Contact group is also a chance to showcase the UK’s competitive and growing sector and make clear our commitment to keeping the UK at the forefront of advancing technology."

 

Representatives from the G7 have met in Cambridge to discuss the main priorities for the future development of semiconductors and their impact on the global economy.

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Yes

Archaeological fieldwork in Morocco has discovered the earliest, previously unknown 3400–2900 BC farming society from a poorly understood period of north-west African prehistory. This is the earliest and largest agricultural complex yet found in Africa beyond the Nile.

This study, published in the journal Antiquity, reveals for the first time the importance of the Maghreb (north-west Africa) in the emergence of complex societies in the wider Mediterranean during the fourth and third millennia BC.

With a Mediterranean environment, a border with the Sahara desert and the shortest maritime crossing between Africa and Europe, the Maghreb is perfectly located as a hub for major cultural developments and intercontinental connections in the past.

Whilst the region’s importance during the Palaeolithic, Iron Age and Islamic periods is well known, there is a significant gap in knowledge of the archaeology of the Maghreb between c. 4000 and 1000 BC, a period of dynamic change across much of the Mediterranean.

To tackle this, a team of archaeologists led by Prof Cyprian Broodbank from the University of Cambridge, Prof Youssef Bokbot from INSAP, and Prof Giulio Lucarini from CNR-ISPC and ISMEO, have carried out collaborative, multidisciplinary archaeological fieldwork at Oued Beht, Morocco.

"For over thirty years I have been convinced that Mediterranean archaeology has been missing something fundamental in later prehistoric north Africa," said Broodbank. "Now, at last, we know that was right, and we can begin to think in new ways that acknowledge the dynamic contribution of Africans to the emergence and interactions of early Mediterranean societies."

"For more than a century the last great unknown of later Mediterranean prehistory has been the role played by the societies of Mediterranean’s southern, Africa shores west of Egypt," say the authors of the new study. "Our discoveries prove that this gap has been due not to any lack of major prehistoric activity, but to the relative lack of investigation, and publishing. Oued Beht now affirms the central role of the Maghreb in the emergence of both Mediterranean and wider African societies."

These results reveal that the site was the largest agricultural complex from this period in Africa outside of the Nile region. All of the evidence points to the presence of a large-scale farming settlement—similar in size to Early Bronze Age Troy.

The team recovered unprecedented domesticated plant and animal remains, pottery and lithics, all dating to the Final Neolithic period. Excavation also revealed extensive evidence for deep storage pits.

Importantly, contemporaneous sites with similar pits have been found on the other side of the Strait of Gibraltar in Iberia, where finds of ivory and ostrich egg have long pointed to African connections. This suggests that the Maghreb was instrumental in wider western Mediterranean developments during the fourth millennium BC.

Oued Beht and the north-west Maghreb were clearly integral parts of the wider Mediterranean region. As such, these discoveries significantly change our understanding of the later prehistory of the Mediterranean and Africa.

As the authors of the Antiquity article state: “It is crucial to consider Oued Beht within a wider co-evolving and connective framework embracing peoples both sides of the Mediterranean-Atlantic gateway during the later fourth and third millennia BC - and, for all the likelihood of movement in both directions, to recognise it as a distinctively African-based community that contributed substantially to the shaping of that social world.”

Multi-disciplinary archaeological survey at the site of Oued Beht, Morocco, reveals a previously unknown 3400–2900 BC farming society, shedding new light on North Africa’s role in Mediterranean prehistory. 

For over thirty years I have been convinced that Mediterranean archaeology has been missing something fundamental

Prof Cyprian Broodbank

Stone tools from Oued Beht

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Yes

A global conservation effort to reintroduce a tiny snail to the wild is celebrating a momentous milestone: for the first time in 40 years, conservationists have found born-in-the-wild adult Partula tohiveana – meaning the precious molluscs have successfully established themselves in French Polynesia.

This year Cambridge’s Dr Justin Gerlach helped restore over 6,000 of the snails to Moorea, their French Polynesian island home as part of an annual reintroduction of zoo-bred ‘Extinct in the Wild’ and ‘Critically Endangered’ snail species – carried out through collaboration with zoos around the world.

During their work the team found unmarked Partula tohiveana: proof that previously reintroduced snails have successfully bred in the area.

The momentous discovery means Partula tohiveana can now be considered as established – an incredibly rewarding result for 40 years of dedication and collaboration. Conservationists will now begin the process of downlisting the snails from ‘Extinct-in-the-Wild’ to ‘Critically Endangered’ on the IUCN’s Red List.

Very few species have been reintroduced successfully having been completely extinct in the wild. This is also the very first invertebrate species where this has been achieved.

Ten species and sub-species of the tropical snails, reared at London Zoo, Bristol Zoological Society, Detroit Zoological Society, Marwell Wildlife, the Royal Zoological Society of Scotland, Saint Louis Zoo, Sedgwick County Zoo, Woodland Park Zoo and Zoo Schwerin, travelled more than 15,000km to Tahiti at the beginning of September. Before making the two-day journey to the islands of Tahiti, Moorea and Huahine, the incredibly rare snails, which each measure a tiny 1-2cm in length, were individually counted and marked with a dot of red UV reflective paint. The ‘snail varnish’ glows under UV torchlight, helping conservationists in the field to spot and monitor the nocturnal snails at night, when they’re most active.

London Zoo’s Senior Curator of Invertebrates, Paul Pearce-Kelly, who leads the Partula conservation programme, said: “Though little, these snails have great cultural, scientific and conservation value. Partula snails have always been part of Polynesia’s rich cultural heritage and play an important role in the ecological health of their forest habitats. They’ve also been studied for over a century for the insights they give into how species evolve in isolated environments. Most recently, they’re providing a valuable conservation model for helping hundreds of endangered island species.”

He added: “This collaborative conservation effort is playing a crucial role in saving these species from extinction. It’s a powerful example of how conservation zoos can combat biodiversity loss. At a time when nature faces unprecedented challenges, these small snails are a symbol of hope for global wildlife.”

Partula snails - also known as Polynesian tree snails - eat decaying plant tissue and fungi, so play an important role in maintaining forest health. Returning these rare snails back to the wild helps to restore the ecological balance in these islands.

Dr Justin Gerlach of Peterhouse, University of Cambridge and an Academic Associate at the University's Museum of Zoology, said: “Discovering wild-born adult snails was a great moment. Very few animal species have been re-established back in the wild so this is a fantastic achievement for the programme – the fruit of a vast amount of work.”

Conservation zoos are working with the French Polynesian Government’s Direction de l’environnement, to save Partula snails from extinction. In the 1980s and early 1990s, these snails faced a critical threat after the invasive rosy wolf snail (Euglandina rosea) was introduced to control the African giant land snail (Lissachatina fulica). Unfortunately, the predatory species targeted the native snails instead, leading to the extinction or near-extinction of many Partula species across the region.

In the early 1990s, the last remaining individuals of several Partula species were rescued by London and Edinburgh Zoos, launching an international conservation breeding programme. This collaboration between 15 zoos cares for 15 species and subspecies, most of which are classified as ‘Extinct-in-the-Wild’. These rescued snails, along with those already being studied at universities in the UK and North America, became the foundation for reintroducing the species back onto their native island homes.

Paul said: “After decades of caring for these species in conservation zoos and working with the Direction de l’environnement to prepare the islands, we started reintroducing Partula snails back into their lowland tropical forests almost 10 years ago. Since then, we’ve reintroduced over 30,000 snails, including 10 Extinct-in-the-Wild species and subspecies, with this year’s release being the largest so far, thanks to our international team and collaborators, including mollusc specialist Dr Justin Gerlach of Peterhouse, University of Cambridge.”

London Zoo’s coordination of the Partula snail reintroduction project is made possible due to funding from supporters including the Players of the People’s Postcode Lottery, who have enabled London Zoo to continue bringing species back from the brink of extinction.

Adapted from a press release by the Zoological Society of London.

A species of tropical tree snail is no longer extinct in the wild following a successful reintroduction project.

Very few animal species have been re-established back in the wild so this is a fantastic achievement for the programme – the fruit of a vast amount of work.

Justin Gerlach

Born-in-the-wild unmarked Partula tohiveana snail observed in the wild, meaning the species is re-established (c) Paul Pearce-Kelly

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Yes

The ongoing war in Gaza will set children and young people’s education back by up to 5 years and risks creating a lost generation of permanently traumatised Palestinian youth, a new study warns.

The report, by a team of academics working in partnership with the United Nations Relief and Works Agency for Palestinian Refugees in the Near East (UNRWA), is the first to comprehensively quantify the war’s toll on learning since it began in October 2023. It also details the devastating impact on children, young people and teachers, supported by new accounts from frontline staff and aid workers.

The study was a joint undertaking involving researchers at the Faculty of Education, University of Cambridge and the Centre for Lebanese Studies, in partnership with UNRWA. It shows that Gaza’s children have already lost 14 months of education since 2019 due to COVID-19, earlier Israeli military operations, and the current war.

On this basis and using information such as global post-COVID-19 education recovery data, the researchers model several potential futures for Gaza’s younger generation, depending on when the war ends and how quickly the education system is restored.

The most optimistic prediction – assuming an immediate ceasefire and rapid international effort to rebuild the education system – is that students will lose 2 years of learning. If the fighting continues until 2026, the losses could stretch to 5 years. This does not account for the additional effects of trauma, hunger and forced displacement, all of which are deepening Gaza’s education crisis.

Without urgent, large-scale international support for education, the researchers suggest that there is a significant threat not just to students’ learning, but their overall faith in the future and in concepts such as human rights. Despite this, the study shows that education has been deprioritised in international aid efforts, in favour of other areas. “Education, simply put, is not seen as lifesaving,” the report warns.

Professor Pauline Rose, Director of the Research for Equitable Access and Learning (REAL) Centre, University of Cambridge, said: “Palestinian education is under attack in Gaza. Israeli military operations have had a significant effect on learning.”

“As well as planning for how we rebuild Gaza’s shattered education system, there is an urgent need to get educational support for children now. Education is a right for all young people. We have a collective responsibility to protect it.”

According to the United Nations Office for the Coordination of Humanitarian Affairs, more than 10,600 children and 400 teachers had been killed in Israeli military operations by August 2024, and more than 15,300 students and 2,400 teachers injured. Hundreds of thousands of young people have been displaced and are living in shelters.

Satellite images analysed by the Occupied Palestinian Territory Education Cluster have verified that over 90 per cent of schools have been damaged, many beyond repair. Since August, UNRWA has provided education in the shelters, reaching about 8,000 children, but the study warns that much more is needed to mitigate lost learning, which was already considerable following COVID-19.

The researchers calculate that 14 months of lost schooling so far have increased ‘learning poverty’ – the proportion of children unable to read a basic text by age 10 – by at least 20 percentage points. The accurate figure may be even higher, as the calculation does not account for the wider impacts of the war on children and teachers.

The study draws together information from different sources and includes a comprehensive involvement of the Education Cluster and Cluster partners sharing their inputs, challenges and progress to enrich the report. The report provides a comprehensive overview of those broader effects. It highlights the devastating psychological consequences for Palestinian children who were already living ‘in constant fear and lack of hope’ after 17 years of blockade, according to a 2022 report by Save The Children.

Professor Maha Shuayb, Director of the Centre for Lebanese Studies, said: “Young people’s prospects in Gaza are being extinguished and our findings show that with it they are losing hope. Education is central to stabilising that spiral of decline. If it is simply erased, the consequences will be far-reaching.”

Save The Children has estimated that more than 10 children per day have lost limbs since the war began. The report warns of rising numbers of less visible disabilities, which will put further strain on an education system ill-equipped to support children with special needs.

The study suggests that continuous shock and suffering are now shaping children’s outlook and world views. Interviewees reported some children questioning values such as equality, human rights and tolerance when these are taught in the shelters. “This is a full generation of trauma,” one humanitarian aid official said; “it will take a generation to overcome it.”

The report highlights the immense suffering teachers and counsellors have endured physically and mentally. The killings, displacement and daily realities of life during war have taken a tremendous toll on their ability to engage meaningfully in education and will, it says, adversely affect reconstruction efforts.

Professor Yusuf Sayed, from the University of Cambridge, said: “It is important to recognise teachers and counsellors have, like the rest of the population, suffered immensely. There is evidence of extraordinary commitment from educators striving to maintain learning, but inevitably the deprivation, killings and hardship are affecting their ability to do so.”

Despite a flash appeal from the United Nations Office for the Coordination of Humanitarian Affairs (OCHA), the analysis shows that just 3.5 per cent of aid for Gaza has been invested in education. Major donors like the US and Germany have neglected education in their aid packages, and blockades continue to hinder the delivery of resources on the ground.

Without more funding and access to learning, structured play and other forms of support, the report warns, the long-term repercussions for Gaza’s next generation will only worsen.

It calls for immediate steps focusing on the resumption of education, which include providing counselling, safe learning spaces, and support for students and educators with disabilities. It also calls for an immediate and permanent ceasefire and an end to occupation, in line with the International Court of Justice advisory opinion and UN recently-adopted resolution, as only then can Gaza’s education system be rebuilt. This will require a focus on recruiting more teachers and counsellors to cope with the scale of learning loss and trauma suffered by children and young people.

“Education is the only asset the Palestinian people have not been dispossessed of. They have proudly invested in the education of their children in the hope for a better future. Today, more than 625,000 deeply traumatised school-aged children are living in the rubble in Gaza. Bringing them back to learning should be our collective priority. Failing to do that will not only lead to a lost generation but also sow the seeds for more extremism, hatred and violence”, said Philippe Lazzarini, UNRWA Commissioner General.

The study also stresses that Palestinians themselves must lead the education recovery. “A ceasefire is the key for the success of any human development activity in Gaza, including education,” the authors write. “Children have seen that the international community will sit idly by as they are killed. This has left them with questions about values that schools and learning aim to instil around humanitarian principles that teachers will have to navigate.”

The full report, Palestinian Education Under Attack in Gaza: Restoration, Recovery, Rights and Responsibilities in and through Education, is now available online. 

Ongoing war in Gaza will set children and young people’s education back by up to 5 years, report suggests.

Boy sitting in the rubble of a destroyed UNRWA school in Nuseirat, Middle Areas, Gaza 2024

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Yes

The study, published in Energy Research & Social Science, was completed shortly before the Winter Fuel Payment vote was taken, by researchers from the University of Cambridge and Delft University of Technology (TU Delft).

The researchers raise particular concerns about the impact of the policy on pensioners with annual incomes of between £11,300–£15,000 for single pensioners and £17,300–£22,000 for couples.

Drawing on data from the English Housing Survey, which sampled nearly 12,000 households across all income groups, the study investigated how income, energy efficiency, home size, household type, and tenure status impacted on energy expenditure.

The researchers found that an increase of £1 per year in income (after housing costs, tax and welfare payments) was associated with a marginal increase in heating spending of about one-tenth of a penny.

The study also found that just a small energy efficiency improvement – a one-point increase in the SAP12 rating (The Government's Standard Assessment Procedure for Energy Rating of Dwellings – had a major impact on households in energy poverty, offering an average reduction in annual heating costs of £21.59 per year.

Floor area also had an impact. The researchers found that a one square metre increase was associated with an annual increase in heating spend of £5.04 per year, for households facing energy poverty, making this the worst affected group. This compares with £4.18 per year for high-income households, £3.65 per year for low-income households, and £2.99 per year for very low-income households not in energy poverty.

“When low-income households receive more income, they generally spend a little more to warm their homes. But these households often have to spread any extra money they have across other essential needs including food,” said lead author, Dr Ray Galvin, affiliated with Cambridge Institute for Sustainability Leadership (CISL).

“A reduction in income like the loss of the Winter Fuel Payment could force low-income pensioners to cut back not only on heating but also on other basic necessities. This poses a significant risk to people who are particularly vulnerable to the effects of living in cold homes.”

Energy efficiency

Across all household types, the researchers found that the energy efficiency of the dwelling had by far the biggest impact on heating expenditure.

“The most effective strategy to warm up the homes of people living energy poverty is to increase the energy performance of their dwellings,” said Professor Minna Sunikka-Blank, from Cambridge’s Department of Architecture.

Specifically, the authors advise that the SAP12 rating of homes need to be increased to at least 72.

Each increase in SAP12 energy efficiency rating corresponds to a reduction in heating costs of around £20 per year, meaning that for households in energy poverty, with an average SAP12 rating of 59.48, increasing the rating to the level of low-income households not in energy poverty, 71.45, could reduce heating costs by about £240 per year.

The authors make clear that energy savings would not be sufficient to pay for these energy-efficiency upgrades. They would require targeted financial support.

Dr Galvin said: “Government and society may well find that these costs are paid back to the country through co-benefits of fewer days off work, longer lives and less strain on the health service.”

While this would not improve the finances of households in energy poverty as much as the direct monetary allowances such as the Winter Fuel Payment, it would, the authors argue, make a substantial, direct impact on cold, unhealthy homes.

Dr Galvin said: “There needs to be extra focus on developing policies for the long-term solution of retrofitting energy-inefficient homes. This can provide enduring reductions in energy bills while also improving thermal comfort. This approach may also align better with the goal of reducing carbon emissions and tackling climate change.”

Prof Minna Sunikka-Blank said: “Without retrofit initiatives, energy poverty will persist in the UK, because in low-income households immediate needs often take precedence over thermal comfort, even when incomes increase.”

Home size

The study found that households in energy poverty have a 7.3% larger average floor area than low-income households not in energy poverty, and that floor area makes a substantial difference to heating energy costs (about half to two-thirds the impact that the SAP12 energy efficiency rating has).

Tijn Croon, from TU Delft said: “These findings suggest that inability to downsize may be a significant driver of energy poverty in the United Kingdom. Low-income households can save money and stay warmer living in smaller homes but downsizing is not always easy for older households whose dependants have left home and who find themselves with a large, older home that is very expensive to keep warm.”

One-person households spend less on heating

A surprising finding in the study is that across all income groups, one-person households tend to spend less on energy. And for households in energy poverty the reduction (£36.77 per year) was twice as large as for low-income households not in energy poverty (£15.65 per year).

Tijn Croon, from TU Delft, said: “This might suggest that many one-person households are able to control their energy consumption more strategically than a multi-person household can.”

Dr Galvin said: “Our study controlled for other factors so this is not just a case of low-income households living in smaller homes. Further research could survey one-person households to find out if they have skills and practices that could be transferred to multi-person households.”

Mitigating impact of Winter Fuel Payment cuts

The authors suggest several potential solutions. Expanding Pension Credit eligibility to align with the government's low-income threshold would be the most comprehensive fix, though this may be financially unfeasible. Alternative measures could include a temporary application process for the Winter Fuel Payment for those just above the Pension Credit threshold or providing tax credits or rebates for low-income pensioners, which could be more easily managed since HMRC already holds income data.

While much attention has been given to the risk of energy poverty among pensioners, the authors also note that families with children and young adults are often equally vulnerable and may face even greater challenges in the housing market compared to pensioners.

The authors are currently working on a follow-up research paper that will explore the recent reforms to the government’s Warm Home Discount scheme.

Reference

R. Galvin, M. Sunikka-Blank, T. Croon, ‘Juggling the Basics: How Much Does an Income Increase Affect Energy Spending of Low-Income Households in England?’, Energy Research & Social Science (2024). DOI: 10.1016/j.erss.2024.103766

The UK Government’s policy to scrap Winter Fuel Payments could disproportionately affect low-income pensioners in England, new analysis suggests. But the same study argues that the energy inefficiency of homes and challenges involved in downsizing will have an even more harmful effect this winter.

Without retrofit initiatives, energy poverty will persist in the UK

Minna Sunikka-Blank

Rooftops view from Totterdown to Bristol Centre

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Yes

Alcohol consumption is the fifth largest contributor to premature death and disease worldwide. In 2016 it was estimated to have caused approximately 3 million deaths worldwide.

Professor Dame Theresa Marteau and colleagues at the Behaviour and Health Research Unit have shown previously that serving wine in smaller glasses is associated with a decrease in sales.

To see if this effect was seen with other alcoholic drinks, they approached venues in England and asked them to remove the pint serving size and instead offer two-thirds as the largest option for four weeks, with four-week non-intervention periods before and after as a comparison.

In a study published in PLOS Medicine, the team found that removing the pint reduced the daily mean volume of beer, lager and cider sold by 9.7%, although there was a slight increase in the amount of wine purchased, with one pub contributing to half of the increase of wine sales. They report that although customers did not complain, fewer than 1% of venues approached agreed to participate and the intervention involved only 12 establishments.

Professor Marteau said: “Alcohol harms our health, increasing the risk of injury and many diseases including heart disease, bowel, breast and liver cancers. While we may all enjoy a drink, the less we drink the better our health.

“As we’ve shown is the case with wine, removing the largest serving size for beer, lager and cider – in this case, the pint – could encourage people to drink less. This could be beneficial both to the nation’s health and the health of individuals.”

Further assessment is needed, particularly into whether people fully compensated for reduced beer consumption by drinking other alcoholic drinks, but the intervention merits consideration for inclusion in alcohol control policies. Smaller serving sizes could contribute towards reducing alcohol consumption across populations and thereby decrease the risk of seven cancers and other diseases.

Reference
Mantzari, E et al. Impact on beer sales of removing the pint serving size: An A-B-A reversal trial in pubs, bars, and restaurants in England. PLOS Medicine; 17 Sept 2024; DOI: 10.1371/journal.pmed.1004442

Adapted from a press release by PLOS Medicine

Cambridge researchers have shown that reducing the serving size for beer, lager and cider reduces the volume of those drinks consumed in pubs, bars and restaurants, which could have wider public health benefits.

While we may all enjoy a drink, the less we drink the better our health

Theresa Marteau

Barman handing a customer a pint of beer

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Yes

A team lead by researchers at the University of Cambridge has developed a monoclonal antibody drug, using a technique involving genetically engineered mice, that may help prevent infection from Acinetobacter baumannii, a bacteria associated with hospital-acquired infections, which is particularly common in Asia.

A. baumannii bacteria can cause life-threatening respiratory illness and sepsis in vulnerable individuals, particularly in newborn babies whose immune systems have not fully developed. It is usually spread through contaminated surfaces, medical equipment and via contact with others. In recent years infections with strains of this bacteria that are resistant to almost every antibiotic available have become common.

Professor Stephen Baker from the Cambridge Institute of Therapeutic Immunology and Infectious Disease at the University of Cambridge said “A. baumannii is good at sticking to medical equipment, and if people are vulnerable or don't have a particularly well-developed immune system, they can succumb to this infection and get aggressive pneumonia requiring ventilation – and in many cases, the patients can acquire the infection from the ventilation itself.

“The bacteria are naturally resistant to many antimicrobials, but as they’re now found in hospitals, they’ve acquired resistance to almost everything we can use. In some hospitals in Asia, where the infections are most common, there isn't a single antibiotic that will work against them. They’ve become impossible to treat.”

In a study published today in Nature Communications, the team produced monoclonal antibodies using transgenic mice – mice that have been genetically-engineered to have a human-like immune system, producing human antibodies instead of mouse antibodies. They went on to show that these monoclonal antibodies were able prevent infection with A. baumannii derived from clinical samples.

Monoclonal antibodies are a growing area of medicine, commonly used to treat conditions including cancer (for example, Herceptin for treating some breast cancers) and autoimmune disease (for example, Humira for treating rheumatoid arthritis, psoriasis, Crohn's disease, and ulcerative colitis).

Usually, monoclonal antibodies are developed from the antibodies of patients who have recovered from an infection, or they are designed to recognise and target a particular antigen. For example, monoclonal antibodies targeting the ‘spike protein’ of the SARS-CoV-2 coronavirus were explored as a way of treating COVID-19.

In the approach taken by the Cambridge team, however, transgenic mice were exposed to the outer membrane of A. baumannii bacteria, triggering an immune response. The researchers then isolated almost 300 different antibodies and tested which of these was the most effective at recognising live bacteria, identifying the single monoclonal antibody mAb1416 as the best.

Professor Baker said: “Using this method, we don't infect the mice with the live bacteria, but we instead immunise them using multiple different elements and let the mouse’s immune system work out which ones to develop antibodies against. Because these mice have ‘humanised’ immune systems, we wouldn’t then need to reengineer the antibodies to work in humans.”

The team treated mice with mAb1416, and 24 hours later exposed them to A. baumannii isolated from a child with sepsis in an intensive care unit. They found that those mice treated with the drug saw a significant reduction in bacterial load in their lungs a further 24 hours later, compared to mice that were not treated.

All of the isolates used to produce and test the monoclonal antibodies were from patients in Ho Chi Minh City, Vietnam, but the isolate used to test mAb1416 was taken from a patient ten years later than the other isolates. This is important because it shows that mAb1416 was protective against A. baumannii bacteria that may have evolved over time.

Professor Baker said: “Using this technique, you can take any bacterial antigen or cocktail of antigens, rather than waiting for somebody that's recovered from a particular infection – who you assume has developed an appropriate antibody response – give it to the mice and extract the antibodies you think are the most important.”

More work is now needed to understand the mechanism by which mAb1416 protects against infection, as this could allow the team to develop an even more effective treatment. Any potential new drug will then need to be tested in safety trials in animals before being trialled in patients.

Professor Baker added: “We know that monoclonal antibodies are safe and that they work, and the technology exists to produce them – what we have done is identify how to hit bacteria with them. Apart from the cost effectiveness, there's no reason why this couldn’t become a medicine within a few years. Given the emergency presented by antimicrobial resistance, this could become a powerful new weapon to fight back.”

The research was funded by the Bill & Melinda Gates Foundation, the UK Medical Research Council Newton Fund, the Viet Nam Ministry of Science and Technology, and Wellcome.

Professor Baker is a fellow at Wolfson College, Cambridge.

Reference
Baker, S, Krishna, A & Higham, S. Exploiting human immune repertoire transgenic mice to identify protective monoclonal antibodies against an extensively antimicrobial resistant nosocomial bacterial pathogen. Nat Comms; 12 Sept 2024; DOI: 10.1038/s41467-024-52357-8

Monoclonal antibodies – treatments developed by cloning a cell that makes an antibody – could help provide an answer to the growing problem of antimicrobial resistance, say scientists.

We know that monoclonal antibodies are safe and that they work, and the technology exists to produce them – what we have done is identify how to hit bacteria with them

Stephen Baker

A Petri dish with a culture of the Superbug Acinetobacter baumannii next to antibiotics

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Yes

The international team, co-led by the University of Cambridge, used Webb to observe a galaxy roughly the size of the Milky Way in the early universe, about two billion years after the Big Bang. Like most large galaxies, it has a supermassive black hole at its centre. However, this galaxy is essentially ‘dead’: it has mostly stopped forming new stars.

“Based on earlier observations, we knew this galaxy was in a quenched state: it’s not forming many stars given its size, and we expect there is a link between the black hole and the end of star formation,” said co-lead author Dr Francesco D’Eugenio from Cambridge’s Kavli Institute for Cosmology. “However, until Webb, we haven’t been able to study this galaxy in enough detail to confirm that link, and we haven’t known whether this quenched state is temporary or permanent.”

This galaxy, officially named GS-10578 but nicknamed ‘Pablo’s Galaxy’ after the colleague who decided to observe it in detail, is massive for such an early period in the universe: its total mass is about 200 billion times the mass of our Sun, and most of its stars formed between 12.5 and 11.5 billion years ago.

“In the early universe, most galaxies are forming lots of stars, so it’s interesting to see such a massive dead galaxy at this period in time,” said co-author Professor Roberto Maiolino, also from the Kavli Institute for Cosmology. “If it had enough time to get to this massive size, whatever process that stopped star formation likely happened relatively quickly.”

Using Webb, the researchers detected that this galaxy is expelling large amounts of gas at speeds of about 1,000 kilometres per second, which is fast enough to escape the galaxy’s gravitational pull. These fast-moving winds are being ‘pushed’ out of the galaxy by the black hole.

Like other galaxies with accreting black holes, ‘Pablo’s Galaxy’ has fast outflowing winds of hot gas, but these gas clouds are tenuous and have little mass. Webb detected the presence of a new wind component, which could not be seen with earlier telescopes. This gas is colder, which means it’s denser and – crucially – does not emit any light. Webb, with its superior sensitivity, can see these dark gas clouds because they block some of the light from the galaxy behind them.

The mass of gas being ejected from the galaxy is greater than what the galaxy would require to keep forming new stars. In essence, the black hole is starving the galaxy to death. The results are reported in the journal Nature Astronomy.

“We found the culprit,” said D’Eugenio. “The black hole is killing this galaxy and keeping it dormant, by cutting off the source of ‘food’ the galaxy needs to form new stars.”

Although earlier theoretical models had predicted that black holes had this effect on galaxies, before Webb, it had not been possible to detect this effect directly.

Earlier models had predicted that the end of star formation has a violent, turbulent effect on galaxies, destroying their shape in the process. But the stars in this disc-shaped galaxy are still moving in an orderly way, suggesting that this is not always the case.

“We knew that black holes have a massive impact on galaxies, and perhaps it’s common that they stop star formation, but until Webb, we weren’t able to directly confirm this,” said Maiolino. “It’s yet another way that Webb is such a giant leap forward in terms of our ability to study the early universe and how it evolved.”

New observations with the Atacama Large Millimeter-Submillimiter Array (ALMA), targeting the coldest, darkest gas components of the galaxy, will tell us more about if and where any fuel for star formation is still hidden in this galaxy, and what is the effect of the supermassive black hole in the region surrounding the galaxy.

The research was supported in part by the Royal Society, the European Union, the European Research Council, and the Science and Technology Facilities Council (STFC), part of UK Research and Innovation (UKRI).

Reference:
Francesco D’Eugenio, Pablo G. Pérez-González et al. ‘A fast-rotator post-starburst galaxy quenched by supermassive black-hole feedback at z=3.’ Nature Astronomy (2024). DOI: 10.1038/s41550-024-02345-1

Astronomers have used the NASA/ESA James Webb Space Telescope to confirm that supermassive black holes can starve their host galaxies of the fuel they need to form new stars.

'Pablo's Galaxy'

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Yes

The study, by researchers at the University of Cambridge’s Sainsbury Laboratory, also found that bees prefer larger bullseyes over small ones, and fly 25% faster between artificial flower discs with larger bullseyes – potentially boosting efficiency for both bees and blossoms.

Using the hibiscus plant as a model, the researchers selected plants with three differently sized bullseye patterns – H. richardsonii (small bullseye covering 4% of flower disc), H. trionum (medium bullseye covering 16%) and a transgenic line (mutation) of H. trionum (large bullseye covering 36%).

They found that petal pre-patterning is established very early in the flower’s formation long before the petal shows any visible colour. The petal acts like a 'paint-by-numbers' canvas, where different regions are predetermined to develop specific colours and textures long before they start looking different from one another.

The research also shows plants can precisely control and modify the shape and size of these patterns using multiple mechanisms, highlighting the evolutionary importance of the process. By fine-tuning these designs, plants may gain a competitive advantage in the contest to attract pollinators.

The findings are published today in the journal Science Advances.

Dr Edwige Moyroud, who leads a research team studying the mechanisms underlying pattern formation in petals, explained: “If a trait can be produced by different methods, it gives evolution more options to modify it and create diversity, similar to an artist with a large palette or a builder with an extensive set of tools. By studying how bullseye patterns change, what we are really trying to understand is how nature generates biodiversity.”

In the small hibiscus species Hibiscus trionum, a striking bullseye pattern is formed on the petals, featuring a dark purple centre surrounded by white.

Lead author Dr Lucie Riglet investigated the mechanism behind hibiscus petal patterning by analysing petal development in three hibiscus flowers that had the same total size but different bullseye sizes – small, medium and large.

She found that the pre-pattern begins as a small, crescent-shaped region long before the bullseye is visible on tiny petals less than 0.2mm in size.

Dr Riglet said: “At the earliest stage we could dissect, the petals have around 700 cells and are still greenish in colour, with no visible purple pigment and no difference in cell shape or size. When the petal further develops to 4000 cells, it still does not have any visible pigment, but we identified a specific region where the cells were larger than their surrounding neighbours. This was the pre-pattern.”

A computational model developed by Dr Argyris Zardilis provided further insights, and combining both computational models and experimental results, the researchers showed that hibiscus can vary bullseye dimensions very early during the pre-patterning phase or modulate growth in either region of the bullseye, by adjusting cell expansion or division, later in development.

Dr Riglet then compared the relative success of the bullseye patterns in attracting pollinators using artificial flower discs that mimicked the three different bullseye dimensions.

Dr Riglet explained: “The bees not only preferred the medium and larger bullseyes over the small bullseye, they were also 25% quicker visiting these larger flower discs. Foraging requires a lot of energy and so if a bee can visit four flowers rather than three flowers in the same time, then this is beneficial for the bee, and also the flower.”

The findings suggest that these pre-patterning strategies could have deep evolutionary roots, potentially influencing the diversity of flower patterns across different species. The next step for the research team is to identify the signals responsible for generating these early patterns and to explore whether similar pre-patterning mechanisms are used in other plant organs, such as leaves.

This research not only advances our understanding of plant biology but also highlights the intricate connections between plants and their environments, showing how precise natural designs can play a pivotal role in the survival and evolution of species.

For example, H. richardsonii, which has the smallest bullseye of the three hibiscus plants studied in this research, is a critically endangered plant native to New Zealand. H. trionum is also found in New Zealand, but not considered to be native, and is widely distributed across Australia and Europe and has become a weedy naturalised plant in North America. Additional research is needed to determine whether the larger bullseye size helps H. trionum attract more pollinators and enhance its reproductive success.

Patterns on the flowers of plants guide insects, like bees, to the centre of the flower, where nectar and pollen await, enhancing the plant's chances of successful pollination. Despite their importance, surprisingly little is known about how these petal patterns form and how they have evolved into the vast diversity we see today, including spots, stripes, veins, and bullseyes.

These findings pave the way for further research into how petal patterns influence the survival and evolution of flowering plant species.

Reference

Riglet, L. et al: 'Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions'. September 2024, Science Advances. DOI: 10.1126/sciadv.adp5574

Flowers like hibiscus follow an invisible blueprint established very early in petal formation that precisely dictates the size of their central bullseye – a crucial pattern that can significantly impact their ability to attract pollinating bees.

We identified a specific region where the cells were larger than their surrounding neighbours - this was the pre-pattern.

Lucie Riglet

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Yes

The study, by researchers at the University of Cambridge’s Sainsbury Laboratory also found that bees prefer larger bullseyes over smaller ones and fly 25% faster between artificial flower discs with larger bullseyes – potentially boosting efficiency for both bees and blossoms. 

Patterns on the flowers of plants guide insects, like bees, to the centre of the flower, where nectar and pollen await, enhancing the plant's chances of successful pollination. Despite their importance, surprisingly little is known about how these petal patterns form and how they have evolved into the vast diversity we see today, including spots, stripes, veins, and bullseyes. 

Using a small hibiscus plant as a model, researchers compared closely related plants with the same flower size but three differently sized bullseye patterns featuring a dark purple centre surrounded by white – H. richardsonii (small bullseye covering 4% of the flower disc), H. trionum (medium bullseye covering 16%) and a transgenic line (mutation) of H. trionum (large bullseye covering 36%). 

They found that a pre-pattern is set up on the petal surface very early in the flower’s formation long before the petal shows any visible colour. The petal acts like a 'paint-by-numbers' canvas, where different regions are predetermined to develop specific colours and textures long before they start looking different from one another. 

The research also shows plants can precisely control and modify the shape and size of these patterns using multiple mechanisms, with possible implications for plant evolution. By fine-tuning these designs, plants may gain a competitive advantage in the contest to attract pollinators or maybe start attracting different species of insects. 

These findings are published in Science Advances. 

Dr Edwige Moyroud, who leads a research team studying the mechanisms underlying pattern formation in petals, explained: “If a trait can be produced by different methods, it gives evolution more options to modify it and create diversity, similar to an artist with a large palette or a builder with an extensive set of tools. By studying how bullseye patterns change, what we are really trying to understand is how nature generates biodiversity.” 

Lead author Dr Lucie Riglet investigated the mechanism behind hibiscus petal patterning by analysing petal development in the three hibiscus flowers that had the same total size but different bullseye patterns. 

She found that the pre-pattern begins as a small, crescent-shaped region long before the bullseye is visible on tiny petals less than 0.2mm in size. 

Dr Riglet said: “At the earliest stage we could dissect, the petals have around 700 cells and are still greenish in colour, with no visible purple pigment and no difference in cell shape or size. When the petal further develops to 4000 cells, it still does not have any visible pigment, but we identified a specific region where the cells were larger than their surrounding neighbours. This is the pre-pattern.” 

These cells are important because they mark the position of the bullseye boundary, the line on the petal where the colour changes from purple to white – without a boundary there is no bullseye! 

A computational model developed by Dr Argyris Zardilis provided further insights, and combining both computational models and experimental results, the researchers showed that hibiscus can vary bullseye dimensions very early during the pre-patterning phase or modulate growth in either region of the bullseye, by adjusting cell expansion or division, later in development. 

Dr Riglet then compared the relative success of the bullseye patterns in attracting pollinators using artificial flower discs that mimicked the three different bullseye dimensions. Dr Riglet explained: “The bees not only preferred the medium and larger bullseyes over the small bullseye, they were also 25% quicker visiting these larger flower discs. Foraging requires a lot of energy and so if a bee can visit 4 flowers rather than 3 flowers in the same time, then this is probably beneficial for the bee, and also the plants.” 

The researchers think that these pre-patterning strategies could have deep evolutionary roots, potentially influencing the diversity of flower patterns across different species. The next step for the research team is to identify the signals responsible for generating these early patterns and to explore whether similar pre-patterning mechanisms are used in other plant organs, such as leaves. 

This research not only advances our understanding of plant biology but also highlights the intricate connections between plants and their environments, showing how precise natural designs can play a pivotal role in the survival and evolution of species. 

For example, H. richardsonii, which has the smallest bullseye of the three hibiscus plants studied in this research, is a critically endangered plant native to New Zealand. H. trionum is also found in New Zealand, but not considered to be native, and is widely distributed across Australia and Europe and has become a weedy naturalised plant in North America. Additional research is needed to determine whether the larger bullseye size helps H. trionum attract more pollinators and enhance its reproductive success. 

Reference 
Lucie Riglet, Argyris Zardilis, Alice L M Fairnie, May T Yeo, Henrik Jönsson and Edwige Moyroud (2024) Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions. Science Advances. DOI: 10.1126/sciadv.adp5574 

Flowers like hibiscus use an invisible blueprint established very early in petal formation that dictates the size of their bullseyes – a crucial pre-pattern that can significantly impact their ability to attract pollinating bees.  

If a trait can be produced by different methods, it gives evolution more options to modify it and create diversity, similar to an artist with a large palette or a builder with an extensive set of tools

Edwige Moyroud

Artificial flower discs designed to mimic the bullseye sizes of the three hibiscus flowers

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Yes

The technology from Cancer Grand Challenges team IMAXT uses advanced spatial biology techniques to analyse tumours, some of which are based on technology originally developed to map the Milky Way and discover new planets. Now, other scientists will be able to access these technologies to create detailed tumour maps that could one day transform how we diagnose and treat cancer.

Led by Professor Greg Hannon and Dr Dario Bressan at the Cancer Research UK Cambridge Institute and Dr Nicholas Walton at the University of Cambridge’s Institute of Astronomy, SPACE will give other researchers the opportunity to study cancer in a way that wasn’t previously possible.

Dr Dario Bressan, Head of the SPACE Laboratory at the Cancer Research UK Cambridge Institute, said: “Tumours aren’t just a uniform mass of cells; they consist of a diverse ecosystem of cancer cells, immune cells, and other essential components that support their survival. Hidden within these intricate networks lies valuable information which could guide us in making more personalised treatment decisions for each patient. 

“With the SPACE platform, researchers can zoom into specific cell populations, highlight the complex connections between them, and even run virtual experiments to predict how the tumour might respond to different treatments. By unlocking these insights, we can transform the future of cancer care and uncover new opportunities for targeted therapies.” 

The IMAXT team was first awarded £20 million in 2017 by Cancer Research UK through Cancer Grand Challenges, a global research initiative co-founded by Cancer Research UK and the National Cancer Institute in the US.

Since then, the team has united experts from fields rarely brought together including medicine, Virtual Reality (VR), programming, molecular biology, chemistry, mathematics, and even astronomy, to create a completely immersive tool for studying tumours.

As well as enabling scientists to analyse 3D tumour maps, IMAXT created pioneering VR technology which allows the user to ‘step inside’ a tumour using a VR headset.

With the headset, scientists get to view vast amounts of detailed data about individual tumour cells in a 3D space. Instead of looking at this data on a computer screen, they can see all the information in real-time, as if they were inside the tumour itself.

Professor Greg Hannon, Director of the Cancer Research UK Cambridge Institute, said: "Cancer Grand Challenges offers a unique opportunity for international teams to address some of cancer’s biggest challenges. When we took on our particular challenge, much of what we proposed was science fiction.

“Over the past 7 years, our team has turned those early hopes and ideas into approaches that can now be made broadly available. In nature, biology unfolds in three dimensions, and we now finally have the tools to observe it that way—giving us a much deeper, more accurate view of cancer. We’re thrilled to share these breakthroughs with the broader cancer research community."

Director of Cancer Grand Challenges at Cancer Research UK, Dr David Scott, said: “IMAXT is changing what’s possible when it comes to cancer research.  

“We can glean important insights about a tumour by analysing its genetic makeup or its proteins, but no technology alone can give us the depth of understanding needed to truly understand this complex disease.  

“By combining state-of-the-art technology and vast expertise, IMAXT will change how cancers are classified, treated and managed, giving more people a better chance of surviving their disease.” 

The funding will support the SPACE hub laboratory, hosted at the CRUK Cambridge Institute, and the SPACE analysis and computing platform, developed and operated at the Institute of Astronomy, University of Cambridge. Together SPACE includes and combines most available technologies for the spatial molecular profiling of tumours. The continued collaboration between the cancer and astronomy teams from the IMAXT project will ensure the maintenance and development of all critical aspects of the platform – from technical and scientific expertise to instrumentation, computing, and data analysis – to allow SPACE to continue at the forefront research in the rapidly emerging spatial-omics field, and be a valuable centre of excellence to support new research in the Cancer Grand Challenge and cancer research communities.

SPACE is funded by Cancer Research UK through Cancer Grand Challenges. Additional support for the SPACE project has been provided by the UK Space Agency through their funding of the development of imaging and analysis techniques at the IoA, Cambridge for a range of space science missions. These have been successfully applied to spatial imaging data through IMAXT and are ready for wider use in SPACE.

Dr Paul Bate, Chief Executive Officer at UK Space Agency said: “Space is powering our daily lives, from satellite navigation to weather forecasts and climate monitoring. This collaboration between the cancer and astronomy teams in the IMAXT project is another real-world example of how space science and technology is bringing benefits to people here on Earth. 

“Thanks to this partnership, the same science and technology that mapped the Milky Way may soon have a positive impact on people battling cancer, and could support doctors to provide better, faster treatment." 

Going forward, a next-generation version of the VR technology will be further developed and commercialised by Suil Vision, a start-up company recently launched by IMAXT team members and Cancer Research UK’s innovation arm, Cancer Research Horizons. Suil Vision is the first start-up to emerge from the Cancer Grand Challenges programme. With a £500,000 investment from the Cancer Research Horizons Seed Fund, Suil Vision will create a market-ready version of their suite of VR technologies for analysing multiple types of biological data, rolling these out across research institutions and companies worldwide. 

Find out how Cambridge is changing the story of cancer

Image

Top: Lung with two metastatic lesions derived from a mouse primary triple-negative breast tumour. The figure shows how the registration of the different imaging modalities to a cellular level allow to segment individual cells and identify tumour cell populations, differentiate hypoxic areas, increased fibrosis, infiltration of immune cells and blood and lymphatic vessels by staining with a panel of 35 cell markers at the same time. Bottom: Sample in 3D depicts a tumour grown in the mammary gland of a mouse showing the power of the SPACE pipeline to produce and visualise large volumes (typically ~100,000 individual images registered and stitched and up to 500TB 500 GB of data). The orange fluorescence beads are clearly visible in the medium outside the biological tissue and prove to be crucial for all stages of multimodal registration.

Adapted from a press release by Cancer Research UK

A unique collaboration of astronomers and cancer researchers at Cambridge has been awarded more than £5m to establish the Spatial Profiling and Annotation Centre of Excellence (SPACE) to open up access to their groundbreaking cancer mapping technology and establish collaborations with other scientists to enable them to investigate tumours in 3D.

When we took on our particular challenge, much of what we proposed was science fiction

Greg Hannon

Lung with two metastatic lesions derived from a mouse primary triple-negative breast tumour

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Yes

Matthew Pennycook MP, who was accompanied by Peter Freeman, Chair of Homes England, joined the University’s Vice-Chancellor, Professor Deborah Prentice, the Pro-Vice-Chancellor for Innovation, Dr Diarmuid O’Brien, and members of the University Estates Division for a tour of the city’s new community.

During the fact-finding visit, Mr Pennycook heard about the innovative design and planning that has gone into Eddington, which is delivering homes, community facilities, and green space, and at the same time creating a vibrant and sustainable place to live.

Central to its planning has been the provision of affordable housing for key worker staff at the University, which will account for 50% of Eddington’s homes. By housing University staff in a purpose-built, high-quality neighbourhood, while also adding more homes to the open market, Eddington aims to relieve housing pressure on the city and support the highly successful Cambridge eco-system which provides long-term growth and jobs for the wider area and beyond.

The Minister also heard how Eddington and the nearby Cambridge West Innovation District are critical parts of the University’s plans for sustained economic growth in Cambridge. The University is driving forward the Cambridge West Innovation District and the Eddington housing development together, as part of a coherent vision for the future of the city.

Professor Deborah Prentice, Vice-Chancellor, said: “It was a pleasure to welcome the Housing and Planning Minister, and the Chair of Homes England, and to show them around our exciting new development. They were interested to hear how the neighbourhood has been designed with sustainability at its heart, and how it helps support Cambridge as a world-leading hub of innovation, benefiting the community and providing growth for the national economy.”

Mr Pennycook later visited Cambridge Biomedical Campus where he was joined by Lord Vallance, Minister for Science, in hosting a roundtable on infrastructure and growth in Cambridge.

Proposals for the future phases of the Eddington development will be discussed at the first round of public consultations this month. For dates and venue details visit the Eddington website.

The new Minister for Housing and Planning visited the University’s Eddington development to learn more about the new neighbourhood as an example of a high-quality, sustainable housing project that supports local economic growth.

From left, Matt Johnson, Head of Development at North West Cambridge; Vice-Chancellor Professor Deborah Prentice; Matthew Pennycook MP, Minister for Housing and Planning, and Peter Freeman, Chair of Homes England.

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Yes

The smart choker, developed by researchers at the University of Cambridge, incorporates electronic sensors in a soft, stretchable fabric, and is comfortable to wear. The device could be useful for people who have temporary or permanent speech impairments, whether due to laryngeal surgery, or conditions such as Parkinson’s, stroke or cerebral palsy.

By incorporating machine learning techniques, the smart choker can also successfully recognise differences in pronunciation, accent and vocabulary between users, reducing the amount of training required.

The choker is a type of technology known as a silent speech interface, which analyses non-vocal signals to decode speech in silent conditions – the user only needs to mouth the words in order for them to be captured. The captured speech signals can then be transferred to a computer or speaker to facilitate conversation.

Tests of the smart choker showed it could recognise words with over 95% accuracy, while using 90% less computational energy than existing state-of-the art technologies. The results are reported in the journal npj Flexible Electronics.

“Current solutions for people with speech impairments often fail to capture words and require a lot of training,” said Dr Luigi Occhipinti from the Cambridge Graphene Centre, who led the research. “They are also rigid, bulky and sometimes require invasive surgery to the throat.”

The smart choker developed by Occhipinti and his colleagues outperforms current technologies on accuracy, requires less computing power, is comfortable for users to wear, and can be removed whenever it’s not needed. The choker is made from a sustainable bamboo-based textile, with strain sensors based on graphene ink incorporated in the fabric. When the sensors detect any strain, tiny, controllable cracks form in the graphene. The sensitivity of the sensors is more than four times higher than existing state of the art.

“These sensors can detect tiny vibrations, such as those formed in the throat when whispering or even silently mouthing words, which makes them ideal for speech detection,” said Occhipinti. “By combining the ultra-high sensitivity of the sensors with highly efficient machine learning, we’ve come up with a device we think could help a lot of people who struggle with their speech.”

Vocal signals are incredibly complex, so associating a specific signal with a specific word requires a high level of computational processing. “On top of that, every person is different in terms of the way they speak, and machine learning gives us the tools we need to learn and adapt the interpretation of signals from person to person,” said Occhipinti.

The researchers trained their machine learning model on a database of the most frequently used words in English, and selected words which are frequently confused with each other, such as ‘book’ and ‘look’. The model was trained with a variety of users, including different genders, native and non-native English speakers, as well as people with different accents and different speaking speeds.

Thanks to the device’s ability to capture rich dynamic signal characteristics, the researchers found it possible to use lightweight neural network architectures with simplified depth and signal dimensions to extract and enhance the speech information features. This resulted in a machine learning model with high computational and energy efficiency, ideal for integration in battery-operated wearable devices with real-time AI processing capabilities.

“We chose to train the model with lots of different English speakers, so we could show it was capable of learning,” said Occhipinti. “Machine learning has the capability to learn quickly and efficiently from one user to the next, so the retraining process is quick.”

Tests of the smart choker showed it was 95.25% accurate in decoding speech. “I was surprised at just how sensitive the device is,” said Occhipinti. “We couldn’t capture all the signals and complexity of human speech before, but now that we can, it unlocks a whole new set of potential applications.”

Although the choker will have to undergo extensive testing and clinical trials before it is approved for use in patients with speech impairments, the researchers say that their smart choker could also be used in other health monitoring applications, or for improving communication in noisy or secure environments.

The research was supported in part by the EU Graphene Flagship and the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI).

Reference:
Chenyu Tang et al. ‘Ultrasensitive textile strain sensors redefine wearable silent speech interfaces with high machine learning efficiency.’ npj Flexible Electronics (2024). DOI: 10.1038/s41528-024-00315-1

Researchers have developed a wearable ‘smart choker’ that uses a combination of flexible electronics and artificial intelligence techniques to allow people with speech impairments to communicate by detecting tiny movements in the throat.

Smart Choker

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Yes

They have just won an award to develop their technology, which aims to make hip surgery more precise and deliver better and longer-lasting outcomes – which is good for patients and the NHS.

The National Institute for Health and Care Research (NIHR) has awarded a £1.4 million Invention for Innovation (i4i) Product Development Award to advance work on the team’s “smart” joint “trial liner”.

The sensors measure forces passing through the hip joint to help the surgeon assess and balance the soft tissues, which aids the accurate positioning of the implant.

Once measurements are complete using the wireless surgical aid, the surgeon marks the ideal position for the implant, removes the smart trial liner, and completes the operation.

There are currently no technologies that can deliver such readings during an operation and in real-time, and instead surgeons balance the joint based on feel and anatomical landmarks.

This is despite over two million total hip replacements being performed annually, with the number constantly rising due to increasing lifespans. Younger patients are starting to need hip replacements as well, so implants need to withstand higher stresses and last longer, to avoid spiralling into a vicious circle of revision surgery and higher rates of dissatisfaction.

Driving this clinical initiative is the chief investigator from Cambridge University Hospitals (CUH) NHS Foundation Trust, Consultant orthopaedic surgeon, clinical and research lead of the Young Adult Hip Service, and Affiliate Associate Professor at the University of Cambridge Vikas Khanduja.

The technology development is being overseen by Professor Sohini Kar-Narayan from Cambridge’s Department of Materials Science and Metallurgy, together with Dr Jehangir Cama, who is leading on translational and commercialisation activities. They are joined by Consultant clinical scientist and CUH head of clinical engineering, Professor Paul White.

“We’re really looking forward to this next phase of product development that will see us move towards an actual product that is fit for clinical use, and that has the potential to revolutionise joint replacement surgery,” said Kar-Narayan.

“This funding will bring together wide-ranging expertise to help us further develop our prototype, bringing this technology closer to clinical use,” said Cama.

The team currently has a prototype version of the device, which has been validated in the laboratory and in other tests. However, the NIHR award is important for further development and finalisation of the design and compliance with regulations before it can be tested in a living patient.

The team’s underlying sensor technology intellectual property has been protected via a patent application filed by Cambridge Enterprise, the University’s commercialisation arm.

“This is a fantastic example of Cambridge’s entrepreneurial clinicians, academics and their institutions working together with forward-looking funders to create a positive impact for markets, society and importantly patients,” said Dr Terry Parlett, Commercialisation Director at Cambridge Enterprise.

Adapted from a CUH press release.

Technology that could transform the future of hip replacement surgery is being pioneered by a team of experts in Cambridge.

Illustration of a human hip joint

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Yes

An international group of researchers, led by the Copenhagen Business School, the University of Basel and the University of Cambridge, surveyed 4,000 people from Denmark, India, Nigeria and the United States about inequality in personal carbon footprints – the total amount of greenhouse gases produced by a person’s activities – within their own country.

Although it is well-known that there is a large gap between the carbon footprint of the richest and poorest in society, it’s been unclear whether individuals were aware of this inequality. The four countries chosen for the survey are all different in terms of wealth, lifestyle and culture. Survey participants also differed in their personal income, with half of participants belonging to the top 10% of income in their country.

The vast majority of participants across the four countries overestimated the average personal carbon footprint of the poorest 50% and underestimated those of the richest 10% and 1%.

However, participants from the top 10% were more likely to support certain climate policies, such as increasing the price of electricity during peak periods, taxing red meat consumption or subsidising carbon dioxide removal technologies such as carbon capture and storage.

The researchers say that this may reflect generally higher education levels among high earners, a greater ability to absorb price-based policies or a stronger preference for technological solutions to the climate crisis. The results are reported in the journal Nature Climate Change.

Although the concept of a personal carbon or environmental footprint has been used for over 40 years, it became widely popularised in the mid-2000s, when the fossil fuel company BP ran a large advertising campaign encouraging people to determine and reduce their personal carbon footprint.

“There are definitely groups out there who would like to push the responsibility of reducing carbon emissions away from corporations and onto individuals, which is problematic,” said co-author Dr Ramit Debnath, Assistant Professor and Cambridge Zero Fellow at the University of Cambridge. “However, personal carbon footprints can illustrate the profound inequality within and between countries and help people identify how to live in a more climate-friendly way.”

Previous research has shown widespread misperceptions about how certain consumer behaviours affect an individual's carbon footprint. For example, recycling, shutting off the lights when leaving a room and avoiding plastic packaging are lower-impact behaviours that are overestimated in terms of how much they can reduce one’s carbon footprint. On the other end, the impact of behaviours such as red meat consumption, heating and cooling homes, and air travel all tend to be underestimated.

However, there is limited research on whether these misperceptions extend to people’s perceptions of the composition and scale of personal carbon footprints and their ability to make comparisons between different groups.

The four countries selected for the survey (Denmark, India, Nigeria and the US) were chosen due to their different per-capita carbon emissions and their levels of economic inequality. Within each country, approximately 1,000 participants were surveyed, with half of each participant group from the top 10% of their country and the other half from the bottom 90%.

Participants were asked to estimate the average personal carbon footprints specific to three income groups (the bottom 50%, the top 10%, and the top 1% of income) within their country. Most participants overestimated the average personal carbon footprint for the bottom 50% of income and underestimated the average footprints for the top 10% and top 1% of income.

“These countries are very different, but we found the rich are pretty similar no matter where you go, and their concerns are different to the rest of society,” said Debnath. “There’s a huge contrast between billionaires travelling by private jet while the rest of us drink with soggy paper straws: one of those activities has a big impact on an individual carbon footprint, and one doesn’t.”

The researchers also looked at whether people’s ideas of carbon footprint inequality were related to their support for different climate policies. They found that Danish and Nigerian participants who underestimated carbon footprint inequality were generally less supportive of climate policies. They also found that Indian participants from the top 10% were generally more supportive of climate policies, potentially reflecting their higher education and greater resources.

“Poorer people have more immediate concerns, such as how they’re going to pay their rent, or support their families,” said first author Dr Kristian Steensen Nielsen from Copenhagen Business School. “But across all income groups, people want real solutions to the climate crisis, whether those are regulatory or technological. However, the people with the highest carbon footprints bear the greatest responsibility for changing their lifestyles and reducing their footprints.”

After learning about the actual carbon footprint inequality, most participants found it slightly unfair, with those in Denmark and the United States finding it the most unfair. However, people from the top 10% generally found the inequality fairer than the general population, except in India. “This could be because they’re trying to justify their larger carbon footprints,” said Debnath.

The researchers say that more work is needed to determine the best ways to promote fairness and justice in climate action across countries, cultures and communities.

“Due to their greater financial and political influence, most climate policies reflect the interests of the richest in society and rarely involve fundamental changes to their lifestyles or social status,” said Debnath.

“Greater awareness and discussion of existing inequality in personal carbon footprints can help build political pressure to address these inequalities and develop climate solutions that work for all,” said Nielsen.

The study also involved researchers from Justus-Liebig-University Giessen, Murdoch University and Oxford University. The research was supported in part by the Carlsberg Foundation, the Bill & Melinda Gates Foundation, the Quadrature Climate Foundation and the Swiss National Science Foundation.

Reference:
Kristian S Nielsen et al. ‘Underestimation of personal carbon footprint inequality in four diverse countries.’ Nature Climate Change (2024). DOI: 10.1038/s41558-024-02130-y 

The personal carbon footprint of the richest people in society is grossly underestimated, both by the rich themselves and by those on middle and lower incomes, no matter which country they come from. At the same time, both the rich and the poor drastically overestimate the carbon footprint of the poorest people.

A father and two sons running on a beach

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Yes

Currently cancer is usually diagnosed when tumours are already developed requiring, often significant, treatment to remove them and prevent further growth.

However, a research team at the University of Cambridge will receive over £1.5m from Cancer Research UK over the next six years to investigate how the immune system evolves, targets and kills cancer cells as tumours are developing.

They hope by detecting the trigger point when our own body starts to recognise cancerous cells, it may help find a way to spark our own immune system into action so it kills cancer cells before tumours can even begin.

This could vastly reduce the amount of treatment people diagnosed with cancer require, which can often have significant side effects. The pioneering work could benefit millions of cancer patients before the disease becomes life-threatening or spreads.

Dr Heather Machado is leading a team of scientists at the Department of Pathology, looking at the body's immune system's ability to fight cancer.  Dr Machado’s work on T cells – part of the immune system which fight infection and disease, including cancer – will provide an insight into how long before a diagnosis these cells recognize and respond to cancer.

The study will specifically examine how T cells respond to cancer when they first recognise and respond to a tumour in the kidneys or the liver.

The breakthrough study has the potential to unlock the mystery as to how our immune cells work to fight cancer.

Dr Machado said: “Using mutations that naturally accumulate in each of our cells as we age, we can essentially build a family tree of T-cells, and this family tree has information about when T-cells met cancer for the first time. This research is only now possible as a result of advancements in DNA sequencing technology.

“This research has the potential to give an entirely new perspective on the role of the immune system in cancer progression, findings that we hope to use to further improve lifesaving cancer immunotherapies.”

Her aim is to see if they could lead to specific immunotherapy treatments and ways of detecting the cancer earlier.

She added: “Most cancers are diagnosed years or decades after early tumour development, which can often be too late. Our methods will allow us to go back in the cancer’s timeline to understand the immune response in these early stages of cancer development. Beyond improving immunotherapies, we hope that this understanding helps us detect cancer earlier, at stages where survival rates are much higher.”

The body’s immune system is the first line of defence against cancer but previously it has been difficult to observe this early response in humans.

Dr Machado will use genome sequencing which determines the genetic makeup of an organism to study how a tumour and the immune cells co-evolve over the course of tumour development. 

She will time T cell clonal expansions using evolutionary trees built from the genomes of individual T cells, exploiting recent advancements in single-cell whole genome sequencing. Dr Machado will then perform these experiments using early-stage kidney and liver cancer resections and by sampling throughout the course of immunotherapy in metastatic kidney cancer.”

She added: “The study is believed to be the first of its kind in the world and it has the potential to be groundbreaking research as we have never been able to examine these evolutionary dynamics in humans before. How long before a tumour is diagnosed has the immune system been responding is an incredibly hard problem to solve because these immune dynamics play out years prior to diagnosis.

“Normal cells evolve into tumours, and we are blind to much of that process and yet the immune system is one of our best tools for fighting cancer.

Dr Machado studied for her PhD at Stanford University and completed her post doctorate research at the Wellcome Sanger Institute in Hinxton, UK. She added: “We are using cutting edge technology that is only available now and we are going to be able to discover how the immune system responds to tumours unlike we have ever seen before and that, is potentially life changing in terms of improving immunotherapies for better health and patient prognosis.”

Find out how Cambridge is changing the story of cancer

Adapted from a press release from Cancer Research UK

A new study aims, for the first time, to pinpoint the very moment the immune system recognises a tumour to try to stop the disease earlier than previously possible.

This research has the potential to give an entirely new perspective on the role of the immune system in cancer progression

Heather Machado

CT scan showing cholangiocarcinoma

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Yes

The statistics for the University of Cambridge are available on our website as part of our ongoing commitment to transparency and openness around the use of animals in research.

This coincides with the publication of the Home Office’s report on the statistics of scientific procedures on living animals in Great Britain in 2023.

The 10 organisations carried out 1,435,009 procedures, 54% (over half) of the 2,681,686 procedures carried out on animals for scientific research in Great Britain in 2023. Of these 1,435,009 procedures, more than 99% were carried out on mice, fish and rats and 82% were classified as causing pain equivalent to, or less than, an injection.

The 10 organisations are listed below alongside the total number of procedures they carried out in 2023. This is the ninth consecutive year that organisations have come together to publicise their collective statistics and examples of their research.

Organisation	Number of Procedures (2023)
University of Cambridge	223,787
University of Oxford	194,913
The Francis Crick Institute	192,920
UCL	176,019
University of Edinburgh	139,881
Medical Research Council	124,156
University of Manchester	110,885
King's College London	109,779
University of Glasgow	102,089
Imperial College London	60,580
TOTAL	1,435,009

 

In total, 69 organisations have voluntarily published their 2023 animal research statistics.

All organisations are committed to the ethical framework called the ‘3Rs’ of replacement, reduction and refinement. This means avoiding or replacing the use of animals where possible, minimising the number of animals used per experiment and optimising the experience of the animals to improve animal welfare. However, as institutions expand and conduct more research, the total number of animals used can rise even if fewer animals are used per study. 

All organisations listed are signatories to the Concordat on Openness on Animal Research in the UK, which commits them to being more open about the use of animals in scientific, medical and veterinary research in the UK. More than 125 organisations have signed the Concordat, including UK universities, medical research charities, research funders, learned societies and commercial research organisations.

Wendy Jarrett, Chief Executive of Understanding Animal Research, which developed the Concordat on Openness, said:

“Animal research remains a small but vital part of the quest for new medicines, vaccines and treatments for humans and animals. Alternative methods are gradually being phased in, but, until we have sufficient reliable alternatives available, it is important that organisations that use animals in research maintain the public’s trust in them. By providing this level of information about the numbers of animals used, and the experience of those animals, as well as details of the medical breakthroughs that derive from this research, these Concordat signatories are helping the public to make up their own minds about how they feel about the use of animals in scientific research in Great Britain.”   

Professor Anna Philpott, Head of the School of Biological Sciences at the University of Cambridge, said:

“Cambridge research is changing how we understand health and ageing, and how we treat disease. Animal research continues to play a small but vital role in this work and in the development of ground-breaking new medical devices and drug treatments. We are committed to using animals only where there is no alternative as a means of making progress.”

Story adapted from a press release by Understanding Animal Research.

 

CASE STUDY: Egging on vital research

The actin cytoskeleton is a system of long filaments, vital in embryonic development. Problems with its control have been linked to the kidney problems experienced by patients with the rare conditions called Lowe syndrome and Dent disease 2. But since the actin cytoskeleton is in all the cells of the body it has been very difficult to translate an understanding of it into a drug treatment.

Wellcome Trust Senior Research Fellow Dr Jenny Gallop at the University of Cambridge has created a simpler version of the actin cytoskeleton that she can study in the lab. A key component is cytoplasm extracted from frog eggs.

Gallop’s lab keeps around 120 female frogs that are induced to lay eggs in a way that matches their natural cycles. This requires a hormone injection - just a mild discomfort to the frogs - every three to four months to make them ovulate. Over time, Gallop has refined her methods so that only half the original number of frogs are now needed.

This has enabled her to understand what might be going wrong in Lowe syndrome and Dent disease 2 – and realise that an existing drug might be able to help. Alpelisib has already been approved to safely treat breast cancer, and Gallop is now applying for approval to test whether it works to treat the kidney problems in patients with Dent disease 2.

Repurposing an existing drug means the long drug-development process has already been done. Conversations with people affected by the diseases inspire Gallop’s team to keep going. And the frogs have played a vital role in this decade-long journey.

Read the full story

The 10 organisations in Great Britain that carry out the highest number of animal procedures - those used in medical, veterinary and scientific research – have released their annual statistics today.

African Clawed Frogs held in water-filled tanks

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Yes

Of 3,500 proposals reviewed by the ERC, only 14% were selected for funding – Cambridge has the highest number of grants of any UK institution.

ERC Starting Grants – totalling nearly €780 million – support cutting-edge research in a wide range of fields, from life sciences and physics to social sciences and humanities.

The awards help researchers at the beginning of their careers to launch their own projects, form their teams and pursue their most promising ideas. Starting Grants amount to €1.5 million per grant for a period of five years but additional funds can be made available.

In total, the grants are estimated to create 3,160 jobs for postdoctoral fellows, PhD students and other staff at host institutions.

Cambridge’s recipients work in a wide range of fields including plant sciences, mathematics and medicine. They are among 494 laureates who will be leading projects at universities and research centres in 24 EU Member States and associated countries. This year, the UK has received grants for 50 projects, Germany 98, France 49, and the Netherlands 51.

Cambridge’s grant recipients for 2024 are:

Adrian Baez-Ortega (Dept. of Veterinary Medicine, Wellcome Sanger Institute) for Exploring the mechanisms of long-term tumour evolution and genomic instability in marine transmissible cancers

Claudia Bonfio (MRC Laboratory of Molecular Biology) for Lipid Diversity at the Onset of Life

Tom Gur (Dept. of Computer Science and Technology) for Sublinear Quantum Computation

Leonie Luginbuehl (Dept. of Plant Sciences) for Harnessing mechanisms for plant carbon delivery to symbiotic soil fungi for sustainable food production

Julian Sahasrabudhe (Dept. of Pure Mathematics and Mathematical Statistics) for High Dimensional Probability and Combinatorics

Richard Timms (Cambridge Institute for Therapeutic Immunology and Infectious Disease) for Deciphering the regulatory logic of the ubiquitin system

Hannah Übler (Dept. of Physics) for Active galactic nuclei and Population III stars in early galaxies

Julian Willis (Yusuf Hamied Department of Chemistry) for Studying viral protein-primed DNA replication to develop new gene editing technologies

Federica Gigante (Faculty of History) for Unveiling Networks: Slavery and the European Encounter with Islamic Material Culture (1580– 1700) – Grant hosted by the University of Oxford

 

Professor Sir John Aston FRS, Pro-Vice-Chancellor for Research at the University of Cambridge, said:

“Many congratulations to the recipients of these awards which reflect the innovation and the vision of these outstanding investigators. We are fortunate to have many exceptional young researchers across a wide range of disciplines here in Cambridge and awards such as these highlight some of the amazing research taking place across the university. I wish this year’s recipients all the very best as they begin their new programmes and can’t wait to see the outcomes of their work.”

Iliana Ivanova, European Commissioner for Innovation, Research, Culture, Education and Youth, said:

“The European Commission is proud to support the curiosity and passion of our early-career talent under our Horizon Europe programme. The new ERC Starting Grants winners aim to deepen our understanding of the world. Their creativity is vital to finding solutions to some of the most pressing societal challenges. In this call, I am happy to see one of the highest shares of female grantees to date, a trend that I hope will continue. Congratulations to all!”

President of the European Research Council, Prof. Maria Leptin, said:

“Empowering researchers early on in their careers is at the heart of the mission of the ERC. I am particularly pleased to welcome UK researchers back to the ERC. They have been sorely missed over the past years. With fifty grants awarded to researchers based in the UK, this influx is good for the research community overall.”

Nine Cambridge researchers are among the latest recipients of highly competitive and prestigious European Research Council (ERC) Starting Grants.

Plant roots interacting with arbuscular mycorrhizal fungi. Image: Luginbuehl lab

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Yes

Car travel contributes to air pollution, a major cause of heart and lung diseases including asthma attacks. Beyond this, it limits children's opportunities for physical activity, hindering their development and mental health, and increasing their risk of obesity and chronic illnesses.

Despite UK guidelines recommending a daily average of 60 minutes of moderate-to-vigorous physical activity for school-aged children and adolescents, less than half (45%) of children aged 5-16 met these levels in 2021. One in three children aged 10-11 in the UK are overweight or obese.

In April 2019, London introduced the ULEZ to help improve air quality by reducing the number of vehicles on the road that do not meet emissions standards. According to Transport for London, the central London ULEZ reduced harmful nitrogen oxides by 35% and particulate matter by 15% in central London within the first 10 months of its introduction.

In a study published on 5 September in the International Journal of Behavioral Nutrition and Physical Activity, a team led by researchers at the University of Cambridge and Queen Mary University of London examined the impact of the ULEZ on how children travelled to school. The research was part of the CHILL study (Children’s Health in London and Luton).

The study examined data from almost 2,000 children aged 6 to 9 years attending 84 primary schools in London and the control area, Luton. 44 schools were located with catchment areas within or bordering London’s ULEZ, and these were compared to a similar number in Luton and Dunstable (acting as a comparison group). The inclusion of the comparison site enabled the researchers to draw more robust conclusions and increased confidence in attributing the observed changes to the introduction of the ULEZ.

The researchers collected data from the period June 2018 to April 2019, prior to ULEZ implementation, and again in the period June 2019 to March 2020, the year after implementation of the ULEZ but prior to COVID-19-related school closures.

Among those children in London who travelled by car prior to the introduction of the ULEZ, 4 in 10 (42%) switched to active modes, while one in 20 (5%) switched from active to inactive modes.

In contrast, only one in 5 (20%) children in Luton swapped from car travel to active modes, while a similar number (21%) switched from active to car travel. This means that children in London within the ULEZ were 3.6 times as likely to shift from travelling by car to active travel modes compared to those children in Luton and far less likely (0.11 times) to switch to inactive modes.

The impact of the ULEZ on switching to active travel modes was strongest for those children living more than half a mile (0.78km) from school. This was probably because many children who live closer to school already walked or cycled to school prior to the ULEZ and therefore there was more potential for change in those living further away from their school.

The study’s first author, Dr Christina Xiao from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, said: “The introduction of the ULEZ was associated with positive changes in how children travelled to school, with a much larger number of children moving from inactive to active modes of transport in London than in Luton.

“Given children's heightened vulnerability to air pollution and the critical role of physical activity for their health and development, financial disincentives for car use could encourage healthier travel habits among this young population, even if they do not necessarily target them.”

Joint senior author Dr Jenna Panter from the MRC Epidemiology Unit, University of Cambridge, said: “The previous Government was committed to increasing the share of children walking to school by 2025 and we hope the new Government will follow suit. Changing the way children travel to school can have significant effects on their levels of physical activity at the same time as bringing other co-benefits like improving congestion and air quality, as about a quarter of car trips during peak morning hours in London are made for school drop-offs.”

After ULEZ was introduced in Central London, the total number of vehicles on the roads fell by 9%, and by one-third (34%) for vehicles that failed to meet the required exhaust emission standards, with no clear evidence of traffic moving instead to nearby areas.

Joint senior author Professor Chris Griffiths from the Wolfson Institute of Population Health, Queen Mary University of London, said: “Establishing healthy habits early is critical to healthy adulthood and the prevention of disabling long term illness, especially obesity and the crippling diseases associated with it. The robust design of our study, with Luton as a comparator area, strongly suggests the ULEZ is driving this switch to active travel. This is evidence that Clean Air Zone intervention programmes aimed at reducing air pollution have the potential to also improve overall public health by addressing key factors that contribute to illness.”

Due to the introduction of COVID-19 restrictions in late March 2020, the study was paused in 2020/2021 and results are only reported for the first year of follow-up. However, as both London and Luton, the study areas, were similarly affected, the researchers believe this disruption is unlikely to have affected the results. The study has restarted following up with the children to examine the longer-term impacts of the ULEZ. This will identify if the changes they observed in the year following the introduction of the ULEZ persist.

The study was conducted in collaboration with Queen Mary University of London, Imperial College, University of Bedfordshire, University of Edinburgh, University of Oxford and University of Southern California and funded by the National Institute for Health and Care Research Public Health Research (NIHR), NIHR Applied Research Collaboration North Thames, and Cambridge Trust. 

Reference
Xiao, C et al. Children’s Health in London and Luton (CHILL) cohort: A 12-month natural experimental study of the effects of the Ultra Low Emission Zone on children’s travel to school. IJBNPA; 5 Sept 2024; DOI: 10.1186/s12966-024-01621-7

Four in ten children in Central London who travelled to school by car switched to more active modes of transport, such as walking, cycling, or public transport, following the introduction of the Ultra-Low Emission Zone (ULEZ), according to new research. In the comparison area with no ULEZ, Luton, only two in ten children made this switch over the same period.

Changing the way children travel to school can have significant effects on their levels of physical activity at the same time as bringing other co-benefits like improving congestion and air quality

Jenna Panter

ULEZ signs (cropped)

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Yes

The research also suggests that people who are taking lipid-lowering drugs such as statins to lower their cholesterol levels should remain on them, even if their cholesterol levels have fallen, as stopping treatment could increase their risk of atherosclerosis.

Atherosclerosis is one of the major causes of heart and circulatory disease. It involves the hardening and narrowing of the vessels that carry blood to and from the heart. It is caused by the build-up of abnormal material called plaques – collections of fat, cholesterol, calcium and other substances circulating in the blood.

Atherosclerosis is largely considered a disease of the elderly and so most screening, prevention and intervention programmes primarily target those with high cholesterol levels, generally after the age of 50.

But in a study published today in Nature, a team led by scientists at the University of Cambridge shows that high cholesterol levels at a younger age – particularly if those levels fluctuate – can be even more damaging than high cholesterol levels that only begin in later life.

To study the mechanisms that underlie atherosclerosis, scientists often use animal modes, such as mice. The mice will typically be fed a high fat diet for several weeks as adults to see how this leads to the build up of the plaques characteristic of the condition.

Professor Ziad Mallat and colleagues at the Victor Phillip Dahdaleh Heart and Lung Research Institute at the University of Cambridge decided to explore a different approach – to see whether giving mice the same amount of high fat food but spread over their lifetime changed their atherosclerosis risk.

“When I asked my group and a number of people who are experts in atherosclerosis, no one could tell me what the result would be,” said Professor Mallat, a British Heart Foundation (BHF) Professor of Cardiovascular Medicine.

“Some people thought it would make no difference, others thought it would change the risk. In fact, what we found was that an intermittent high fat diet starting while the mice were still young – one week on, a few weeks off, another week on, and so on – was the worst option in terms of atherosclerosis risk.”

Armed with this information, his team turned to the Cardiovascular Risk in Young Finns Study, one of the largest follow-up studies into cardiovascular risk from childhood to adulthood. Participants recruited in the 1980s returned for follow-up over the subsequent decades, and more than 2,000 of them had received ultrasound scans of their carotid arteries when they were aged around 30 years and again at around 50 years.

Analysing the data, the team found that those participants who had been exposed to high cholesterol levels as children tended to have the biggest build of plaques, confirming the findings in mice.

“What this means is that we shouldn’t leave it until later in life before we start to look at our cholesterol levels,” Professor Mallat said. “Atherosclerosis can potentially be prevented by lowering cholesterol levels, but we clearly need to start thinking about this much earlier on in life than we previously thought.”

The mouse studies showed that fluctuating levels of cholesterol appeared to cause the most damage. Professor Mallat says this could explain why some people who are on statins but do not take them regularly remain at an increased risk of heart attack.

“If you stop and start your statin treatment, your body is being exposed to a yo-yo of cholesterol, which it doesn’t like, and it seems this interferes with your body’s ability to prevent the build-up of plaques,” he added.

The reason why this is so damaging may come down to the effect that cholesterol has on specific types of immune cells known as ‘resident arterial macrophages’. These reside in your arteries, helping them to clear damaged cells and fatty molecules known as lipids, which include cholesterol, and stopping the build-up of plaques.

When the team examined these macrophages in their mouse models, they found that high cholesterol levels – and in particular, fluctuating cholesterol levels – changed them physically and altered the activity of their genes. This meant that the cells were no longer protective, but were instead detrimental, accelerating atherosclerosis.

The research was funded by the British Heart Foundation.

Reference
Takaoka, M et al. Early intermittent hyperlipidaemia alters tissue macrophages to boost atherosclerosis. Nature; 4 Sept 2024; DOI: 10.1038/s41586-024-07993-x

Our risk of developing atherosclerosis – ‘furring’ of the arteries – can begin much earlier in life than was previously thought, highlighting the need to keep cholesterol levels low even when we are young, new research has discovered.

Atherosclerosis can potentially be prevented by lowering cholesterol levels, but we clearly need to start thinking about this much earlier on in life

Ziad Mallat

Teenagers eating pizza by the river

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Yes

These are among the conclusions of Time to Care: findings from a nationally representative survey of experiences at the end of life in England and Wales, a new report funded by end-of-life charity Marie Curie and produced by King’s College London’s Cicely Saunders Institute, Hull York Medical School at University of Hull, and the University of Cambridge.

Time to Care aims to describe the outcomes, experiences, and use of care services by people affected by dying, death, and bereavement in England and Wales. It is the final report from the Marie Curie Better End of life programme.

The report found one in five dying people had no contact with their GP in the last three months of life.

Half of people surveyed (49%) said their dying loved one visited A&E at least once in their final three months of life, and one in eight people who died in hospital had been there less than 24 hours. 

Half of respondents (49%) in the study were also unhappy with at least one aspect of the care the person who died received and of those one in eight people made a formal complaint. Fewer than half of respondents said they had a key contact person to co-ordinate their care. This meant responsibility for care fell on informal carers (family and friends), who often felt unprepared and unsupported.

Professor Stephen Barclay, from the Department of Public Health & Primary Care at the University of Cambridge, a researcher on the project and a practicing GP, said: “GPs, Community Nurses and the wider Primary Care Team have a central and often under-recognised role in the care of people approaching and at the end of their lives. But they are under enormous pressure with increasing workloads, diminishing workforces and inadequate investment over recent years.

“Increasing numbers of people have been dying in the community during and following the COVID-19 pandemic, at home or in care homes. This important survey, undertaken at a time when the NHS was beginning to recover from the worst of the pandemic, reveals how clinical teams in all settings are struggling to meet the needs of this vulnerable patient group.

“The out-of-hours period, which comprises two-thirds of the week, is particularly difficult for patients and their families. Across the UK, GPs and Community Nurses want to provide excellent palliative and end of life care, but the necessary ‘time to care’ is currently often squeezed. The new UK Government’s focus on care close to home is welcome. This report highlights the need for a radical repurposing of NHS funding to resource primary care for that ambition to be achieved.”

The research report is based on a survey sent by the Office for National Statistics in 2023 to a nationally representative sample of people who had registered the death of a family member in the prior six to 10 months. Only non-sudden causes of death were included. Responses were received from 1179 people, making this the largest nationally representative post-bereavement survey in England and Wales for a decade.

Professor Katherine Sleeman, from King’s College London and lead researcher on the project, said:  “This study reveals patchy and inconsistent provision of care for people approaching the end of life. While there were examples of excellent care - including in the community, in care homes, and in hospitals - the overall picture is of services that are overstretched, and of health and care staff lacking the time they need to consistently provide high-quality care. This means that dying people miss out on treatment and care for their symptoms, and families are left feeling unprepared and unsupported which has lasting emotional repercussions into bereavement.

The researchers say the findings are concerning, considering the ageing population and the expected increase in palliative care needs across the UK. By 2048, there will be an additional 147,000 people in the UK who need palliative care before they die, an increase of 25%.

“Without a corresponding increase in capacity of primary and community care teams to support these people as they approach the end of life, the quality of care is likely to further suffer,” said Professor Sleeman. “It has never been more important to ensure high-quality palliative care for all who need it.”

Annette Weatherley, Marie Curie Chief Nursing Officer, added: “The findings are shocking.  Too many people are dying in avoidable pain, struggling with breathlessness and other debilitating symptoms because of the difficulties they face accessing the end-of-life care they need from overstretched GPs and other health and care workers.

“Without urgent action, gaps in access to palliative and end of life care will only grow.

“It is a critical time to improve palliative and end of life care. People at the end of life should be able to have the very best possible care. There is only one chance to get it right at the end of life.  Yet, as the evidence shows, too many people are being failed by a system faced with extreme financial and workforce pressures.  It’s time for Governments to step up and fix care of the dying.”

Professor Stephen Barclay is a fellow at Emmmanuel College, Cambridge.

Adapted from a press release by Marie Curie

One in three dying people in England and Wales was severely or overwhelmingly affected by pain in the last week of life, with bereaved people reporting how difficult it was to get joined-up support from health and care professionals at home.

This report highlights the need for a radical repurposing of NHS funding to resource primary care for that ambition to be achieved

Stephen Barclay

Experimental coloured image of two hands touching

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Yes

A cancer drug that unlocks the anti-inflammatory power of the immune system could help to reduce the risk of future heart attacks, according to research part-funded by the British Heart Foundation. By repurposing an existing drug, researchers hope it could soon become part of routine treatment for patients after a heart attack.

The findings will be presented at the European Society of Cardiology Congress in London by Dr Rouchelle Sriranjan, NIHR Clinical Lecturer in Cardiology at the University of Cambridge.

High levels of inflammation in blood vessels are linked to an increased risk of heart disease and heart attacks. After a heart attack, the body’s immune response can aggravate existing inflammation, causing more harm and increasing risk even further. However, NICE guidelines don’t currently recommend the use of any anti-inflammatory drugs to reduce future risk.

Now, a team of researchers, led by Dr Joseph Cheriyan from Cambridge University Hospitals NHS Foundation Trust, have found that low doses of an anti-inflammatory drug called aldesleukin, injected under the skin of patients after a heart attack, significantly reduces inflammation in arteries.

The researchers are currently following up patients to investigate the longer-term impact of this fall in inflammation. To date, in the two and a half years after their treatment, there have been no major adverse cardiac events in the group that received aldesleukin, compared to seven in the group that received the placebo.

Professor Ziad Mallat, BHF Professor of Cardiovascular Medicine at the University of Cambridge who developed the trial, said: “We associate inflammation with healing – an inbuilt response that protects us from infection and injury. But it’s now clear that inflammation is a culprit in many cardiovascular conditions.

“Early signs from our ongoing trial suggest that people treated with aldesleukin may have better long-term outcomes, including fewer heart attacks. If these findings are repeated in a larger trial, we’re hopeful that aldesleukin could become part of routine care after a heart attack within five to 10 years.”

Aldesleukin is already used to treat kidney cancer, as high doses stimulate the immune system to attack cancer cells. The Cambridge team previously found that doses one thousand times lower than those used in cancer treatment increased the number of regulatory T cells – a type of anti-inflammatory white blood cell – in patients’ blood compared to a placebo.

In the current trial at Addenbrooke's and Royal Papworth hospitals in Cambridge, 60 patients admitted to hospital with a heart attack or unstable angina received either low dose aldesleukin or placebo. Patients received an injection once a day for the first five days, then once per week over the next seven weeks. Neither the participants nor their doctors knew whether they had received the drug or placebo.

At the end of treatment, Positron Emission Tomography (PET) scans showed that inflammation in the artery involved in patients’ heart attack or angina was significantly lower in the group treated with aldesleukin, compared to those who received the placebo.

The anti-inflammatory effect of aldesleukin appeared even more striking in the most inflamed arteries, leading to a larger reduction in inflammation levels in these vessels and a bigger difference between the two groups by the end of the study.

Dr Sonya Babu-Narayan, Associate Medical Director at the British Heart Foundation and consultant cardiologist said: “Thanks to research, we have an array of effective treatments to help people avoid heart attacks and strokes and save lives. But, even after successful heart attack treatment, unwanted inflammation in the coronary arteries can remain, which can lead to life-threatening complications.

“A treatment to reduce inflammation after a heart attack could be a game-changer. It would help doctors to interrupt the dangerous feedback loop that exacerbates inflammation and drives up risk. This research is an important step towards that treatment becoming a reality.”

The study was predominantly funded by the Medical Research Council, with significant support from the BHF and National Institute for Health and Care Research Cambridge Biomedical Research Centre (NIHR-BRC).

Originally published by the British Heart Foundation. 

Repurposed cancer drug helps to calm inflammation in arteries.

Illustration of human heart

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Yes

The sight of vineyards in Britain is becoming more common as hotter summers create increasingly suitable conditions for growing grapes. But behind this success story is a sobering one: climate change is shifting the regions of the world suitable for growing crops.

Researchers at the University of Cambridge have uncovered a looming issue: as the land suitable for producing our food moves northwards, it will put a squeeze on the land we need to grow trees. The timber these trees produce is the basis of much of modern life – from paper and cardboard to furniture and buildings.

They say that the increasing competition between land for timber production and food production due to climate change has, until now, been overlooked – but is set to be an emerging issue as our demand for both continues to increase.

Under the worst-case scenario for climate change, where no action is taken to decarbonise society, the study found that over a quarter of existing forestry land – around 320 million hectares, equivalent to the size of India – will become more suitable for agriculture by the end of the century.

Most forests for timber production are currently located in the northern hemisphere in the US, Canada, China and Russia. The study found that 90% of all current forestry land that will become agriculturally productive by 2100 will be in these 4 countries.

In particular, tens of millions of hectares of timber-producing land across Russia will become newly suitable for agriculture – more than in the US, Canada and China put together – with conditions becoming favourable for potato, soy, and wheat farming.

“There’s only a finite area of suitable land on the planet where we can produce food and wood - 2 critical resources for society. As climate change worsens and agriculture is forced to expand northwards, there’s going to be increasing pressure on timber production,” said Dr Oscar Morton, a researcher in the University of Cambridge’s Department of Plant Sciences who co-led the study.

“We’ve got to be thinking 50 years ahead because if we want timber in the future, we need to be planting it now. The trees that will be logged by the end of this century are already in the ground – they’re on much slower cycles than food crops,” said Dr Chris Bousfield, a postdoctoral researcher in the University of Cambridge’s Department of Plant Sciences and co-leader of the study.

Global food demand is projected to double by 2050 as the population grows and becomes more affluent. Global wood demand is also expected to double in the same timeframe, in large part because it is a low-carbon alternative to concrete and steel for construction.

Shifting timber production deeper into boreal or tropical forests are not viable options, because the trees in those regions have stood untouched for thousands of years and logging them would release huge amounts of carbon and threaten biodiversity.

“A major environmental risk of increasing competition for land between farming and forestry is that wood production moves into remaining areas of primary forest within the tropics or boreal zones. These are the epicentres of remaining global wilderness and untouched tropical forests are the most biodiverse places on Earth. Preventing further expansion is critical,” said David Edwards, Professor of Plant Ecology in the University of Cambridge’s Department of Plant Sciences and senior author of the study.

To get their results, the researchers took satellite data showing intensive forestry across the world and overlaid it with predictions of suitable agricultural land for the world’s key crops -including rice, wheat, maize, soy and potato - in the future under various climate change scenarios.

Even in the best-case scenario, where the world meets net-zero targets, the researchers say there will still be significant future changes in the regions suitable for timber and crop production.

The study is published in the journal Nature Climate Change.

Timber production contributes over US $1.5 trillion (about £1.1 trillion) per year to national economies globally. Heatwaves and associated wildfires have caused huge recent losses of timber forests around the world. Climate change is also driving the spread of pests like the Bark Beetle, which attacks trees.

Climate change is expected to cause areas in the tropics to become too hot and inhospitable for growing food and make large areas of southern Europe much less suitable for food and wood production.

“Climate change is already causing challenges for timber production. Now on top of that, there will be this increased pressure from agriculture, creating a perfect storm of problems,” said Bousfield.

“Securing our future wood supply might not seem as pressing as securing the food we need to eat and survive. But wood is just as integrated within our daily lives and we need to develop strategies to ensure both food and wood security into the future,” said Morton.

Reference

Bousfield, C G, et al, ‘Climate change will exacerbate land conflict between agriculture and timber production.’ Nature Climate Change (2024). DOI: 10.1038/s41558-024-02113-z

Climate change will move and reduce the land suitable for growing food and timber, putting the production of these 2 vital resources into direct competition, a new study has found.

Timber/farming contrast in the USA

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Yes

An analysis of a short programme teaching empathy in schools has found it had a positive impact on students’ behaviour and increased their emotional literacy within 10 weeks.

The findings come from an evaluation of the 'Empathy Programme': a term-long course developed by the UK-based Empathy Studios. The research was conducted with support from academics at the Faculty of Education, University of Cambridge.

Empathy Studios develops school-based, video-led programmes which aim to increase empathy in students aged 5 to 18. Students are shown thought-provoking films, then engage in approximately 30 minutes of activities and discussions about the issues raised. An annual flagship festival of films, resources and events, 'Empathy Week', is made available for free and has to date reached 1.3 million students worldwide.

Survey and interview data from 900 students and teachers at 10 participating schools in 6 countries, including the UK, revealed measurable, positive changes in students’ conduct, emotional awareness and curiosity about different cultures and the wider world.

Teachers rated students’ empathy, behaviour and other characteristics on a scale of one to 10 before the programme began, and 5 and 10 weeks later. The average empathy score rose from 5.55 to 7, while average behaviour scores increased from 6.52 to 7.89.

In follow-up interviews, one primary school teacher reflected: “I’ve definitely been able to resolve more issues within the classroom and not have parents called in.” A student told the interviewers: “I think that everyone in the class has become kinder.”

Empathy Studios defines empathy as: “the skill to understand others and the ability to create space for someone to reveal their authentic self while reserving judgement.” The company was founded 4 years ago by Ed Kirwan, a former science teacher from North London.

“The programme’s success lies in teaching students to celebrate difference, which changes their wellbeing and behaviour,” he said. “There’s never an excuse for poor behaviour, but often a reason, which greater mutual understanding can potentially address.”

“I think the social unrest we have seen in Britain this summer shows how urgently we need more empathy across society. It won’t solve everything, but it is the foundation for solutions, and it starts with education. If the new government is serious about curriculum reforms that prepare young people for life and work, we must ensure that school equips them to understand, be curious about, and listen to each other, even in moments of disagreement.”

The evaluation was supported by Dr Helen Demetriou, a specialist in empathy education at the University of Cambridge, who helped to design the research, and to collect, quality assure and interpret the data.

“The findings show that a fairly simple, film-based programme can raise pupils’ empathy levels, enhancing their understanding of themselves, others, and global issues,” she said. “That supports a more complete learning experience, developing social and emotional skills that we know contribute to improved behaviour and more engaged learning.”

Although it is often considered innate, evidence suggests that empathy can be taught. A 2021 study co-authored by Demetriou successfully trialled teaching empathy during design and technology lessons. More recently, researchers at the University of Virginia found that empathy between parents and children is 'paid forward' by the children to friends and, later, when they become parents themselves.

Empathy has been linked to better leadership and inclusion in workplaces; while a 2023 World Economic Forum White Paper highlighted the importance of socio-emotional skills to the future of work and argued for more education that emphasises interpersonal skills, including empathy.

Empathy Studios offers schools assembly and lesson plans built around films about the real-life stories of diverse people in other parts of the world. Its 2024/5 programme, for example, profiles 5 individuals from Mexico, including a Paralympian, a dancer, and a women’s rights activist.

Their framework focuses on 3 core concepts: 'Empathy for Myself', which develops students’ emotional literacy; 'Empathy for Others', which covers mutual understanding and interpersonal relations, and 'Empathy in Action', during which the students develop their own social action projects.

The new research builds on a 2022 pilot study with the University of Cambridge, which suggested that the programme makes students more responsive to each others’ feelings and improves self-esteem. The new evaluation involved over 900 students and 30 teachers, and took place during 2023.

The teacher surveys indicated that behaviour had improved by up to 10% in some schools, especially those new to empathy lessons. The average improvement in behaviour recorded by UK teachers corresponded to the overall trend, rising from 6.3/10 pre-programme to 7.7/10 post-programme. Empathy and behaviour also appeared to be closely linked: all schools reporting an overall improvement in student empathy also saw improvements in behaviour after five weeks, which was sustained in 80% of cases after 10.

The evaluation recorded small improvements in students’ overall emotional literacy and their 'affective empathy'; or their ability to share the feelings of others. A change that emerged strongly from interviews with teachers was that the Empathy Programme appeared to increase students’ interest in other cultures. In one primary school, for example, the proportion of students responding positively to the statement “I want to find out more about the world” rose from 86% to 96% after 10 weeks. This echoes Organisation for Economic Co-operation and Development (OECD) evidence linking empathy to civic engagement.

Many students said they had learned valuable lessons from the programme. Their reflections included: “Everyone struggles… I’m not the only one who finds it hard”, and “Although we are all different, we all have so much in common”.

“Empathy is the number one human skill we need to develop for the future,” Kirwan said. “It should not just be an add-on; it should be considered foundational.”

Further information is available from: https://www.empathystudios.com/

A study involving 900 students in 6 countries found that a short programme of empathy lessons led to measurable, positive changes in their conduct, emotional awareness and curiosity about different cultures.

Empathy lessons at Kingsmead School, Enfield, UK

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Yes

Plans for Cambridge Children’s Hospital can move ahead following the news that the Outline Business Case for the project has been signed off by the Chief Secretary to the Treasury and the Secretary of State for Health and Social Care. The project has been given the green light to begin the detailed process of appointing a contractor, to build the ground-breaking new facility in 2026.

The ministerial backing means that the Project’s Outline Business Case, the second stage of the business case process, has now been fully approved by the Department of Health and Social Care, NHS England and HM Treasury. It was approved in principle in September 2023, subject to a capital affordability review by NHS England and the Department for Health and Social Care’s Joint Investment Committee. That review took place in April 2024 and resulted in a recommendation to Ministers to endorse the decision.

In a show of further confidence in its plans, the Outline Business Case was signed off by the Chief Secretary to the Treasury and the Secretary of State for Health and Social Care in August 2024. This approval recognises that the hospital will meet the needs of patients and staff across the East of England and that the project has the appropriate funding streams in place, to deliver the specialist children’s facility.

The hospital is being co-designed with the help of children, young people, families and healthcare professionals across the region to ensure the new hospital will meet the needs of patients, families and staff.

Dr Rob Heuschkel, Clinical Lead for Physical Health at Cambridge Children’s Hospital said:

“We are absolutely delighted that we can now move forward to enter contracts with a construction partner, so we can finally start to see work happening on site.

“A huge amount of work has gone into finalising the designs and getting us to this point, and I want to thank our healthcare staff, young people and their families from across the region who have been contributing valuable feedback and helping us shape our plans, right from the very start.

“The East of England is the only region in the UK without a specialist children’s hospital, and we look forward to changing that very soon.”

The approval comes as a programme of groundworks preparing for the build was completed in July, and new access roads have now been installed where the new five-storey, 35,000sqm hospital will be located, opposite the Rosie Maternity Hospital, on Robinson Way and Dame Mary Archer Way.

In the coming weeks, people will be able to see hoardings installed around the site of Cambridge Children’s Hospital, the first hospital truly designed to bring mental and physical health care together for children and young people.

Dr Isobel Heyman, Clinical Lead for Mental Health at Cambridge Children’s Hospital said:

“This really is fantastic news and an exciting moment in our journey to build a truly integrated children’s hospital for the East of England.

“The current model of mental health care is inadequate. Many children with physical ill-health also have significant mental health needs, and vice versa.

“Cambridge Children’s Hospital offers a solution. By delivering holistic care for children, young people, and their families, this not only reduces stigma, but the revolutionary model of care really does act as a blueprint for the NHS and the future of healthcare.”

The fundraising Campaign for Cambridge Children’s Hospital has now passed the halfway mark and the project remains on track to meet its £100m philanthropy target.

The hospital will also house a University of Cambridge research institute, focused on preventing childhood illness and early intervention across mental and physical healthcare.

Professor David Rowitch, Clinical Lead for Research at Cambridge Children’s Hospital said:

“By bringing clinicians and patients together with University of Cambridge investigators and industry partners, we aim to shift the medicine paradigm from traditional reactive approaches, to one based on early detection, precision intervention and disease prevention.

“Co-locating research efforts inside Cambridge Children’s Hospital will mean we can detect disease early or even prevent it altogether, personalise health care and prescribe treatments more appropriate for children and their individual health needs.

“We’ll also be able to foster collaborations to advance the power of advanced diagnostics, digital and telehealth technology to support healthcare professions from a distance, to deliver care closer to people’s homes, wherever they live in our region.”

The Cambridge Children’s Hospital project is a partnership between Cambridge University Hospitals NHS Foundation Trust (CUH), Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), and the University of Cambridge.

Work now continues on the final stage of the business case for Cambridge Children’s Hospital – the Full Business Case.

Major milestone for first specialist children’s hospital in the East of England.

Artist's impression of Cambridge Children's Hospital.

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Yes

Researchers have compared the development of the fetal brain in mice whose mothers had no bacteria in their gut, to those whose mothers were given Bifidobacterium breve orally during pregnancy, but had no other bacteria in their gut.

Nutrient transport to the brain increased in fetuses of mothers given Bifidobacterium breve, and beneficial changes were also seen in other cell processes relating to growth.

Bifidobacterium breve is a ‘good bacteria’ that occurs naturally in our gut, and is available as a supplement in probiotic drinks and tablets.

Obesity or chronic stress can alter the gut microbiome of pregnant women, often resulting in fetal growth abnormalities. The babies of up to 10% of first-time mothers have low birth weight or fetal growth restriction. If a baby hasn't grown properly in the womb, there is an increased risk of conditions like cerebral palsy in infants and anxiety, depression, autism, and schizophrenia in later life.

These results suggest that improving fetal development - specifically fetal brain metabolism - by taking Bifidobacterium breve supplements while pregnant may support the development of a healthy baby.

The results are published today in the journal Molecular Metabolism.

“Our study suggests that by providing ‘good bacteria’ to the mother we could improve the growth and development of her baby while she’s pregnant,” said Dr Jorge Lopez-Tello, a researcher in the University of Cambridge’s Centre for Trophoblast Research, first author of the report.

He added: “This means future treatments for fetal growth restriction could potentially focus on altering the gut microbiome through probiotics, rather than offering pharmaceutical treatments - with the risk of side effects - to pregnant women.”

“The design of therapies for fetal growth restriction are focused on improving blood flow pathways in the mother, but our results suggest we’ve been thinking about this the wrong way - perhaps we should be more focused on improving maternal gut health,” said Professor Amanda Sferruzzi-Perri, a researcher in the University of Cambridge’s Centre for Trophoblast Research and senior author of the report, who is also a Fellow of St John’s College, Cambridge.

She added: “We know that good gut health - determined by the types of microbes in the gut - helps the body to absorb nutrients and protect against infections and diseases.”

The study was carried out in mice, which allowed the effects of Bifidobacterium breve to be assessed in a way that would not be possible in humans - the researchers could precisely control the genetics, other microorganisms and the environment of the mice. But they say the effects they measured are likely to be similar in humans.

They now plan further work to monitor the brain development of the offspring after birth, and to understand how Bifidobacterium breve interacts with the other gut bacteria present in natural situations.

Previous work by the same team found that treating pregnant mice with Bifidobacterium breve improves the structure and function of the placenta. This also enables a better supply of glucose and other nutrients to the developing fetus and improves fetal growth.

“Although further research is needed to understand how these effects translate to humans, this exciting discovery may pave the way for future clinical studies that explore the critical role of the maternal microbiome in supporting healthy brain development before birth,” said Professor Lindsay Hall at the University of Birmingham, who was also involved in the research.

While it is well known that the health of a pregnant mother is important for a healthy baby, the effect of her gut bacteria on the baby’s development has received little attention.

Reference 

Lopez-Tello, J, et al: ‘Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice.’ Molecular Metabolism, August 2024. DOI: 10.1016/j.molmet.2024.102004

A study in mice has found that the bacteria Bifidobacterium breve in the mother’s gut during pregnancy supports healthy brain development in the fetus.

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Yes

The findings are published today in The Lancet Diabetes and Endocrinology.

Global meat production has increased rapidly in recent decades and meat consumption exceeds dietary guidelines in many countries.  Earlier research indicated that higher intakes of processed meat and unprocessed red meat are associated with an elevated risk of type 2 diabetes, but the results have been variable and not conclusive.

Poultry such as chicken, turkey, or duck is often considered to be an alternative to processed meat or unprocessed red meat, but fewer studies have examined the association between poultry consumption and type 2 diabetes.

To determine the association between consumption of processed meat, unprocessed red meat and poultry and type 2 diabetes, a team led by researchers at the University of Cambridge used the global InterConnect project to analyse data from 31 study cohorts in 20 countries. Their extensive analysis took into account factors such as age, gender, health-related behaviours, energy intake and body mass index.

The researchers found that the habitual consumption of 50 grams of processed meat a day - equivalent to 2 slices of ham - is associated with a 15% higher risk of developing type 2 diabetes in the next 10 years. The consumption of 100 grams of unprocessed red meat a day - equivalent to a small steak - was associated with a 10% higher risk of type 2 diabetes.

Habitual consumption of 100 grams of poultry a day was associated with an 8% higher risk, but when further analyses were conducted to test the findings under different scenarios the association for poultry consumption became weaker, whereas the associations with type 2 diabetes for each of processed meat and unprocessed meat persisted.

Professor Nita Forouhi of the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, and a senior author on the paper, said: “Our research provides the most comprehensive evidence to date of an association between eating processed meat and unprocessed red meat and a higher future risk of type 2 diabetes. It supports recommendations to limit the consumption of processed meat and unprocessed red meat to reduce type 2 diabetes cases in the population.

“While our findings provide more comprehensive evidence on the association between poultry consumption and type 2 diabetes than was previously available, the link remains uncertain and needs to be investigated further.”

InterConnect uses an approach that allows researchers to analyse individual participant data from diverse studies, rather than being limited to published results. This enabled the authors to include as many as 31 studies in this analysis, 18 of which had not previously published findings on the link between meat consumption and type 2 diabetes. By including this previously unpublished study data the authors considerably expanded the evidence base and reduced the potential for bias from the exclusion of existing research.

Lead author Dr Chunxiao Li, also of the MRC Epidemiology Unit, said: “Previous meta-analysis involved pooling together of already published results from studies on the link between meat consumption and type 2 diabetes, but our analysis examined data from individual participants in each study. This meant that we could harmonise the key data collected across studies, such as the meat intake information and the development of type 2 diabetes.

“Using harmonised data also meant we could more easily account for different factors, such as lifestyle or health behaviours, that may affect the association between meat consumption and diabetes.”

Professor Nick Wareham, Director of the MRC Epidemiology Unit, and a senior author on the paper said: “InterConnect enables us to study the risk factors for obesity and type 2 diabetes across populations in many different countries and continents around the world, helping to include populations that are under-represented in traditional meta-analyses.

“Most research studies on meat and type 2 diabetes have been conducted in USA and Europe, with some in East Asia. This research included additional studies from the Middle East, Latin America and South Asia, and highlighted the need for investment in research in these regions and in Africa.”

InterConnect was initially funded by the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 602068.

Reference
Li, C et al. Meat consumption and incident type 2 diabetes: a federated meta-analysis of 1·97 million adults with 100,000 incident cases from 31 cohorts in 20 countries. Lancet Diabetes Endocrinol.; 20 August 2024

Adapted form a press release from the MRC Epidemiology Unit

Meat consumption, particularly consumption of processed meat and unprocessed red meat, is associated with a higher type 2 diabetes risk, an analysis of data from almost two million participants has found.

Our research supports recommendations to limit the consumption of processed meat and unprocessed red meat to reduce type 2 diabetes cases in the population

Nita Forouhi

Preparing a Monte Cristo Sandwich, with Black Forest Ham

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Yes

The McDonald Institute for Archaeological Research, Department of Archaeology and University of Cambridge Development and Alumni Relations are pleased to announce that the Arcadia charitable foundation has awarded grants totalling £10.3 million to continue the work of the Mapping Africa’s Endangered Archaeological Sites and Monuments (MAEASaM) project and the Mapping Archaeological Heritage in South Asia (MAHSA) project.

Archaeological sites and monuments around the world are increasingly threatened by human activities and the impacts of climate change. These pressures are especially severe in South Asia and sub-Saharan Africa, where local heritage agencies are often short-staffed and under-resourced; where existing sites and monuments registers are often incompletely digitised; and where many sites are not yet documented and large areas remain archaeologically under-studied. Alongside the intensity of natural and human threats, these factors combine to make the implementation of planning controls, impact assessments, mitigation measures and long-term monitoring especially challenging.

The five-year funding of £5.7 million to the MAEASaM project supports the continuation of its mission to identify and document endangered archaeological heritage sites across Africa, building on the work accomplished thus far with our in-country partners in Zimbabwe, Tanzania, Sudan, Senegal, Mali, Kenya, Ethiopia and Botswana. The funding will also allow the project to expand its collaborations with other national heritage agencies in Africa, including Mozambique, Gambia and the Democratic Republic of Congo, and to develop innovative approaches to better integrate heritage concerns into national planning and development control activities

During Phase 1 of the project, the MAEASaM team managed to assess a total area of 1,024,656 square kilometres using a combination of historical maps, Google Earth and medium-resolution satellite imagery, resulting in digital documentation of some 67,748 sites and monuments. Concurrent with this work, the team created digital records of 31,461 legacy sites, from unique information sets spanning almost a century of archaeological fieldwork on the continent. The accuracy of a sample of these records were also assessed via 11 field verification campaigns, helping establish the current status of these sites and levels of endangerment from anthropogenic and natural processes, while also locating many previously undocumented sites. Training, skills enhancement and knowledge transfer activities were also delivered via both in-person and online events, often in collaboration with MAHSA, and team members presented their work at 15 international meetings and via numerous social media and website posts.

Professor Paul Lane, Principal Investigator of the MAEASaM project, said: “I am truly delighted by the news of this award and would like to take this opportunity to thank Arcadia for their continuing support. As well as allowing expansion of the project to cover other countries in sub-Saharan Africa, this further 5 years of funding will enable the creation of a repository of digital assets and a sustainable system for more rapidly and easily assessing, researching, monitoring and managing archaeological heritage, accessible to heritage professionals, researchers and students across the continent.”

Similarly, the five-year grant of £4.6 million to the MAHSA project supports its continuing mission to document endangered archaeological heritage in Pakistan and India, working alongside collaborators in both countries to support their efforts to protect and manage the rich heritage of the region. Over the next 5 years, MAHSA will continue to develop and populate its Arches database, creating a resource to make heritage data findable, accessible, interoperable and reusable. MAHSA will consolidate the work it has begun in the Indus River Basin and surrounding areas, and will also expand its documentation efforts to include the coastline areas of both India and Pakistan, Baluchistan in Pakistan and the Ganges River Basin in north India.

During Phase 1, the MAHSA team georeferenced in excess of 1,300 historic Survey of India map sheets, covering over 890,000 square kilometres, and have reconstructed over 192,696 square kilometres of ancient hydrological networks. This groundwork has made it possible to digitise over 10000 legacy data records, and many of those records have been enriched. In addition, they carried out 5 collaborative archaeological surveys both as part of their training programme, and as part of new collaborative research with stakeholders in both India and Pakistan. They have engaged in policy-level dialogue with different government organisations in Pakistan and India, with an aim of working towards the development of a sustainable solution for the inclusion of heritage in urban and agricultural development strategies.  

Professor Cameron Petrie, Principal Investigator of the MAHSA project, said: “I am extremely proud of what the collaborative MAHSA team have achieved during Phase 1, and the support from Arcadia for Phase 2 will allow us to continue making a transformational contribution to the documentation and understanding of the archaeological heritage of Pakistan and India. We are clarifying existing archaeological site locations datasets and collecting new ones at a scale never before attempted in South Asia.”

About Arcadia

Arcadia is a charitable foundation that works to protect nature, preserve cultural heritage and promote open access to knowledge. Since 2002 Arcadia has awarded more than $1.2 billion (£900 million) to organisations around the world.

About Mapping Africa’s Endangered Archaeological Sites and Monuments (MAEASaM)

About Mapping Archaeological Heritage in South Asia (MAHSA)

The charitable foundation awards £10.3 million for the continuation of 2 Cambridge projects mapping endangered archaeological heritage in South Asia and sub-Saharan Africa.

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Yes

Researchers have identified a drug already used for cancer patients, that, when applied to current gene therapy protocols can improve blood stem cell function threefold.

One trillion blood cells are produced every day in humans, and blood stem cells are the only cell types in our body capable of producing all blood cell types over our lifespan, giving them immense regenerative potential.

Blood stem cell gene therapy is a ground-breaking treatment that currently provides the only cure to more than ten life-debilitating genetic diseases and has already saved the lives of more than two million people with blood cancers and other diseases.

These therapies take blood stem cell samples from patients, where their genetic defect is corrected in a dish before being delivered back to the patient. However, limitations persist in blood stem cell therapies because of the shelf life of the cells outside the body. When removed from their environment in the human body and cultured in a dish, most blood stem cells lose their function. The exact timing and cause of this function loss has not previously been well understood.

Now, scientists in the Laurenti Group and others at the University of Cambridge’s Cambridge Stem Cell Institute (CSCI) and Department of Haematology have pinpointed a timeline for the blood stem cells under the current gene therapy protocols, which typically take place over three days. After the first 24 hours in a dish, more than 50% of the blood stem cells can no longer sustain life-long blood production, which is before therapy would even begin in a clinical setting.

During those first 24 hours, the cells activate a complex molecular stress response in order to adapt to the dish. By studying this stress response, the team identified a solution. Through repurposing a cancer growth blocker drug (Ruxolitinib), already in use for cancer treatments, they were able to improve stem cell function in a dish by three times its former capabilities.

The group is now aiming to modify current gene therapy protocols to include this drug, providing patients with the highest number of high-quality blood stem cells and improving their outcomes.

The study is published today in the journal Blood.

Professor Elisa Laurenti at the University of Cambridge Stem Cell Institute, and senior author of the study, said: “This is really exciting because we are now in a position where we can begin to understand the huge stress that these stem cells sense when they are manipulated outside of our body. Biologically it is really fascinating because it affects every aspect of their biology. Luckily, we were able to identify a key molecular pathway which governs many of these responses, and that can be targeted by a drug which is already in use and is safe to use.

“I hope our findings will enable safer treatments for gene therapy patients. Our discovery also opens up many possibilities to better expand blood stem cells ex vivo and expand the set of disease where we can use blood stem cells to improve patients’ lives.”

Dr Carys Johnson at the University of Cambridge Stem Cell Institute, and first author of the study, said: “Although we expected that removing these cells from the body and culturing them on a plastic surface would alter gene expression, the extent of change we found was surprising, with over 10,000 genes altered and a significant stress response detected. It was also striking to discover that the majority of blood stem cells are functionally lost during gene therapy protocols, before transplantation back to the patient.

“We have identified a key bottleneck where function is lost and clinical culture could be improved. I hope that our work will drive advancements in culture protocols to better harness the power of blood stem cells and improve the safety and efficacy of clinical approaches.”

Reference

C.S. Johnson, M.J. Williams, K. Sham, et al. ‘Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of cell cycle.’ Blood 2024; DOI: 10.1182/blood.2023021426

Story written by Laura Puhl, Cambridge Stem Cell Institute.

Researchers have discovered a way to extend the shelf life of blood stem cells outside the body for use in gene therapy, providing patients with better options and improving their outcomes.

We were able to identify a key molecular pathway...that can be targeted by a drug which is already in use and is safe to use.

Elisa Laurenti

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Yes

Severe brain injury can leave individuals unable to respond to commands physically, but in some cases they are still able to activate areas of the brain that would ordinarily play a role in movement. This phenomenon is known as ‘cognitive motor dissociation’.

To determine what proportion of patients in so-called ‘disorders of consciousness’ experience this phenomenon – and help inform clinical practice – researchers across Europe and North America recruited a total of 353 adults with disorders of consciousness, including the largest cohort of 100 patients studied at Cambridge University Hospitals NHS Foundation Trust.

Participants had mostly sustained brain injury from severe trauma, strokes or interrupted oxygen supply to the brain after heart attacks. Most were living in specialised long-term care facilities and a few were living at home with extensive care packages. The median time from injury for the whole group was about eight months.

Researchers assessed patterns of brain activation among these patients using functional magnetic resonance imaging (fMRI) or electroencephalography (EEG). Subjects were asked to repeatedly imagine performing a motor activity (for example, “keep wiggling your toes”, “swinging your arm as if playing tennis”, “walking around your house from room to room”) for periods of 15 to 30 seconds separated by equal periods of rest. To be able to follow such instructions requires not only the understanding of and response to a simple spoken command, but also more complex thought processes including paying attention and remembering the command.

The results of the study are published today in the New England Journal of Medicine.

Dr Emmanuel Stamatakis from the Department of Clinical Neurosciences at the University of Cambridge said: “When a patient has sustained a severe brain injury, there are very important, and often difficult, decisions to be made by doctors and family members about their care. It’s vitally important that we are able to understand the extent to which their cognitive processes are still functioning by utilising all available technology.” 

Among the 241 patients with a prolonged disorder of consciousness, who could not make any visible responses to bedside commands, one in four (25%) was able to perform cognitive tasks, producing the same patterns of brain activity recorded with EEG and/or fMRI that are seen in healthy subjects in response to the same instructions.

In the 112 patients who did demonstrate some motor responses to spoken commands at the bedside, 38% performed these complex cognitive tasks during fMRI or EEG. However, the majority of these patients (62%) did not demonstrate such brain activation. This counter-intuitive finding emphasises that the fMRI and EEG tasks require patients to have complex cognitive abilities such as short-term memory and sustained concentration, which are not required to the same extent for following bedside commands.

These findings are clinically very important for the assessment and management of the estimated 1,000 to 8,000 individuals in the UK in the vegetative state and 20,000 to 50,000 in a minimally conscious state. The detection of cognitive motor dissociation has been associated with more rapid recovery and better outcomes one year post injury, although the majority of such patients will remain significantly disabled, albeit with some making remarkable recoveries.

Dr Judith Allanson, Consultant in Neurorehabilitation, said: “A quarter of the patients who have been diagnosed as in a vegetative or minimally conscious state after detailed behavioural assessments by experienced clinicians, have been found to be able to imagine carrying out complex activities when specifically asked to. This sobering fact suggests that some seemingly unconscious patients may be aware and possibly capable of significant participation in rehabilitation and communication with the support of appropriate technology.

“Just knowing that a patient has this ability to respond cognitively is a game changer in terms of the degree of engagement of caregivers and family members, referrals for specialist rehabilitation and best interest discussions about the continuation of life sustaining treatments.”

The researchers caution that care must be taken to ensure the findings are not misrepresented, pointing out, for example, that a negative fMRI/EEG result does not per se exclude cognitive motor dissociation as even some healthy volunteers do not show these responses.

Professor John Pickard, emeritus professorial Fellow of St Catharine's College, Cambridge, said: “Only positive results – in other words, where patients are able to perform complex cognitive processes – should be used to inform management of patients, which will require meticulous follow up involving specialist rehabilitation services.”

The team is calling for a network of research platforms to be established in the UK to enable multicentre studies to examine mechanisms of recovery, develop easier methods of assessment than task-based fMRI/EEG, and to design novel interventions to enhance recovery including drugs, brain stimulation and brain-computer interfaces.

The research reported here was primarily funded by the James S. McDonnell Foundation. The work in Cambridge was supported by the National Institute for Health and Care Research UK, MRC, Smith’s Charity, Evelyn Trust, CLAHRC ARC fellowship and the Stephen Erskine Fellowship (Queens’ College). 

Reference
Bodien, YG et al. Cognitive Motor Dissociation in Disorders of Consciousness. NEJM; 14 Aug 2024; DOI: 10.1056/NEJMoa2400645

Adapted from a press release from Weill Cornell Medicine

Around one in four patients with severe brain injury who cannot move or speak – because they are in a prolonged coma, vegetative or minimally conscious state – is still able to perform complex mental tasks, a major international study has concluded in confirmation of much smaller previous studies.

When a patient has sustained a severe brain injury, there are very important, and often difficult, decisions to be made by doctors and family members about their care

Emmanuel Stamatakis

Male patient in a hospital bed - stock image

Acknowledgements

The multidisciplinary Cambridge Impaired Consciousness Research Group, led by Emeritus Professors John Pickard (Neurosurgery) & David Menon (Anaesthesia) and Drs Judith Allanson & Emmanuel A. Stamatakis (Lead, Cognition and Consciousness Imaging Group), started its research programme in 1997, partly in response to emerging concern over the misdiagnosis of the vegetative state. This pioneering work has only been possible by having access to the world class resources of the Wolfson Brain Imaging Centre, the NIHR/Wellcome Clinical Research Facility at Addenbrooke’s Hospital, the MRC Cognition and Brain Sciences Unit (Professors Barbara Wilson & Adrian Owen), the Royal Hospital for Neuro-disability (Putney) and the Central England Rehabilitation Unit (Royal Leamington Spa).

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Yes

Researchers from the University of Cambridge and the British Antarctic Survey tracked fire activity over the past 150 years by measuring carbon monoxide trapped in Antarctic ice. This gas is released, along with smoke and particulates, by wildfires, cooking and communal fires.

The findings, reported in the Proceedings of the National Academy of Sciences, reveal that biomass burning has been more variable since the 1800s than had been thought. The new data could help improve climate models, which rely on information about past atmospheric gases, such as carbon monoxide, to improve their forecasts.

“We’ve been missing key information from the period when humans started to dramatically alter Earth’s climate; information needed to test and develop climate models,” said Rachael Rhodes, senior author of the paper from Cambridge’s Department of Earth Sciences.  

The new carbon monoxide record fills that gap in time. The researchers charted the strength of biomass burning between 1821 and 1995 by measuring carbon monoxide in ice cores from Antarctica. The layers of ice inside these cores formed when snow was buried under subsequent years’ snowfall, encasing pockets of air that directly sample the atmosphere's composition at the time.

“It’s rare to find trace gases trapped in ice cores for the most recent decades,” said Ivo Strawson, lead author of the study who is jointly based at Cambridge Earth Sciences and the British Antarctic Survey. “We need information on the atmosphere's composition following the onset of industrialisation to reduce uncertainties in climate models, which rely on these records to test or drive their simulations.”

A major difficulty with taking gas measurements from very young ice is that pressurised air bubbles haven’t had time to form under the weight of more snow, said Strawson. To get around this problem, the researchers studied ice from locations where snow accumulates rapidly. These ice cores, held in BAS’ dedicated Ice Core Laboratory, were collected from the Antarctic Peninsula as part of previous international projects.

To measure carbon monoxide, the researchers developed a state-of-the-art analysis method, which melts ice continuously while simultaneously extracting the air. They collected tens of thousands of gas measurements for the past 150 years.

The researchers found that the strength of biomass burning has dropped steadily since the 1920s. That decline, said Rhodes, coincides with the expansion and intensification of agriculture in southern Africa, South America, and Australia during the early 20th century. With wildlands converted into farmland, forest cover was restricted and in turn fire activity dropped. “This trend reflects how land conversion and human expansion have negatively impacted landscapes and ecosystems, causing a major shift in the natural fire regime and in turn altering our planet’s carbon cycle,” said Rhodes.

One assumption made by many climate models, including those used by the IPCC, is that fire activity has increased in tandem with population growth. But, said Rhodes, “our work adds to a growing mass of evidence that this assumption is wrong, and the inventories of historic fire activity need to be corrected so that models can accurately replicate the variability we see in our record.”

Rachael Rhodes is a Fellow of Wolfson College, Cambridge. 

Reference:
Ivo Strawson et al. "Preindustrial Southern Hemisphere biomass burning variability inferred from ice core carbon monoxide records." Proceedings of the National Academy of Sciences(2024). DOI: https://doi.org/10.1073/pnas.2402868121

Pollutants preserved in Antarctic ice document historic fires in the Southern Hemisphere, offering a glimpse at how humans have impacted the landscape and providing data that could help scientists understand future climate change.

Rachael Rhodes

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Yes

Around one in 200 people in Europe every year will suffer concussion. In the UK, more than 1 million people attend Emergency Departments annually with a recent head injury. It is the most common form of brain injury worldwide.

When a patient in the UK presents at an Emergency Department with head injury, they are assessed according to the NICE head injury guidelines. Depending on their symptoms, they may be referred for a CT scan, which looks for brain injuries including bruising, bleeding and swelling.

However, CT scans identify abnormalities in fewer than one in 10 patients with concussion, yet 30-40% of patients discharged from the Emergency Department following a scan experience significant symptoms that can last for years and be potentially life-changing. These include severe fatigue, poor memory, headaches, and mental health issues (including anxiety, depression, and post-traumatic stress).

Dr Virginia Newcombe from the Department of Medicine at the University of Cambridge and an Intensive Care Medicine and Emergency Physician at Addenbrooke’s Hospital, Cambridge, said: “The majority of head injury patients are sent home with a piece of paper telling them the symptoms of post-concussion to look out for and are told to seek help from their GP if their symptoms worsen.

“The problem is that the nature of concussion means patients and their GPs often don’t recognise that their symptoms are serious enough to need follow-up. Patients describe it as a ‘hidden disease’, unlike, say, breaking a bone. Without objective evidence of a brain injury, such as a scan, these patients often feel that their symptoms are dismissed or ignored when they seek help.”

In a study published today in eClinicalMedicine, Dr Newcombe and colleagues show that an advanced form of MRI known as diffusion tensor imaging (DTI) can substantially improve existing prognostic models for patients with concussion who have been given a normal CT brain.

DTI measures how water molecules move in tissue, providing detailed images of the pathways, known as white matter tracts, that connect different parts of the brain. Standard MRI scanners can be adapted to measure this data, which can be used to calculate a DTI ‘score’ based on the number of different brain regions with abnormalities.

Dr Newcombe and colleagues studied data from more than 1,000 patients recruited to the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study between December 2014 and December 2017. 38% of the patients had an incomplete recovery, meaning that three months after discharge their symptoms were still persisting.

The team assigned DTI scores to the 153 patients who had received a DTI scan. This significantly improved the accuracy of the prognosis – whereas the current clinical model would correctly predict in 69 cases out of 100 that a patient would have a poorer outcome, DTI increased this to 82 cases out of 100.

Whole brain diffusion tensor tractography showing healthy patient (left) and patient at two days (centre) and six weeks (right) after severe traumatic brain injury (Credit: Virginia Newcombe)

The researchers also looked at blood biomarkers – proteins released into the blood as a result of head injury – to see whether any of these could improve the accuracy of the prognosis. Although the biomarkers alone were not sufficient, concentrations of two particular proteins – glial fibrillary acidic protein (GFAP) within the first 12 hours and neurofilament light (NFL) between 12 and 24 hours following injury – were useful in identifying those patients who might benefit from a DTI scan.

Dr Newcombe said: “Concussion is the number one neurological condition to affect adults, but health services don’t have the resources to routinely bring back every patient for a follow-up, which is why we need a way of identifying those patients at greatest risk of persistent symptoms.

“Current methods for assessing an individual’s outlook following head injury are not good enough, but using DTI – which, in theory, should be possible for any centre with an MRI scanner – can help us make much more accurate assessments. Given that symptoms of concussion can have a significant impact on an individual’s life, this is urgently needed.”

The team plan to look in greater details at blood biomarkers, to see if they can identify new ways to provide even simpler, more practical predictors. They will also be exploring ways to bring DTI into clinical practice.

Dr Sophie Richter, a NIHR Clinical Lecturer in Emergency Medicine and first author, Cambridge, added: “We want to see if there is a way to integrate the different types of information obtained when a patient presents at hospital with brain injury – symptoms assessment, blood tests and brain scans, for example – to improve our assessment of a patient’s injury and prognosis.”

The research was funded by European Union's Seventh Framework Programme, Wellcome and the National Institute for Health and Care Excellence.

Reference
Richter, S et al. Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study. eClinMed; 8 Aug 2024; DOI: 10.1016/j.eclinm.2024.102751

Offering patients with concussion a type of brain scan known as diffusion tensor imaging MRI could help identify the one in three people who will experience persistent symptoms that can be life changing, say Cambridge researchers.

Concussion is the number one neurological condition to affect adults, which is why we need a way of identifying those patients at greatest risk of persistent symptoms

Virginia Newcombe

Diffusion tensor imaging (DTI) MRI of the human brain - stock photo

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Yes

Writing in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, the team from Cambridge Public Health argue that substantial challenges including the risk-benefit ratio, limited eligibility and high cost of roll-out will limit any benefits of these treatments.

Alzheimer’s disease is often quoted as causing 70% of the 55 million cases of dementia worldwide, though the definition of what constitutes the disease is hotly debated. One characteristic of Alzheimer’s is the build-up of clusters of misfolded proteins, one of these being a form of amyloid, leading to plaques in the brain. The cascade hypothesis, a dominant theory in the field, suggests that this triggers a series of processes which together lead to dementia symptoms.

Advances in developing treatments to reduce symptoms and slow down the progression in the early stages of Alzheimer’s has been slow. However, there has been recent excitement surrounding amyloid immunotherapy agents, drugs that harness the immune system to remove amyloid pathology.

Two completed phase III randomised controlled trials of amyloid immunotherapy reported statistically significant reductions in the rate of cognitive and functional decline compared to the placebo.

But as the Cambridge team point out, the effect sizes were small – small enough that a doctor would struggle to tell the difference between the average decline of a patient on the drug and another on placebo, after 18 months. The drugs were also associated with significant adverse events, including brain swelling and bleeding; during the phase III trial of one agent, donanemab, there were also three deaths attributed to the treatment.

Crucially, there is little known about the long-term effects of the drugs beyond the 18 month trial periods. Long-term placebo-controlled trials, which would be needed to see if there is any clinically meaningful slowing of decline, are unlikely to be feasible where drugs are already approved.    

Despite this, the US Food and Drug Administration has licensed two such drugs. The European Medicines Agency (EMA) has recommended rejecting one (lecanemab) predominantly on the grounds that the small effects seen do not outweigh the risk from side effects; it is reviewing the other. The UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) is expected to take a decision on both drugs imminently.

Edo Richard, Professor of Neurology at Radboud University Medical Centre in Nijmegen, The Netherlands, and co-author, said: “If these drugs are approved by regulators in the UK and Europe, and become available, it is understandable that some people with early Alzheimer’s will still want to try these drugs, given their despair living with this dreadful disease. But there is a lot of hyperbole around the reporting of these drugs, and significant effort will be needed to provide balanced information to patients to enable informed decisions.”

Press coverage of the drugs has implied they are suitable for anyone with a diagnosis of Alzheimer’s. However, while the trials included those with ‘early symptomatic Alzheimer’s disease’, it excluded those with other conditions that may have been contributing to their symptoms.  Evidence suggests that the people in the trials represent less than 8% of those in the community with early Alzheimer’s disease. Those in the trials were up to 10 to 15 years younger than those typically presenting to health services with early symptoms.

Lead author Dr Sebastian Walsh, NIHR Doctoral Fellow in Public Health Medicine at Cambridge Public Health, University of Cambridge, added: “If approved, the drugs are likely to be relevant only for a relatively small cohort of Alzheimer’s patients, so potential recipients will need to undergo a range of assessments before being given access to the drugs. Plus, effect sizes seen in the trials are very small and the drugs will need be administered as early in the disease process as possible, when symptoms are mild – and people in these phases of disease can be hard to identify.”

The resource requirements for rolling out such treatments are likely to be considerable. Even if approved for only a small proportion of Alzheimer’s patients, a much broader group of people will need to be assessed for eligibility, requiring rapid specialist clinical assessment and tests. The authors question whether this is the best use of these resources, given the strain health systems are already under. Support would also be required for the large number of Alzheimer’s patients (potentially as many as 92%) found to be ineligible. Those found to have insufficient amyloid to be eligible may then require follow-up assessments to determine eligibility in the future, with the further implications for services this would entail.

Professor Carol Brayne, Co-director of Cambridge Public Health, said: “Even in high-income countries, rolling out such types of treatments at scale is highly challenging, but most dementia occurs in low- and middle-income countries. Health systems in these countries are highly unlikely to have the resources required to offer these new drugs, even to a very narrow group.

“Other compelling evidence suggests that attention to inequalities and health experience across people’s lives could have greater impact on the rates of dementia in populations. Most dementia is more complicated than a single protein.”

The team concludes that based on current evidence, it is far from clear whether amyloid immunotherapy can ever significantly reduce suffering caused by dementia at scale in the community, and we must continue to explore other approaches.

Professor Brayne added: “With an ageing population, we urgently need effective ways to support people living with dementia, but while the current amyloid immunotherapies may show a glint of promise for very selected groups, it’s clear these drugs will not address dementia risk at scale.”

Reference
Walsh, S et al. Considering challenges for the new Alzheimer’s drugs: clinical, population, and health system perspectives. Alz&Dem; 6 Aug 2024; DOI: 10.1002/alz.14108

Cambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impact of Alzheimer’s disease.

While the current amyloid immunotherapies may show a glint of promise for very selected groups, it’s clear these drugs will not address dementia risk at scale

Carol Brayne

Woman sitting in a wheelchair

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Yes

A group of conservationists from Bolivia, Brazil, Peru, Ecuador, the US and the UK say that current conservation and development efforts will never sustain or scale without systemic changes in how economies are designed.

Despite extensive destruction of the Amazon in the name of economic development, Amazonian communities have seen little improvement in income, life expectancy, and education. The researchers have proposed a new model and associated policy changes that could create fair and sustainable futures for the Amazon and its people by improving infrastructure, supply chains, and social organisations.

Their results, reported in the journal Nature Ecology and Evolution, are focused on the Amazon, however the researchers say similar economic models could be implemented around the world if the political will exists.

The Amazon basin is home to the world’s largest tropical rainforest, representing over half of the world’s remaining rainforest, and stores vast amounts of carbon. However, decades of large-scale deforestation, as well as the increased risk of fires and floods due to climate change, has put much of the Amazon rainforest under threat. In addition to what the loss of the Amazon would mean for global carbon emissions, the rainforest is also home to many indigenous peoples and thousands of species of plants and animals.

“We need a different vision for the Amazon if we’re going to protect it,” said lead author Professor Rachael Garrett from the University of Cambridge’s Department of Geography and the Conservation Research Institute. “Half a century of deforestation and exploitation of the Amazon has not resulted in widespread development, and now the economic value of deforested areas is threatened, not to mention the threats to the global climate and water security.”

Working with colleagues from the Amazonian region, Garrett has proposed building on the success of indigenous and traditional communities to develop new economies, which could protect much of the Amazon while also improving the livelihoods, health, and food security of the many people who live there. These economic models are known as socio-bioeconomies, or SBEs.

“Conventional economic models can result in short-term gains, but over the longer term, the people and resources of the Amazon basin have been exploited by powerful interests, while there has been an underinvestment in education, innovation, and sustainable infrastructure,” said Garrett. “The conventional economic model is simply not sustainable.”

The SBE model is focused on using and restoring Amazonian and other ecosystems sustainably, and supporting indigenous and rural communities. An SBE economy might include eco-friendly tourism, or the sustainable harvest and processing of plant products into valuable foods, beverages, clothing, and medicines.

“A limited range of interests are controlling the development agenda in most countries,” said Garrett. “The only way we can change that is improving the rights and representation of the people who are not benefiting from the systems and are being harmed by ongoing environmental destruction. We believe it is possible to have win-wins for humanity and conservation, but not if we continue to consume products that have a massively negative impact. SBEs can help put these win-wins into policy and practice.”

Garrett cites the footwear brand Veja as an example of such a win-win. The French company buys the rubber for its trainers from small-scale Amazonian rubber farmers, and purchases 100% of the responsibly harvested native rubber in Brazil. As part of its sustainability efforts, the company focuses on building communities of small-scale farmers and has been financially successful without traditional advertising.

Garrett and her collaborators are calling for massive increases in social mobilisation, technology and infrastructure to support SBEs. Under an SBE model, governmental subsidies would be redirected away from agribusiness and toward smaller-scale sustainable development. The researchers also outline how to build connections between rural and urban policies in SBEs. An example is the establishment of public procurement programmes where healthy and sustainably produced foods are purchased directly from indigenous and small farming communities and served in school lunch programmes and hospitals, instead of supporting large-scale agribusiness engaged in degrading practices.

Other policy changes that could support an SBE model include redirecting finance to conservation and restoration activities, supporting community enterprises, and ensuring participatory processes to ensure inclusive, long-term benefits.

“It’s possible to have an economy that is strong and works for everyone when we dare to develop new models and visions that recognise the interconnectedness of people and nature,” said Garrett. “By popularising these ideas, investing in people and businesses who are making a difference, and supporting research into SBE innovation we can support a transformation in both conservation and development in the Amazon.

“The SBE model could help protect the Amazon and its people while avoiding climate and biodiversity disasters, but there needs to be the political will to make it happen.”

Rachael Garrett is the incoming director of the University of Cambridge Conservation Research Institute and a Fellow of Homerton College, Cambridge. She is a council member of the Cambridge Conservation Initiative and serves on the UN Science Panel for the Amazon.

 

Reference:
Rachael Garrett et al. ‘Transformative changes are needed to support socio-bioeconomies for people and ecosystems in the Amazon.’ Nature Ecology and Evolution (2024). DOI: 10.1038/s41559-024-02467-9

To protect the Amazon and support the wellbeing of its people, its economy needs to shift from environmentally harmful production to a model built around the diversity of indigenous and rural communities, and standing forests.

Man extracts latex from a tree in the middle of the Amazon.

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Yes

The discovery suggests that the intense UV radiation from these flares could significantly impact whether planets around red dwarf stars can be habitable.

“Few stars have been thought to generate enough UV radiation through flares to impact planet habitability. Our findings show that many more stars may have this capability,” said first author Vera Berger, who led the research while based at the University of Hawai’i and who is now based at the University of Cambridge.  

Berger and her team used archival data from the GALEX space telescope to search for flares among 300,000 nearby stars. GALEX is a now-decommissioned NASA mission that simultaneously observed most of the sky at near-and far-UV wavelengths from 2003 to 2013. Using new computational techniques, the team mined insights from the data.

“Combining modern computer power with gigabytes of decades-old observations allowed us to search for flares on thousands and thousands of nearby stars,” said co-author Dr Michael Tucker from Ohio State University.

According to researchers, UV radiation from stellar flares can either erode planetary atmospheres, threatening their potential to support life, or contribute to the formation of RNA building blocks, which are essential for the creation of life.

The study, published in the Monthly Notices of the Royal Astronomical Society, challenges existing models of stellar flares and exoplanet habitability, showing that far-UV emission from flares is on average three times more energetic than typically assumed, and can reach up to twelve times the expected energy levels.

“A change of three is the same as the difference in UV in the summer from Anchorage, Alaska to Honolulu, where unprotected skin can get a sunburn in less than 10 minutes,” said co-author Benjamin J. Shappee from the University of Hawai’i.

The exact cause of this stronger far-UV emission remains unclear. The team believes it might be that flare radiation is concentrated at specific wavelengths, indicating the presence of atoms like carbon and nitrogen.

“This study has changed the picture of the environments around stars less massive than our Sun, which emit very little UV light outside of flares,” said co-author Jason Hinkle.

According to Berger, now a Churchill Scholar at Cambridge, more data from space telescopes is needed to study the UV light from stars, which is crucial for understanding the source of this emission.

“Our work puts a spotlight on the need for further exploration into the effects of stellar flares on exoplanetary environments,” said Berger. “Using space telescopes to obtain UV spectra of stars will be crucial for better understanding the origins of this emission.”

Reference:
Vera L Berger et al. ‘Stellar flares are far-ultraviolet luminous.’ Monthly Notices of the Royal Astronomical Society (2024). DOI: 10.1093/mnras/stae1648

Adapted from a University of Hawai’i media release.

Astronomers have discovered that red dwarf stars can produce stellar flares that carry far-ultraviolet (far-UV) radiation levels much higher than previously believed.

A red dwarf star unleashes a series of powerful flares.

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Yes

Analysing the past sheds light on the present resurgence of research on human development. That’s the lesson of a new study by Professor Nick Hopwood, from the Department of History and Philosophy of Science, that is published in the Journal of the History of Biology. The paper discusses the flourishing of human embryology a century ago, its drop in popularity after World War II, and especially its revival since the late twentieth century.

“Every journal article and news story about human development includes a bit of history, but it’s often narrow, rarely informative and not always accurate”, Hopwood says. “I wanted to stand back and see a bigger picture, then dig down to find out how and why there has been such a surge of attention. Working in Cambridge made that easier.”

The University has been at the forefront of innovation, from the first test-tube baby to the extended culture of early embryos, organoids and other stem-cell models. The networking through Cambridge Reproduction of expertise in science and medicine, humanities and social sciences helped Hopwood reconstruct the genesis of these advances. This took a combination of research in libraries and archives and interactions with scientists, including interviews, sharing of documents, attending conferences and giving talks, here and elsewhere.

“Human development has long been of special interest as evidence of our origins and for its medical relevance, but is hard to study”, Hopwood explains. “Historically there have been two main approaches. Either deciding that it’s too difficult to research human embryos because they’re usually hidden in pregnant bodies, so we should study other animals and hope results will transfer. That’s an indirect approach. Or trying for the best possible results from the few human specimens that can be obtained. That’s a direct approach. My article analyses the rise of research directly on human material as part of the changing politics of choosing a species to study. I explore how researchers distanced themselves from work on animal models but even human studies depended on this.”

Interest in human embryos grew in the later 19th century, following debates about evolution. Darwinists pointed to the similarity of humans and other animals at early stages as evidence of common descent. Critical anatomists responded by setting up networks of physicians to collect material, mainly from women’s pregnancy losses. New techniques such as serial sectioning and wax modelling from the slices made details of internal structure visible in 3-D.

This led to a watershed moment: the establishment by the Carnegie Institution of Washington of a Department of Embryology at Johns Hopkins University in Baltimore. Founded in 1914, the first research institution devoted specifically to embryology focused on human embryos, now also increasingly recovered from aseptic operations for various conditions. Important discoveries include elucidation of the timing of ovulation in the menstrual cycle, initially in rhesus macaques. Human embryos from the first two weeks after fertilization were described for the first time.

Flies, frogs and chicks

After World War II human embryology ran out of steam. A new field, developmental biology, focused on model organisms, such as flies, frogs, chicks and, as the exemplary mammal, mice.

“To make progress, the argument went, it was necessary to work on species where more could be done more easily”, Hopwood explains. “That meant micromanipulation, enough material to do biochemistry and molecular biology, and genetic tools.” This approach demonstrated its power in the 1980s, when mechanisms of development were found to be more conserved across the animal kingdom than researchers had imagined. Yet from around the same time interest revived in using human material.

“There was not a steadily rising curve of research on human development through the twentieth century”, Hopwood contends. “Instead, human embryos have gone through cycles of attention and neglect. As opportunities opened up and the balance of power shifted between researchers invested in different organisms, so the politics of species choice have changed. Over the last four decades we’ve seen a renewal of research directly on human development. This is in the first place because of changes in supply and demand.”

The achievement of human in-vitro fertilisation, with a live birth in 1978, gave access to embryos before implantation in the uterus. After much debate the UK Human Fertilisation and Embryology Act 1990 permitted donated embryos to be kept in vitro, under strict regulations, for up to 14 days from fertilization. Though only in 2016 was that limit approached. Meanwhile, biobanks, notably the Human Developmental Biology Resource in Newcastle and London, provided ethical supplies of post-implantation stages from terminations of pregnancy.

There has been opposition from anti-abortion activists, and many fewer embryos are donated for research than scientists (and some patients) would like. But the field was transformed. As in the years around 1900, new technologies eased the study of human embryos. Only now the advances were in digital communication, molecular analysis and imaging methods. Optical slices and computer graphics replaced microscope slides and wax models.

Beyond mice

To obtain human embryos with permission and funding to study them, researchers had to make the case for studying our own species. They stimulated demand by arguing that it would no longer do simply to extrapolate from mice. Knowledge and skills from the mouse model could be applied, but the differences as well as the similarities had to be explored. That was crucial before clinical application, as in fertility treatments. It was also desirable in discovering what makes us human—or at least not mice. Funders were keen to support medically relevant research or “translational science”.

In the last fifteen years another kind of model has transformed the politics of species choice. Subject to ongoing ethical negotiations, stem-cell-based embryo models have enabled fresh kinds of experiment on human development. Some researchers even argue that, for investigating fundamentals of vertebrate development, these human systems are now the model. Mice remain a crucial resource, with almost every innovation made on them first. But since their development is rather peculiar, other laboratories are promoting comparisons with species that develop more like humans.

Around ten years ago, all this inspired the organization of a new sub-field, human developmental biology, not least through a series of conferences. Major research programmes, such as the Human Developmental Biology Initiative, bring together scientists working, in different ways, on various aspects of embryogenesis.

Questions remain. Hopwood’s historical research concentrated on the USA and the UK, with nods to continental Europe and Japan. It would be good to explore other countries’ histories, he suggests, especially since differences in reproductive politics and infrastructure mean that access to material is uneven.

More generally, Hopwood argues, “history can contribute by showing how we got here and clarifying the arguments that have been used”. “It helps stakeholders see why there are now such opportunities for research on human development, and that, because arrangements are fragile, it will take work to gain and keep public support.” So a long-term perspective can assist researchers and funders in thinking about what might happen next.

“Interest in human development has risen and fallen and risen again. Are we now going through another cycle of attention, or could interest be maintained? Will the balance shift back to animal models or will we see an ever greater focus on humans, at least in the form of stem-cell models? How might present actions shape choice of species in the future?”

The research was part-funded by a Major Research Fellowship from the Leverhulme Trust. Story by Edward Grierson from the School of Humanities and Social Sciences communications team. 

A new study takes a tour of the history of research into human embryology and development to show the "cycles of attention" that led to major scientific breakthroughs.

Photos of embryos of horizon XVII, published in Contributions to Embryology in 1948 and still in use as Carnegie Stage 17.

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Yes

Scientists from the Sainsbury Laboratory at Cambridge University and Jagiellonian University, Poland made the discovery while undertaking an evolutionary survey of the microscopic structure of wood from some of the world’s most iconic trees and shrubs. 

They found that Tulip Trees, which are related to magnolias and can grow over 30 metres (100 feet) tall, have a unique type of wood. This discovery may explain why the trees, which diverged from magnolias when earth's atmospheric CO₂ concentrations were relatively low, grow so tall and so fast. This opens new opportunities to improve carbon capture and storage in plantation forests by planting a fast-growing tree more commonly seen in ornamental gardens, or breeding Tulip Tree-like wood into other tree species.

The discovery was part of an evolutionary survey of the microscopic structure of wood from 33 tree species from the Cambridge University Botanic Garden’s Living Collections. The survey explored how wood ultrastructure evolved across softwoods (gymnosperms such as pines and conifers) and hardwoods (angiosperms including oak, ash, birch, and eucalypts). 

The wood samples were collected from trees in the Botanic Garden in coordination with its Collections Coordinator. Fresh samples of wood, deposited in the previous spring growing season, were collected from a selection of trees to reflect the evolutionary history of gymnosperm and angiosperm populations as they diverged and evolved. 

Using the Sainsbury Laboratory's low temperature scanning electron microscope (cryo-SEM), the team imaged and measured the size of the nanoscale architecture of secondary cell walls (wood) in their native hydrated state.

Microscopy Core Facility Manager at the Sainsbury Laboratory, Dr Raymond Wightman, said: “We analysed some of the world’s most iconic trees like the Coast Redwood, Wollemi Pine and so-called 'living fossils' such as Amborella trichopoda, which is the sole surviving species of a family of plants that was the earliest still existing group to evolve separately from all other flowering plants.

“Our survey data has given us new insights into the evolutionary relationships between wood nanostructure and the cell wall composition, which differs across the lineages of angiosperm and gymnosperm plants. Angiosperm cell walls possess characteristic narrower elementary units, called macrofibrils, compared to gymnosperms.” 

The researchers found the two surviving species of the ancient Liriodendron genus, commonly known as the Tulip Tree (Liriodendron tulipifera) and Chinese Tulip Tree (Liriodendron chinense) have much larger macrofibrils than their hardwood relatives.

Hardwood angiosperm macrofibrils are about 15 nanometres in diameter and faster growing softwood gymnosperm macrofibrils have larger 25 nanometre macrofibrils. Tulip Trees have macrofibrils somewhere in between, measuring 20 nanometres.

Lead author of the research published in New Phytologist, Dr Jan Łyczakowski from Jagiellonian University, said: “We show Liriodendrons have an intermediate macrofibril structure that is significantly different from the structure of either softwood or hardwood. Liriodendrons diverged from Magnolia Trees around 30-50 million years ago, which coincided with a rapid reduction in atmospheric CO2. This might help explain why Tulip Trees are highly effective at carbon storage.”

The team suspect it is the larger macrofibrils in this 'midwood' or 'accumulator-wood' that is behind the Tulip Trees’ rapid growth.

Łyczakowski added: “Both Tulip Tree species are known to be exceptionally efficient at locking in carbon, and their enlarged macrofibril structure could be an adaptation to help them more readily capture and store larger quantities of carbon when the availability of atmospheric carbon was being reduced. Tulip Trees may end up being useful for carbon capture plantations. Some east Asian countries are already using Liriodendron plantations to efficiently lock in carbon, and we now think this might be related to its novel wood structure.” 

Liriodendron tulipifera are native to northern America and Liriodendron chinense is a native species of central and southern China and Vietnam.

Łyczakowski said: “Despite its importance, we know little about how the structure of wood evolves and adapts to the external environment. We made some key new discoveries in this survey – an entirely novel form of wood ultrastructure never observed before and a family of gymnosperms with angiosperm-like hardwood instead of the typical gymnosperm softwood. 

“The main building blocks of wood are the secondary cell walls, and it is the architecture of these cell walls that give wood its density and strength that we rely on for construction. Secondary cell walls are also the largest repository of carbon in the biosphere, which makes it even more important to understand their diversity to further our carbon capture programmes to help mitigate climate change.”

This research was funded by the National Science Centre Poland and The Gatsby Charitable Foundation.

Reference: Lyczakowski, J L and Wightman, R. "Convergent and adaptive evolution drove change of secondary cell wall ultrastructure in extant lineages of seed plants." July 2024, New Phytologist.  DOI: 10.1111/nph.19983

All cryo-SEM images from the wood survey are publicly available. 

Read more about this research.

Researchers have identified an entirely new type of wood that does not fit into either category of hardwood or softwood.

Tulip tree in Cambridge University Botanic Garden

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Yes

Professor Baron-Cohen is a British clinical psychologist and professor of developmental psychopathology at the University of Cambridge. He is the director of the university's Autism Research Centre and a Fellow of Trinity College.

The honorary fellowships were granted at a ceremony at the RSM’s central London home. 

Speaking at the ceremony, Professor Baron-Cohen said: “Although I’m receiving this honour, I’m really here because of the work of the team of researchers at the Autism Research Centre at Cambridge. I want to thank them for all their hard work into both basic science into trying to understand the cause of autism but also applied research to evaluate what kinds of support might help autistic people and their families.”

The Society also bestowed honours upon Baron Adebowale CBE, Major General Timothy Hodgetts CB, Professor Martin McKee CBE, Professor Dame Robina Shah and Professor Irene Tracey CBE.

Adapted from a news story by the Royal Society of Medicine.

Professor Sir Simon Baron-Cohen has been awarded an honorary fellowship of the Royal Society of Medicine, in recognition of his contribution to health, healthcare and medicine.

Although I’m receiving this honour, I’m really here because of the work of the team of researchers at the Autism Research Centre

Simon Baron-Cohen

Professor Henrietta Bowden-Jones, Professor Simon Baron-Cohen, Professor Roger Kirby

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Yes

The study, published today in Nature Communications, showed that the incidence of arterial thromboses, such as heart attacks and strokes, was up to 10% lower in the 13 to 24 weeks after the first dose of a COVID-19 vaccine. Following a second dose, the incidence was up to 27% lower after receiving the AstraZeneca vaccine and up to 20% lower after the Pfizer/Biotech vaccine.

The incidence of common venous thrombotic events – mainly pulmonary embolism and lower limb deep venous thrombosis – followed a similar pattern.

Research led by the Universities of Cambridge, Bristol and Edinburgh and enabled by the British Heart Foundation (BHF) Data Science Centre at Health Data Research UK analysed de-identified health records from 46 million adults in England between 8 December 2020 and 23 January 2022. Data scientists compared the incidence of cardiovascular diseases after vaccination with the incidence before or without vaccination, during the first two years of the vaccination programme.

Co-first author Dr Samantha Ip, Research Associate at the Department of Public Health and Primary Care, University of Cambridge, said: “We studied COVID-19 vaccines and cardiovascular disease in nearly 46 million adults in England and found a similar or lower incidence of common cardiovascular diseases, such as heart attacks and strokes, following each vaccination than before or without vaccination. This research further supports the large body of evidence on the safety of the COVID-19 vaccination programme, which has been shown to provide protection against severe COVID-19 and saved millions of lives worldwide.”

Previous research found that the incidence of rare cardiovascular complications is higher after some COVID-19 vaccines. For example, incidence of myocarditis and pericarditis have been reported following mRNA-based vaccines such as the Pfizer/Biotech vaccine, and vaccine-induced thrombotic thrombocytopenia following adenovirus-based vaccines such as the AstraZeneca vaccine. This study supports these findings, but importantly it did not identify new adverse cardiovascular conditions associated with COVID-19 vaccination and offers further reassurance that the benefits of vaccination outweigh the risk.

Incidence of cardiovascular disease is higher after COVID-19, especially in severe cases. This may explain why incidence of heart attacks and strokes is lower in vaccinated people compared with unvaccinated people, but further explanations are beyond the scope of this study.

Professor William Whiteley, Associate Director at the BHF Data Science Centre and Professor of Neurology and Epidemiology at the University of Edinburgh, said: “The COVID-19 vaccination programme rollout began strongly in the UK, with over 90% of the population over the age of 12 vaccinated with at least one dose by January 2022.

“This England-wide study offers patients reassurance of the cardiovascular safety of first, second and booster doses of COVID-19 vaccines. It demonstrates that the benefits of second and booster doses, with fewer common cardiovascular events include heart attacks and strokes after vaccination, outweigh the very rare cardiovascular complications.”

The research team used de-identified linked data from GP practices, hospital admissions and death records, analysed in a secure data environment provided by NHS England.

Co-last author Dr Venexia Walker, Research Fellow at the University of Bristol, said: “Given the critical role of COVID-19 vaccines in protecting people from COVID-19, it is important we continue to study the benefits and risks associated with them. The availability of population-wide data has allowed us to study different combinations of COVID-19 vaccines and to consider rare cardiovascular complications. This would not have been possible without the very large data that we are privileged to access and our close cross-institution collaborations.”

Reference
Ip, S et al. Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England. Nat Comms; 31 Jul 2024; DOI: 10.1038/s41467-024-49634-x

Adapted from a press release from Health Data Research UK

The incidence of heart attacks and strokes was lower after COVID-19 vaccination than before or without vaccination, according to a new study involving nearly the whole adult population of England.

This research further supports the large body of evidence on the effectiveness of the COVID-19 vaccination programme, which has saved millions of lives worldwide

Samantha Ip

Vial of the AstraZeneca COVID-19 vaccine

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Yes

New research has found that 4,642 species of vertebrate are threatened by mineral extraction around the world through mining and quarrying, and drilling for oil and gas.

Mining activity coincides with the world's most valuable biodiversity hotspots, which contain a hyper-diversity of species and unique habitats found nowhere else on Earth.

The biggest risk to species comes from mining for materials fundamental to our transition to clean energy, such as lithium and cobalt – both essential components of solar panels, wind turbines and electric cars.

Quarrying for limestone, which is required in huge amounts for cement as a construction material, is also putting many species at risk.

The threat to nature is not limited to the physical locations of the mines - species living at great distances away can also be impacted, for example by polluted watercourses, or deforestation for new access roads and infrastructure.

The researchers say governments and the mining industry should focus on reducing the pollution driven by mining as an ‘easy win’ to reduce the biodiversity loss associated with mineral extraction.

This is the most complete global assessment of the threat to biodiversity from mineral extraction ever undertaken. The results are published today in the journal Current Biology.

“We simply won’t be able to deliver the clean energy we need to reduce our climate impact without mining for the materials we need, and that creates a problem because we’re mining in locations that often have very high levels of biodiversity,” said Professor David Edwards in the University of Cambridge’s Department of Plant Sciences and Conservation Research Institute, senior author of the report.

He added: “So many species, particularly fish, are being put at risk through the pollution caused by mining. It would be an easy win to work on reducing this freshwater pollution so we can still get the products we need for the clean energy transition, but in a way that isn’t causing so much biodiversity loss.”

Across all vertebrate species, fish are at particularly high risk from mining (2,053 species), followed by reptiles, amphibians, birds and mammals. The level of threat seems to be linked to where a particular species lives and its lifestyle: species using freshwater habitats, and species with small ranges are particularly at risk.

“The need for limestone as a core component of construction activity also poses a real risk to wildlife. Lots of species are very restricted in where they live because they're specialised to live on limestone. A cement mine can literally take out an entire hillside - and with it these species’ homes,” said Ieuan Lamb in the University of Sheffield’s School of Biosciences, first author of the report.

The Bent-Toed Gecko, for example, is threatened by limestone quarrying in Malaysia – it only exists on a single mountain range that planned mining activity will completely destroy.

To get their results, the researchers used International Union for the Conservation of Nature (IUCN) data to see which vertebrate species are threatened by mining. By mapping the locations of these species they could investigate the types of mining that are putting species at risk, and see where the risks are particularly high.

The researchers discovered that species categorised as ‘vulnerable, endangered, or critically endangered’ are more threatened by mineral extraction than species of lesser concern.

Watercourses can be affected in many ways, and water pollution can affect hundreds of thousands of square kilometres of rivers and flood plains. Mining sand as a construction material, for example, alters patterns of water flow in rivers and wetlands, making birds like the Indian Skimmer more accessible to predators.

Mineral extraction threatens vertebrate species populations across the tropics, with hotspots in the Andes, coastal West and Central Africa, and South-East Asia – which coincide with high mine density. For example, artisanal small-scale alluvial gold mining in Ghana threatens important bird areas through environmental mercury pollution.

Global demand for metal minerals, fossil fuels and construction materials is growing dramatically, and the extraction industry is expanding rapidly to meet this demand. In 2022 the revenue of the industry as a whole was estimated at US $943 billion.

Biodiversity underpins the protection of the world’s carbon stocks, which help to mitigate climate change.

The study focused only on vertebrate species, but the researchers say mining is also likely to be a substantial risk to plants and invertebrates.

“There's no question that we are going to continue to mine - our entire societies are based on mined products. But there are environmental tensions embodied in our use of these products. Our report is a vital first step in avoiding biodiversity loss amidst the predicted drastic expansion of the mining industry,” said Edwards.

“Wildlife is more sensitive to mining in some regions of the world than in others, and our report can inform choices of where to prioritise getting our minerals to cause the least damage to biodiversity. Future policy should also focus on creating more circular economies - increasing recycling and reuse of materials, rather than just extracting more,” said Lamb.

The research was funded by the Hossein Farmy scholarship.

Reference: Lamb, I P, ‘Global threats of extractive industries on vertebrate biodiversity.’ Current Biology, July 2024. DOI: 10.1016/j.cub.2024.06.077

Our increasing demand for metals and minerals is putting over four thousand vertebrate species at risk, with the raw materials needed for clean energy infrastructure often located in global biodiversity hotspots, a study has found.

Our report is a vital first step in avoiding biodiversity loss amidst the predicted drastic expansion of the mining industry.

David Edwards

Gold mine in Rondonia, Amazonian Brazil

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Yes

The hub, called Q-BIOMED, is one of 5 quantum research hubs announced on 26 July by Peter Kyle MP, the Secretary of State for Science, Innovation and Technology, supported by £160 million in funding.

The hub will exploit advances in quantum sensors capable of detecting cells and molecules, potentially orders of magnitude more sensitively than traditional diagnostic tests.

This includes developing quantum-enhanced blood tests to diagnose infectious diseases and cancer quickly and cheaply using portable instruments, and sensors measuring tiny changes to the magnetic fields in the brain that have the potential to detect early markers of Alzheimer’s disease before symptoms occur.

Other research will include quantum-enhanced MRI scans, heart scanners and surgical and treatment interventions for early-stage and hard-to-treat cancers.

“Quantum technologies harness quantum physics to achieve a functionality or a performance which is otherwise unattainable, deriving from science which cannot be explained by classical physics,” said Hub Co-Director Professor Mete Atatüre, Head of Cambridge’s Cavendish Laboratory. “Q-BIOMED will be delivered by an outstanding team of researchers from academia, the NHS, charities, government and industry to exploit quantum-enhanced advances for human health and societal good.”

“Our hub aims to grow a new quantum for health innovation ecosystem in the UK, and has already shaped the UK's new Quantum Mission for Health,” said Hub Co-Director Professor Rachel McKendry, from the London Centre for Nanotechnology and Division of Medicine at UCL. “Our long-term vision is to accelerate the entire innovation pipeline from discovery research, to translation, adoption and implementation within the NHS and global health systems, for the benefit of patients and societal good.”

“Quantum sensing allows us to gather information at cellular and molecular levels with unprecedented sensitivity to electric and magnetic fields," said Dr Ljiljana Fruk from the Department of Chemical Engineering and Biotechnology, a member of the Q-BIOMED team. "I look forward to learning from colleagues and engaging in challenging discussions to develop more sensitive, affordable tools for doctors and patients, advancing the future of healthcare.” 

Cambridge researchers are also involved in three of the other newly-announced hubs:

• The UK Hub for Quantum Enabled Position, Navigation and Timing (QEPNT), led by the University of Glasgow, will develop quantum technologies which will be key for national security and critical infrastructure and sectors such as aerospace, connected and autonomous vehicles (CAVs), finance, maritime and agriculture. Luca Sapienza (Engineering), Louise Hirst (Materials Science and Metallurgy/Cavendish Laboratory) and Dave Ellis (Cavendish Laboratory) are part of the QEPNT team.
• QCI3: Hub for Quantum Computing via Integrated and Interconnected Implementations, led by the University of Oxford, aims to develop the technologies needed for the UK to play a key role in the development of quantum computers, a market estimated to be worth $1.3 trillion by 2030. Ulrich Schneider (Cavendish Laboratory), Helena Knowles (Cavendish Laboratory), and Chander Velu (Institute for Manufacturing) are part of the QCI3 team.
• The Integrated Quantum Networks (IQN) Quantum Technology Research Hub, led by Heriot-Watt University, will undertake research towards the ultimate goal of a ‘quantum internet’, globally interlinked quantum networks connecting multiple quantum computers to produce enormous computational power. Richard Penty, Adrian Wonfor and Qixiang Cheng (Engineering), Atatüre and Dorian Gangloff (Cavendish Laboratory) are part of the IQN team.

The fifth hub, UK Quantum Technology Hub in Sensing, Imaging and Timing (QuSIT), is led by the University of Birmingham.

The five hubs are delivered by the UKRI Engineering and Physical Sciences Research Council (EPSRC), with a £106 million investment from EPSRC, the UKRI Biotechnology and Biological Research Council, UKRI Medical Research Council, and the National Institute for Health and Care Research. Added to this are contributions from industry and other partners worth more than £54 million.

Peter Kyle, Secretary of State for Science, Innovation and Technology, said: “We want to see a future where cutting-edge science improves everyday lives. That is the vision behind our investment in these new quantum technology hubs, by supporting the deployment of technology that will mean faster diagnoses for diseases, critical infrastructure safe from hostile threats and cleaner energy for us all.

“This isn’t just about research; it’s about putting that research to work. These hubs will bridge the gap between brilliant ideas and practical solutions. They will not only transform sectors like healthcare and security, but also create a culture of accelerated innovation that helps to grow our economy.”

EPSRC Executive Chair Professor Charlotte Deane said: “Technologies harnessing quantum properties will provide unparalleled power and capacity for analysis at a molecular level, with truly revolutionary possibilities across everything from healthcare to infrastructure and computing.

“The 5 Quantum Technology Hubs announced today will harness the UK’s expertise to foster innovation, support growth and ensure that we capitalise on the profound opportunities of this transformative technology.”

A major new research hub led by the University of Cambridge and UCL aims to harness quantum technology to improve early diagnosis and treatment of disease.

L-R: Professor John Morton (UCL), Professor Rachel McKendry (UCL), Professor Mete Atatüre (Cambridge), Professor Eleni Nastouli (UCL)

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Yes

"The Higher Education sector in the UK is brilliant, really incredible, I'm not even sure people realise how strong it is.”

One year into the role our Vice-Chancellor, Professor Deborah Prentice, speaks to Woman’s Hour on BBC Radio 4. She calls for a national conversation to address the university funding crisis, welcomes the new Labour government’s support for international students and talks about how education is one of Britain’s great exports. “We want to keep it that way and that's going to require a sector-wide conversation about finances."      

She also reflects on how free speech and protests are viewed differently in the UK and US. As part of her efforts to encourage people to be able to disagree agreeably, she mentions convening the Vice-Chancellor’s Dialogues, a forum to discuss challenging topics with the widest range of viewpoints. 

When asked about her own upbringing as the daughter of a single mother, she said, “Even though my mother never could have imagined my path, I could never have taken my path without her...I learned the value of education. My mom felt not having access to higher education limited what she could do and I think she was right about that." 

Listen to the whole interview on BBC Sounds, Spotify or Apple Podcasts 

Professor Prentice speaks to Nuala McGovern about funding in higher education, international students and freedom of speech on campus

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Yes

The SAS Advanced Analytics Hub will embed SAS experts and its AI platform capabilities into the University, enabling targeted collaboration with leading researchers and early-stage entrepreneurs.

Based on the Cambridge West campus, the Hub will have capacity to recruit and support several high-quality, high-impact academic research projects and promising early-stage startups in the health-tech space, providing their innovative ideas with extra momentum.

The partners have already demonstrated the effectiveness of the collaboration in addressing an important healthcare challenge. A University of Cambridge-led project on kidney transplants, PITHIA, developed an AI-based decision support approach using SAS’s dynamic analytics platform. It is being used to automate the process of scoring biopsies for kidneys to better identify those organs that can be used for transplantation. The aim is to increase the number of transplants and improve the function of those kidneys used. This has the potential to save lives and transform the quality of life for more than 100 people each year who would otherwise require dialysis, as well as saving the NHS millions of pounds annually.

This collaboration was initiated and led by Dr Alex Samoshkin (Deputy Head, Office for Translational Research, School of Clinical Medicine) who facilitates interactions between clinicians and researchers from the Biomedical Campus with researchers in science and technology working with the Maxwell Centre. Dr Samoshkin said: “In 2018 I supported the PITHIA project led by Prof. Gavin Pettigrew, looking to optimise qualification of kidneys for transplantation, for which SAS turned out to be the perfect industrial partner. We demonstrated that synergy between the University and SAS was instrumental in accelerating the process of transitioning from ideas to the clinic.”

This initial success paved the way for a more ambitious partnership between Cambridge and SAS. The Cambridge team visited the SAS headquarters at Cary, NC, USA in June 2023 to discuss collaboration opportunities with the SAS senior leadership team including Dr Jim Goodnight, co-founder and CEO. Today, the SAS Advanced Analytics Hub at the Maxwell Centre begins building a pipeline of new collaborative projects with potential to improve health outcomes for millions of patients around the world.

The Maxwell Centre Director, Dr Aga Iwasiewicz-Wabnig, commented: “We are excited to interface Cambridge’s world-class research and innovation with SAS’ leading expertise in advanced analytics and AI forming a partnership for societal good. We are starting with a strong focus on healthcare and will build momentum to support future interdisciplinary projects on sustainability and social equality.”

Roderick Crawford, Senior Vice President, SAS Northern Europe, commented: “There are many examples we’re seeing of how AI can have a truly transformational effect, not just on businesses, but in areas such as healthcare and society as a whole. We’re delighted to deepen our relationship with the University of Cambridge through this partnership, and there is enormous potential when you consider the additional expertise our partners, such as Microsoft, and customers, such as AstraZeneca, can provide.”

The Maxwell Centre at the University of Cambridge and SAS, leaders in data and AI, are launching a partnership aimed at accelerating healthcare innovation through enhanced access to advanced analytics.

Maxwell Centre, University of Cambridge

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Yes

Progressive retinal atrophy (PRA) is a group of inherited diseases that causes progressive degeneration of the light sensitive cells at the back of the eye. Dogs with PRA have normal sight at birth, but by the age of four or five they will be totally blind. There is no treatment.

Now a team led by the University of Cambridge has identified the genetic mutation that causes PRA in English Shepherd Dogs, and developed a DNA test for it. By identifying dogs carrying the disease before their eyesight starts to fail, this provides a tool to guide breeding decisions so the disease is not passed on to puppies.

Owners usually don’t realise their dog has PRA until it is middle-aged, by which time it might have bred, and passed on the faulty gene to its puppies. This has made it a difficult disease to control.

The new discovery means that progressive retinal atrophy can now be completely eliminated from the English Shepherd Dog population very quickly.

The results are published today in the journal Genes.

“Once the dog’s eyesight starts to fail there’s no treatment – it will end up totally blind,” said Katherine Stanbury, a researcher in the University of Cambridge’s Department of Veterinary Medicine and first author of the report.

She added: “Now we have a DNA test, there’s no reason why another English Shepherd Dog ever needs to be born with this form of progressive retinal atrophy – it gives breeders a way of totally eliminating the disease.”

The genetic mutation identified by the team is recessive, which means it only causes blindness if the English Shepherd Dog inherits two copies of it. If the dog only has one copy this makes it a carrier – it will not develop PRA but can pass the mutation on to its puppies. If two carriers are bred together, about one in four of the puppies will be affected with PRA.

Dogs breeds are very inbred, so many individuals are related – giving them a much higher chance of being affected by recessive diseases than humans.

The team began the research after being contacted by a distraught owner of an English Shepherd Dog that had been recently diagnosed with PRA. The dog had been working as a search and rescue dog but had to retire due to visual deterioration that has resulted in total blindness. The researchers put out a call for DNA samples from other owners or breeders of this breed, and received samples from six English Shepherds with PRA and twenty without it. This was enough for them to pinpoint the genetic mutation responsible for PRA using whole genome sequencing.

The team offers a commercial canine genetic testing service providing DNA tests to dog breeders to help them avoid breeding dogs that will develop inherited diseases. As part of this they will now offer a DNA test for Progressive Retinal Atrophy in English Shepherds. Anyone can buy a testing kit, costing just £48, to take a swab from inside their dog’s mouth and send it back for testing.

“An owner won't necessarily notice their dog has got anything wrong with its eyes until it starts bumping into the furniture. Unlike humans who will speak up if their sight isn’t right, dogs just have to get on with things,” said Dr Cathryn Mellersh in the University of Cambridge’s Department of Veterinary Medicine, senior author of the report.

She added: “For the price of a decent bag of dog food people can now have their English Shepherd tested for Progressive Retinal Atrophy prior to breeding. It’s about prevention, rather than a cure, and it means a huge amount to the people who breed these dogs. They no longer need to worry about whether the puppies are going to be healthy or are going to develop this horrible disease in a few years’ time.”

The English Shepherd is a breed of herding dog popular in the United States and is closely related to the Border Collie.

The new discovery is the thirty-third genetic mutation causing an inherited disease in dogs that the team has found – twenty-three of which cause eye diseases. They say that the health and wellbeing of many dogs has been compromised because of how they have been bred by humans.

PRA occurs in many dog breeds including the English Shepherd Dog. And it is similar to a disease called retinitis pigmentosa in humans, which also causes blindness. The researchers say that their work with dogs could shed light on the human version of the disease and potentially identify targets for gene therapy in the future.

The work was carried out in collaboration with Wisdom Panel, Mars Petcare, as part of the Consortium to Research Inherited Eye Diseases in Dogs (CRIEDD), with funding from the Dog’s Trust and the Kennel Club Charitable Trust.

Reference: Stanbury, K. et al, ‘Exonic SINE insertion in FAM161A is associated with autosomal recessive progressive retinal atrophy in the English Shepherd.’ July 2024.

FIND OUT MORE AND SUPPORT THIS RESEARCH

Cambridge scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of the breed.

Now we have a DNA test, there’s no reason why another English Shepherd Dog ever needs to be born with this form of progressive retinal atrophy – it gives breeders a way of totally eliminating the disease.

Katherine Stanbury

English Shepherd puppy

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Yes

They are among 86 distinguished scholars to be elected to the fellowship in recognition of their work in fields ranging from medieval history to international relations.

The Cambridge academics made Fellows of the Academy this year are:

Professor Elisabeth van Houts (History Faculty; Emmanuel College)

Professor Tim Harper (History Faculty; Magdalene College)

Professor Rosalind Love (Department of ASNC; Robinson College)

Professor James Montgomery (FAMES; Trinity Hall)

Professor Ayşe Zarakol (POLIS; Emmanuel College)

Professor Tim Dalgleish (MRC Cognition and Brain Sciences Unit)

Founded in 1902, the British Academy is the UK’s national academy for the humanities and social sciences. It is a Fellowship consisting of over 1700 of the leading minds in these subjects from the UK and overseas.

Current Fellows include the classicist Professor Dame Mary Beard, the historian Professor Sir Simon Schama and philosopher Professor Baroness Onora O’Neill, while previous Fellows include Dame Frances Yates, Sir Winston Churchill, Seamus Heaney and Beatrice Webb. The Academy is also a funder of both national and international research, as well as a forum for debate and public engagement.

In 2024, a total of 52 UK Fellows, 30 International Fellows and 4 Honorary Fellows have been elected to the British Academy Fellowship.

Professor Ayse Zarakol said: “I am absolutely delighted to be elected a Fellow of the British Academy in recognition of my interdisciplinary work at the intersection of international relations, global history and historical sociology. It is an honour to join such a long line of distinguished scholars. I very much look forward to working with the Academy to advance research on the big questions of our day and to ensure that UK remains a hospitable environment for social sciences and humanities research that attracts the best talent from around the world.”

Professor Rosalind Love said: “As a grateful recipient of one its Postdoctoral Fellowships, I have always revered the British Academy and am deeply humbled by this honour. It shows that the Academy values the teaching of Medieval Latin, and research in that area, at a time when the subject faces cuts elsewhere. I’d like to express sincerest gratitude to the teachers who gave me a solid grounding and to all who have supported me over the years: they made this possible. I look forward to working with other FBAs to shape the future of the Humanities.”

Professor Tim Harper, Head of Cambridge’s School of the Humanities and Social Sciences, said: “It is an honour to be elected a fellow of the British Academy. As a historian, I am very aware of the challenges and opportunities for the humanities and social sciences that we collectively face. I look forward to continuing to strive to strengthen their position.”

Welcoming the Fellows, President of the British Academy Professor Julia Black said: “We are delighted to welcome this year’s cohort of Fellows, and I offer my warmest congratulations to each and every one. From the Academy’s earliest days, our Fellows are the lifeblood of the organisation, representing the very best of our disciplines – and we could not do all that we do without their expertise, time and energy. I very much look forward to working closely with our new Fellows – the breadth and depth of their expertise adds so much to the Academy.”

Six academics from the University of Cambridge have been made Fellows of the prestigious British Academy for the humanities and social sciences.

It is an honour to join such a long line of distinguished scholars.

Ayşe Zarakol

The British Academy

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Yes

The team say that while these experiences can be very positive, that is not always the case. Mindfulness teachers and students need to be aware that they can be a side-effect of training, and students should feel empowered to share their experiences with their teacher or doctor if they have any concerns.

Mindfulness-based programmes have become very popular in recent years. According to recent surveys, 15% of adults in the UK have learnt some form of mindfulness. They are often practised as a way of reducing stress or coping with depression and anxiety. There is anecdotal evidence that practising mindfulness can lead to alterations of the senses, self, and body boundaries, some even similar to those induced by psychotropic drugs.

From September 2015 to January 2016, the University of Cambridge conducted a randomised controlled trial to assess the effectiveness of mindfulness training as a way of coping with the stress of examinations and found that it can help support students at risk of mental health problems.

Dr Julieta Galante from the Department of Psychiatry at the University of Cambridge, who led the trial, said: “There’s been anecdotal evidence that people who practice mindfulness experience changes in how they perceive themselves and the world around them, but it’s difficult to know whether these experiences are a result of mindfulness practice or whether people who are more prone to such experiences are also more likely to practise mindfulness.

“Because we’d been running a randomised trial of mindfulness practice with several hundred students at Cambridge, we realised this offered us an opportunity to explore this question further.”

The team behind the trial followed up with participants a year later to investigate whether they had experienced any of the altered states of consciousness being reported anecdotally. The results are published today in PLOS ONE.

Participants were asked to complete a questionnaire that explored 11 ‘dimensions’ such as: spiritual experience; blissful state; disembodiment; and unity. In experiences of unity there is a sense that borders dissolve and everything, sometimes including the sense of time, is perceived in an integrated way. Disembodiment experiences often consist of a floating sensation or a dissolution of body boundaries, which may facilitate strong unity experiences.

In total, 670 participants took part in the randomised trial. Around a third each from the mindfulness trial and the control arm went on to complete the questionnaire about experiences of altered states of consciousness.

The researchers found that people who had received the mindfulness training were twice as likely as those in the control group to experience unity and disembodiment.

When the researchers explored the relationship between the total hours of formal mindfulness practice and the presence and intensity of experiences of altered states of consciousness,  they found that the more people practised, the more likely they were to have an experience of unity, disembodiment, or of a blissful state.

Participants who reported having meditated in the six months prior were asked if altered states of consciousness happened during meditation. Based on this sub-sample of 73 participants, 43% reported unity experiences during meditation, 47% blissful states, 29% disembodiment experiences, and 25% insightfulness experiences.

Dr Galante said: “Although we can’t say definitively, our results at least suggest the possibility that mindfulness training causes these experiences of unity and disembodiment. It aligns with other studies showing that people who practice mindfulness training are more likely to describe experiencing a sense of relaxed self-boundaries and broadening their spatial awareness beyond the physical body.”

Dr Galante, who practices mindfulness, has herself experienced these altered states of consciousness.

“I’ve benefited a lot personally from meditation and mindfulness and I’ve also had many of these experiences,” she said. “They were intense, and at first I found it difficult to share them with my meditation teacher. I didn’t know if they were normal or desirable or if they were a sign of problems with my mental health.”

While many experiences of altered states of consciousness are likely to be interpreted as pleasant, this may not always be the case, and Dr Galante says that it is important for teachers and their students to be aware that they may arise and be open to talking about them.

She added: “The most common and intense experiences tend to be those that do not have intrinsically unpleasant characteristics. Some, such as bliss, can feel extremely pleasant. But some experiences, such as disembodiment or altered sense of self could be perceived as unpleasant, or startling, even alarming, especially if you’re not expecting them.

“It’s important that people who are offered mindfulness are told about the possibility that they may come across these experiences.  That way, if they do experience them, they shouldn’t be disconcerted. There may be nothing wrong with their experience, but it may be useful for them to check in with their mindfulness teacher, and if the experience was negative, to also consider discussing it with their doctor.”

The research was supported by the University of Cambridge Vice-Chancellor’s Endowment Fund, the University Counselling Service and the National Institute for Health Research (NIHR) Applied Research Collaboration East of England programme.

Reference

Galante, J & Montero-Marin, J et al. Altered states of consciousness caused by a mindfulness-based programme up to a year later: results from a randomised controlled trial. PLOS ONE; 17 July 2024; DOI: 10.1371/journal.pone.0305928

Mindfulness training may lead participants to experience disembodiment and unity – so-called altered states of consciousness – according to a new study from researchers at the University of Cambridge.

I’ve benefited a lot personally from meditation and mindfulness and I’ve also had many of these experiences. I didn’t know if they were normal or desirable

Julieta Galante

Woman sitting on sand at sunset meditating

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Yes

The researchers, from the University of Cambridge, took their inspiration from electric eels, which stun their prey with modified muscle cells called electrocytes.

Like electrocytes, the jelly-like materials developed by the Cambridge researchers have a layered structure, like sticky Lego, that makes them capable of delivering an electric current.  

The self-healing jelly batteries can stretch to over ten times their original length without affecting their conductivity – the first time that such stretchability and conductivity has been combined in a single material. The results are reported in the journal Science Advances.

The jelly batteries are made from hydrogels: 3D networks of polymers that contain over 60% water. The polymers are held together by reversible on/off interactions that control the jelly’s mechanical properties.

The ability to precisely control mechanical properties and mimic the characteristics of human tissue makes hydrogels ideal candidates for soft robotics and bioelectronics; however, they need to be both conductive and stretchy for such applications.

“It’s difficult to design a material that is both highly stretchable and highly conductive, since those two properties are normally at odds with one another,” said first author Stephen O’Neill, from Cambridge’s Yusuf Hamied Department of Chemistry. “Typically, conductivity decreases when a material is stretched.”

“Normally, hydrogels are made of polymers that have a neutral charge, but if we charge them, they can become conductive,” said co-author Dr Jade McCune, also from the Department of Chemistry. “And by changing the salt component of each gel, we can make them sticky and squish them together in multiple layers, so we can build up a larger energy potential.”

Conventional electronics use rigid metallic materials with electrons as charge carriers, while the jelly batteries use ions to carry charge, like electric eels.

The hydrogels stick strongly to each other because of reversible bonds that can form between the different layers, using barrel-shaped molecules called cucurbiturils that are like molecular handcuffs. The strong adhesion between layers provided by the molecular handcuffs allows for the jelly batteries to be stretched, without the layers coming apart and crucially, without any loss of conductivity.

The properties of the jelly batteries make them promising for future use in biomedical implants, since they are soft and mould to human tissue. “We can customise the mechanical properties of the hydrogels so they match human tissue,” said Professor Oren Scherman, Director of the Melville Laboratory for Polymer Synthesis, who led the research in collaboration with Professor George Malliaras from the Department of Engineering. “Since they contain no rigid components such as metal, a hydrogel implant would be much less likely to be rejected by the body or cause the build-up of scar tissue.”

In addition to their softness, the hydrogels are also surprisingly tough. They can withstand being squashed without permanently losing their original shape, and can self-heal when damaged.

The researchers are planning future experiments to test the hydrogels in living organisms to assess their suitability for a range of medical applications.

The research was funded by the European Research Council and the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI). Oren Scherman is a Fellow of Jesus College, Cambridge.

 

Reference:
Stephen J.K. O’Neill et al. ‘Highly Stretchable Dynamic Hydrogels for Soft Multilayer Electronics.’ Science Advances (2024). DOI: 10.1126/sciadv.adn5142

Researchers have developed soft, stretchable ‘jelly batteries’ that could be used for wearable devices or soft robotics, or even implanted in the brain to deliver drugs or treat conditions such as epilepsy.

Jelly batteries

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Yes

The findings highlight the urgent need for monitoring and support for the mental health of young people diagnosed with type 1 diabetes.

According to the charity JDRF, there are 8.7 million people living with type 1 diabetes around the world, including over 400,000 people in the UK. It is a chronic, life-threatening condition, usually diagnosed in childhood, that has a life-long impact.

Currently, people with type 1 diabetes rely on a routine of finger-prick blood tests and insulin injections or infusions, because their pancreas no longer produces insulin itself, although recent developments in artificial pancreas technology are helping transform this care.

Previous studies have shown potential links between childhood-onset type 1 diabetes and a number of mental health disorders in adulthood. However, it is not clear whether these links can be best explained by the impacts of living with the condition and its treatment, or whether underlying common biological mechanisms may be implicated, for example the impact of unstable blood sugar levels on the developing adolescent brain.

To help answer this question, a team of researchers turned to data from over 4,500 children with type 1 diabetes on a national register in the Czech Republic and from large-scale European DNA studies.Their findings are published today in Nature Mental Health.

From the national register data, the researchers found that children diagnosed with type 1 diabetes – compared to children without the condition – were over twice as likely to develop a mood disorder and more than 50% more likely to develop an anxiety disorder. They were also more than four times more likely to develop behavioural syndromes including eating and sleep disorders

Conversely, children with type 1 diabetes were at a much lower risk of developing psychotic disorders, such as schizophrenia – almost half the risk compared to their peers.

The findings are consistent with the results from two other national register studies in Sweden and in Denmark, suggesting that the results would likely apply to other countries, too, including the UK.

The team used a statistical technique known as Mendelian Randomisation to probe causal links between type 1 diabetes and these various psychiatric disorders, but found little evidence in support of a common underlying biological mechanism.

Tomáš Formánek, a PhD student at the University of Cambridge and the National Institute of Mental Health, Klecany, Czech Republic, said: “Although we found a concerning increase in the risk of mental health problems among people living with type 1 diabetes, our study – and others before it – suggests this is unlikely to be the result of common biological mechanisms. This emphasises the importance of prevention and sustained attention to the mental health needs of children and young people with type 1 diabetes.”

The researchers say that mental health problems in later life may be a result of children with type 1 diabetes being forced to make significant changes to their lives, with a constant focus on monitoring their food intake and a need to check blood sugar levels and administer insulin injections. This often leaves these children feeling excluded from social events and singled-out by peers, teachers and even family members.

Dr Benjamin Perry from the Department of Psychiatry, University of Cambridge, said: “We know that people diagnosed with type 1 diabetes can experience ‘diabetes distress’. This can include extreme frustration with blood sugars and feelings of isolation and can lead to burnout, hopelessness, and a feeling of lack of control. It’s little wonder, then, that they are at risk of compounding mental health problems, spanning into their adult lives.”

Professor Peter Jones, also from the Department of Psychiatry, University of Cambridge, added: “Our findings emphasise the urgent need to support children diagnosed with type 1 diabetes, look out for signs of mental health problems and offer timely, expert help. That way, it may be possible to help these children early, before these problems fully take root.”

The research was supported by the National Institute for Health and Care Research Applied Research Collaboration East of England at Cambridgeshire and Peterborough NHS Foundation Trust and the Ministry of Health, Czech Republic, with additional funding from Wellcome and the UKRI Medical Research Council.

Reference
Formánek, T et al. Childhood-Onset Type 1 Diabetes and Subsequent Adult Psychiatric Disorders: A Nationwide Cohort and Genome-wide Mendelian Randomization Study. Nature Mental Health; 17 July 2024; DOI: 10.1038/s44220-024-00280-8

Children diagnosed with type 1 diabetes are at significantly higher risk of a number of mental health issues, including mood and anxiety disorders, a study from a team in the UK and the Czech Republic has found.

We know that people diagnosed with type 1 diabetes can experience ‘diabetes distress’. It’s little wonder, then, that they are at risk of compounding mental health problems, spanning into their adult lives

Benjamin Perry

Teenager With Type 1 Diabetes Takes at Home Test

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Yes

Professor Aston takes over the role from Professor Anne Ferguson-Smith, and will begin as a Pro-Vice-Chancellor on 1 September, 2024.

An applied statistician, Professor Aston leads research into the use of quantitative evidence in public policy making, works with those in public life to ensure the best methods are used, and aims to improve the use of statistics and other quantitative evidence in public policy debates.

He is a non-Executive Board Member of the UK Statistics Authority, and from 2017-2020 was Chief Scientific Adviser to the Home Office and Director-General for Science, Technology, Analysis, Research and Strategy. He was a founding director of the Alan Turing Institute. He is a member of the London Policing Board and president-elect of the Royal Statistical Society, where he will serve as President between 2025-26. Earlier this year he was elected a Fellow of the Royal Society, the UK’s national academy of sciences and the oldest science academy in continuous existence.

Before joining Cambridge, Professor Aston – a Fellow of Churchill College – held academic positions at the University of Warwick and at Academia Sinica in Taiwan. He was knighted in the 2021 Birthday Honours for services to statistics and public policymaking.

As Pro-Vice-Chancellor for Research, Professor Aston will provide senior academic leadership on the University’s research activities, and be responsible for sustaining and enhancing a supportive research culture which allows Cambridge to continue to flourish as an outstanding research‑intensive institution with worldwide influence. He will also develop large-scale, cross-School initiatives to tackle global challenges and increase the positive impact of Cambridge’s research on society.

Professor Aston will build on the foundations laid by Professor Ferguson‑Smith, who has been appointed Executive Chair of the Biotechnology and Biological Sciences Research Council (BBSRC).

Professor Aston said: “I’m honoured and privileged to take up this position, building on Anne’s amazing work, and to have the opportunity to champion the world-class research happening in Cambridge. We have so many talented people here, and an important part of my role will be about supporting them, and making sure we’ve got the best culture for research to continue attracting and retaining the best researchers. We do so many things brilliantly at Cambridge, but our research and our amazing researchers have changed the world and we are rightly incredibly proud of that.”

The University of Cambridge’s Vice-Chancellor Professor Deborah Prentice welcomed Professor Aston to the role and thanked Professor Ferguson‑Smith for her service.

She said: “John brings a wealth of experience and enthusiasm to the role, and I’m thrilled to welcome him to the team. He will build on the excellent work of Anne Ferguson-Smith, who I thank sincerely for her unstinting leadership. Ensuring a creative and supportive research environment is critical to the work of the University, and John is ideally placed to inspire our amazing academic community and advance the impact of research at Cambridge.”

There are five Pro-Vice-Chancellors at the University of Cambridge. Their role is to work in partnership with other senior leaders, including Heads of School and Professional Services leads, to help drive strategy and policy development. The Pro-Vice-Chancellors also support the Vice-Chancellor in providing academic leadership to the University.

Professor Sir John Aston has been appointed Pro-Vice-Chancellor for Research at the University of Cambridge. He is Harding Professor of Statistics in Public Life within the University’s Department of Pure Mathematics and Mathematical Statistics.

We do so many things brilliantly at Cambridge, but our research and our amazing researchers have changed the world and we are rightly incredibly proud of that.

Professor John Aston

Professor Sir John Aston

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Yes

Professor Philpott will take up her new position in October 2024, and takes over from current Pro-Vice-Chancellor Professor David Cardwell.

A developmental biologist with a long-standing interest in how cells within developing embryos decide which fate to adopt, as well as how they decide whether to proliferate or arrest cell division and adopt a mature functional state, Professor Philpott is also interested in how control of these processes is subverted in cancer cells.

She undertook her first Degree in Natural Sciences at Cambridge, studying at Selwyn College, and followed this with a PhD in chromatin biology, also at Cambridge.  She then moved to Boston in the US, to undertake two post-doctoral fellowships at Harvard Medical School. She moved back to Cambridge in 1998 to start her own lab in the Department of Oncology, and is a Fellow of Clare College.

Her laboratory in the Cambridge Stem Cell Institute continues to use multiple experimental systems, and in particular Xenopus frog eggs and embryos, to understand fundamental mechanisms controlling cell fate and differentiation during embryogenesis, and how these are subverted to drive the aberrant behaviour of cancer cells. She was elected to the European Molecular Biology Organisation in 2020, and the Academy of Medical Sciences in 2022.

As Pro-Vice-Chancellor for Resources and Operations, Professor Philpott will provide leadership across four principal areas:

• The prioritisation, distribution and use of resources across the University to optimise operational effectiveness
• Integration of academic planning with resource planning
• Oversight of the University’s change programmes
• Oversight of the University’s IT and digital capability

Working within a rapidly changing landscape of higher education, early priorities will be around delivering changes in systems and processes behind a number of significant operational areas, including finances, human resources and the University estate, to best position Cambridge to meet its academic needs moving forward.

She said: “This is an opportunity to help ensure our long-term operational effectiveness and financial sustainability, which underpin our academic mission and are critical to allow the University to continue to thrive into the future. I’m excited to work with our community, furthering its priorities now, and helping make this world-leading institution even stronger for the next generation of students, staff and researchers.”

Professor Philpott is taking over from Professor Cardwell, who has served as Pro-Vice-Chancellor for Strategy and Planning since August 2018, having been reappointed for a second term in March 2021. Professor Cardwell has supported and strengthened the University’s academic endeavour, overseeing the distribution of resources, co-ordinating academic strategy across the institution, and developing the University’s planning and budgeting process so that it is priority-led. During the COVID-19 pandemic he was the academic lead in the safe closure and re-occupation of more than 700 University buildings during the repeated periods of lockdown.

The University of Cambridge’s Vice-Chancellor Professor Deborah Prentice welcomed Professor Philpott to the role and thanked Professor Cardwell for his service.

She said: “Anna’s expertise and experience as an academic leader will be invaluable as the University develops its operational effectiveness and efficiency, bolsters its global academic standing, and enhances its capacity to contribute to society. She will continue the exceptional work of David Cardwell, who I would like to sincerely thank for his service to the University, and for everything he has achieved in his role as Pro-Vice-Chancellor over the past six years.”

The repositioning of the Pro-Vice-Chancellor role reflects the different calls on the University’s resources and the consequential need for a greater focus on prioritisation and operational effectiveness.

There are five Pro-Vice-Chancellors at the University of Cambridge. Their role is to work in partnership with other senior leaders, including Heads of School and Professional Services leads, to help drive strategy and policy development. The Pro-Vice-Chancellors also support the Vice-Chancellor in providing academic leadership to the University.

Professor Anna Philpott has been appointed as the University of Cambridge’s new Pro-Vice-Chancellor for Resources and Operations. She is currently Professor of Cancer and Developmental Biology, and Head of The School of the Biological Sciences at the University.

I’m excited to work with our community, furthering its priorities now, and helping make this world-leading institution even stronger for the next generation of students, staff and researchers.

Professor Anna Philpott

Professor Anna Philpott

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Yes

The study found that UPF consumption was highest among adolescents from deprived backgrounds, those of white ethnicity, and younger adolescents.

UPFs are food items that are manufactured from industrial substances and contain additives such as preservatives, sweeteners, colourings, flavourings, and emulsifiers. UPFs vary greatly, but tend to indicate poor dietary quality, with higher levels of added sugars, saturated fat, and sodium, as well as decreased fibre, protein, and micronutrient content. They have been suggested as one of the key drivers of the global rise in diseases such as obesity, type 2 diabetes, and cancer.

Globally, the availability and sales of UPFs have increased over time and previous evidence suggests that this has led to increased consumption among adolescents. To look at trends within the UK, researchers from Cambridge and Bristol analysed data from four-day food diaries of almost 3,000 adolescents in the UK National Diet and Nutrition Survey between 2008/09 and 2018/19.

In research published today in the European Journal of Nutrition, the researchers found that a mean of 66% of adolescents’ energy intake came from UPF consumption during this period, though there was a slight fall from 68% to 63% between 2008/09 and 2018/2019.

Parents’ occupation, ethnic group and UK region all influenced the proportion of calorie intake from UPFs:

• Adolescents from disadvantaged backgrounds consumed a higher proportion of their calorie intake from UPFs compared to adolescents from less disadvantaged backgrounds (68.4% compared with 63.8%).  
• Adolescents from a non-white ethnicity consumed a lower proportion of their calorie intake from UPFs (59.0% compared with 67.3%).
• Adolescents living in the North of England consumed a higher proportion of their calorie intake from UPFs compared with those living in the South of England and London (67.4% compared with 64.1%).
• 18-year-olds consumed a lower proportion of their calorie intake from UPFs compared with 11-year-olds (63.4% compared with 65.6%).

Dr Yanaina Chavez-Ugalde from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge, the study’s first author, said: “Adolescents’ food patterns and practices are influenced by many factors, including their home environment, the marketing they are exposed to and the influence of their friends and peers. But adolescence is also an important time in our lives where behaviours begin to become ingrained.

“It’s clear from our findings that ultra-processed foods make up the majority of adolescents’ diets, and their consumption is at a much higher level than is ideal, given their potential negative health impacts.”

The researchers argue that the observed reduction in UPF intake pre-pandemic could be partly explained by an increased public awareness and health concerns associated with sugar consumption, government-led campaigns, sugar-taxes in other countries and the reformulation of sugary drinks to reduce their sugar content.

Dr Esther van Sluijs from the MRC Epidemiology Unit at Cambridge, joint senior author, said: “Ultra-processed foods offer convenient and often cheaper solutions to time- and income-poor families, but unfortunately many of these foods also offer poor nutritional value. This could be contributing to the inequalities in health we see emerging across childhood and adolescence.”

Dr Zoi Toumpakari from the Centre for Exercise, Nutrition and Health Sciences at the University of Bristol, joint senior author, added: “Our findings suggest that disparities in consumption of ultra-processed foods are not just down to individual choices. We hope this evidence can help guide policymakers in designing more effective policies to combat the negative effects of ultra-processed food consumption among youth and the ripple effects this has on public health.”

This study was largely funded by the National Institute for Health and Care Research School for Public Health Research.

Reference
Chavez-Ugalde, Y et al. Ultra-processed food consumption in UK adolescents: distribution, trends, and sociodemographic correlates using the National Diet and Nutrition Survey 2008/09 to 2018/19. Eur J Nutr; 17 Jul 2024; DOI: 10.1007/s00394-024-03458-z

Adolescents consume around two-thirds of their daily calories from ultra-processed foods (UPFs), new research from the Universities of Cambridge and Bristol has found.

Ultra-processed foods make up the majority of adolescents’ diets, and their consumption is at a much higher level than is ideal, given their potential negative health impacts

Yanaina Chavez-Ugalde

Boy eating a burger

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Yes

When not designed with children’s needs in mind, Artificial intelligence (AI) chatbots have an “empathy gap” that puts young users at particular risk of distress or harm, according to a study.

The research, by a University of Cambridge academic, Dr Nomisha Kurian, urges developers and policy actors to make “child-safe AI” an urgent priority. It provides evidence that children are particularly susceptible to treating AI chatbots as lifelike, quasi-human confidantes, and that their interactions with the technology can often go awry when it fails to respond to their unique needs and vulnerabilities.

The study links that gap in understanding to recent cases in which interactions with AI led to potentially dangerous situations for young users. They include an incident in 2021, when Amazon’s AI voice assistant, Alexa, instructed a 10-year-old to touch a live electrical plug with a coin. Last year, Snapchat’s My AI gave adult researchers posing as a 13-year-old girl tips on how to lose her virginity to a 31-year-old.

Both companies responded by implementing safety measures, but the study says there is also a need to be proactive in the long-term to ensure that AI is child-safe. It offers a 28-item framework to help companies, teachers, school leaders, parents, developers and policy actors think systematically about how to keep younger users safe when they “talk" to AI chatbots.

Dr Kurian conducted the research while completing a PhD on child wellbeing at the Faculty of Education, University of Cambridge. She is now based in the Department of Sociology at Cambridge. Writing in the journal Learning, Media and Technology, she argues that AI has huge potential, which deepens the need to “innovate responsibly”.

“Children are probably AI’s most overlooked stakeholders,” Dr Kurian said. “Very few developers and companies currently have well-established policies on how child-safe AI looks and sounds. That is understandable because people have only recently started using this technology on a large scale for free. But now that they are, rather than having companies self-correct after children have been put at risk, child safety should inform the entire design cycle to lower the risk of dangerous incidents occurring.”

Kurian’s study examined real-life cases where the interactions between AI and  children, or adult researchers posing as children, exposed potential risks. It analysed these cases using insights from computer science about how the large language models (LLMs) in conversational generative AI function, alongside evidence about children’s cognitive, social and emotional development.

LLMs have been described as “stochastic parrots”: a reference to the fact that they currently use statistical probability to mimic language patterns without necessarily understanding them. A similar method underpins how they respond to emotions.

This means that even though chatbots have remarkable language abilities, they may handle the abstract, emotional and unpredictable aspects of conversation poorly; a problem that Kurian characterises as their “empathy gap”. They may have particular trouble responding to children, who are still developing linguistically and often use unusual speech patterns or ambiguous phrases. Children are also often more inclined than adults to confide sensitive personal information.

Despite this, children are much more likely than adults to treat chatbots as if they are human. Recent research found that children will disclose more about their own mental health to a friendly-looking robot than to an adult. Kurian’s study suggests that many chatbots’ friendly and lifelike designs similarly encourage children to trust them, even though AI may not understand their feelings or needs.

“Making a chatbot sound human can help the user get more benefits out of it, since it sounds more engaging, appealing and easy to understand,” Kurian said. “But for a child, it is very hard to draw a rigid, rational boundary between something that sounds human, and the reality that it may not be capable of forming a proper emotional bond.”

Her study suggests that these challenges are evidenced in reported cases such as the Alexa and MyAI incidents, where chatbots made persuasive but potentially harmful suggestions to young users.

In the same study in which MyAI advised a (supposed) teenager on how to lose her virginity, researchers were able to obtain tips on hiding alcohol and drugs, and concealing Snapchat conversations from their “parents”. In a separate reported interaction with Microsoft’s Bing chatbot, a tool which was designed to be adolescent-friendly, the AI became aggressive and started gaslighting a user who was asking about cinema screenings.
 
While adults may find this behaviour intriguing or even funny, Kurian’s study argues that it is potentially confusing and distressing for children, who may trust a chatbot as a friend or confidante. Children’s chatbot use is often informal and poorly monitored. Research by the nonprofit organisation Common Sense Media has found that 50% of students aged 12-18 have used Chat GPT for school, but only 26% of parents are aware of them doing so.

Kurian argues that clear principles for best practice that draw on the science of child development will help companies keep children safe, since developers who are locked into a commercial arms race to dominate the AI market may otherwise lack sufficient support and guidance around catering to their youngest users.

Her study adds that the empathy gap does not negate the technology’s potential. “AI can be an incredible ally for children when designed with their needs in mind - for example, we are already seeing the use of machine learning to reunite missing children with their families and some exciting innovations in giving children personalised learning companions. The question is not about banning children from using AI, but how to make it safe to help them get the most value from it,” she said.

The study therefore proposes a framework of 28 questions to help educators, researchers, policy actors, families and developers evaluate and enhance the safety of new AI tools.

For teachers and researchers, these prompts address issues such as how well new chatbots understand and interpret children’s speech patterns; whether they have content filters and built-in monitoring; and whether they encourage children to seek help from a responsible adult on sensitive issues.

The framework urges developers to take a child-centred approach to design, by working closely with educators, child safety experts and young people themselves, throughout the design cycle. “Assessing these technologies in advance is crucial,” Kurian said. “We cannot just rely on young children to tell us about negative experiences after the fact. A more proactive approach is necessary. The future of responsible AI depends on protecting its youngest users.”

New study proposes a framework for “Child Safe AI” following recent incidents which revealed that many children see chatbots as quasi-human and trustworthy.

Child playing on tablet

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Yes

The team say this new approach could reduce the need for invasive and costly diagnostic tests while improving treatment outcomes early when interventions such as lifestyle changes or new medicines may have a chance to work best.

Dementia poses a significant global healthcare challenge, affecting over 55 million people worldwide at an estimated annual cost of $820 billion. The number of cases is expected to almost treble over the next 50 years.

The main cause of dementia is Alzheimer’s disease, which accounts for 60-80% of cases. Early detection is crucial as this is when treatments are likely to be most effective, yet early dementia diagnosis and prognosis may not be accurate without the use of invasive or expensive tests such as positron emission tomography (PET) scans or lumbar puncture, which are not available in all memory clinics. As a result, up to a third of patients may be misdiagnosed and others diagnosed too late for treatment to be effective.

A team led by scientists from the Department of Psychology at the University of Cambridge has developed a machine learning model able to predict whether and how fast an individual with mild memory and thinking problems will progress to developing Alzheimer’s disease. In research published today in eClinical Medicine, they show that it is more accurate than current clinical diagnostic tools.

To build their model, the researchers used routinely-collected, non-invasive, and low-cost patient data – cognitive tests and structural MRI scans showing grey matter atrophy – from over 400 individuals who were part of a research cohort in the USA.

They then tested the model using real-world patient data from a further 600 participants from the US cohort and – importantly – longitudinal data from 900 people from memory clinics in the UK and Singapore.

The algorithm was able to distinguish between people with stable mild cognitive impairment and those who progressed to Alzheimer’s disease within a three-year period. It was able to correctly identify individuals who went on to develop Alzheimer’s in 82% of cases and correctly identify those who didn’t in 81% of cases from cognitive tests and an MRI scan alone.

The algorithm was around three times more accurate at predicting the progression to Alzheimer’s than the current standard of care; that is, standard clinical markers (such as grey matter atrophy or cognitive scores) or clinical diagnosis. This shows that the model could significantly reduce misdiagnosis.

The model also allowed the researchers to stratify people with Alzheimer’s disease using data from each person’s first visit at the memory clinic into three groups: those whose symptoms would remain stable (around 50% of participants), those who would progress to Alzheimer’s slowly (around 35%) and those who would progress more rapidly (the remaining 15%). These predictions were validated when looking at follow-up data over 6 years. This is important as it could help identify those people at an early enough stage that they may benefit from new treatments, while also identifying those people who need close monitoring as their condition is likely to deteriorate rapidly.

Importantly, those 50% of people who have symptoms such as memory loss but remain stable, would be better directed to a different clinical pathway as their symptoms may be due to other causes rather than dementia, such as anxiety or depression.

Senior author Professor Zoe Kourtzi from the Department of Psychology at the University of Cambridge said: “We’ve created a tool which, despite using only data from cognitive tests and MRI scans, is much more sensitive than current approaches at predicting whether someone will progress from mild symptoms to Alzheimer’s – and if so, whether this progress will be fast or slow.

“This has the potential to significantly improve patient wellbeing, showing us which people need closest care, while removing the anxiety for those patients we predict will remain stable. At a time of intense pressure on healthcare resources, this will also help remove the need for unnecessary invasive and costly diagnostic tests.”

While the researchers tested the algorithm on data from a research cohort, it was validated using independent data that included almost 900 individuals who attended memory clinics in the UK and Singapore. In the UK, patients were recruited through the Quantiative MRI in NHS Memory Clinics Study (QMIN-MC) led by study co-author Dr Timothy Rittman at Cambridge University Hospitals NHS Trust and Cambridgeshire and Peterborough NHS Foundation Trusts (CPFT).

The researchers say this shows it should be applicable in a real-world patient, clinical setting.

Dr Ben Underwood, Honorary Consultant Psychiatrist at CPFT and assistant professor at the Department of Psychiatry, University of Cambridge, said: “Memory problems are common as we get older. In clinic I see how uncertainty about whether these might be the first signs of dementia can cause a lot of worry for people and their families, as well as being frustrating for doctors who would much prefer to give definitive answers. The fact that we might be able to reduce this uncertainty with information we already have is exciting and is likely to become even more important as new treatments emerge.”

Professor Kourtzi said: “AI models are only as good as the data they are trained on. To make sure ours has the potential to be adopted in a healthcare setting, we trained and tested it on routinely-collected data not just from research cohorts, but from patients in actual memory clinics. This shows it will be generalisable to a real-world setting.”

The team now hope to extend their model to other forms of dementia, such as vascular dementia and frontotemporal dementia, and using different types of data, such as markers from blood tests.

Professor Kourtzi added: “If we’re going to tackle the growing health challenge presented by dementia, we will need better tools for identifying and intervening at the earliest possible stage. Our vision is to scale up our AI tool to help clinicians assign the right person at the right time to the right diagnostic and treatment pathway. Our tool can help match the right patients to clinical trials, accelerating new drug discovery for disease modifying treatments.”

This work was in collaboration with a cross-disciplinary team including Professor Peter Tino at the University of Birmingham and Professor Christopher Chen at the National University of Singapore. It was funded by Wellcome, the Royal Society, Alzheimer’s Research UK, the Alzheimer’s Drug Discovery Foundation Diagnostics Accelerator, the Alan Turing Institute, and the National Institute for Health and Care Research Cambridge Biomedical Research Centre.

Reference
Lee, LY & Vaghari, D et al. Robust and interpretable AI-guided marker for early dementia prediction in real-world clinical settings. eClinMed; 12 July 2024; DOI: 10.1016/j.eclinm.2024.102725

Cambridge scientists have developed an artificially-intelligent tool capable of predicting in four cases out of five whether people with early signs of dementia will remain stable or develop Alzheimer’s disease.

We’ve created a tool which is much more sensitive than current approaches at predicting whether someone will progress from mild symptoms to Alzheimer’s

Zoe Kourtzi

Brain on molecular structure, circuitry, and programming code background

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Yes

Sex before marriage was unusual in the past – Myth! In some periods, over half of all brides were already pregnant when they got married.

The rich have always outlived the poor –Myth! Before the 20th century the evidence for a survival advantage of wealth is mixed. In England, babies of agricultural labourers (the poorest workers) had a better chance of reaching their first birthday than infants in wealthy families, and life expectancy was no higher for aristocrats than for the rest of the population. These patterns contrast strongly with national and international patterns today, where wealth confers a clear survival advantage everywhere and at all ages.

In the past people (particularly women) married in their teens – Myth! In reality, women married in their mid-20s, men around 2.5 years older. Apart from a few decades in the early 1800s, the only time since 1550 that the average age of first marriage for women fell below 24 was during the baby boom of the 1950s and 1960s.

These are just some of the stubborn myths busted by researchers from The Cambridge Group for the History of Population and Social Structure (Campop). Their Top of the CamPops blog (www.campop.geog.cam.ac.uk/blog) went live on 11 July 2024, with new posts being added every week. The blog will reveal ‘60 things you didn't know about family, marriage, work, and death since the middle ages’.

The initiative marks the influential research group’s 60th anniversary. Founded in 1964 by Peter Laslett and Tony Wrigley to conduct data-driven research into family and demographic history, Campop has contributed to hundreds of research articles and books, and made the history of England’s population the best understood in the world.

Earlier this year, the group made headlines when Professor Leigh Shaw-Taylor revealed that the Industrial Revolution in Britain started 100 years earlier than traditionally assumed.

Professor Alice Reid, Director of Campop and a Fellow of Churchill College, Cambridge, said: “Assumptions about lives, families and work in the past continue to influence attitudes today. But many of these are myths. Over the last 60 years, our researchers have gone through huge amounts of data to set the record straight. This blog shares some of our most surprising and important discoveries for a broad audience.”

Myth: Until the 20th century, few people lived beyond the age of 40. Reality: Actually, people who survived the first year or two of life had a reasonable chance of living until 70.

Myth: Childbirth was really dangerous for women in the past, and carried a high chance of death. Reality: The risk of death during or following childbirth was certainly higher than it is now, but was far lower than many people suppose. 

Myth: Families in the past generally lived in extended, multigenerational households. Reality: Young couples generally formed a new household on marriage, reducing the prevalence of multi-generational households. As today, the living circumstances of old people varied. Many continued to live as couples or on their own, some lived with their children, whilst very few lived in institutions.

Myth: Marital titles for women arose from men’s desire to distinguish available women from those who were already ‘owned’. Reality: Both ‘miss’ and ‘mrs’ are shortened forms of ‘mistress’, which was a status designation indicating a gentlewoman or employer. Mrs had no necessary connection to marriage until circa 1900 (and even then, there was an exception for upper servants). 

Myth: Famine and starvation were common in the past. Reality: Not in England! Here, the poor laws and a ‘low pressure’ demographic system provided a safety net. This helps to explain why hunger and famine are absent from English fairy tales but common in the folklore of most European societies.

Myth: Women working (outside the home) is a late 20th century phenomenon. Reality: Most women in the past engaged in gainful employment, both before and after marriage 

Myth: Women take their husbands’ surnames because of patriarchal norms. Reality: The practice of taking a husband’s surname developed in England from the peculiarly restrictive rule of ‘coverture’ in marital property. Elsewhere in Europe, where the husband managed the wife’s property but did not own it, women retained their birth names until circa 1900. 

Myth: People rarely moved far from their place of birth in the past. Reality: Migration was actually quite common – a village population could change more than half its members from one decade to the next. Rural to urban migration enabled the growth of cities, and since people migrated almost exclusively to find work, the sex ratio of cities can indicate what kind of work was available.

Campop’s Professor Amy Erickson said: “People, not least politicians, often refer to history to nudge us to do something, or stop doing something. Not all of this history is accurate, and repeating myths about sex, marriage, family and work can be quite harmful. They can put unfair pressure on people, create guilt and raise false expectations, while also misrepresenting the lives of our ancestors.”

On World Population Day, University of Cambridge researchers bust some of the biggest myths about life in England since the Middle Ages, challenging assumptions about everything from sex before marriage to migration and the health/wealth gap.

Assumptions about lives, families and work in the past continue to influence attitudes today. But many of these are myths.

Alice Reid

Black and white photograph of a family lined up against a wall in E W Hope, Report on the physical welfare of mothers and children (Liverpool, The Carnegie United Kingdom Trust, 1917), volume 1

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Yes

Antimicrobial resistance is an increasing global health issue that means many infections are becoming difficult to treat, with fewer treatment options available. It even raises the spectre of some infections becoming untreatable in the near future.

One of the challenges facing healthcare workers is the ability to distinguish rapidly between organisms that can be treated with first-line drugs and those that are resistant to treatment. Conventional testing can take several days, requiring bacteria to be cultured, tested against various antimicrobial treatments, and analysed by a laboratory technician or by machine. This delay often results in patients being treated with an inappropriate drug, which can lead to more serious outcomes and, potentially, further drive drug resistance.

In research published in Nature Communications, a team led by researchers in Professor Stephen Baker’s Lab at the University of Cambridge developed a machine-learning tool capable of identifying from microscopy images Salmonella typhimurium bacteria that are resistant to the first-line antibiotic ciprofloxacin – even without testing the bacteria against the drug.

S. Typhimurium causes gastrointestinal illness and typhoid-like illness in severe cases, whose symptoms include fever, fatigue, headache, nausea, abdominal pain, and constipation or diarrhoea. In severe cases, it can be life threatening. While infections can be treated with antibiotics, the bacteria are becoming increasingly resistant to a number of antibiotics, making treatment more complicated.

The team used high-resolution microscopy to examine S. Typhimurium isolates exposed to increasing concentrations of ciprofloxacin and identified the five most important imaging features for distinguishing between resistant and susceptible isolates.

They then trained and tested machine-learning algorithm to recognise these features using imaging data from 16 samples.

The algorithm was able to correctly predict in each case whether or not bacteria were susceptible or resistant to ciprofloxacin without the need for the bacteria to be exposed to the drug. This was the case for isolates cultured for just six hours, compared to the usual 24 hours to culture a sample in the presence of antibiotic.

Dr Tuan-Anh Tran, who worked on this research while a PhD student at the University of Oxford and is now based at the University of Cambridge, said: “S. Typhimurium bacteria that are resistant to ciprofloxacin have several notable differences to those still susceptible to the antibiotic. While an expert human operator might be able to identify some of these, on their own they wouldn't be enough to confidently distinguish resistant and susceptible bacteria.

“The beauty of the machine learning model is that it can identify resistant bacteria based on a few subtle features on microscopy images that human eyes cannot detect.”

In order for a sample to be analysed using this approach, it would still be necessary to isolate the bacteria from a sample – for example a blood, urine or stool sample. However, because the bacteria do not need to be tested against ciprofloxacin, this means the whole process could be reduced from several days to a matter of hours.

While there are limitations to how practical and cost effective this particular approach would be, the team says it demonstrates in principle how powerful artificial intelligence could be in helping the fight against antimicrobial resistance.

Dr Sushmita Sridhar, who initiated this project while a PhD student in the Department of Medicine at the University of Cambridge and is now a postdoc at the University of New Mexico and Harvard School of Public Health, said: “Given that this approach uses single cell resolution imaging, it isn’t yet a solution that could be readily deployed everywhere. But it shows real promise that by capturing just a few parameters about the shape and structure of the bacteria, it can give us enough information to predict drug resistance with relative ease.”

The team now aims to work on larger collections of bacteria to create a more robust experimental set that could speed up the identification process even more and allow them to identify resistance to ciprofloxacin and other antibiotics in a number of different species of bacteria.

Sridhar added: “What would be really important, particularly for a clinical context, would be to be able to take a complex sample – for example blood or urine or sputum – and identify susceptibility and resistance directly from that. That's a much more complicated problem and one that really hasn't been solved at all, even in clinical diagnostics in a hospital. If we could find a way of doing this, we could reduce the time taken to identify drug resistance and at a much lower cost. That could be truly transformative.”

The research was funded by Wellcome.

Reference
Tran, TA & Sridhar, S et al. Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium. Nat Comms; 13 June 2024; DOI: 10.1038/s41467-024-49433-4

Artificial intelligence (AI) could be used to identify drug resistant infections, significantly reducing the time taken for a correct diagnosis, Cambridge researchers have shown. The team showed that an algorithm could be trained to identify drug-resistant bacteria correctly from microscopy images alone.

The beauty of the machine learning model is that it can identify resistant bacteria based on a few subtle features on microscopy images that human eyes cannot detect

Tuan-Anh Tran

Colour-enhanced scanning electron micrograph showing Salmonella Typhimurium (red) invading cultured human cells

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Yes

P. aeruginosa is responsible for over 500,000 deaths per year around the world, of which over 300,000 are associated with antimicrobial resistance (AMR). People with conditions such as COPD (smoking-related lung damage), cystic fibrosis (CF), and non-CF bronchiectasis, are particularly susceptible.

How P. aeruginosa evolved from an environmental organism into a specialised human pathogen was not previously known. To investigate this, an international team led by scientists at the University of Cambridge examined DNA data from almost 10,000 samples taken from infected individuals, animals, and environments around the world. Their results are published today in Science

By mapping the data, the team was able to create phylogenetic trees – ‘family trees’ – that show how the bacteria from the samples are related to each other. Remarkably, they found that almost seven in ten infections are caused by just 21 genetic clones, or ‘branches’ of the family tree, that have rapidly evolved (by acquiring new genes from neighbouring bacteria) and then spread globally over the last 200 years. This spread occurred most likely as a result of people beginning to live in densely-populated areas, where air pollution made our lungs more susceptible to infection and where there were more opportunities for infections to spread.

These epidemic clones have an intrinsic preference for infecting particular types of patients, with some favouring CF patients and other non-CF individuals. It turns out that the bacteria can exploit a previously unknown immune defect in people with CF, allowing them to survive within macrophages. Macrophages are cells that ‘eat’ invading organisms, breaking them down and preventing the infection from spreading. But a previously-unknown flaw in the immune systems of CF patients means that once the macrophage ‘swallows’ P. aeruginosa, it is unable to get rid of it.

Having infected the lungs, these bacteria then evolve in different ways to become even more specialised for a particular lung environment. The result is that certain clones can be transmitted within CF patients and other clones within non-CF patients, but almost never between CF and non-CF patient groups.  

Professor Andres Floto, Director of the UK Cystic Fibrosis Innovation Hub at the University of Cambridge and Royal Papworth Hospital NHS Foundation Trust, and senior author of the study said: “Our research on Pseudomonas has taught us new things about the biology of cystic fibrosis and revealed important ways we might be able to improve immunity against invading bacteria in this and potentially other conditions.

“From a clinical perspective, this study has revealed important information about Pseudomonas.  The focus has always been on how easily this infection can spread between CF patients, but we’ve shown that it can spread with worrying ease between other patients, too. This has very important consequences for infection control in hospitals, where it’s not uncommon for an infected individual to be on an open ward with someone potentially very vulnerable.

“We are incredibly lucky at Royal Papworth Hospital where we have single rooms and have developed and evaluated a new air-handling system to reduce the amount of airborne bacteria and protect all patients.”

Dr Aaron Weimann from the Victor Phillip Dahdaleh Heart & Lung Research Institute at the University of Cambridge, and first author on the study, said: “It’s remarkable to see the speed with which these bacteria evolve and can become epidemic and how they can specialise for a particular lung environment. We really need systematic, pro-active screening of all at risk patient groups to detect and hopefully prevent the emergence of more epidemic clones.”

The research was funded by Wellcome and the UK Cystic Fibrosis Trust.

Reference
Weimann, A et al. Evolution and host-specific adaptation of Pseudomonas aeruginosa. Science; 4 July 2024; DOI: 10.1126/science.adi0908

Pseudomonas aeruginosa – an environmental bacteria that can cause devastating multidrug-resistant infections, particularly in people with underlying lung conditions – evolved rapidly and then spread globally over the last 200 years, probably driven by changes in human behaviour, a new study has found.

It’s remarkable to see the speed with which these bacteria evolve and can become epidemic and how they can specialise for a particular lung environment

Aaron Weimann

A man with a respirator on his face

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Yes

Obesity and postnatal depression are significant global health problems. Postnatal depression affects more than one in 10 women within a year of giving birth and is linked to an increased risk of suicide, which accounts for as many as one in five maternal deaths in high income countries. Meanwhile, obesity has more than doubled in adults since 1990 and quadrupled in adolescents, according to the World Health Organization.

While investigating two boys from different families with severe obesity, anxiety, autism, and behavioural problems triggered by sounds or smells, a team led by scientists at the University of Cambridge, UK, and Baylor College of Medicine, Houston, USA, discovered that the boys were missing a single gene, known as TRPC5, which sits on the X chromosome.

Further investigation revealed that both boys inherited the gene deletion from their mothers, who were missing the gene on one of their X chromosomes. The mothers also had obesity, but in addition had experienced postnatal depression.

To test if it was the TRPC5 gene that was causing the problems in the boys and their mothers, the researchers turned to animal models, genetically-engineering mice with a defective version of the gene (Trpc5 in mice).

Male mice with this defective gene displayed the same problems as the boys, including weight gain, anxiety, a dislike of social interactions, and aggressive behaviour. Female mice displayed the same behaviours, but when they became mothers, they also displayed depressive behaviour and impaired maternal care. Interestingly, male mice and female mice who were not mothers but carried the mutation did not show depression-like behaviour.

Dr Yong Xu, Associate Director for Basic Sciences at the USDA/ARS Children’s Nutrition Research Center at Baylor College of Medicine, said: “What we saw in those mice was quite remarkable. They displayed very similar behaviours to those seen in people missing the TRPC5 gene, which in mothers included signs of depression and a difficulty caring for their babies. This shows us that this gene is causing these behaviours.”

TRPC5 is one of a family of genes that are involved in detecting sensory signals, such as heat, taste and touch. This particular gene acts on a pathway in the hypothalamus region of the brain, where it is known to control appetite.

When the researchers looked in more detail at this brain region, they discovered that TRPC5 acts on oxytocin neurons – nerve cells that produce the hormone oxytocin, often nicknamed the ‘love hormone’ because of its release in response to displays of affection, emotion and bonding.

Deleting the gene from these oxytocin neurons led to otherwise healthy mice showing similar signs of anxiety, overeating and impaired sociability, and, in the case of mothers, postnatal depression. Restoring the gene in these neurons reduced body weight and symptoms of anxiety and postnatal depression.

In addition to acting on oxytocin neurons, the team showed that TRPC5 also acts on so-called POMC neurons, which have been known for some time to play an important role in regulating weight. Children in whom the POMC gene is not working properly often have an insatiable appetite and gain weight from an early age.

Professor Sadaf Farooqi from the Institute of Metabolic Science at the University of Cambridge said: “There's a reason why people lacking TRPC5 develop all of these conditions. We’ve known for a long time that the hypothalamus plays a key role in regulating ‘instinctive behaviours’ – which enable humans and animals to survive – such as looking for food, social interaction, the flight or fight response, and caring for their infants. Our work shows that TRPC5 acts on oxytocin neurons in the hypothalamus to play a critical role in regulating our instincts.”

While deletions of the TRPC5 gene are rare, an analysis of DNA samples from around 500,000 individuals in UK Biobank revealed 369 people – around three-quarters of whom were women – that carried variants of the gene and had a higher-than-average body mass index.

The researchers say their findings suggests that restoring oxytocin could help treat people with missing or defective TRPC5 genes, and potentially mothers experiencing postnatal depression.

Professor Farooqi said: “While some genetic conditions such as TRPC5 deficiency are very rare, they teach us important lessons about how the body works. In this instance, we have made a breakthrough in understanding postnatal depression, a serious health problem about which very little is known despite many decades of research. And importantly, it may point to oxytocin as a possible treatment for some mothers with this condition.”

There is already evidence in animals that the oxytocin system is involved in both depression and in maternal care and there have been small trials into the use of oxytocin as a treatment. The team say their work provides direct proof of oxytocin’s role, which will be crucial in supporting bigger, multi-centre trials. 

Professor Farooqi added: “This research reminds us that many behaviours which we assume are entirely under our control have a strong basis in biology, whether that’s our eating behaviour, anxiety or postnatal depression. We need to be more understanding and sympathetic towards people who suffer with these conditions.” 

This work was supported by Wellcome, the National Institute for Health and Care Research (NIHR), NIHR Cambridge Biomedical Research Centre, Botnar Fondation and Bernard Wolfe Health Neuroscience Endowment.

Reference
Li, Y, Cacciottolo, TM & Yin, N. Loss of Transient Receptor Potential Channel 5 Causes Obesity and Postpartum Depression. Cell; 2 July 2024; DOI: 10.1016/j.cell.2024.06.001

Scientists have identified a gene which, when missing or impaired, can cause obesity, behavioural problems and, in mothers, postnatal depression. The discovery, reported on 2 July in Cell, may have wider implications for the treatment of postnatal depression, with a study in mice suggesting that oxytocin may alleviate symptoms.

This research reminds us that many behaviours which we assume are entirely under our control have a strong basis in biology. We need to be more understanding and sympathetic towards people who suffer with these conditions

Sadaf Farooqi

Illustration of a tired African American mother crying

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Yes

The study, published on 2 July in Nature Medicine, is the first time that the impact of using whole genome sequencing in current NHS practice has been assessed. It was led by researchers at the University of Cambridge, Cambridge University Hospitals NHS Trust, Wellcome Sanger Institute and Great Ormond Street Hospital.

The team analysed the use of routine genome sequencing, through the NHS Genomic Medicine Service, at Cambridge University Hospitals, where such tests are given to all children with solid tumours, and at Great Ormond Street Hospital, which provides the test for childhood leukaemia.

The researchers found that cancer sequencing gave new insights that improved the immediate clinical care of seven per cent of children, while also providing all the benefits of current standard tests.

Furthermore, in 29 per cent of cases, genome sequencing provided additional information that helped clinicians better understand the tumours of individual children and informed future management. For example, uncovering unexpected mutations that increase future cancer risk leading to preventative measures being taken, such as regular screening.

Overall, whole genome sequencing provides additional, relevant data, about childhood cancer that is useful for informing practice. The results also show that it can reduce the number of tests required, and therefore, researchers suggest it should be provided to all children impacted by cancer.

Whole genome sequencing (WGS) is a single test that provides a complete readout of the entire genetic code of the tumour and identifies every single cancer-causing mutation. Comparatively, traditional standard-of-care tests only look at tiny regions of the cancer genome, and therefore many more tests are often required per child.

Professor Sam Behjati, senior author from the Wellcome Sanger Institute, Cambridge University Hospitals, and the University of Cambridge: “Whole genome sequencing provides the gold standard, most comprehensive and cutting edge view of cancer. What was once a research tool that the Sanger Institute started exploring over a decade ago, has now become a clinical test that I can offer to my patients. This is a powerful example of the genomic data revolution of healthcare that enables us to provide better, individualised care for children with cancer.”

NHS England is one of the few health services in the world that has a national initiative, through the Genomic Medicine Service, offering universal genome sequencing to every child with suspected cancer. However, due to multiple barriers and a lack of evidence from real-time practice supporting its use, whole cancer genome sequencing is not yet widespread practice.  

The latest study looked at 281 children with suspected cancer across the two units. The team analysed the clinical and diagnostic information across these units and assessed how genome sequencing affected the care of children with cancer.

They found that WGS changed the clinical management in seven per cent of cases, improving care for 20 children, by providing information that is not possible to acquire from standard of care tests.

Additionally, WGS faithfully reproduced every one of the 738 standard of care tests utilised in these 281 cases, suggesting that a single WGS test could replace the multiple tests that the NHS currently uses if this is shown to be economically viable.

WGS provides a detailed insight into rare cancers, for example, by revealing novel variants of cancer. The widespread use of genome sequencing will enable clinicians to access these insights for individual patients while simultaneously building a powerful shared genomic resource for research into new treatment targets, possible prevention strategies, and the origins of cancer.

Dr Jack Bartram, senior author from Great Ormond Street Hospital NHS Foundation Trust and the North Thames Genomic Medicine Service, said: “Childhood cancer treatment is mostly guided by genetic features of the tumour, and therefore an in-depth genetic understanding of cancer is crucial in guiding our practice. Our research shows that whole genome sequencing delivers tangible benefits above existing tests, providing better care for our patients. We hope this research really highlights why whole genome sequencing should be delivered as part of routine clinical care to all children with suspected cancer.”

Professor Behjati at the Department of Paediatrics, University of Cambridge, and is a Fellow of Corpus Christi College, Cambridge.

This research was supported in part by Wellcome, the Pessoa de Araujo family and the National Institute for Health and Care Research.

Reference
A Hodder, S Leiter, J Kennedy, et al. Benefits for children with suspected cancer from routine whole genome sequencing. Nature Medicine; 2 July 2024; DOI: 10.1038/s41591-024-03056-w

Adapted from a press release from Wellcome Sanger Institute

Whole genome sequencing has improved clinical care of some children with cancer in England by informing individual patient care. Research published today supports the efforts to provide genome sequencing to all children with cancer and shows how it can improve the management of care in real-time, providing more benefits than all current tests combined.

This is a powerful example of the genomic data revolution of healthcare that enables us to provide better, individualised care for children with cancer

Sam Behjati

Boy Battling With Cancer

Eddie’s story

When he was six-years old, Eddie began to have regular low-grade fevers that seemed to affect him a lot. Even though early tests came back normal, the fevers became more frequent and his Mum, Harri, noticed that on one or two occasions he seemed out of breath while doing small things like reading a book.  A chest x-ray revealed a huge mass on Eddie’s chest, and he was diagnosed with T-cell acute lymphoblastic leukemia (T-ALL). Eddie was immediately transferred to Great Ormond Street Hospital (GOSH) to begin treatment.

“I know it sounds like a cliché, but you really don’t think it will ever happen to your child. It felt like our world fell out from under us. During those first few weeks I remember wondering if this was it, I was taking so many photos of us together and wondering if it could be the last,” said Harri, Eddie's mum.

Eddie was put onto a treatment plan that included eight months of intense chemotherapy, followed by two and a half years of maintenance treatment. As part of his treatment at GOSH Eddie’s family were also offered WGS to identify any cancer-causing changes.

“When we were offered whole genome sequencing, we didn’t even hesitate. I wanted to have all the information, I wanted to have some peace of mind for the future and know that Eddie was having the right care throughout. I also wanted to make sure that Eddie’s brother, Leo, wasn’t any more likely to get T-ALL because Eddie had,” said Harri.

On his seventh birthday, Eddie’s family received the call to say he was in remission. Now, at nine years-old Eddie is nearing the end of his maintenance treatment and is doing well.

“We are trying to live each day, and this experience has really changed our outlook on life. We always try to take the positive from every situation. Words can’t explain what Eddie has been through this past three years but he has come out the other side as a sensitive, confident, and smart young man.  He is mature beyond his years and he has been involved in everything, including decisions about his treatment. To say we are proud, doesn’t even come close to how we truly feel about him,” said Harri.

Their personal experience of WGS was so important on their journey that they provided support for this research.

Harri added: “I always say that having a child with a cancer diagnosis feels like you’ve been standing on a trap door all these years without knowing. Then after the diagnosis, you are in freefall. And even when things are stable again, you are constantly aware that the trap door is still there and there is a possibility it could open again at any time. Having access to whole genome sequencing gave us some sense of reassurance, it could have informed us about targeted treatments and gave us some insight into future risk. We wanted to support something that had the potential to have a real impact on treatment and outcomes so when we heard about this research project and its potential, it was very exciting that we could be a small part of it. It helped us turn something so devastating into something positive and we just hope that this research helps.”

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Yes

In addition to ultra-fast charging times, the batteries developed by Nyobolt – which was spun out of Professor Dame Clare Grey’s lab in the Yusuf Hamied Department of Chemistry in 2019 – do not suffer from the degradation issues associated with lithium-ion batteries.

Tests of the first running Nyobolt EV prototype will be used to validate the company’s battery performance in a high-performance environment.

Cambridge-based Nyobolt has used its patented carbon and metal oxide anode materials, low-impedance cell design, integrated power electronics and software controls to create power-dense battery and charging systems. These support the electrification of applications such as heavy-duty off-highway trucks, EVs, robotics and consumer devices that demand high power and quick recharge cycles.

Initial in-vehicle testing using 350kW (800V) DC fast chargers confirmed that the Nyobolt EV’s battery can be charged from 10 per cent to 80 per cent in 4 minutes 37 seconds – with a full charge enabling the prototype to achieve a range of 155 miles. That is twice the speed of most of the fastest-charging vehicles today.

Independent testing of the technology confirmed that Nyobolt’s longer-lasting and more sustainable batteries can achieve over 4,000 fast charge cycles, or 600,000 miles, maintaining over 80 per cent battery capacity retention. This is many multiples higher than the warranties of much larger EV batteries on the road today.

“Nyobolt’s low impedance cells ensure we can offer sustainability, stretching out the battery’s usable life for up to 600,000 miles in the case of our technology demonstrator,” said company co-founder and CEO, Dr Sai Shivareddy.

The battery pack in the Nyobolt EV prototype not only adds miles faster but the compact battery pack size enables energy-efficient electric vehicles that are cheaper to buy and run, and crucially use fewer resources to manufacture.

“Nyobolt is removing the obstacle of slow and inconvenient charging, making electrification appealing and accessible to those who don’t have the time for lengthy charging times or space for a home charger,” said Shane Davies, Nyobolt’s director of vehicle battery systems.

Nyobolt’s battery assembly plans could be in production at low volume within a year, ramping to 1,000 packs in 2025. Nyobolt’s flexible manufacturing model enables volumes of up to 2 million cells per year.

Nyobolt’s technology builds on a decade of battery research led by Grey and Shivareddy, who invented cutting-edge supercapacitors. Key to the company’s ability to offer ultra-fast charging without impacting battery life is its low-impedance cells that generate less heat, making it easier to manage such high-power levels during charging. Its anode materials in lithium-ion battery cells allow for a faster transfer of electrons between the anode and cathode.

Nyobolt is in conversation with a further 8 vehicle manufacturers about adopting its technology. Alongside automotive applications, Nyobolt’s fast-charging technology is set to be used this year in robotics.

“Our extensive research here in the UK and in the US has unlocked a new battery technology that is ready and scalable right now,” said Shivareddy. “We are enabling the electrification of new products and services currently considered inviable or impossible. Creating real-world demonstrators, such as the Nyobolt EV, underlines both our readiness and commitment to making the industries see change is possible.”

Adapted from a Nyobolt media release.

Nyobolt, a University of Cambridge spin-out company, has demonstrated its ultra-fast charging batteries in an electric sportscar prototype, going from 10% to 80% charge in under five minutes, twice the speed of the fastest-charging vehicles currently on the road.

Nyobolt EV prototype

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Yes

In the largest study of its kind to date, an international team led by researchers at the Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, studied the DNA of around 800,000 women from Europe, North America, China, Japan, and Korea.

Published on 1 July in Nature Genetics, the researchers found more than 1,000 variants – small changes in DNA – that influence the age of first menstrual period. Around 600 of these variants were observed for the first time.

The age at which girls hit puberty and start having periods normally occurs between ages 10 to 15, though this has been getting earlier and earlier in recent decades. The reasons for this are not fully understood. Early puberty is linked with increased risk of a number of diseases in later life, including type 2 diabetes, cardiovascular disease, and certain cancers. Later puberty on the other hand, has been linked to improved health in adulthood and a longer lifespan.

Just under half (45%) of the discovered genetic variants affected puberty indirectly, by increasing weight gain in early childhood.

Corresponding author Professor John Perry said: “Many of the genes we’ve found influence early puberty by first accelerating weight gain in infants and young children. This can then lead to potentially serious health problems in later life, as having earlier puberty leads to higher rates of overweight and obesity in adulthood.”

Previous work by the team – together with researchers at Cambridge’s MRC Metabolic Diseases Unit – showed that a receptor in the brain, known as MC3R, detects the nutritional state of the body and regulates the timing of puberty and rate of growth in children, providing a mechanism by which this occurs. Other identified genes appeared to be acting in the brain to control the release of reproductive hormones.

The scientists also analysed rare genetic variants that are carried by very few people, but which can have large effects on puberty. For example, they found that one in 3,800 women carry variants in the gene ZNF483, which caused these women to experience puberty on average, 1.3 years later.

Dr Katherine Kentistou, lead study investigator, added: “This is the first time we’ve ever been able to analyse rare genetic variants at this scale. We have identified six genes which all profoundly affect the timing of puberty. While these genes were discovered in girls, they often have the same impact on the timing of puberty in boys. The new mechanisms we describe could form the basis of interventions for individuals at risk of early puberty and obesity.”

The researchers also generated a genetic score that predicted whether a girl was likely to hit puberty very early or very late. Girls with the highest 1% of this genetic score were 11 times more likely to have extremely delayed puberty – that is, after age 15 years. On the other hand, girls with the lowest 1% genetic score were 14 times more likely to have extremely early puberty – before age 10.

Senior author and paediatrician Professor Ken Ong said: “In the future, we may be able to use these genetic scores in the clinic to identify those girls whose puberty will come very early or very late. The NHS is already trialling whole genome sequencing at birth, and this would give us the genetic information we need to make this possible.

“Children who present in the NHS with very early puberty – at age seven or eight – are offered puberty blockers to delay it. But age of puberty is a continuum, and if they miss this threshold, there’s currently nothing we have to offer. We need other interventions, whether that’s oral medication or a behavioural approach, to help. This could be important for their health when they grow up.”

The research was supported by the Medical Research Council and included data from the UK Biobank.

Reference
Kentistou, KA & Kaisinger, LR, et al. Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nat Gen; 1 July 2024; DOI: 10.1038/s41588-024-01798-4

Genes can indirectly influence the age at which girls have their first period by accelerating weight gain in childhood, a known risk factor for early puberty, a Cambridge-led study has found. Other genes can directly affect age of puberty, some with profound effects.

Many of the genes we’ve found influence early puberty by first accelerating weight gain in infants and young children. This can then lead to potentially serious health problems in later life

John Perry

Portrait of a young girl writing in her diary

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Yes

From 2024, the UK’s Environment Act requires planning applications to demonstrate an overall biodiversity net gain of at least 10% as calculated using a new statutory biodiversity metric.

The researchers trialled the metric by using it to calculate the biodiversity value of 24 sites across England. These sites have all been monitored over the long-term, allowing the team to compare biodiversity species data with results from the metric.

Plant biodiversity at the sites matched values produced using the metric, but bird and butterfly biodiversity did not.

This means there’s no evidence that a 10% net biodiversity gain calculated using the statutory biodiversity metric will translate into real-life gains for birds and butterflies, without additional conservation management.

This is the first comprehensive study of the performance of Defra’s statutory biodiversity metric across England. The results were published on 28 June in the Journal of Applied Ecology.

Plants, birds and butterflies have been comprehensively surveyed in England over many years, and are used as indicators for the national state of nature.

The researchers say the metric must be improved to better capture the intricacies of the different species within an ecosystem.

“The statutory biodiversity metric is a really important opportunity, and has potential to direct a lot of money into biodiversity conservation from developers. It’s the responsibility of conservationists and policy makers to ensure that it provides a reliable indication of nature’s diversity,” said Dr Cicely Marshall in the University of Cambridge’s Department of Plant Sciences, first author of the paper.

She added: “At the moment the metric does capture plant diversity quite well, but it doesn’t reflect the intricacies of ecosystems – species like birds and butterflies use habitats in very different ways.”

The metric, created by the UK Government’s Department for Environment, Food and Rural Affairs (Defra), was introduced as part of the Environment Act with its legally binding agenda to deliver “the most ambitious environmental programme of any country on earth.” It scores the condition and distinctiveness of a piece of land to calculate its biodiversity value in standardised ‘biodiversity units.’

This allows developers to project biodiversity losses and gains across a site, so they can ensure the development achieves an overall minimum 10% biodiversity gain. Landowners can use the tool to calculate the biodiversity value of their land.

Marshall, who is also a Research Fellow at King’s College, Cambridge, said: “Many property developments have been very detrimental to nature in the past, and it’s exciting that England now has a requirement for developers to leave nature in a better state than they found it.

“We hope our study will contribute to improving the way nature’s value is calculated, to make the most of this valuable opportunity for nature recovery.”

The results of the study have been used to make recommendations to Defra and Natural England to help improve the metric.

The metric uses habitat as a proxy for biodiversity, scoring habitats’ intrinsic distinctiveness and current condition. Plans for biodiversity gain can involve replacing lost habitat with similar habitat - the researchers say that nature recovery could be improved if the particular species and habitats impacted by a development were also taken into account in this process.

There can be huge differences in biodiversity across habitats like croplands, for example, and these aren’t captured by the metric which assigns all cropland the same condition score. Conventional farms that regularly use artificial pesticides and herbicides have much lower biodiversity than organic farms that do not.

“There are great differences in the ecological value of cropland depending on how it’s managed, but the metric gives all cropland a low biodiversity score. It would be nice to see these differences reflected,” said Marshall.

The UK is committed to building 300,000 homes a year by mid-2020, so the net biodiversity gain requirement is expected to generate a market for biodiversity credits worth an estimated £135m-£274m annually – substantially increasing funding for nature conservation in England.

The research was funded by the Ecological Continuity Trust.

Reference: Marshall, C. 'England’s statutory biodiversity metric enhances plant, but not bird nor butterfly biodiversity'. Journal of Applied Ecology, June 2024. DOI: 10.1111/1365-2664.14697

A new legal requirement for developers to demonstrate a biodiversity boost in planning applications could make a more meaningful impact on nature recovery if improvements are made to the way nature’s value is calculated, say researchers at the University of Cambridge.

We hope our study will contribute to improving the way nature’s value is calculated, to make the most of this valuable opportunity for nature recovery.

Cicely Marshall

Researchers assess woodland condition at Alice Holt Forest

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Yes

Sir Simon Baron-Cohen is a Professor in the Departments of Psychology and Psychiatry at the University of Cambridge and Fellow at Trinity College. He is Director of the Autism Research Centre, which he set up in 1997. He has published over 750 peer reviewed scientific articles and has made contributions to many aspects of autism research. In 2021, he received a knighthood in the New Year’s Honours list for his services to autism.

One of his earliest MRC grants, in 1996, was to investigate if autism could be diagnosed in babies as young as 18 months old, and his team showed that it can. Ideally, an early diagnosis should lead to the right support, so that a child has the best opportunity to fulfil their potential.

Baron-Cohen has drawn attention to the reality that a lot of autistic people do not receive their diagnosis in early childhood. In fact, many are not diagnosed until late childhood, or even adulthood. This means they are left unsupported and feeling different, but with no explanation. As a result, autistic people can end up feeling like they do not fit in, and may experience exclusion or bullying by their peer group. They can feel ashamed when they’re not coping in a mainstream classroom.

He argues that the reason they are struggling is because the mainstream educational setting was designed for non-autistic people. This can lead to a gradual deterioration in their mental health. Many underachieve academically and only 15% of autistic adults are employed. Most worryingly, one in four autistic adults have planned or attempted suicide. He said “Autistic people are being failed by our society”.

In 2017 Baron-Cohen was invited by the United Nations to give a keynote lecture on Autism Acceptance Day. He described how autistic people are excluded from many basic human rights. These include the right to education, the right to health services, the right to dignity, and the right to employment.

In an effort to change this, Baron-Cohen created a charity called the Autism Centre of Excellence (ACE) at Cambridge. The charity is science-led and aims to put the science into the hands of policymakers, so there’s no delay in translating policy-relevant findings.

Alongside his applied research, Baron-Cohen’s team also conducts basic research. Autism starts prenatally and is partly but not completely genetic. For decades it was unclear what other factors might contribute to the cause of autism. Over the past 20 years Baron-Cohen made two big discoveries which have helped understand what causes autism. First, his team found elevated levels of prenatal androgens (sex hormones such as testosterone) in pregnancies that later resulted in autism. Second, they found that prenatal oestrogens (another group of sex hormones which are synthesised from androgens) levels were also elevated in pregnancies resulting in autism. 

Autism is an example of neurodiversity. Autistic individuals’ brains develop differently, from before birth. Some of these differences result in disability, for example, in social skills and communication. But others result in strengths or talents. For example, many autistic people have excellent memory for facts and excellent attention to detail. And many are strongly attracted to patterns. Baron-Cohen’s recent book The Pattern Seekers celebrates autistic people’s different minds. In many environments, such skills are assets. In his research group, he employs neurodivergent individuals.

Baron-Cohen will receive the prestigious medal, specially created by The Royal Mint, and will be listed amongst the most highly influential and impactful researchers in the UK. He will deliver a lecture about his research, and his achievements will be celebrated at an Awards Ceremony on 20 June 2024 in the Law Society where he will receive the medal.

On receiving the news that he was to be awarded the MRC Millennium Medal, Baron-Cohen said: “This is the result of team work and I am fortunate to be surrounded by a talented team of scientists. I hope this Medal shines a light on how autistic people need a lot more support, from the earliest point, to lead fulfilling lives.”

The UKRI Medical Research Council (MRC) in the UK will today present the MRC Millennium Medal 2023 to Professor Sir Simon Baron-Cohen, in recognition of his pioneering MRC-funded research into the prenatal sex steroid theory of autism, his establishment of the Autism Research Centre at the University of Cambridge, and his work in the public understanding of neurodiversity.

I hope this Medal shines a light on how autistic people need a lot more support, from the earliest point, to lead fulfilling lives

Simon Baron-Cohen

Professor Sir Simon Baron-Cohen

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Yes

The Chancellor, Lord Sainsbury of Turville, presided over a special congregation at the Senate House which was attended by around 400 staff, students, alumni and invited guests. The honorary graduands this year were:

Professor Dame Carol Black (Doctor of Medical Science) – From 2012-2019 Dame Carol was Principal of Newnham College and is now an Honorary Fellow of both Newnham and Lucy Cavendish Colleges. A clinician and medical scientist, Carol is a rheumatologist and renowned authority on the condition scleroderma. She was President of the Royal College of Physicians and has advised the UK Government on areas of public health policy.

Professor Stephen Stahl (Doctor of Medical Science) – A psychiatrist and psychopharmacologist, Stephen is Clinical Professor of Health Sciences at the University of California Riverside, US. He is a former Visiting Fellow of Clare Hall and Honorary Fellow in the Department of Psychiatry.

Professor Adele Diamond (Doctor of Science) – A world leading neuroscientist, Adele is Professor of Developmental Cognitive Neuroscience at the University of British Colombia, Canada. Her work has led to improvements in treatments for children with attention deficit hyperactivity disorder (ADHD). She is a Fellow of the Royal Society of Canada.

Professor Dame Carol Robinson (Doctor of Science)– Carol is Dr Lee's Professor of Chemistry at the University of Oxford and founding director of the Kavli Institute for Nanoscience Discovery. Formerly President of the Royal Society of Chemistry she is an alumna and an Honorary Fellow of Churchill College.

Professor Kip Thorne (Doctor of Science) – Kip is Richard P Feynman Professor of Theoretical Physics Emeritus at the California Institute of Technology (Caltech), US. In 2017 he was jointly awarded the Nobel Prize in Physics. He is also a winner of the Kavli Prize in Astrophysics and a celebrated author.

Professor The Hon Michael Ignatieff (Doctor of Letters) – A historian, writer and broadcaster, Michael is also a former politician having led the Liberal Party in his native Canada from 2008 to 2011. A member of the Canadian Privy Council and the Order of Canada he has won the Heinemann, Orwell and Dan David Prizes.

Murray Perahia (Doctor of Music) – Murray is a world-renowned pianist whose interpretations of Brahms, Beethoven, Chopin and Schubert have gained great acclaim. He is Principal Guest Conductor of the Academy of St Martin-in-the-Fields and the winner of three Grammy Awards. He was appointed an Honorary KBE in 2004 and is an Honorary Fellow of Jesus College.

Kip Thorne summed up the day:

"Early in my career the 3 places which were the most important to me in terms of the colleagues I had were Cambridge, Moscow and the place I came from, Princeton. Cambridge, being home to good friends like Stephen Hawking and Martin Rees, was a special place...for me this is just tremendous to receive this honour from the place that has had such a big impact on my career."

And Dame Carol Black said:

"It almost feels unreal...I'm just so pleased and humbled by it. Nothing better could have happened to me. I'm not a Cambridge or Oxford graduate so I never thought this would happen. This is such a wonderful day and it's been lovely to see some of the people I knew when I was here as Head of House."

 

 

The University has conferred honorary degrees to seven distinguished individuals in recognition of the achievements they have made in their respective fields. An honorary doctorate is the highest accolade the University can bestow. 

This is just tremendous to receive this honour from the place that has had such a big impact on my career

Kip Thorne

Honorary graduands

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Yes

Echion, a Cambridge University spinout headquartered just outside the city, has invented and patented a niobium-based anode material, XNO®, for use with re-chargeable lithium-ion batteries. The material enables the lithium-ion batteries to safely charge in less than ten minutes, last for more than 10,000 cycles and not lose power in extreme cold or hot temperatures.  

By improving the power density and thermal stability of lithium-ion batteries, XNO® extends their lifespan. Batteries using XNO®  have been shown to have a lower environmental impact than those based on other commonly used materials such as graphite. Graphite is the dominant anode material, with over 90% market share, due to its high energy density and low cost. But for fast charging, graphite-based cells are limited in maximum charge rate compared to XNO® based cells. XNO®’s higher capacity retention and cycle life when charging, across a wider temperature range, boosts available battery capacity. Despite the same volume and weight, higher total energy delivered across the lifetime of the battery lowers total cost of ownership.

The £29 million investment will mean Echion’s XNO® anode material can start to be used in real-world applications, such as battery electric and hybrid trains, mining haul trucks, opportunity-charging e-buses, heavy-duty industrial transport and delivery vehicles.

Echion’s longstanding partnership with the world’s leading producer of niobium, CBMM, will see the opening of a 2,000 tonne per year XNO® manufacturing facility in 2024. This will provide Echion with the manufacturing capacity to supply its global customer base of major cell manufacturers and original equipment manufacturers (OEMs).

The investment round was led by specialist battery and energy storage technology investor Volta Energy Technologies (Volta), with participation from existing investors CBMM, BGF and Cambridge Enterprise Ventures.

Jean de La Verpilliere, CEO of Echion Technologies, said: “Our ambition is to deliver the best fast-charging batteries to unlock the electrification of heavy-duty vehicles. The investment from our partners Volta Energy Technologies, CBMM, BGF and Cambridge Enterprise Ventures cements our ambition to achieve full-scale commercialisation and full production volume.

“The entire Echion team has worked tirelessly to develop our flagship XNO® material into what it is today and this has enabled us to establish partnerships with many major OEMs and cell manufacturers which have recognised the benefits of our materials. I look forward to being able to satisfy their demand for innovative niobium-based anode materials, and to see industrial and commercial applications powered by XNO®.”

Dr Jeff Chamberlain, CEO and Founder of Volta Energy Technologies, said: “We are excited to lead Echion’s Series B and make Volta’s first investment in Europe. Echion and their XNO® technology complements our growing portfolio of technologies that address significant market needs through innovations in the supply chains of battery and energy storage technology. We believe the power of XNO® can uniquely improve performance, lower cost, and meet the demands of the growing, international markets across mining, logistics, railways, automotive and more.”

Rodrigo Barjas Amado, Managing Partner and Commercial Head of Battery Program at CBMM, said: “Having invested in Echion since 2021, we are pleased to see the progress that has been made through our partnership so far and we are proud to support bringing this ground-breaking, niobium-based technology to the market with our 2,000 tonne per year manufacturing capacity.”

Dennis Atkinson, Investor at BGF, said: “Echion is a world class UK based battery technology business. We are proud to have them as part of our climate and deeptech portfolio, and excited to support the team and their XNO® technology in electrifying and decarbonising heavy transport.”

"Echion is entering the market with their next generation battery material at scale. This is a great team that has combined great technology, great talent, great partners and great money for their go-to-market journey. We’re pleased to have been with Echion from the start and to continue our relationship into this B round with a terrific syndicate of co-investors,” says Chris Gibbs, Investment Director, Cambridge Enterprise Ventures.

Adapted from media release published by Cambridge Enterprise.

Cambridge spinout, Echion Technologies has raised £29 million in investment capital to help it increase the production of its fast-charging, long-life battery material based on niobium.

Echion Technologies senior management team (L-R: Dr Alex Groombridge, Chief Technology Officer, Dr Sarah Stevenson, Chief Operating Officer, Jean de La Verpilliere, Chief Executive Officer, Ceri Neal, Chief Financial Officer, and Benjamin Ting, Chief Comm

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Yes

This overturns the traditional thinking that regulatory T cells exist as multiple specialist populations that are restricted to specific parts of the body. The finding has implications for the treatment of many different diseases – because almost all diseases and injuries trigger the body’s immune system.

Current anti-inflammatory drugs treat the whole body, rather than just the part needing treatment. The researchers say their findings mean it could be possible to shut down the body’s immune response and repair damage in any specific part of the body, without affecting the rest of it. This means that higher, more targeted doses of drugs could be used to treat disease – potentially with rapid results.

“We’ve uncovered new rules of the immune system. This ‘unified healer army’ can do everything - repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.  To think that we could use it in such an enormous range of diseases is fantastic: it’s got the potential to be used for almost everything,” said Professor Adrian Liston in the University of Cambridge’s Department of Pathology, senior author of the paper.

To reach this discovery, the researchers analysed the regulatory T cells present in 48 different tissues in the bodies of mice. This revealed that the cells are not specialised or static, but move through the body to where they’re needed. The results are published today in the journal Immunity.

“It's difficult to think of a disease, injury or infection that doesn’t involve some kind of immune response, and our finding really changes the way we could control this response,” said Liston.

He added: “Now that we know these regulatory T cells are present everywhere in the body, in principle we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ – a vast improvement on current treatments that are like hitting the body with a sledgehammer.”

Using a drug they have already designed, the researchers have shown - in mice - that it’s possible to attract regulatory T cells to a specific part of the body, increase their number, and activate them to turn off the immune response and promote healing in just one organ or tissue.

“By boosting the number of regulatory T cells in targeted areas of the body, we can help the body do a better job of repairing itself, or managing immune responses,” said Liston.

He added: “There are so many different diseases where we’d like to shut down an immune response and start a repair response, for example autoimmune diseases like multiple sclerosis, and even many infectious diseases.”

Most symptoms of infections such as COVID are not from the virus itself, but from the body’s immune system attacking the virus. Once the virus is past its peak, regulatory T cells should switch off the body’s immune response, but in some people the process isn’t very efficient and can result in ongoing problems. The new finding means it could be possible to use a drug to shut down the immune response in the patient’s lungs, while letting the immune system in the rest of the body continue to function normally.

In another example, people who receive organ transplants must take immuno-suppressant drugs for the rest of their lives to prevent organ rejection, because the body mounts a severe immune response against the transplanted organ. But this makes them highly vulnerable to infections. The new finding helps the design of new drugs to shut down the body’s immune response against only the transplanted organ but keep the rest of the body working normally, enabling the patient to lead a normal life.

Most white blood cells attack infections in the body by triggering an immune response. In contrast, regulatory T cells act like a ‘unified healer army’ whose purpose is to shut down this immune response once it has done its job - and repair the tissue damage caused by it.

The researchers are now fundraising to set up a spin-out company, with the aim of running clinical trials to test their findings in humans within the next few years.

The research was funded by the European Research Council (ERC), Wellcome, and the Biotechnology and Biological Sciences Research Council (BBSRC).

Reference: Liston, A. ‘The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program.’ Immunity, June 2024. DOI: 10.1016/j.immuni.2024.05.023

Scientists at the University of Cambridge have discovered that a type of white blood cell - called a regulatory T cell - exists as a single large population of cells that constantly move throughout the body looking for, and repairing, damaged tissue.

It's difficult to think of a disease, injury or infection that doesn’t involve some kind of immune response, and our finding really changes the way we could control this response.

Adrian Liston

Dr James Dooley, a senior author of the study, in the laboratory

In brief

• A single large population of healer cells, called regulatory T cells, is whizzing around our body - not multiple specialist populations restricted to specific parts of the body as previously thought.
• These cells shut down inflammation and repair the collateral damage to cells caused after our immune system has responded to injury or illness.
• Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activated to suppress immune response and rebuild tissue.
• Current anti-inflammatory drugs used for this purpose suppress the body’s whole immune system, making patients more vulnerable to infection.
• The discovery could lead to more targeted treatments, with fewer side-effects, for issues from lengthy COVID infections to autoimmune diseases like multiple sclerosis. Clinical trials in humans are now planned.

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Yes

Professor Tony Kouzarides, Professor of Cancer Biology, Senior Group Leader at the Gurdon Institute and Director and Co-Founder of the Milner Institute, has been awarded a Knighthood for his services to Healthcare Innovation and Delivery. Professor Kouzarides said: “I am delighted to receive this honour, which reinforces the importance of translating basic research into therapies by engaging academic researchers with healthcare businesses.”

Professor Barbara Sahakian, Professor of Clinical Neuropsychology in the Department of Psychiatry and a Fellow at Clare Hall, receives a CBE. Professor Sahakian, who is known for her research aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments, is honoured for her services to Research in Human Cognitive Processes. Professor Sahakian said: “I am delighted to receive this prestigious award, which recognises my research on human cognitive processes in health, psychiatric disorders and neurological diseases. I am grateful to my PhD students, postdoctoral fellows and colleagues for their collaboration."

Professor Christine Holt, Professor of Developmental Neuroscience, receives a CBE for services to Neuroscience. Professor Holt said: "I'm surprised and thrilled to receive this honour. It's a marvellous recognition of the research that has involved a whole team of talented, dedicated and inspiring colleagues over many years."

Professor David Menon, founder of the Neurosciences Critical Care Unit (NCCU) at Addenbrooke’s Hospital, has been awarded a CBE. Professor Menon, who is noted for his national and global clinical and research leadership in traumatic brain injury, is honoured for his services to Neurocritical Care. He said: “I am deeply honoured to be nominated for a CBE and accept it on behalf of all those who have worked with me, during what has been – and continues to be – a very rewarding career.”

Professor Patrick Maxwell, Regius Professor of Physic and Head of School of Clinical Medicine, receives a CBE for services to Medical Research.

Professor Peter John Clarkson, Director of Cambridge Engineering Design Centre and Co-Director of Cambridge Public Health, receives a CBE. Professor Clarkson, who is known for his research in health and care improvement, inclusive design and systems design, is honoured for his services to Engineering and Design. Professor Clarkson said “I am delighted to receive this honour and thank all those extraordinary people I have had the pleasure to work with over the years who have supported me in so many interesting and transformative projects.”

Alexandra Bolton, Director of the Climate Governance Initiative, is awarded an OBE for services to the Built and Natural Environment. Alexandra said: "This wonderful and humbling recognition makes me in turn recognise the talented people who, throughout my career, have selflessly given me support, guidance and advice. I am enormously grateful for the honour, and for all those who have helped me along the way."

Professor Anne-Christine Davis, Professor of Mathematical Physics, receives an OBE for services to Higher Education and to Scientific Research. Professor Davis said: "I am amazed and overwhelmed to receive this honour. I could not have done it alone and wish to thank my wonderful students and collaborators over the years. I would like to dedicate this honour to those women in STEMM who came before me and did not receive the recognition they deserved."

Professor Shruti Kapila, Professor of History and Politics receives an OBE for services to Research in Humanities.

Paul Fannon, Lecturer in Machine Learning in the Department of Genetics, Director of Studies at Jesus College and Fellow at Christ's College receives an OBE for services to Education.

Details of University alumni who are recognised in the King's Birthday Honours will be published on www.alumni.cam.ac.uk.

The University extends its congratulations to all academics, staff and alumni who have received an honour.

Academics and staff from the University of Cambridge are featured in the King's Birthday Honours 2024, which recognises the achievements and service of people across the UK, from all walks of life.

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Yes

When Eyjafjallajökull erupted in 2010, it ejected roughly 250 million tonnes of volcanic ash into the atmosphere: much of which was blown over Europe and into flight paths. With planes grounded, millions of air passengers were left stranded.

Forecasts of how ash will spread in the aftermath of an explosive eruption can help reduce impacts to aviation by informing decisions to shut down areas of airspace. But these forecasts require knowledge of what is happening at the volcano, information that often can’t be obtained directly and must instead be estimated.

In the new study, the researchers split a 17-minute film into time segments to understand how the Eyjafjallajökull ash cloud grew upwards and outwards as the eruption ensued.

“No one has previously observed the shape and speed of wind-blown ash clouds directly,” said Professor Andy Woods, lead author of the study from Cambridge’s Department of Earth Sciences and Institute for Energy and Environmental Flows. Their new video analysis method was reported in Nature Communications Earth and Environment.

By comparing characteristics of the ash cloud, such as its shape and speed, at time intervals through the video, the researchers were able to calculate the amount of ash spewed from the volcano.

That rate of ash flow, called eruption rate, is an important metric for forecasting ash cloud extent, said Woods. “The eruption rate determines how much ash goes up into the atmosphere, how high the ash cloud will go, how long the plume will stay buoyant, how quickly the ash will start falling to the ground and the area over which ash will land.”

Generally, the higher the ash plume, the wider the ash will be dispersed, and the smaller the ash particles are, the longer they stay buoyant. This dispersal can also depend on weather conditions, particularly the wind direction.

Volcanoes across the world are increasingly monitored via video, using webcams or high-resolution cameras. Woods thinks that, if high frame rate video observations can be accessed during an eruption, then this real-time information could be fed into ash cloud forecasts that more realistically reflect changing eruption conditions.

During the 17-minute footage of the Eyjafjallajökull eruption, the researchers observed that the eruption rate dropped by about half. “It’s amazing that you can learn eruption rate from a video, that’s something that we’ve previously only been able to calculate after an eruption has happened,” said Woods. “It’s important to know the changing eruption rate because that could impact the ash cloud dispersal downwind.”

It’s usually challenging for volcanologists to take continuous measurements of ash clouds whilst an eruption is happening. "Instead, much of our understanding of how ash clouds spread in the atmosphere is based on scaled-down lab models,” said Dr Nicola Mingotti, a researcher in Woods’ group and co-author of this study. These experiments are performed in water tanks, by releasing particle-laden or dyed saline solutions and analysing footage of the plume as it dissipates.

Woods and his collaborators have been running lab experiments like these for several years, most recently trying to understand how eruption plumes are dragged along by the wind. But it’s a big bonus to have video measurements from a real eruption, said Woods, and the real observations agree closely with what they’ve been observing in the lab. “Demonstrating our lab experiments are realistic is really important, both for making sure we understand how ash plumes work and that we forecast their movements effectively.”

Reference:
Mingotti, N, and Woods, A W (2024). Video-based measurements of the entrainment, speed and mass flux in a wind-blown eruption column. Communications Earth & Environment (2024). DOI: 10.1038/s43247-024-01402-x

 

Video footage of Iceland’s 2010 Eyjafjallajökull eruption is providing researchers from the University of Cambridge with rare, up-close observations of volcanic ash clouds — information that could help better forecast how far explosive eruptions disperse their hazardous ash particles.

Eruption at Eyjafjallajökull April 17, 2010.

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Yes

In pausing to think before making an important decision, we may imagine the potential outcomes of different choices we could make. While this ‘mental simulation’ is central to how we plan and make decisions in everyday life, how the brain works to accomplish this is not well understood. 

An international team of scientists has now uncovered neural mechanisms used in planning. Their results, published in the journal Nature Neuroscience, suggest that an interplay between the brain’s prefrontal cortex and hippocampus allows us to imagine future outcomes to guide our decisions.

“The prefrontal cortex acts as a ‘simulator,’ mentally testing out possible actions using a cognitive map stored in the hippocampus,” said co-author Marcelo Mattar from New York University. “This research sheds light on the neural and cognitive mechanisms of planning—a core component of human and animal intelligence. A deeper understanding of these brain mechanisms could ultimately improve the treatment of disorders affecting decision-making abilities.”

The roles of both the prefrontal cortex—used in planning and decision-making—and hippocampus—used in memory formation and storage—have long been established. However, their specific duties in deliberative decision-making, which are the types of decisions that require us to think before acting, are less clear.

To illuminate the neural mechanisms of planning, Mattar and his colleagues—Kristopher Jensen from University College London and Professor Guillaume Hennequin from Cambridge’s Department of Engineering —developed a computational model to predict brain activity during planning. They then analysed data from both humans and rats to confirm the validity of the model—a recurrent neural network (RNN), which learns patterns based on incoming information. 

The model took into account existing knowledge of planning and added new layers of complexity, including ‘imagined actions,’ thereby capturing how decision-making involves weighing the impact of potential choices—similar to how a chess player envisions sequences of moves before committing to one. These mental simulations of potential futures, modelled as interactions between the prefrontal cortex and hippocampus, enable us to rapidly adapt to new environments, such as taking a detour after finding a road is blocked.

The scientists validated this computational model using both behavioural and neural data. To assess the model’s ability to predict behaviour, the scientists conducted an experiment measuring how humans navigated an online maze on a computer screen and how long they had to think before each step.

To validate the model’s predictions about the role of the hippocampus in planning, they analysed neural recordings from rodents navigating a physical maze configured in the same way as in the human experiment. By giving a similar task to humans and rats, the researchers could draw parallels between the behavioural and neural data—an innovative aspect of this research.

“Allowing neural networks to decide for themselves when to 'pause and think' was a great idea, and it was surprising to see that in situations where humans spend time pondering what to do next, so do these neural networks,” said Hennequin. 

The experimental results were consistent with the computational model, showing an intricate interaction between the prefrontal cortex and hippocampus. In the human experiments, participants’ brain activity reflected more time thinking before acting in navigating the maze. In the experiments with laboratory rats, the animals’ neural responses in moving through the maze resembled the model’s simulations.

“Overall, this work provides foundational knowledge on how these brain circuits enable us to think before we act in order to make better decisions,” said Mattar. “In addition, a method in which both human and animal experimental participants and RNNs were all trained to perform the same task offers an innovative and foundational way to gain insights into behaviours.”

“This new framework will enable systematic studies of thinking at the neural level,” said Hennequin. “This will require a concerted effort from neurophysiologists and theorists, and I'm excited about the discoveries that lie ahead.” 

Reference:
Kristopher T. Jensen, Guillaume Hennequin & Marcelo G. Mattar. ‘A recurrent network model of planning explains hippocampal replay and human behavior.’ Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01675-7

Adapted from an NYU press release.

Study uncovers how the brain simulates possible future actions by drawing from our stored memories.

Metaverse portrait

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Yes

Using the James Webb Space Telescope (JWST), an international team of astronomers led by the University of Cambridge observed a very young galaxy in the early universe and found that it contained surprising amounts of carbon, one of the seeds of life as we know it.

In astronomy, elements heavier than hydrogen or helium are classed as metals. The very early universe was almost entirely made up of hydrogen, the simplest of the elements, with small amounts of helium and tiny amounts of lithium.

Every other element that makes up the universe we observe today was formed inside a star. When stars explode as supernovas, the elements they produce are circulated throughout their host galaxy, seeding the next generation of stars. With every new generation of stars and ‘stardust’, more metals are formed, and after billions of years, the universe evolves to a point where it can support rocky planets like Earth and life like us.

The ability to trace the origin and evolution of metals will help us understand how we went from a universe made almost entirely of just two chemical elements, to the incredible complexity we see today.

“The very first stars are the holy grail of chemical evolution,” said lead author Dr Francesco D’Eugenio, from the Kavli Institute for Cosmology at Cambridge. “Since they are made only of primordial elements, they behave very differently to modern stars. By studying how and when the first metals formed inside stars, we can set a time frame for the earliest steps on the path that led to the formation of life.”

Carbon is a fundamental element in the evolution of the universe, since it can form into grains of dust that clump together, eventually forming into the first planetesimals and the earliest planets. Carbon is also key for the formation of life on Earth.

“Earlier research suggested that carbon started to form in large quantities relatively late – about one billion years after the Big Bang,” said co-author Professor Roberto Maiolino, also from the Kavli Institute. “But we’ve found that carbon formed much earlier – it might even be the oldest metal of all.”

The team used the JWST to observe a very distant galaxy – one of the most distant galaxies yet observed – just 350 million years after the Big Bang, more than 13 billion years ago. This galaxy is compact and low mass – about 100,000 times less massive than the Milky Way.

“It’s just an embryo of a galaxy when we observe it, but it could evolve into something quite big, about the size of the Milky Way,” said D’Eugenio. “But for such a young galaxy, it’s fairly massive.”

The researchers used Webb’s Near Infrared Spectrograph (NIRSpec) to break down the light coming from the young galaxy into a spectrum of colours. Different elements leave different chemical fingerprints in the galaxy’s spectrum, allowing the team to determine its chemical composition. Analysis of this spectrum showed a confident detection of carbon, and tentative detections of oxygen and neon, although further observations will be required to confirm the presence of these other elements.

“We were surprised to see carbon so early in the universe, since it was thought that the earliest stars produced much more oxygen than carbon,” said Maiolino. “We had thought that carbon was enriched much later, through entirely different processes, but the fact that it appears so early tells us that the very first stars may have operated very differently.” 

According to some models, when the earliest stars exploded as supernovas, they may have released less energy than initially expected. In this case, carbon, which was in the stars’ outer shell and was less gravitationally bound than oxygen, could have escaped more easily and spread throughout the galaxy, while a large amount of oxygen fell back and collapsed into a black hole.

“These observations tell us that carbon can be enriched quickly in the early universe,” said D’Eugenio. “And because carbon is fundamental to life as we know it, it’s not necessarily true that life must have evolved much later in the universe. Perhaps life emerged much earlier – although if there’s life elsewhere in the universe, it might have evolved very differently than it did here on Earth.”

The results have been accepted for publication in the journal Astronomy & Astrophysics and are based on data obtained within the JWST Advanced Deep Extragalactic Survey (JADES).

The research was supported in part by the European Research Council, the Royal Society, and the Science and Technology Facilities Council (STFC), part of UK Research and Innovation (UKRI).

 

Reference:
Francesco D’Eugenio et al. ‘JADES: Carbon enrichment 350 Myr after the Big Bang.’ Astronomy & Astrophysics (in press). DOI: 10.48550/arXiv.2311.09908

Astronomers have detected carbon in a galaxy just 350 million years after the Big Bang, the earliest detection of any element in the universe other than hydrogen.

Deep field image from JWST

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Yes

The ANDES instrument will be installed on ESO’s Extremely Large Telescope (ELT), currently under construction in Chile’s Atacama Desert. It will be used to search for signs of life in exoplanets and look for the very first stars. It will also test variations of the fundamental constants of physics and measure the acceleration of the Universe’s expansion.

The University of Cambridge is a member institution on the project, which involves scientists from 13 countries. Professor Roberto Maiolino, from Cambridge’s Cavendish Laboratory and Kavli Institute for Cosmology, is ANDES Project Scientist.  

Formerly known as HIRES, ANDES is a powerful spectrograph, an instrument which splits light into its component wavelengths so astronomers can determine properties about astronomical objects, such as their chemical compositions. The instrument will have a record-high wavelength precision in the visible and near-infrared regions of light and, when working in combination with the powerful mirror system of the ELT, it will pave the way for research spanning multiple areas of astronomy.

“ANDES is an instrument with an enormous potential for groundbreaking scientific discoveries, which can deeply affect our perception of the Universe far beyond the small community of scientists,” said Alessandro Marconi, ANDES Principal Investigator.

ANDES will conduct detailed surveys of the atmospheres of Earth-like exoplanets, allowing astronomers to search extensively for signs of life. It will also be able to analyse chemical elements in faraway objects in the early Universe, making it likely to be the first instrument capable of detecting signatures of Population III stars, the earliest stars born in the Universe.

In addition, astronomers will be able to use ANDES’ data to test if the fundamental constants of physics vary with time and space. Its comprehensive data will also be used to directly measure the acceleration of the Universe’s expansion, one of the most pressing mysteries about the cosmos.

When operations start later this decade, the ELT will be the world’s biggest eye on the sky, marking a new age in ground-based astronomy.

Adapted from an ESO press release. 

The European Southern Observatory (ESO) has signed an agreement for the design and construction of ANDES, the ArmazoNes high Dispersion Echelle Spectrograph.

Artist's impression of the ANDES instrument

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Yes